1993
Neuroendocrine and behavioral effects of the selective kappa agonist spiradoline in Tourette's syndrome: A pilot study
Chappell P, Leckman J, Scahill L, Hardin M, Anderson G, Cohen D. Neuroendocrine and behavioral effects of the selective kappa agonist spiradoline in Tourette's syndrome: A pilot study. Psychiatry Research 1993, 47: 267-280. PMID: 8396784, DOI: 10.1016/0165-1781(93)90084-t.Peer-Reviewed Original ResearchMeSH KeywordsAdultAnalgesicsArousalDose-Response Relationship, DrugGrowth HormoneHumansInjections, IntramuscularMaleNeurologic ExaminationPilot ProjectsPyrrolidinesReceptors, Opioid, kappaSocial BehaviorTourette SyndromeConceptsNormal control subjectsTourette syndromeTic frequencyControl subjectsTS patientsMicrograms/Clinician ratingsKappa agonist spiradolineInvolvement of opioidRole of opioidsGrowth hormone secretionDual modulatory effectsDose-response studyMotor tic frequencyMore growth hormoneTic symptomsHormone secretionNeuroendocrine effectsKappa receptorsPhonic ticsSpiradoline mesylateIntermediate doseLow doseModulatory effectsSpiradoline
1992
Tryptophan loading in hyperserotonemic and normoserotonemic adults
Cook E, Anderson G, Heninger G, Fletcher K, Freedman D, Leventhal B. Tryptophan loading in hyperserotonemic and normoserotonemic adults. Biological Psychiatry 1992, 31: 525-528. PMID: 1581428, DOI: 10.1016/0006-3223(92)90264-z.Peer-Reviewed Original ResearchAdministration, OralAdultArousalAutistic DisorderBlood PlateletsDose-Response Relationship, DrugHumansInfusions, IntravenousMaleSerotoninTryptophan