2017
Effects of Selective Serotonin Reuptake Inhibitors on Interregional Relation of Serotonin Transporter Availability in Major Depression
James GM, Baldinger-Melich P, Philippe C, Kranz GS, Vanicek T, Hahn A, Gryglewski G, Hienert M, Spies M, Traub-Weidinger T, Mitterhauser M, Wadsak W, Hacker M, Kasper S, Lanzenberger R. Effects of Selective Serotonin Reuptake Inhibitors on Interregional Relation of Serotonin Transporter Availability in Major Depression. Frontiers In Human Neuroscience 2017, 11: 48. PMID: 28220069, PMCID: PMC5292566, DOI: 10.3389/fnhum.2017.00048.Peer-Reviewed Original ResearchSelective serotonin reuptake inhibitorsPositron emission tomographySerotonin reuptake inhibitorsMajor depressive disorderHealthy controlsReuptake inhibitorsSerotonergic neurotransmissionBrain regionsState functional magnetic resonance imaging studySerotonin transporterMagnetic resonance imaging studyReuptake of serotoninSerotonin transporter availabilityResonance imaging studyFunctional magnetic resonance imaging studyAnterior cingulate cortexSSRI doseAntidepressant effectsAntidepressant treatmentClinical outcomesSSRI administrationMDD patientsDepressive disorderMajor depressionMDD pathophysiology
2015
Interaction between 5-HTTLPR and 5-HT1B genotype status enhances cerebral 5-HT1A receptor binding
Baldinger P, Kraus C, Rami-Mark C, Gryglewski G, Kranz GS, Haeusler D, Hahn A, Spies M, Wadsak W, Mitterhauser M, Rujescu D, Kasper S, Lanzenberger R. Interaction between 5-HTTLPR and 5-HT1B genotype status enhances cerebral 5-HT1A receptor binding. NeuroImage 2015, 111: 505-512. PMID: 25652393, DOI: 10.1016/j.neuroimage.2015.01.049.Peer-Reviewed Original ResearchConceptsPositron emission tomographySerotonin transporterSerotonin releaseRespective projection areasReuptake of serotoninExtracellular serotonin concentrationBilateral parahippocampal gyrusComplex receptor interactionsProtein expression levelsProjection areaSerotonin 1ASerotonergic transmissionSerotonergic effectsSerotonin concentrationsSerotonergic toneRaphe regionSerotonergic neurotransmissionWhole-brain ANOVAReceptor expressionSerotonergic systemSerotonin systemGenotype statusHealthy subjectsSerotonergic structuresParahippocampal gyrus