2024
Evidence-based guideline: premature ovarian insufficiency†‡
ASRM C, Panay N, Anderson R, Bennie A, Cedars M, Davies M, Ee C, Gravholt C, Kalantaridou S, Kallen A, Kim K, Misrahi M, Mousa A, Nappi R, Rocca W, Ruan X, Teede H, Vermeulen N, Vogt E, Vincent A. Evidence-based guideline: premature ovarian insufficiency†‡. Climacteric 2024, 27: 510-520. PMID: 39647506, DOI: 10.1080/13697137.2024.2423213.Peer-Reviewed Original ResearchConceptsProvision of careGuideline development groupAnti-Mullerian hormoneFollicle stimulating hormoneHealthcare professionalsHormone therapyScoping surveyClinical questionsSurvey of womenElevated follicle stimulating hormoneFollicle stimulating hormone measurementsEuropean Society of Human Reproduction and Embryology (ESHREDevelopment groupQuality of lifeRandomized controlled trialsCombined oral contraceptivesPractice careGeneral well-beingAnti-Mullerian hormone testCognitive healthIntegrative reviewNon-hormonal treatmentsESHRE Executive CommitteeWomen's healthMuscle healthProspective solutions to ovarian reserve damage during the ovarian tissue cryopreservation and transplantation procedure
Mercier A, Johnson J, Kallen A. Prospective solutions to ovarian reserve damage during the ovarian tissue cryopreservation and transplantation procedure. Fertility And Sterility 2024, 122: 565-573. PMID: 39181229, DOI: 10.1016/j.fertnstert.2024.08.330.Peer-Reviewed Original ResearchConceptsOvarian tissue cryopreservationPrimordial follicle growth activationOvarian reserve damageTissue cryopreservationLoss of primordial folliclesThawing protocolRestoration of ovarian functionTransplantation techniquesAmerican Society for Reproductive MedicineSusceptible to ischemic reperfusion injuryIschemic reperfusion injuryEfficacy of adjuvantsAssisted reproductive technologyOvarian cortexPrimordial folliclesGonadotoxic treatmentOvarian reserveAdjuvant treatmentImmature folliclesLive birthsOvarian functionOvarian tissueSlow-freezing approachReperfusion injuryTransplant procedures
2023
hMG addition affects the change in progesterone level during IVF stimulation and LBR: a retrospective cohort study
Wesevich V, Seckin S, Kelk D, Kallen A, Kodaman P. hMG addition affects the change in progesterone level during IVF stimulation and LBR: a retrospective cohort study. Reproductive Biology And Endocrinology 2023, 21: 117. PMID: 38057813, PMCID: PMC10699021, DOI: 10.1186/s12958-023-01150-1.Peer-Reviewed Original ResearchConceptsClinical pregnancy rateFresh embryo transferPeak P levelsPregnancy outcomesEmbryo transferPregnancy rateIVF stimulationCohort studyHigher clinical pregnancy rateOvarian hyperstimulation IVFSingle fertility centerMethodsRetrospective cohort studyRetrospective cohort studyClinical pregnancy outcomesDay of triggerFrozen embryo transferMultivariable logistic modelLower pregnancy ratesP riseEndometrial receptivityProvider recommendationFertility centerProgesterone levelsConclusionsOur dataHigher LBRThe Aging Ovary and the Tales Learned Since Fetal Development
Lopez J, Hohensee G, Liang J, Sela M, Johnson J, Kallen A. The Aging Ovary and the Tales Learned Since Fetal Development. Sexual Development 2023, 17: 156-168. PMID: 37598664, PMCID: PMC10841896, DOI: 10.1159/000532072.Peer-Reviewed Original ResearchConceptsOvarian agingGerm cell populationsQuality of oocytesTreatment of ovarian agingStem cell exhaustionOocyte behaviorWoman's reproductive lifespanFollicle poolOvarian reserveFetal lifeFetal developmentAging ovariesReproductive ageCell exhaustionCell populationsOocytesFolliclesOvaryReproductive lifespanGenomic instabilityOverall agingHallmarks of agingAgeTelomere attritionDNA damage
2020
Emerging roles for noncoding RNAs in female sex steroids and reproductive disease
Zhang R, Wesevich V, Chen Z, Zhang D, Kallen AN. Emerging roles for noncoding RNAs in female sex steroids and reproductive disease. Molecular And Cellular Endocrinology 2020, 518: 110875. PMID: 32668269, PMCID: PMC7609472, DOI: 10.1016/j.mce.2020.110875.Peer-Reviewed Original ResearchConceptsRole of ncRNAsSteroid hormone productionFemale gametogenesisNcRNA expressionRegulatory networksDNA blueprintNoncoding RNAsFunctional RNAsCentral dogmaNcRNAsBiological processesMolecular biologyRNAMessenger RNAParticular disease stateHormone productionSex steroid hormone productionCritical roleProteinTherapeutic targetReproductive pathologiesPotential diagnostic markerPolycystic ovary syndromeReproductive diseasesFemale sex steroidsUpdates on molecular and environmental determinants of luteal progesterone production
DeWitt NA, Whirledge S, Kallen AN. Updates on molecular and environmental determinants of luteal progesterone production. Molecular And Cellular Endocrinology 2020, 515: 110930. PMID: 32610113, PMCID: PMC7484338, DOI: 10.1016/j.mce.2020.110930.Peer-Reviewed Original ResearchConceptsProgesterone productionKey sex steroidsLuteal progesterone productionGranulosa cell functionCAMP/PKA pathwayLuteal progesteroneEarly pregnancyGonadotropin stimulationProgesterone levelsSex steroidsHormonal factorsClassic mediatorsCorpus luteumNarrative reviewCritical hormoneSteroid hormonesExogenous environmental chemicalsCell functionEnvironmental chemicalsHormoneRecent evidenceEndogenous hormonesProgesteronePKA pathwayLocal productionThe relationship between H19 and parameters of ovarian reserve
Xia X, Burn MS, Chen Y, Karakaya C, Kallen A. The relationship between H19 and parameters of ovarian reserve. Reproductive Biology And Endocrinology 2020, 18: 46. PMID: 32404103, PMCID: PMC7218823, DOI: 10.1186/s12958-020-00578-z.Peer-Reviewed Original ResearchConceptsOvarian reserveDecreased ovarian reserveOocyte retrievalH19 expressionInfertility evaluationCumulus cellsTransvaginal oocyte retrievalDiminished ovarian reserveAnti-Mullerian hormoneDownregulation of H19H19 expression levelsGazi University SchoolParticipantsA totalAMH levelsSerum AMHIVF patientsOocyte yieldLow respondersBlood samplesNovel biomarkersExpression levelsFurther studiesPatientsUniversity SchoolH19
2019
A counterintuitive lesson in family planning? Patience first: taking a “gap year” after live birth from assisted reproductive technology before frozen embryo transfer is performed
Seifer DB, Kallen AN. A counterintuitive lesson in family planning? Patience first: taking a “gap year” after live birth from assisted reproductive technology before frozen embryo transfer is performed. Fertility And Sterility 2019, 111: 1109-1110. PMID: 31056317, DOI: 10.1016/j.fertnstert.2019.03.017.Peer-Reviewed Original ResearchTranslational activation of maternally derived mRNAs in oocytes and early embryos and the role of embryonic poly(A) binding protein (EPAB)
Esencan E, Kallen A, Zhang M, Seli E. Translational activation of maternally derived mRNAs in oocytes and early embryos and the role of embryonic poly(A) binding protein (EPAB). Biology Of Reproduction 2019, 100: 1147-1157. PMID: 30806655, PMCID: PMC8127035, DOI: 10.1093/biolre/ioz034.Peer-Reviewed Original ResearchConceptsTranslational activationBinding proteinSpecific protein complexesTranslation of mRNAsOocyte maturationCis-acting sequencesEarly embryo developmentProtein complexesXenopus modelEarly embryosKey regulatorGene expressionMolecular mechanismsEmbryo developmentTargeted disruptionMechanistic detailsProteinEarly developmentMRNAMice resultsKey mechanismOocytesActivationMaturationTranscription
2018
Untapped Reserves: Controlling Primordial Follicle Growth Activation
Kallen A, Polotsky AJ, Johnson J. Untapped Reserves: Controlling Primordial Follicle Growth Activation. Trends In Molecular Medicine 2018, 24: 319-331. PMID: 29452791, PMCID: PMC6482944, DOI: 10.1016/j.molmed.2018.01.008.Peer-Reviewed Original ResearchConceptsPrimordial follicle growth activationDormant primordial folliclesRecovery of eggsCare treatmentHuman ovaryCommon causeLive birthsPrimordial folliclesOocyte qualityOvarian folliclesHealthy offspringGrowth activationReproductive technologiesFolliclesBirthHigh-quality eggsActivationEpigenetic strategiesInfertilityWomen
2016
The Steroidogenic Acute Regulatory Protein (StAR) Is Regulated by the H19/let-7 Axis
Men Y, Fan Y, Shen Y, Lu L, Kallen AN. The Steroidogenic Acute Regulatory Protein (StAR) Is Regulated by the H19/let-7 Axis. Endocrinology 2016, 158: 402-409. PMID: 27813675, PMCID: PMC5413078, DOI: 10.1210/en.2016-1340.Peer-Reviewed Original ResearchConceptsSteroidogenic acute regulatory proteinRegulatory proteinsAcute regulatory proteinPost-transcriptional levelRate-limiting stepMicroRNA let-7H19/letRegulation of reproductionMurine cell linesLet-7Overexpression of H19Long noncoding RNA H19Regulation of steroidogenesisCellular growthSpecific tissuesNovel mechanismMultiple rolesNovel targetRNA H19StAR expressionExpression variesCell linesRegulationH19Protein
2015
Poor ovarian response in women undergoing in vitro fertilization is associated with altered microRNA expression in cumulus cells
Karakaya C, Guzeloglu-Kayisli O, Uyar A, Kallen AN, Babayev E, Bozkurt N, Unsal E, Karabacak O, Seli E. Poor ovarian response in women undergoing in vitro fertilization is associated with altered microRNA expression in cumulus cells. Fertility And Sterility 2015, 103: 1469-1476.e3. PMID: 25910568, PMCID: PMC5648585, DOI: 10.1016/j.fertnstert.2015.02.035.Peer-Reviewed Original ResearchConceptsIVF-intracytoplasmic sperm injectionMiR-21-5p expressionPoor respondersMiR-21-5pMiR-21-3pCumulus cellsHuman granulosa-like tumor cellsMicro-ribonucleic acid (miRNA) expressionMiR-21-3p expressionLower serum E2 levelsMiR-21Elevated expressionPoor ovarian responseSerum E2 levelsReverse transcription real-time polymerase chain reactionTranscription real-time polymerase chain reactionNumber of oocytesLower E2 concentrationsAcademic medical centerReal-time polymerase chain reactionRespective age groupsMicroRNA microarray analysisOvarian responseAltered miRNA expressionE2 levelsBlood type predicts live birth in the infertile population
Goldsammler M, Jindal SK, Kallen A, Mmbaga N, Pal L. Blood type predicts live birth in the infertile population. Journal Of Assisted Reproduction And Genetics 2015, 32: 551-555. PMID: 25701141, PMCID: PMC4380903, DOI: 10.1007/s10815-015-0441-2.Peer-Reviewed Original ResearchConceptsIVF cycle outcomesIU/LLive birthsBlood type ABlood type BBlood typeBaseline FSHInfertile womenCycle outcomeMultivariable logistic regression analysisIVF cycle parametersBlood type OPatient's blood typeType BLogistic regression analysisType AType OOvulatory infertilityPatient characteristicsIVF outcomesMethodsRetrospective studyInfertile populationHigher oddsAcademic centersInfertility
2013
Hormone Therapy
Fischer C, Kallen AN, Pal L. Hormone Therapy. Menopause The Journal Of The North American Menopause Society 2013, 20: 1204-1206. PMID: 23921519, DOI: 10.1097/gme.0b013e31829cd38d.Peer-Reviewed Original ResearchThe Imprinted H19 LncRNA Antagonizes Let-7 MicroRNAs
Kallen AN, Zhou XB, Xu J, Qiao C, Ma J, Yan L, Lu L, Liu C, Yi JS, Zhang H, Min W, Bennett AM, Gregory RI, Ding Y, Huang Y. The Imprinted H19 LncRNA Antagonizes Let-7 MicroRNAs. Molecular Cell 2013, 52: 101-112. PMID: 24055342, PMCID: PMC3843377, DOI: 10.1016/j.molcel.2013.08.027.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBinding SitesCell DifferentiationComputational BiologyDatabases, GeneticGene Expression ProfilingGene Expression RegulationGenomic ImprintingGenotypeHEK293 CellsHuman Umbilical Vein Endothelial CellsHumansMiceMicroRNAsMuscle DevelopmentMyoblasts, SkeletalPhenotypeRibonucleoproteinsRNA InterferenceRNA, Long NoncodingTime FactorsTransfectionConceptsLet-7 familyWide transcriptome analysisHuman genetic disordersNoncanonical binding siteLet-7 microRNALet-7 overexpressionGene functionH19 depletionTranscriptome analysisMuscle differentiationMolecular spongeUnexpected modeImportant regulatorAdult muscleH19 knockdownRecent implicationMiR-675Physiological significanceMicroRNAsH19Binding sitesGenetic disordersOverexpressionImportant roleFetal tissuesAberrant endocrinology and ovarian response to clomiphene citrate during the course of an undiagnosed early intrauterine pregnancy: a case report.
Kallen AN, Luk J, Pal L. Aberrant endocrinology and ovarian response to clomiphene citrate during the course of an undiagnosed early intrauterine pregnancy: a case report. The Journal Of Reproductive Medicine 2013, 58: 256-60. PMID: 23763012.Peer-Reviewed Original ResearchConceptsEarly pregnancyOI cyclesFollicular responseOvulation inductionSerum progesteroneTreatment cyclesEmbryonic exposureBeta-hCG testingEarly intrauterine pregnancyRepeat treatment cyclesLow serum levelsProgression of pregnancyIntrauterine pregnancyReview of literatureThin endometriumOvarian responseSerum levelsFertility drugsTransvaginal ultrasoundEstradiol levelsSuccessful pregnancyInfertile patientsCase reportPregnancy progressionRepeat treatment
2011
Cardiovascular disease and ovarian function
Kallen AN, Pal L. Cardiovascular disease and ovarian function. Current Opinion In Obstetrics & Gynecology 2011, 23: 258-267. PMID: 21681091, DOI: 10.1097/gco.0b013e3283488a21.Peer-Reviewed Original ResearchConceptsCoronary heart diseaseHormone therapyCHD riskOvarian functionExogenous estrogenCHD risk profileFemale reproductive hormonesProcess of atherosclerosisExogenous hormone therapyCause of deathProcess of atherogenesisEndogenous ovarian estrogensDuration of exposurePostmenopausal womenCardiac benefitsOvarian hormonesVascular protectionMenopausal womenOvarian estrogenHeart diseaseCardiovascular diseaseEstrogenic milieuOvarian senescenceReproductive hormonesOvarian physiology
2010
Review: Gender Differences in Cardiovascular Disease: Hormonal and Biochemical Influences
Pérez-López FR, Larrad-Mur L, Kallen A, Chedraui P, Taylor HS. Review: Gender Differences in Cardiovascular Disease: Hormonal and Biochemical Influences. Reproductive Sciences 2010, 17: 511-531. PMID: 20460551, PMCID: PMC3107852, DOI: 10.1177/1933719110367829.Peer-Reviewed Original ResearchConceptsDevelopment of CVDCardiovascular diseaseSex hormonesSmooth muscle cell wallVascular wall thicknessOvert atherosclerosisCardiovascular changesAccumulation of cellsLower riskEndocrine factorsGender differencesEndocrine influencesAtherosclerosisHormoneBiochemical influencesDiseaseOverview of factorsGenetic backgroundExtracellular matrixWall thicknessAndrogensEstradiolPubMedEndotheliumHormonalEndothelin Type A Receptor (ETA) Expression Is Regulated by HOXA10 in Human Endometrial Stromal Cells
Penna IA, Hongling Du, Kallen AN, Taylor HS. Endothelin Type A Receptor (ETA) Expression Is Regulated by HOXA10 in Human Endometrial Stromal Cells. Reproductive Sciences 2010, 17: 471-476. PMID: 20371740, PMCID: PMC3107845, DOI: 10.1177/1933719110361961.Peer-Reviewed Original ResearchConceptsHuman endometrial stromal cell lineEndometrial stromal cellsEndometrial stromal cell lineFirst trimester decidual cellsStromal cellsHuman endometrial stromal cellsEndometrial epithelial cell lineHuman endometrial epithelial cell lineFirst trimester deciduaVascular smooth muscle cellsReverse transcriptase-polymerase chain reactionQuantitative reverse transcriptase-polymerase chain reactionTranscriptase-polymerase chain reactionSmooth muscle cellsCell linesStromal cell growthG protein-coupled receptorsReproductive-age individualsEndometrial biopsyProtein-coupled receptorsEndometrial receptivityNormal endometriumDecidual samplesElective terminationEpithelial cell line