2016
Fibroblast Growth Factor 2 Modulates Hypothalamic Pituitary Axis Activity and Anxiety Behavior Through Glucocorticoid Receptors
Salmaso N, Stevens HE, McNeill J, ElSayed M, Ren Q, Maragnoli ME, Schwartz ML, Tomasi S, Sapolsky RM, Duman R, Vaccarino FM. Fibroblast Growth Factor 2 Modulates Hypothalamic Pituitary Axis Activity and Anxiety Behavior Through Glucocorticoid Receptors. Biological Psychiatry 2016, 80: 479-489. PMID: 27133954, PMCID: PMC8009045, DOI: 10.1016/j.biopsych.2016.02.026.Peer-Reviewed Original ResearchConceptsFibroblast growth factor-2Hippocampal glucocorticoid receptor expressionGlucocorticoid receptor expressionAdrenal axis activityKO miceAxis activityAnxiety behaviorReceptor expressionHypothalamic-pituitary axis activityReceptor KO miceFGF2 administrationWild-type miceGrowth factor 2Receptor subtypesTherapeutic effectNeuroendocrine studiesAdult miceGlucocorticoid receptorGR promoter regionsFGF2 levelsMeasures of anxietyMiceMotor behaviorFGF2 geneFactor 2
1994
Excitatory amino acid receptors in glial progenitor cells: Molecular and functional properties
Gallo V, Patneau D, Mayer M, Vaccarino F. Excitatory amino acid receptors in glial progenitor cells: Molecular and functional properties. Glia 1994, 11: 94-101. PMID: 7927651, DOI: 10.1002/glia.440110204.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsMeSH Keywords6-Cyano-7-nitroquinoxaline-2,3-dioneAnimalsCells, CulturedCerebral CortexDNA-Binding ProteinsEarly Growth Response Protein 1Gene Expression RegulationGenes, Immediate-EarlyGlutamic AcidImmediate-Early ProteinsKainic AcidMembrane PotentialsNerve Tissue ProteinsNeurotoxinsN-MethylaspartateOligodendrogliaRatsReceptors, GlutamateStem CellsTranscription FactorsConceptsCG-4 cellsAMPA receptor antagonist CNQXWhole-cell patch-clamp recordingsExcitatory amino acid receptorsProgenitor cellsAmino acid receptorsRat cerebral cortexPatch-clamp recordingsGlial progenitor cellsGlutamate receptor subunitsAgonists L-glutamateGlutamate-gated channelsImmediate early gene NGFIAntagonist CNQXCerebral cortexGABA antibodyPrimary cell linesGlutamate receptorsTransient elevationAcid receptorsReceptor subunitsOligodendrocyte lineageOligodendrocyte progenitorsL-glutamateKainate
1993
Induction of immediate early genes by cyclic AMP in primary cultures of neurons from rat cerebral cortex
Vaccarino FM, Hayward MD, Le HN, Hartigan DJ, Duman RS, Nestler EJ. Induction of immediate early genes by cyclic AMP in primary cultures of neurons from rat cerebral cortex. Brain Research 1993, 19: 76-82. PMID: 8103187, DOI: 10.1016/0169-328x(93)90151-e.Peer-Reviewed Original ResearchMeSH Keywords2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepineAnimalsAnimals, NewbornBucladesineCells, CulturedCerebral CortexColforsinCyclic AMPDNA-Binding ProteinsDopamine AgentsEarly Growth Response Protein 1ErgolinesGene Expression RegulationGenes, fosGenes, junGlutamatesGlutamic AcidImmediate-Early ProteinsImmunohistochemistryKineticsNeurogliaNeuronsQuinpiroleRatsRNA, MessengerSecond Messenger SystemsTranscription FactorsVasoactive Intestinal PeptideConceptsVasoactive intestinal peptideRat cerebral cortexCerebral cortexExcitatory amino acid receptor antagonistsDibutyryl cAMPAmino acid receptor antagonistsPrimary culturesC-fosDihydropyridine-sensitive calcium channelsAcid receptor antagonistsIEG inductionCalcium-free mediumCAMP second messenger pathwayIEGs c-fosSKF 38393Immediate-early gene transcription factorsIntestinal peptideReceptor antagonistReceptor agonistSecond messenger pathwaysCalcium channelsDifferentiated neuronsBrief stimulationImmediate early genesIEG expression
1992
Differential induction of immediate early genes by excitatory amino acid receptor types in primary cultures of cortical and striatal neurons
Vaccarino F, Hayward M, Nestler E, Duman R, Tallman J. Differential induction of immediate early genes by excitatory amino acid receptor types in primary cultures of cortical and striatal neurons. Brain Research 1992, 12: 233-241. PMID: 1347632, DOI: 10.1016/0169-328x(92)90089-t.Peer-Reviewed Original ResearchMeSH Keywords1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine6-Cyano-7-nitroquinoxaline-2,3-dioneAnimalsAnimals, NewbornBlotting, NorthernCells, CulturedCerebral CortexCorpus StriatumDNA-Binding ProteinsEarly Growth Response Protein 1Gene Expression RegulationGenes, fosGenes, junGenes, RegulatorGlutamatesGlutamic AcidGlycineImmediate-Early ProteinsIsoquinolinesNeuronsPiperazinesProtein Kinase InhibitorsProto-OncogenesQuinoxalinesQuisqualic AcidRatsReceptors, AMPAReceptors, NeurotransmitterReceptors, N-Methyl-D-AspartateRNA, MessengerSulfonamidesTranscription FactorsConceptsProtein kinase C inhibitor HNGFI-A mRNAC-fosImmediate early genesPrimary culturesC-JunEarly genesGene mRNAN-methyl-D-aspartate receptor typeExcitatory amino acid receptor typesReceptor typesInhibitor HHydroxy-5-methylisoxazolepropionic acidExcitatory amino acid glutamateIEG expressionTransmembrane calcium influxDifferential inductionNMDA receptor channelsNMDA receptor activationAmino acid glutamateMRNAReceptor activationImmediate early gene mRNAsReceptor channelsCerebral cortex