2000
Cerebrospinal Fluid Corticotropin-Releasing Hormone in Healthy Humans: Effects of Yohimbine and Naloxone1
Vythilingam M, Anderson G, Owens M, Halaszynski T, Bremner J, Carpenter L, Heninger G, Nemeroff C, Charney D. Cerebrospinal Fluid Corticotropin-Releasing Hormone in Healthy Humans: Effects of Yohimbine and Naloxone1. The Journal Of Clinical Endocrinology & Metabolism 2000, 85: 4138-4145. PMID: 11095445, DOI: 10.1210/jcem.85.11.6968.Peer-Reviewed Original ResearchConceptsCRH neuronsParaventricular nucleusCSF CRHCerebrospinal fluidPlasma cortisolHypothalamic pituitary adrenal axis activityCSF CRH concentrationsCSF CRH levelsCorticotropin-Releasing HormoneCSF NE levelsEffects of yohimbineAdult normal volunteersPlasma cortisol concentrationsCRH concentrationsCentral norepinephrineOpioid regulationPlacebo administrationPVN neuronsCRH levelsNE levelsCSF norepinephrineHPA axisAxis activityHealthy humansMedian eminence
1995
Cerebrospinal fluid biogenic amines in obsessive compulsive disorder, tourette's syndrome, and healthy controls
Leckman J, Goodman W, Anderson G, Riddle M, Chappell P, McSwiggan-Hardin M, McDougle C, Scahill L, Ort S, Pauls D, Cohen D, Price L. Cerebrospinal fluid biogenic amines in obsessive compulsive disorder, tourette's syndrome, and healthy controls. Neuropsychopharmacology 1995, 12: 73-86. DOI: 10.1016/0893-133x(94)00070-g.Peer-Reviewed Original ResearchObsessive-compulsive disorderTourette syndromeHealthy controlsOCD patientsTS patientsHomovanillic acidCerebrospinal fluidCerebrospinal fluid biogenic aminesMedication-free OCD patientsPathobiology of TSCSF HVA levelsCompulsive disorderLumbar cerebrospinal fluidConcentrations of tyrosineHVA levelsCSF norepinephrineNoradrenergic mechanismsSerotonergic mechanismsCSF MHPGSerotonergic systemHealthy subjectsHealthy volunteersNormal volunteersPatientsSyndromeCerebrospinal Fluid Biogenic Amines in Obsessive Compulsive Disorder, Tourette's Syndrome, and Healthy Controls
Leckman J, Goodman W, Anderson G, Riddle M, Chappell P, McSwiggan-Hardin M, McDougle C, Scahill L, Ort S, Pauls D, Cohen D, Price L. Cerebrospinal Fluid Biogenic Amines in Obsessive Compulsive Disorder, Tourette's Syndrome, and Healthy Controls. Neuropsychopharmacology 1995, 12: 73-86. PMID: 7766289, DOI: 10.1038/sj.npp.1380241.Peer-Reviewed Original ResearchConceptsObsessive-compulsive disorderTourette syndromeHealthy controlsOCD patientsTS patientsHomovanillic acidCerebrospinal fluidCerebrospinal fluid biogenic aminesMedication-free OCD patientsPathobiology of TSCSF HVA levelsCompulsive disorderLumbar cerebrospinal fluidConcentrations of tyrosineHVA levelsCSF norepinephrineNoradrenergic mechanismsSerotonergic mechanismsCSF MHPGSerotonergic systemHealthy subjectsHealthy volunteersNormal volunteersPatientsSyndrome