2023
A systematic review of childhood maltreatment and resting state functional connectivity
Gerin M, Viding E, Herringa R, Russell J, McCrory E. A systematic review of childhood maltreatment and resting state functional connectivity. Developmental Cognitive Neuroscience 2023, 64: 101322. PMID: 37952287, PMCID: PMC10665826, DOI: 10.1016/j.dcn.2023.101322.Peer-Reviewed Original ResearchConceptsResting-state functional connectivityAnterior cingulate cortexFunctional connectivityCingulate cortexChildhood maltreatmentAltered functional connectivityState functional connectivityDorsal anterior cingulate cortexNegative psychiatric outcomesVentral anterior cingulate cortexDorsolateral prefrontal cortexRsFC alterationsAltered connectivityInclusion criteriaAmygdala connectivityNineteen studiesPsychiatric outcomesFuture symptomsSystematic reviewBrain regionsClinical disordersBrain circuitsAnterior insulaPrefrontal cortexMaltreatment exposure
2021
Modulation of Amygdala Response by Cognitive Conflict in Adolescents with Conduct Problems and Varying Levels of CU Traits
Sebastian C, Stafford J, McCrory E, Sethi A, De Brito S, Lockwood P, Viding E. Modulation of Amygdala Response by Cognitive Conflict in Adolescents with Conduct Problems and Varying Levels of CU Traits. Research On Child And Adolescent Psychopathology 2021, 49: 1043-1054. PMID: 33728508, PMCID: PMC8222043, DOI: 10.1007/s10802-021-00787-z.Peer-Reviewed Original ResearchConceptsCallous-unemotional traitsNegative emotional stimuliAmygdala responseConduct problemsEmotional stimuliCognitive conflictTask demandsCognitive task demandsCognitive conflict tasksLow callous-unemotional traitsCP/HCUHealthy adult sampleCognitive controlEmotional facesReactive aggressionAtypical modulationConflict taskNeurocognitive responsesAffect regulationCU traitsPotential translational relevanceConflict conditionsPrefrontal areasHigh conflictAdult samples
2020
Individual differences in sensitivity to the early environment as a function of amygdala and hippocampus volumes: An exploratory analysis in 12-year-old boys
Pluess M, De Brito S, Bartoli A, McCrory E, Viding E. Individual differences in sensitivity to the early environment as a function of amygdala and hippocampus volumes: An exploratory analysis in 12-year-old boys. Development And Psychopathology 2020, 34: 901-910. PMID: 33342453, DOI: 10.1017/s0954579420001698.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAmygdalaBrainChildHippocampusHumansIndividualityMagnetic Resonance ImagingMaleConceptsIndividual differencesLeft amygdalaEnvironmental influencesLeft amygdala volumeNeurobiological sensitivityImportant brain regionsChild behaviorBrain regionsEarly environmentContextual factorsPositive experiencesBrain structuresAmygdala volumePreliminary evidenceAmygdalaGeneral environmental qualityHippocampus volumeExploratory analysisBoysExploratory studyEnvironmental features
2019
Investigating patterns of neural response associated with childhood abuse v. childhood neglect
Puetz V, Viding E, Gerin M, Pingault J, Sethi A, Knodt A, Radtke S, Brigidi B, Hariri A, McCrory E. Investigating patterns of neural response associated with childhood abuse v. childhood neglect. Psychological Medicine 2019, 50: 1398-1407. PMID: 31190662, DOI: 10.1017/s003329171900134x.Peer-Reviewed Original ResearchConceptsNeural reactivityThreat reactivityMaltreatment experiencesChildhood abuseChildhood maltreatmentHigher-order cortical regionsFronto-parietal networkEffects of abuseChildhood abuse experiencesExperiences of neglectPoor mental health outcomesEffects of neglectChildhood maltreatment experiencesMental health outcomesExperiences of abuseCognitive processingBrain imaging analysisFacial cuesNeural responsesNeglect experiencesDifferential effectsAbuse experiencesChildhood neglectDorsal amygdalaVentral amygdalaHeightened amygdala reactivity and increased stress generation predict internalizing symptoms in adults following childhood maltreatment
Gerin M, Viding E, Pingault J, Puetz V, Knodt A, Radtke S, Brigidi B, Swartz J, Hariri A, McCrory E. Heightened amygdala reactivity and increased stress generation predict internalizing symptoms in adults following childhood maltreatment. Journal Of Child Psychology And Psychiatry 2019, 60: 752-761. PMID: 30933355, PMCID: PMC6594878, DOI: 10.1111/jcpp.13041.Peer-Reviewed Original ResearchConceptsMajor stressful life eventsStressful life eventsAmygdala reactivityChildhood maltreatmentLife eventsInternalizing disordersBaseline internalizing symptomsInternalizing symptomsHistory of maltreatmentThreat-related amygdala reactivityDevelopmental insultsPsychiatric riskPropensity scoreSymptomsFuture internalizing symptomsStress exposureMental healthYoung adultsSeverity 1Socioeconomic statusFuture psychopathologyPotent predictorSuch alterationsNonmaltreated peersMaltreatment status
2018
An fMRI investigation of empathic processing in boys with conduct problems and varying levels of callous-unemotional traits
Sethi A, O'Nions E, McCrory E, Bird G, Viding E. An fMRI investigation of empathic processing in boys with conduct problems and varying levels of callous-unemotional traits. NeuroImage Clinical 2018, 18: 298-304. PMID: 29876250, PMCID: PMC5987797, DOI: 10.1016/j.nicl.2018.01.027.Peer-Reviewed Original ResearchConceptsCP/HCUMedial prefrontal cortexCallous-unemotional traitsConduct problemsOwn emotionsAnterior cingulate cortexAnterior insulaEmpathic processingAffective experienceConjunction analysisACC/medial prefrontal cortexBrain areasBayes factor analysisEmpathy deficitsFMRI investigationTD groupNeural responsesConjunction effectOne's feelingsLess empathyEmotionsPrefrontal cortexNeutral scenarioCingulate cortexOccipital cortex
2017
Modulation of amygdala response to task-irrelevant emotion
Sebastian C, McCrory E, De Brito S, Viding E. Modulation of amygdala response to task-irrelevant emotion. Social Cognitive And Affective Neuroscience 2017, 12: 643-650. PMID: 28119506, PMCID: PMC5390695, DOI: 10.1093/scan/nsw174.Peer-Reviewed Original ResearchConceptsAmygdala responseTask demandsPerceptual inputTask performanceConflict conditionsTask-irrelevant emotional stimuliTask-irrelevant emotionFearful facial expressionsCognitive conflict tasksCognitive task performanceSlower reaction timesHigh-conflict conditionPsychophysiological interaction analysisRight amygdala responseLow-conflict conditionsMiddle frontal gyrusFunctional couplingEmotion regulationExecutive demandsEmotional informationConflict taskEmotional stimuliCognitive conflictCognitive demandsEmotional context
2016
Regional grey matter volume and concentration in at-risk adolescents: Untangling associations with callous-unemotional traits and conduct disorder symptoms
Cohn M, Viding E, McCrory E, Pape L, van den Brink W, Doreleijers T, Veltman D, Popma A. Regional grey matter volume and concentration in at-risk adolescents: Untangling associations with callous-unemotional traits and conduct disorder symptoms. Psychiatry Research Neuroimaging 2016, 254: 180-187. PMID: 27479922, DOI: 10.1016/j.pscychresns.2016.07.003.Peer-Reviewed Original Research
2013
Neural responses to fearful eyes in children with conduct problems and varying levels of callous–unemotional traits
Sebastian C, McCrory E, Dadds M, Cecil C, Lockwood P, Hyde Z, De Brito S, Viding E. Neural responses to fearful eyes in children with conduct problems and varying levels of callous–unemotional traits. Psychological Medicine 2013, 44: 99-109. PMID: 23510564, DOI: 10.1017/s0033291713000482.Peer-Reviewed Original ResearchConceptsFunctional magnetic resonance imagingSubgenual anterior cingulate cortexImportant translational implicationsNeural responsesAnterior cingulate cortexAmygdala responseMagnetic resonance imagingFearful eyesConduct problemsTrial participantsEye conditionsCingulate cortexCortex responsesResonance imagingEvidence baseAmygdala reactivityTranslational implicationsHeterogeneous groupTD controlsEyesChildrenFear recognition deficitsNeural levelParticipantsLow levels
2012
Amygdala Response to Preattentive Masked Fear in Children With Conduct Problems: The Role of Callous-Unemotional Traits
Viding E, Sebastian C, Dadds M, Lockwood P, Cecil C, De Brito S, McCrory E. Amygdala Response to Preattentive Masked Fear in Children With Conduct Problems: The Role of Callous-Unemotional Traits. American Journal Of Psychiatry 2012, 169: 1109-1116. PMID: 23032389, DOI: 10.1176/appi.ajp.2012.12020191.Peer-Reviewed Original ResearchConceptsHigh callous-unemotional traitsCallous-unemotional traitsLow callous-unemotional traitsConduct problemsAmygdala responseCalm facesAttention deficit hyperactivity disorderGreater amygdala responsesDifferential amygdala activityLower amygdala reactivityFindings complementMasked fearAffective processingComparison boysNeural basisAmygdala activityAmygdala reactivityConscious awarenessAmygdala involvementHyperactivity disorderNeural responsesUnemotional TraitsAmygdala hypoactivityClassification of childrenAmygdala hyperactivityReduced orbitofrontal and temporal grey matter in a community sample of maltreated children
De Brito S, Viding E, Sebastian C, Kelly P, Mechelli A, Maris H, McCrory E. Reduced orbitofrontal and temporal grey matter in a community sample of maltreated children. Journal Of Child Psychology And Psychiatry 2012, 54: 105-112. PMID: 22880630, DOI: 10.1111/j.1469-7610.2012.02597.x.Peer-Reviewed Original ResearchConceptsMedial orbitofrontal cortexPsychiatric disordersMiddle temporal gyrusOrbitofrontal cortexTemporal lobeGray matterTemporal gyrusConcurrent psychiatric disordersTemporal gray matterGray matter volumeVoxel-based morphometryCommunity sampleLeft middle temporal gyrusAtypical neural structurePrevious neuroimaging studiesNeurobiological risk factorsRisk factorsLevel of anxietyMatter volumePosttraumatic stress symptomsPsychiatric vulnerabilityConcurrent anxietyPrefrontal cortexCortexNeuroimaging studiesNeural Responses to Affective and Cognitive Theory of Mind in Children With Conduct Problems and Varying Levels of Callous-Unemotional Traits
Sebastian C, McCrory E, Cecil C, Lockwood P, De Brito S, Fontaine N, Viding E. Neural Responses to Affective and Cognitive Theory of Mind in Children With Conduct Problems and Varying Levels of Callous-Unemotional Traits. JAMA Psychiatry 2012, 69: 814-822. PMID: 22868935, DOI: 10.1001/archgenpsychiatry.2011.2070.Peer-Reviewed Original ResearchConceptsCallous-unemotional traitsAffective processing taskConduct problemsNeural responsesCognitive theoryMind judgmentsUnique varianceAffective profilesAmygdala reactivityEmpathy componentsProcessing tasksAffective neural responsesDepression/anxiety symptomsConduct problem symptomsFunctional magnetic resonancePotential neural substratesConduct problem groupChildhood conduct problemsAffective stimuliNeural processingNeural substratesAnterior insulaUnemotional TraitsAnxiety symptomsRight amygdala
2011
Heightened neural reactivity to threat in child victims of family violence
McCrory E, De Brito S, Sebastian C, Mechelli A, Bird G, Kelly P, Viding E. Heightened neural reactivity to threat in child victims of family violence. Current Biology 2011, 21: r947-r948. PMID: 22153160, DOI: 10.1016/j.cub.2011.10.015.Peer-Reviewed Original ResearchConceptsAnterior insulaFamily violenceFunctional magnetic resonance imaging studyFunctional magnetic resonance imaging (fMRI) researchNeurobiological risk factorsMagnetic resonance imaging researchAngry cuesMagnetic resonance imaging studyAngry facesThreat cuesSad facesNeural reactivityResonance imaging studyEmotional processingNeural correlatesAmygdala reactivityLater psychopathologyChild victimsAnxiety disordersMaltreatment experiencesPhysical abuseImaging researchPsychopathologyCuesAnxiety