2024
The meso-connectomes of mouse, marmoset, and macaque: network organization and the emergence of higher cognition
Magrou L, Joyce M, Froudist-Walsh S, Datta D, Wang X, Martinez-Trujillo J, Arnsten A. The meso-connectomes of mouse, marmoset, and macaque: network organization and the emergence of higher cognition. Cerebral Cortex 2024, 34: bhae174. PMID: 38771244, PMCID: PMC11107384, DOI: 10.1093/cercor/bhae174.Peer-Reviewed Original ResearchConceptsInter-areal connectionsVisual cortexPrimary visual cortexHigher cortical areasMacaque cortexPrimate specializationHigher cognitionPrimate cortexV1Working memory storageDendritic spine densityTop-down regulationPrefrontal cortexConnection structureSpine densityFunctional segregationCortical areasFrontal areasCortexConnectomeNetwork organizationMemory storageMultimodal association
2022
The Aversive Lens: Stress effects on the prefrontal-cingulate cortical pathways that regulate emotion
Arnsten A, Joyce M, Roberts A. The Aversive Lens: Stress effects on the prefrontal-cingulate cortical pathways that regulate emotion. Neuroscience & Biobehavioral Reviews 2022, 145: 105000. PMID: 36529312, PMCID: PMC9898199, DOI: 10.1016/j.neubiorev.2022.105000.Peer-Reviewed Original ResearchConceptsCortical pathwaysStress exposureDendritic spine lossChronic stress exposureAnti-depressant treatmentDeep brain stimulationPrefrontal cortical areasExcessive dopamineNeuromodulatory treatmentSSRI medicationNorepinephrine releaseSpine lossSubgenual cingulateCortical areasBrain stimulationChronic stressBA25MedicationsDorsolateral PFCTreatmentExposurePsychic painPainKetamineSymptoms
1984
Selective prefrontal cortical projections to the region of the locus coeruleus and raphe nuclei in the rhesus monkey
Arnsten A, Goldman-Rakic PS. Selective prefrontal cortical projections to the region of the locus coeruleus and raphe nuclei in the rhesus monkey. Brain Research 1984, 306: 9-18. PMID: 6466989, DOI: 10.1016/0006-8993(84)90351-2.Peer-Reviewed Original ResearchConceptsRaphe nucleusLocus coeruleusDorsal prefrontal cortexInferior temporal gyrusCortical areasPrefrontal cortexCortical projectionsRhesus monkeysTemporal gyrusAnterograde labeling techniquesCentral superior raphe nucleiPrefrontal cortical projectionsNoradrenergic locus coeruleusContralateral locus coeruleusParietal association cortexSuperior raphe nucleusDorsolateral prefrontal cortexSerotonergic dorsalLabeled fibersCerebral cortexCortical injectionsOrbital prefrontal cortexMonoaminergic innervationRaphe regionSomatosensory cortex