2002
Molecular Genetic Analysis of Plasma Dopamine β-Hydroxylase in Depression
Cubells J, Zabetian C, Anderson G, Price L, Meyers B, Malison R, Nelson J, Nagatsu T, Ichinose H, Gelernter J. Molecular Genetic Analysis of Plasma Dopamine β-Hydroxylase in Depression. Advances In Behavioral Biology 2002, 53: 423-426. DOI: 10.1007/978-1-4757-3538-3_101.Peer-Reviewed Original ResearchDβH proteinEnzyme activityMolecular genetic analysisBiochemical traitsGenetic analysisMajor locusNeurosecretory vesiclesGenetic inheritanceΒ-hydroxylaseDopamine β-hydroxylaseTraitsNeurosecretory cellsProteinDβH levelsConversion of dopamineLociVesiclesPlasma dopamine β-hydroxylaseInheritanceMembraneActivityCells
2001
A Quantitative-Trait Analysis of Human Plasma–Dopamine β-Hydroxylase Activity: Evidence for a Major Functional Polymorphism at the DBH Locus
Zabetian C, Anderson G, Buxbaum S, Elston R, Ichinose H, Nagatsu T, Kim K, Kim C, Malison R, Gelernter J, Cubells J. A Quantitative-Trait Analysis of Human Plasma–Dopamine β-Hydroxylase Activity: Evidence for a Major Functional Polymorphism at the DBH Locus. American Journal Of Human Genetics 2001, 68: 515-522. PMID: 11170900, PMCID: PMC1235285, DOI: 10.1086/318198.Peer-Reviewed Original ResearchConceptsQuantitative trait lociMajor quantitative trait locusMajor genetic markerH activityQuantitative trait analysisStructural geneGenotype/phenotype correlationMutational analysisExtreme phenotypesGenetic markersDBH geneHuman diseasesGenesDBH locusNovel polymorphismsCodominant inheritancePhenotype correlationUnidentified polymorphismsLociPlasma dopamine β-hydroxylase activityΒ-hydroxylase activityPolymorphismFunctional polymorphismsBeta HMajor functional polymorphisms