1994
Noradrenergic and adrenergic functioning in autism
Minderaa R, Anderson G, Volkmar F, Akkerhuis G, Cohen D. Noradrenergic and adrenergic functioning in autism. Biological Psychiatry 1994, 36: 237-241. PMID: 7986888, DOI: 10.1016/0006-3223(94)90605-x.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAnticonvulsantsAutistic DisorderBrainChildEpinephrineFemaleHaloperidolHumansMaleMethoxyhydroxyphenylglycolNorepinephrinePhenothiazinesVanilmandelic AcidConceptsUrinary excretion rateNeurochemical assessmentVanillylmandelic acidAdrenergic functioningExcretion rateNormal control individualsUrinary excretionPlasma levelsNoradrenergic functioningMarked abnormalitiesNormal controlsGroup mean differencesControl groupControl individualsNorepinephrineMean differenceAutistic patients
1988
Plasma MHPG: Within- and across-day stability in children and adults with tourette's syndrome
Riddle M, Leckman J, Anderson G, Ort S, Hardin M, Stevenson J, Cohen D. Plasma MHPG: Within- and across-day stability in children and adults with tourette's syndrome. Biological Psychiatry 1988, 24: 391-398. PMID: 2457395, DOI: 10.1016/0006-3223(88)90175-8.Peer-Reviewed Original ResearchTourette's Syndrome: Clinical and Neurochemical Correlates
RIDDLE M, LECKMAN J, ANDERSON G, ORT S, HARDIN M, STEVENSON J, COHEN D. Tourette's Syndrome: Clinical and Neurochemical Correlates. Journal Of The American Academy Of Child & Adolescent Psychiatry 1988, 27: 409-412. PMID: 3182595, DOI: 10.1097/00004583-198807000-00004.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultChildFemaleGlycolsHomovanillic AcidHumansMaleMethoxyhydroxyphenylglycolMiddle AgedPsychological TestsTourette SyndromeConceptsTourette Syndrome Global ScalePHVA levelsTourette syndromeTS patientsLower CSF HVA levelsPlasma homovanillic acid levelsSimple motor ticsHomovanillic acid levelsCSF HVA levelsSignificant inverse correlationHVA levelsMotor restlessnessMotor ticsPretreatment levelsTotal symptomsNeurochemical correlatesTreatment responsePlasma 3Control groupPatientsSyndromeAcid levelsInverse correlationSignificant correlationIndividual items
1986
Rebound Phenomena in Tourette's Syndrome After Abrupt Withdrawal of Clonidine: Behavioral, Cardiovascular, and Neurochemical Effects
Leckman J, Ort S, Caruso K, Anderson G, Riddle M, Cohen D. Rebound Phenomena in Tourette's Syndrome After Abrupt Withdrawal of Clonidine: Behavioral, Cardiovascular, and Neurochemical Effects. JAMA Psychiatry 1986, 43: 1168-1176. PMID: 3465278, DOI: 10.1001/archpsyc.1986.01800120054011.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentBlood PressureChildClonidineEpinephrineHomovanillic AcidHumansMaleMethoxyhydroxyphenylglycolNorepinephrinePulseSerotoninSubstance Withdrawal SyndromeTourette SyndromeConceptsTourette syndromeNeurochemical effectsAbrupt withdrawalWorsening of ticsClonidine therapyClonidine withdrawalClonidine's effectivenessAdrenergic mechanismsBlood pressureOpen trialTic symptomsUrinary excretionPlasma levelsMotor restlessnessHomovanillic acidClonidine hydrochlorideSyndromeWithdrawal periodPrewithdrawal levelsRebound phenomenonPatientsPulse rateClonidineWithdrawalNorepinephrine
1985
NEUROTRANSMITTER PRECURSORS and METABOLITES IN CSF OF HUMAN NEONATES
Anderson G, Hoder E, Shaywitz B, Cohen D. NEUROTRANSMITTER PRECURSORS and METABOLITES IN CSF OF HUMAN NEONATES. Developmental Medicine & Child Neurology 1985, 27: 207-214. PMID: 2581835, DOI: 10.1111/j.1469-8749.1985.tb03771.x.Peer-Reviewed Original ResearchConceptsHuman neonatesAmino acid precursor tryptophanSignificant subgroup differencesMedical complicationsHomovanillic acidCerebrospinal fluidNeurotransmitter precursorsPrecursor tryptophanNeurotransmitter serotoninOlder childrenMajor metaboliteComplicated groupLatter groupComplicationsSignificant correlationNeonatesSubgroup differencesInfantsPhysiological measuresGroupMetabolitesLarge groupHigh levelsMedicationsNorepinephrine
1984
Neurochemical Correlates of Attention Deficit Disorder
Raskin L, Shaywitz S, Shaywitz B, Anderson G, Cohen D. Neurochemical Correlates of Attention Deficit Disorder. Pediatric Clinics Of North America 1984, 31: 387-396. PMID: 6728523, DOI: 10.1016/s0031-3955(16)34584-9.Peer-Reviewed Original ResearchMeSH KeywordsAttention Deficit Disorder with HyperactivityChildDextroamphetamineDopamineHumansMethoxyhydroxyphenylglycolMethylphenidateNorepinephrineSerotonin
1983
Acute and Chronic CLonidine Treatment in Tourette's Syndrome A Preliminary Report on Clinical Response and Effect on Plasma and Urinary Catecholamine Metabolites, Growth Hormone, and Blood Pressure
LECKMAN J, DETLOR J, HARCHERIK D, YOUNG J, ANDERSON G, SHAYWITZ B, COHEN D. Acute and Chronic CLonidine Treatment in Tourette's Syndrome A Preliminary Report on Clinical Response and Effect on Plasma and Urinary Catecholamine Metabolites, Growth Hormone, and Blood Pressure. Journal Of The American Academy Of Child & Adolescent Psychiatry 1983, 22: 433-440. PMID: 6579101, DOI: 10.1016/s0002-7138(09)61504-1.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentBlood PressureCatecholaminesChildClonidineDouble-Blind MethodGrowth HormoneHomovanillic AcidHumansMaleMethoxyhydroxyphenylglycolTourette SyndromeConceptsChronic clonidine treatmentClonidine treatmentTourette syndromeHomovanillic acidHuman growth hormoneClinical responseBlood pressureGrowth hormoneΑ2-adrenergic receptor agonistTreatment of TSUrinary catecholamine metabolitesClinical response dataChronic neuropsychiatric disorderPlacebo-controlled conditionsA Preliminary ReportClonidine therapyOral clonidineNoradrenergic receptorsSingle doseUnknown etiologyFunctional statusReceptor agonistClinical trialsDopaminergic systemTS patientsTwo-dimensional liquid chromatographic determination of (3-methoxy-4-hydroxyphenyl)glycol in urine.
Anderson G, Schlicht K, Cohen D. Two-dimensional liquid chromatographic determination of (3-methoxy-4-hydroxyphenyl)glycol in urine. Analytical Chemistry 1983, 55: 1399-402. PMID: 6614494, DOI: 10.1021/ac00259a047.Peer-Reviewed Original Research
1982
Clinical neurochemistry of autism and associated disorders
Young J, Kavanagh M, Anderson G, Shaywitz B, Cohen D. Clinical neurochemistry of autism and associated disorders. Journal Of Autism And Developmental Disorders 1982, 12: 147-165. PMID: 6184361, DOI: 10.1007/bf01531305.Peer-Reviewed Original ResearchConceptsNorepinephrine metabolismNeurochemical methodsClinical neurochemistryClinical studiesNeurochemical studiesBehavioral deficitsBiochemical dysfunctionBrain functionAutistic syndromeInfantile autismLow levelsNew studiesAutismDysfunctionSerotoninSyndromeAutistic individualsSymptomsNeurochemistryBrainMajor obstacleDetermination of Neurochemically Important Compounds in Physiological Samples Using HPLC
Anderson G, Young J. Determination of Neurochemically Important Compounds in Physiological Samples Using HPLC. Schizophrenia Bulletin 1982, 8: 333-348. PMID: 6180473, DOI: 10.1093/schbul/8.2.333.Peer-Reviewed Original ResearchAssessment of Brain Function in Clinical Pediatric Research: Behavioral and Biological Strategies
Young J, Cohen D, Shaywitz S, Caparulo B, Kavanagh M, Hunt R, Leckman J, Anderson G, Detlor J, Harcherik D, Shaywitz B. Assessment of Brain Function in Clinical Pediatric Research: Behavioral and Biological Strategies. Schizophrenia Bulletin 1982, 8: 205-235. PMID: 6180470, DOI: 10.1093/schbul/8.2.205.Peer-Reviewed Original ResearchConceptsBrain functionPharmacological challenge testsSerious neuropsychiatric disorderClinical pediatric researchClinical research methodsSpecific neuronal systemsAttention deficit disorderClinical syndromeMetabolic dysfunctionTourette syndromeChallenge testClinical protocolsNew treatmentsClinical disordersNeuropsychiatric disordersNeuronal systemsClinical researchPediatric researchSyndromeDeficit disorderBest treatmentDisordersNovel biological strategiesLanguage disordersChildren
1981
Plasma free MHPG and neuroendocrine responses to challenge doses of clonidine in Tourette's Syndrome: Preliminary report
Young J, Cohen D, Hattox S, Kavanagh M, Anderson G, Shaywitz B, Maas J. Plasma free MHPG and neuroendocrine responses to challenge doses of clonidine in Tourette's Syndrome: Preliminary report. Life Sciences 1981, 29: 1467-1475. PMID: 6946271, DOI: 10.1016/0024-3205(81)90012-6.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultChildClonidineEndocrine GlandsGlycolsGrowth HormoneHumansHydrocortisoneMaleMethoxyhydroxyphenylglycolProlactinThyrotropinThyroxineTourette SyndromeTriiodothyronineConceptsFree MHPGPlasma free MHPGTourette syndromeChallenge doseNeuroendocrine responsesDoses of clonidineSingle oral dosesClonidine administrationResponsive patientsGH responseOral dosesMaintenance treatmentThyroxine indexClonidineTS patientsPatientsMHPGSyndromeT patientsNeuropsychiatric patientsPilot studyPreliminary reportMetabolic responseFurther investigationDoseAmperometric determination of 3-methoxy-4-hydroxyphenylethyleneglycol in human cerebrospinal fluid
Anderson G, Young J, Cohen D, Shaywitz B, Batter D. Amperometric determination of 3-methoxy-4-hydroxyphenylethyleneglycol in human cerebrospinal fluid. Journal Of Chromatography 1981, 222: 112-115. PMID: 7217316, DOI: 10.1016/s0378-4347(00)81038-5.Peer-Reviewed Original Research