2024
Magnetic resonance imaging of regional gray matter volume in persons who died by suicide
Deininger-Czermak E, Spencer L, Zoelch N, Sankar A, Gascho D, Guggenberger R, Mathieu S, Thali M, Blumberg H. Magnetic resonance imaging of regional gray matter volume in persons who died by suicide. Molecular Psychiatry 2024, 1-5. PMID: 39237718, DOI: 10.1038/s41380-024-02730-2.Peer-Reviewed Original ResearchGray matter volumeMatter volumeBrain regionsIn vivo neuroimaging researchRegional gray matter volumeGray matter volume measurementsBrain voxel-based analysisStudy of suicideEmotion regulationNeuroimaging researchSuicide attemptsSelf-perceptionSuicideCompare personsMagnetic resonance imagingSuicide deathsPersonsBrainAmygdalaInsulaStriatumNeuroimagingMotivationIndividualsHypothesis
2022
Aging of the brain in bipolar disorder: Illness- and onset-related effects in cortical thickness and subcortical gray matter volume
Villa L, Colic L, Kim J, Sankar A, Goldman D, Lessing B, Pittman B, Alexopoulos G, van Dyck C, Blumberg H. Aging of the brain in bipolar disorder: Illness- and onset-related effects in cortical thickness and subcortical gray matter volume. Journal Of Affective Disorders 2022, 323: 875-883. PMID: 36526112, PMCID: PMC9839524, DOI: 10.1016/j.jad.2022.12.026.Peer-Reviewed Original ResearchConceptsGray matter volumeOccipital cortical thicknessSubcortical gray matter volumesCortical thicknessBipolar disorderMatter volumeOlder adultsOnset of BDIndividuals age 40Striatal gray matter volumeGray matter reductionsOnset bipolar disorderGray matter decreasesPrefrontal cortical thicknessStructural brain differencesHigh suicide riskCross-sectional designHealthy controlsCognitive dysfunctionTreatment resistanceAge 40Striatal volumeSevere symptomsSuicide attempt historySuicide attempts
2018
Preliminary examination of gray and white matter structure and longitudinal structural changes in frontal systems associated with future suicide attempts in adolescents and young adults with mood disorders
Lippard ETC, Johnston JAY, Spencer L, Quatrano S, Fan S, Sankar A, Weathers J, Pittman B, Oquendo MA, Blumberg HP. Preliminary examination of gray and white matter structure and longitudinal structural changes in frontal systems associated with future suicide attempts in adolescents and young adults with mood disorders. Journal Of Affective Disorders 2018, 245: 1139-1148. PMID: 30699858, PMCID: PMC6487887, DOI: 10.1016/j.jad.2018.11.097.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAnisotropyBipolar DisorderCross-Sectional StudiesDepressive Disorder, MajorDiffusion Tensor ImagingFemaleFrontal LobeGray MatterGyrus CinguliHumansInternal CapsuleMagnetic Resonance ImagingMaleMood DisordersPrefrontal CortexSuicidal IdeationSuicide, AttemptedWhite MatterYoung AdultConceptsMood disordersGray matter volumeLongitudinal structural changesSuicide-related behaviorsFuture suicide attemptsFractional anisotropyWhite matter structuresMatter volumeWhite matterSuicide attemptsHigh-resolution structural magnetic resonance imagingYoung adultsWhite matter fractional anisotropyMajor risk factorStructural magnetic resonance imagingCross-sectional studyFrontal white matterPrefrontal gray matter volumeMatter structuresMagnetic resonance imagingDiffusion tensor imagingInternal capsuleRisk factorsAnterior limbPrevention strategies
2017
Multimodal Neuroimaging of Frontolimbic Structure and Function Associated With Suicide Attempts in Adolescents and Young Adults With Bipolar Disorder
Johnston JAY, Wang F, Liu J, Blond BN, Wallace A, Liu J, Spencer L, Cox Lippard ET, Purves KL, Landeros-Weisenberger A, Hermes E, Pittman B, Zhang S, King R, Martin A, Oquendo MA, Blumberg HP. Multimodal Neuroimaging of Frontolimbic Structure and Function Associated With Suicide Attempts in Adolescents and Young Adults With Bipolar Disorder. American Journal Of Psychiatry 2017, 174: 667-675. PMID: 28135845, PMCID: PMC5939580, DOI: 10.1176/appi.ajp.2016.15050652.Peer-Reviewed Original ResearchConceptsGray matter volumeBipolar disorderWhite matter integrityFunctional connectivityMatter volumeSuicide attemptsAttempt lethalityPrefrontal connectivitySuicidal ideationYoung adult suicide attemptersAmygdala-prefrontal functional connectivityYoung adultsAmygdala functional connectivitySuicide-related symptomsAdult suicide attemptersPrior suicide attemptsRegional gray matter volumeFrontolimbic structuresNonattempter groupFrontolimbic systemsHigh riskSignificant negative correlationFunctional MROrbitofrontal cortexSuicidal behavior
2006
Age, Rapid-Cycling, and Pharmacotherapy Effects on Ventral Prefrontal Cortex in Bipolar Disorder: A Cross-Sectional Study
Blumberg HP, Krystal JH, Bansal R, Martin A, Dziura J, Durkin K, Martin L, Gerard E, Charney DS, Peterson BS. Age, Rapid-Cycling, and Pharmacotherapy Effects on Ventral Prefrontal Cortex in Bipolar Disorder: A Cross-Sectional Study. Biological Psychiatry 2006, 59: 611-618. PMID: 16414030, DOI: 10.1016/j.biopsych.2005.08.031.Peer-Reviewed Original ResearchConceptsHealthy comparison subjectsWhite matter volumeMagnetic resonance imagingMatter volumeBD patientsHigh-resolution structural magnetic resonance imagingYoung adulthoodStructural magnetic resonance imagingTotal brain volumeCross-sectional studyGray matter volumeAge group interactionVentral prefrontal cortexPharmacotherapy effectsPrefrontal cortex functionIllness featuresBD IProtective effectVolume abnormalitiesHC subjectsComparison subjectsBrain volumeVolume deficitsBipolar disorderRapid initial decline