1985
Stress produces opioid-like effects on investigatory behavior
Arnsten A, Berridge C, Segal DS. Stress produces opioid-like effects on investigatory behavior. Pharmacology Biochemistry And Behavior 1985, 22: 803-809. PMID: 4011639, DOI: 10.1016/0091-3057(85)90531-3.Peer-Reviewed Original ResearchConceptsOpioid systemInvestigatory behaviorOpiate antagonist naloxoneOpioid-like effectsAntagonist naloxoneStress-induced reductionLocomotor hypoactivityOpiate agonistsNaive ratsLow dosesCharacteristic alterationsGreater reductionAverage timeNovel environmentRatsNumerous reportsBehavioral activityAlterationsExposureNaloxoneStressorsAgonistsHypoactivityDoses
1983
Naloxone augments electrophysiological signs of selective attention in man
Arnsten A, Segal D, Neville H, Hillyard S, Janowsky D, Judd L, Bloom F. Naloxone augments electrophysiological signs of selective attention in man. Nature 1983, 304: 725-727. PMID: 6888538, DOI: 10.1038/304725a0.Peer-Reviewed Original ResearchConceptsEndogenous opioid systemOpioid systemSelective attentionOpiate antagonist naloxoneSelective information processingNormal human subjectsAntagonist naloxoneOpiate antagonistElectrophysiological signsAuditory attentionOpioid roleElectrophysiological measuresGeneral arousalElectrophysiological evidenceInformation processingBehavioral functionsNaloxoneHuman subjectsSource of stimulusMenPrevious researchArousalAttentionAntagonist