2018
Repint of “Reframing autism as a behavioral syndrome and not a specific mental disorder: Implications of genetic and phenotypic heterogeneity”
Tordjman S, Cohen D, Anderson G, Botbol M, Canitano R, Coulon N, Roubertoux P. Repint of “Reframing autism as a behavioral syndrome and not a specific mental disorder: Implications of genetic and phenotypic heterogeneity”. Neuroscience & Biobehavioral Reviews 2018, 89: 132-150. PMID: 29391184, DOI: 10.1016/j.neubiorev.2018.01.014.Peer-Reviewed Original ResearchConceptsCognitive-behavioral phenotypeMental disordersAutism spectrum disorderPossible common underlying mechanismNon-categorical approachAutism phenotypeBehavioral syndromeNon-syndromic autismSpectrum disorderDevelopmental trajectoriesAutismSpecific mental disordersCommon underlying mechanismSyndromic autismDiverse genetic disordersEtiological heterogeneityDisordersClinical genetic examinationUnknown disorder
2017
4.12 Maternal Whole Blood Serotonin Levels Predict Verbal Ability and Core Symptoms in Children With Autism Spectrum Disorder
Montgomery A, Shuffrey L, Guter S, Anderson G, Jacob S, Sutcliffe J, Turner J, Cook E, Veenstra-VanderWeele J. 4.12 Maternal Whole Blood Serotonin Levels Predict Verbal Ability and Core Symptoms in Children With Autism Spectrum Disorder. Journal Of The American Academy Of Child & Adolescent Psychiatry 2017, 56: s232. DOI: 10.1016/j.jaac.2017.09.228.Peer-Reviewed Original ResearchReframing autism as a behavioral syndrome and not a specific mental disorder: Implications of genetic and phenotypic heterogeneity
Tordjman S, Cohen D, Coulon N, Anderson G, Botbol M, Canitano R, Roubertoux P. Reframing autism as a behavioral syndrome and not a specific mental disorder: Implications of genetic and phenotypic heterogeneity. Neuroscience & Biobehavioral Reviews 2017, 80: 210. PMID: 28153685, DOI: 10.1016/j.neubiorev.2017.01.030.Peer-Reviewed Original ResearchCognitive-behavioral phenotypeMental disordersAutism spectrum disorderPossible common underlying mechanismNon-categorical approachAutism phenotypeBehavioral syndromeNon-syndromic autismSpectrum disorderDevelopmental trajectoriesAutismSpecific mental disordersCommon underlying mechanismSyndromic autismDiverse genetic disordersEtiological heterogeneityDisordersClinical genetic examinationUnknown disorder
2005
Nocturnal excretion of 6-sulphatoxymelatonin in children and adolescents with autistic disorder
Tordjman S, Anderson GM, Pichard N, Charbuy H, Touitou Y. Nocturnal excretion of 6-sulphatoxymelatonin in children and adolescents with autistic disorder. Biological Psychiatry 2005, 57: 134-138. PMID: 15652871, DOI: 10.1016/j.biopsych.2004.11.003.Peer-Reviewed Original ResearchConceptsAutistic disorderNocturnal urinary excretionPineal gland hormoneLow melatonin productionNormal control individualsMelatonin physiologyGroup of childrenUrinary excretionMelatonin administrationTanner stageSleep problemsNormal controlsReported alterationNocturnal excretionControl individualsExcretion rateDisordersGland hormoneMelatoninMelatonin productionAutistic impairmentsExcretionCircadian rhythmBehavioral expressionVerbal communication
2001
Relationship Among Plasma Cortisol, Catecholamines, Neuropeptide Y, and Human Performance During Exposure to Uncontrollable Stress
Morgan C, Wang S, Rasmusson A, Hazlett G, Anderson G, Charney D. Relationship Among Plasma Cortisol, Catecholamines, Neuropeptide Y, and Human Performance During Exposure to Uncontrollable Stress. Psychosomatic Medicine 2001, 63: 412-422. PMID: 11382268, DOI: 10.1097/00006842-200105000-00010.Peer-Reviewed Original ResearchConceptsPosttraumatic stress disorderStress disorderPsychobiological responsesUncontrollable stressThreat response systemStress-related illnessesIndividual differencesTrauma exposurePsychological dissociationAversive experiencesNeurobiological factorsHuman performanceBehavioral indicesSurvival SchoolNeurobiological perturbationsNeurobiological responsesPsychological symptomsCatecholamine functioningMilitary performanceDisordersNeuropeptide YCortisol releaseIndividualsAdrenocortical axisNeuropeptide Y release
2000
Pharmacogenetics and the serotonin system: initial studies and future directions
Veenstra-VanderWeele J, Anderson G, Cook E. Pharmacogenetics and the serotonin system: initial studies and future directions. European Journal Of Pharmacology 2000, 410: 165-181. PMID: 11134668, DOI: 10.1016/s0014-2999(00)00814-1.Peer-Reviewed Original ResearchAdrenomedullary Function During Cognitive Testing in Attention-Deficit/Hyperactivity Disorder
ANDERSON G, DOVER M, YANG B, HOLAHAN J, SHAYWITZ S, MARCHIONE K, HALL L, FLETCHER J, SHAYWITZ B. Adrenomedullary Function During Cognitive Testing in Attention-Deficit/Hyperactivity Disorder. Journal Of The American Academy Of Child & Adolescent Psychiatry 2000, 39: 635-643. PMID: 10802982, DOI: 10.1097/00004583-200005000-00018.Peer-Reviewed Original ResearchConceptsAttention-deficit/hyperactivity disorderEPI excretionHyperactivity disorderCognitive testingOppositional defiant/conduct disorderCognitive test batteryADHD inattentive subtypeTeacher-rated behaviorDiagnostic group differencesCognition-enhancing effectsInattentive behaviorCognitive challengesLearning disorderInattention factorTest batteryConduct disorderCorrelational analysisGroup differencesClassroom performanceContrast groupSympathoadrenomedullary functionDisordersBoysIndividualsFunctioning
1998
Peripheral serotonin measures in prepubertal psychiatric inpatients and normal children: associations with suicidal behavior and its risk factors
Pfeffer C, McBride P, Anderson G, Kakuma T, Fensterheim L, Khait V. Peripheral serotonin measures in prepubertal psychiatric inpatients and normal children: associations with suicidal behavior and its risk factors. Biological Psychiatry 1998, 44: 568-577. PMID: 9787881, DOI: 10.1016/s0006-3223(98)00020-1.Peer-Reviewed Original ResearchConceptsPrepubertal psychiatric inpatientsBlood tryptophanRisk factorsSerotonin contentSuicidal behaviorMood disordersNormal controlsInpatient childrenSuicidal ideationSerotonin-amplified platelet aggregationPsychiatric inpatientsSuicide attemptsPlatelet serotonin contentEthnic differencesRecent suicide attemptSerotonin measuresPrepubertal controlsPlatelet serotoninPrepubertal childrenInpatientsPlatelet aggregationNormal childrenWhole bloodChildrenDisorders
1996
Elevated cerebrospinal fluid corticotropin-releasing ractor in Tourette's syndrome: Comparison to obsessive compulsive disorder and normal controls
Chappell P, Leckman J, Goodman W, Bissette G, Pauls D, Anderson G, Riddle M, Scahill L, McDougle C, Cohen D. Elevated cerebrospinal fluid corticotropin-releasing ractor in Tourette's syndrome: Comparison to obsessive compulsive disorder and normal controls. Biological Psychiatry 1996, 39: 776-783. PMID: 8731518, DOI: 10.1016/0006-3223(95)00221-9.Peer-Reviewed Original ResearchConceptsCorticotropin-releasing factorCSF corticotropin-releasing factorTourette syndromeObsessive-compulsive disorderNormal controlsCerebrospinal fluidPathobiology of TSOCD patientsMedication-free outpatientsCompulsive disorderLumbar cerebrospinal fluidNoradrenergic mechanismsHealthy controlsTS patientsObsessive-compulsive behaviorTic severityCardinal featuresClinical ratingsPatientsSyndromeRelated conditionsStandardized fashionNeurobiological mechanismsGroup differencesDisorders
1994
Preliminary study of eating disorders among French female adolescents and young adults
Tordjman S, Zittoun C, Anderson G, Flament M, Jeammet P. Preliminary study of eating disorders among French female adolescents and young adults. International Journal Of Eating Disorders 1994, 16: 301-305. PMID: 7833965, DOI: 10.1002/1098-108x(199411)16:3<301::aid-eat2260160312>3.0.co;2-y.Peer-Reviewed Original ResearchThe role of central oxytocin in obsessive compulsive disorder and related normal behavior
Leckman J, Goodman W, North W, Chappell P, Price L, Pauls D, Anderson G, Riddle M, McDougle C, Barr L, Cohen D. The role of central oxytocin in obsessive compulsive disorder and related normal behavior. Psychoneuroendocrinology 1994, 19: 723-749. PMID: 7991761, DOI: 10.1016/0306-4530(94)90021-3.Peer-Reviewed Original ResearchConceptsForms of OCDObsessive-compulsive disorderCompulsive disorderCentral oxytocinFeatures of OCDDimensions of behaviorSeries of predictionsBehavioral symptomsOxytocinChallenge proceduresNormal behaviorSexual behaviorAnecdotal dataDisordersExtreme endsBehaviorAlternative hypothesisTreatment responseRelationship
1992
Platelet and whole blood serotonin content in depressed inpatients: Correlations with acute and life-time psychopathology
Mann J, McBride P, Anderson G, Mieczkowski T. Platelet and whole blood serotonin content in depressed inpatients: Correlations with acute and life-time psychopathology. Biological Psychiatry 1992, 32: 243-257. PMID: 1420642, DOI: 10.1016/0006-3223(92)90106-a.Peer-Reviewed Original ResearchConceptsPlatelet serotonin contentBorderline personality disorderBlood serotonin contentSerotonin contentWhole blood serotonin contentSerotonin levelsHealthy controlsPersonality disorderLower platelet serotonin contentComorbid borderline personality disorderHigher serotonin levelsLow serotonin levelsSeverity of depressionPlatelet serotonin levelsLife-time historyBPD attemptersPatient groupMajor depressionPatientsDepressed inpatientsSuicide attemptsSuicidal behaviorNonborderline patientsWhole bloodDisorders
1991
Emergence of Self-Destructive Phenomena in Children and Adolescents during Fluoxetine Treatment
KING R, RIDDLE M, CHAPPELL P, HARDIN M, ANDERSON G, LOMBROSO P, SCAHILL L. Emergence of Self-Destructive Phenomena in Children and Adolescents during Fluoxetine Treatment. Journal Of The American Academy Of Child & Adolescent Psychiatry 1991, 30: 179-186. PMID: 2016219, DOI: 10.1097/00004583-199103000-00003.Peer-Reviewed Original ResearchConceptsFluoxetine treatmentObsessive-compulsive disorderUniversity Clinical Research CenterClinical Research CenterMajor risk factorDrug-induced activationPrior suicidal ideationYounger patientsRisk factorsRegulation of aggressionPatientsSuicidal ideationSelf-destructive behaviorFluoxetineAge 10Apparent associationVulnerable individualsDisordersTreatmentIdeationDe novoHospitalizationSymptoms
1990
Neurotransmitter Assessment in Neuropsychiatric Disorders of Childhood
Rasmusson A, Riddle M, Leckman J, Anderson G, Cohen D. Neurotransmitter Assessment in Neuropsychiatric Disorders of Childhood. 1990, 33-59. DOI: 10.1007/978-1-4613-0525-5_3.Peer-Reviewed Original ResearchChild psychiatric disordersNeurotransmitter assessmentNeuropharmacologic agentsPsychiatric illnessNeurotransmitter systemsPsychiatric disordersNeurobiologic processesClinical investigatorsNeuropsychiatric disordersClinical researchFunctional neuroanatomyConstitutional factorsArea of childNeural substratesPotential roleAdolescent psychiatryPsychodynamic factorsDisordersPathophysiologyPowerful effectEtiologyIllness
1987
Neurotransmitters in Human Epilepsy
Kresch M, Shaywitz B, Shaywitz S, Anderson G, Leckman J, Cohen D. Neurotransmitters in Human Epilepsy. Contemporary Neuroscience 1987, 321-338. DOI: 10.1007/978-1-59259-462-7_11.Peer-Reviewed Original ResearchParotid Gland Salivary Secretion in Tourette's Syndrome and Attention Deficit Disorder: A Model System for the Study of Neurochemical Regulation
COHEN D, ORT S, CARUSO K, ANDERSON G, HUNT R, SHAYWITZ B, KREMENITZER M, LECKMAN J. Parotid Gland Salivary Secretion in Tourette's Syndrome and Attention Deficit Disorder: A Model System for the Study of Neurochemical Regulation. Journal Of The American Academy Of Child & Adolescent Psychiatry 1987, 26: 65-68. PMID: 3034852, DOI: 10.1097/00004583-198701000-00013.Peer-Reviewed Original ResearchConceptsAttention deficit disorderTourette syndromeSalivary amylase concentrationTS patientsAmylase concentrationSalivary secretionNeurochemical regulationReceptor functioningTreatment of TSDeficit disorderSalivary amylase secretionParotid gland secretionSingle dosesSalivary volumeClonidinePatientsAmylase secretionSyndromeADD patientsSalivary measuresSecretionTotal amylaseSalivary amylaseDisordersChildren
1986
Components of attention, methylphenidate dosage, and blood levels in children with attention deficit disorder.
Sebrechts M, Shaywitz S, Shaywitz B, Jatlow P, Anderson G, Cohen D. Components of attention, methylphenidate dosage, and blood levels in children with attention deficit disorder. Pediatrics 1986, 77: 222-8. PMID: 3945535, DOI: 10.1542/peds.77.2.222.Peer-Reviewed Original ResearchConceptsAttention deficit disorderDeficit disorderComponents of attentionDoses of methylphenidateCognitive resourcesCognitive componentsAttentional deficitsParent ratingsMethylphenidate dosageTest batteryMethylphenidateChildrenDisordersTaskDeficitsRatingsSingle testAttentionPerformanceTeachersBlood levelsBatteries
1984
Whole blood serotonin and tryptophan levels in Tourette's disorder: Effects of acute and chronic clonidine treatment
Leckman J, Anderson G, Cohen D, Ort S, Harcherik D, Hoder E, Shaywitz B. Whole blood serotonin and tryptophan levels in Tourette's disorder: Effects of acute and chronic clonidine treatment. Life Sciences 1984, 35: 2497-2503. PMID: 6595491, DOI: 10.1016/0024-3205(84)90435-1.Peer-Reviewed Original ResearchConceptsChronic clonidine treatmentClonidine treatmentTourette's disorder patientsWhole blood serotoninDisorder patientsTourette's disorderBlood serotoninTryptophan levelsMean differenceChronic treatmentAcute doseNormal controlsMean increaseClonidinePatientsDisordersMode of actionTreatmentSignificant differencesSerotoninBaseline conditionsLevelsDifferencesDoseNeurochemical Correlates of Attention Deficit Disorder
Raskin L, Shaywitz S, Shaywitz B, Anderson G, Cohen D. Neurochemical Correlates of Attention Deficit Disorder. Pediatric Clinics Of North America 1984, 31: 387-396. PMID: 6728523, DOI: 10.1016/s0031-3955(16)34584-9.Peer-Reviewed Original Research
1982
Assessment of Brain Function in Clinical Pediatric Research: Behavioral and Biological Strategies
Young J, Cohen D, Shaywitz S, Caparulo B, Kavanagh M, Hunt R, Leckman J, Anderson G, Detlor J, Harcherik D, Shaywitz B. Assessment of Brain Function in Clinical Pediatric Research: Behavioral and Biological Strategies. Schizophrenia Bulletin 1982, 8: 205-235. PMID: 6180470, DOI: 10.1093/schbul/8.2.205.Peer-Reviewed Original ResearchConceptsBrain functionPharmacological challenge testsSerious neuropsychiatric disorderClinical pediatric researchClinical research methodsSpecific neuronal systemsAttention deficit disorderClinical syndromeMetabolic dysfunctionTourette syndromeChallenge testClinical protocolsNew treatmentsClinical disordersNeuropsychiatric disordersNeuronal systemsClinical researchPediatric researchSyndromeDeficit disorderBest treatmentDisordersNovel biological strategiesLanguage disordersChildren