2004
Time course of the effects of the serotonin-selective reuptake inhibitor sertraline on central and peripheral serotonin neurochemistry in the rhesus monkey
Anderson GM, Barr CS, Lindell S, Durham AC, Shifrovich I, Higley JD. Time course of the effects of the serotonin-selective reuptake inhibitor sertraline on central and peripheral serotonin neurochemistry in the rhesus monkey. Psychopharmacology 2004, 178: 339-346. PMID: 15452685, DOI: 10.1007/s00213-004-2011-7.Peer-Reviewed Original ResearchConceptsSelective serotonin reuptake inhibitorsCisternal cerebrospinal fluid (CSF) samplesPg/Young adult male rhesus monkeysRhesus monkeysSerotonin reuptake inhibitorsAdult male rhesus monkeysPlasma drug levelsCerebrospinal fluid samplesExtent of elevationMale rhesus monkeysTime courseNon-human primatesAutoreceptor desensitizationSerotonin neurochemistryReuptake inhibitorsNeurochemical effectsResponse latencyProlonged administrationDrug levelsDrug accumulationDay 0SertralineDiscontinuationBaseline
1986
Rebound Phenomena in Tourette's Syndrome After Abrupt Withdrawal of Clonidine: Behavioral, Cardiovascular, and Neurochemical Effects
Leckman J, Ort S, Caruso K, Anderson G, Riddle M, Cohen D. Rebound Phenomena in Tourette's Syndrome After Abrupt Withdrawal of Clonidine: Behavioral, Cardiovascular, and Neurochemical Effects. JAMA Psychiatry 1986, 43: 1168-1176. PMID: 3465278, DOI: 10.1001/archpsyc.1986.01800120054011.Peer-Reviewed Original ResearchConceptsTourette syndromeNeurochemical effectsAbrupt withdrawalWorsening of ticsClonidine therapyClonidine withdrawalClonidine's effectivenessAdrenergic mechanismsBlood pressureOpen trialTic symptomsUrinary excretionPlasma levelsMotor restlessnessHomovanillic acidClonidine hydrochlorideSyndromeWithdrawal periodPrewithdrawal levelsRebound phenomenonPatientsPulse rateClonidineWithdrawalNorepinephrine