2004
Effects of glucocorticoids on declarative memory function in major depression
Bremner J, Vythilingam M, Vermetten E, Anderson G, Newcomer J, Charney D. Effects of glucocorticoids on declarative memory function in major depression. Biological Psychiatry 2004, 55: 811-815. PMID: 15050862, DOI: 10.1016/j.biopsych.2003.10.020.Peer-Reviewed Original ResearchConceptsMajor depressive disorderDeclarative memory functionVerbal declarative memory functionDay 3Major depressionMemory functionParagraph recallUnipolar major depressive disorderSubset of patientsEffects of glucocorticoidsHealthy human subjectsDepressive disorderTransient impairmentHealthy subjectsRandomized fashionDeclarative memoryGlucocorticoid receptorBrain regionsExogenous cortisolGlucocorticoidsPlaceboDexamethasonePatientsBaselineDepression
1998
Tryptophan Depletion During Continuous CSF Sampling in Healthy Human Subjects
Carpenter L, Anderson G, Pelton G, Gudin J, Kirwin P, Price L, Heninger G, McDougle C. Tryptophan Depletion During Continuous CSF Sampling in Healthy Human Subjects. Neuropsychopharmacology 1998, 19: 26-35. PMID: 9608574, DOI: 10.1016/s0893-133x(97)00198-x.Peer-Reviewed Original ResearchConceptsAmino acid drinkCerebrospinal fluidAcid drinkTRP levelsLow TRP dietTryptophan depletion paradigmBrain serotonin levelsPlasma TRP levelsHealthy adult subjectsHealthy human subjectsCSF TRP levelsPlasma TrpIndwelling catheterLumbar punctureSerotonin levelsTryptophan depletionContinuous cerebrospinal fluidSpecial dietAdult subjectsBehavioral effectsPlasma samplesHuman subjectsCorresponding fallCentral levelNadir