1989
Neurochemical Study of Dopamine Functioning in Autistic and Normal Subjects
MINDERAA R, ANDERSON G, VOLKMAR F, AKKERHUIS G, COHEN D. Neurochemical Study of Dopamine Functioning in Autistic and Normal Subjects. Journal Of The American Academy Of Child & Adolescent Psychiatry 1989, 28: 190-194. PMID: 2925571, DOI: 10.1097/00004583-198903000-00007.Peer-Reviewed Original ResearchConceptsPlasma PRLPlasma prolactinHVA levelsUrinary HVANormal controlsNormal subjectsUrinary DA excretionUrinary HVA excretionHomovanillic acid levelsDose of neurolepticPlasma PRL valuesDopamine functioningDopamine excretionNeuroleptic doseHVA excretionNeuroleptic medicationDA excretionNeurochemical studiesPRL valuesPeripheral indicesExcretion rateAcid levelsHVAExcretionSignificant differences
1988
Tourette's Syndrome: Clinical and Neurochemical Correlates
RIDDLE M, LECKMAN J, ANDERSON G, ORT S, HARDIN M, STEVENSON J, COHEN D. Tourette's Syndrome: Clinical and Neurochemical Correlates. Journal Of The American Academy Of Child & Adolescent Psychiatry 1988, 27: 409-412. PMID: 3182595, DOI: 10.1097/00004583-198807000-00004.Peer-Reviewed Original ResearchConceptsTourette Syndrome Global ScalePHVA levelsTourette syndromeTS patientsLower CSF HVA levelsPlasma homovanillic acid levelsSimple motor ticsHomovanillic acid levelsCSF HVA levelsSignificant inverse correlationHVA levelsMotor restlessnessMotor ticsPretreatment levelsTotal symptomsNeurochemical correlatesTreatment responsePlasma 3Control groupPatientsSyndromeAcid levelsInverse correlationSignificant correlationIndividual items
1986
Brief debrisoquin administration to assess central dopaminergic function in children
Riddle M, Shaywitz B, Leckman J, Anderson G, Shaywitz S, Hardin M, Ort S, Cohen D. Brief debrisoquin administration to assess central dopaminergic function in children. Life Sciences 1986, 38: 1041-1048. PMID: 3456480, DOI: 10.1016/0024-3205(86)90239-0.Peer-Reviewed Original ResearchConceptsCentral dopaminergic functionDopaminergic functionHomovanillic acid levelsBehavioral side effectsActive antihypertensive agentDebrisoquin sulfatePHVA levelsAntihypertensive agentsSix-hour periodSide effectsBrief administrationNeuropsychiatric disordersAdministration methodsMarked reductionPeripheral techniquesAcid levelsAdministrationPatientsChildrenDebrisoquinPHVA