2004
Fibroblast Growth Factor 2 Is Required for Maintaining the Neural Stem Cell Pool in the Mouse Brain Subventricular Zone
Zheng W, Nowakowski RS, Vaccarino FM. Fibroblast Growth Factor 2 Is Required for Maintaining the Neural Stem Cell Pool in the Mouse Brain Subventricular Zone. Developmental Neuroscience 2004, 26: 181-196. PMID: 15711059, DOI: 10.1159/000082136.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBiomarkersBrainCell Cycle ProteinsCell DifferentiationCell DivisionCell LineageCell ProliferationCerebral CortexDown-RegulationImmunohistochemistryLateral VentriclesMiceMice, KnockoutNeurogliaNeuronsOlfactory BulbReceptor Protein-Tyrosine KinasesReceptor, Fibroblast Growth Factor, Type 2Receptors, Fibroblast Growth FactorStem CellsConceptsStem cell poolNeural stem cellsFgf2 knockout miceSlower cell cycle kineticsProgenitor cell populationsSubventricular zoneCell poolNeural stem cell poolGene productsProgenitor populationsFibroblast growth factor-2Olfactory bulbKnockout miceCell cycleOlfactory bulb neurogenesisMolecular markersSmaller olfactory bulbsGrowth factor 2Brain subventricular zoneAnterior subventricular zoneReceptor proteinGlial fibrillary acidic proteinCell cycle kineticsStem cellsFibrillary acidic protein
2002
Chronic hypoxia up-regulates fibroblast growth factor ligands in the perinatal brain and induces fibroblast growth factor-responsive radial glial cells in the sub-ependymal zone
Ganat Y, Soni S, Chacon M, Schwartz ML, Vaccarino FM. Chronic hypoxia up-regulates fibroblast growth factor ligands in the perinatal brain and induces fibroblast growth factor-responsive radial glial cells in the sub-ependymal zone. Neuroscience 2002, 112: 977-991. PMID: 12088755, DOI: 10.1016/s0306-4522(02)00060-x.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBlotting, WesternCerebral CortexCerebral VentriclesEnzyme-Linked Immunosorbent AssayEpendymaFibroblast Growth Factor 1Fibroblast Growth Factor 2HypoxiaImmunohistochemistryNeurogliaRatsReceptor Protein-Tyrosine KinasesReceptor, Fibroblast Growth Factor, Type 1Receptor, Fibroblast Growth Factor, Type 2Receptors, Fibroblast Growth FactorRegenerationUp-RegulationConceptsRadial glial cellsRadial gliaChronic hypoxiaGlial cellsFibroblast growth factor 1Periventricular regionBrain lipid binding proteinMajor receptorChronic hypoxic damageGlial fibrillary acidic proteinHypoxia/ischemiaSub-ventricular zoneImmature glial cellsFibrillary acidic proteinGrowth factor-1Ependymal zoneChronic hypoxemiaCerebral cortexHypoxic damageNeurotrophin familyPerinatal brainFGF receptor 1Rat pupsPostnatal weekGlial phenotype