1991
Modulation of Protein Kinase C Translocation by Excitatory and Inhibitory Amino Acids in Primary Cultures of Neurons
Vaccarino F, Liljequist S, Tallman J. Modulation of Protein Kinase C Translocation by Excitatory and Inhibitory Amino Acids in Primary Cultures of Neurons. Journal Of Neurochemistry 1991, 57: 391-396. PMID: 1649249, DOI: 10.1111/j.1471-4159.1991.tb03765.x.Peer-Reviewed Original ResearchMeSH KeywordsAmino AcidsAnimalsAnimals, NewbornBicucullineCell MembraneCells, CulturedCerebral CortexCorpus StriatumDizocilpine MaleateGlutamatesKineticsNeuronsOxadiazolesPhorbol 12,13-DibutyrateProtein Kinase CRatsRats, Inbred StrainsReceptors, AMPAReceptors, NeurotransmitterReceptors, N-Methyl-D-AspartateTetrodotoxinConceptsProtein kinase CPKC translocationAmino acidsExtracellular mediumProtein kinase C translocationAmino acid stimulationPrimary culturesKinase CC translocationExcitatory amino acid receptorsTranslocationExcitatory amino acid stimulationImine hydrogen maleateExcitatory amino acidsAmino acid receptorsRat cerebral cortexInhibitory amino acidsNMDA receptor antagonistAbsence of calciumAcid receptorsPhysiological concentrationsCerebral cortexMetabotropic receptorsReceptor antagonistAMPA receptors
1986
Modulation of gamma-aminobutyric acid-mediated inhibitory synaptic currents in dissociated cortical cell cultures.
Vicini S, Alho H, Costa E, Mienville JM, Santi MR, Vaccarino FM. Modulation of gamma-aminobutyric acid-mediated inhibitory synaptic currents in dissociated cortical cell cultures. Proceedings Of The National Academy Of Sciences Of The United States Of America 1986, 83: 9269-9273. PMID: 3097650, PMCID: PMC387117, DOI: 10.1073/pnas.83.23.9269.Peer-Reviewed Original ResearchConceptsInhibitory synaptic currentsSynaptic currentsRo 15Whole-cell patch-clamp techniqueActions of flunitrazepamGamma-aminobutyric acid receptorsNeonatal rat cortexCortical cell culturesPatch-clamp techniqueImidazobenzodiazepine Ro 15High-affinity ligandsRat cortexSynaptic transmissionPostsynaptic cellElectrical stimulationEndogenous ligandAcid receptorsImmunocytochemical stainingPrimary culturesNeuronsFlunitrazepamCell culturesIntrinsic activityDerivative methylAllosteric regulatory site
1985
gamma-Aminobutyric acid- and benzodiazepine-induced modulation of [35S]- t-butylbicyclophosphorothionate binding to cerebellar granule cells
Gallo V, Wise BC, Vaccarino F, Guidotti A. gamma-Aminobutyric acid- and benzodiazepine-induced modulation of [35S]- t-butylbicyclophosphorothionate binding to cerebellar granule cells. Journal Of Neuroscience 1985, 5: 2432-2438. PMID: 4032005, PMCID: PMC6565307, DOI: 10.1523/jneurosci.05-09-02432.1985.Peer-Reviewed Original ResearchConceptsGamma-aminobutyric acidIntact cerebellar granule cellsCerebellar granule cellsGranule cellsT-butylbicyclophosphorothionateEffects of muscimolDose-dependent fashionAbsence of diazepamNeuroblastoma cell linesBenzodiazepine receptor ligandsSpecific bindingMicroM diazepamConvulsant activityCerebellar astrocytesMuscimolDiazepamLocke's solutionTotal radioactivityPrimary culturesReceptor ligandsCell linesReceptor complexCarboxylic acid methylesterInhibitionCells