2024
Prospective solutions to ovarian reserve damage during the ovarian tissue cryopreservation and transplantation procedure
Mercier A, Johnson J, Kallen A. Prospective solutions to ovarian reserve damage during the ovarian tissue cryopreservation and transplantation procedure. Fertility And Sterility 2024, 122: 565-573. PMID: 39181229, DOI: 10.1016/j.fertnstert.2024.08.330.Peer-Reviewed Original ResearchConceptsOvarian tissue cryopreservationPrimordial follicle growth activationOvarian reserve damageTissue cryopreservationLoss of primordial folliclesThawing protocolRestoration of ovarian functionTransplantation techniquesAmerican Society for Reproductive MedicineSusceptible to ischemic reperfusion injuryIschemic reperfusion injuryEfficacy of adjuvantsAssisted reproductive technologyOvarian cortexPrimordial folliclesGonadotoxic treatmentOvarian reserveAdjuvant treatmentImmature folliclesLive birthsOvarian functionOvarian tissueSlow-freezing approachReperfusion injuryTransplant procedures
2023
The Aging Ovary and the Tales Learned Since Fetal Development
Lopez J, Hohensee G, Liang J, Sela M, Johnson J, Kallen A. The Aging Ovary and the Tales Learned Since Fetal Development. Sexual Development 2023, 17: 156-168. PMID: 37598664, PMCID: PMC10841896, DOI: 10.1159/000532072.Peer-Reviewed Original ResearchConceptsOvarian agingGerm cell populationsQuality of oocytesTreatment of ovarian agingStem cell exhaustionOocyte behaviorWoman's reproductive lifespanFollicle poolOvarian reserveFetal lifeFetal developmentAging ovariesReproductive ageCell exhaustionCell populationsOocytesFolliclesOvaryReproductive lifespanGenomic instabilityOverall agingHallmarks of agingAgeTelomere attritionDNA damage
2020
Control of Murine Primordial Follicle Growth Activation by IκB/NFκB Signaling
Wright CJ, Cari EL, Sandoval J, Bales E, Sam PK, Zarate MA, Polotsky AJ, Kallen AN, Johnson J. Control of Murine Primordial Follicle Growth Activation by IκB/NFκB Signaling. Reproductive Sciences 2020, 27: 2063-2074. PMID: 32542534, PMCID: PMC7529825, DOI: 10.1007/s43032-020-00225-3.Peer-Reviewed Original ResearchConceptsPrimordial follicle growth activationLargest human genome-wide association studyGrowth activationHuman genome-wide association studiesGenome-wide association studiesLigand/receptor interactionsTranscription factor NFκBInhibitory protein IκBαAssociation studiesIκB proteinsWild-type controlsInhibitory proteinProtein IκBαPrimordial stageNFκB signalingMechanistic insightsReceptor interactionProteinMurine ovariesNFκB pathwayKey membersNFκBSubunit p65NFκB activationIκBβ
2018
Untapped Reserves: Controlling Primordial Follicle Growth Activation
Kallen A, Polotsky AJ, Johnson J. Untapped Reserves: Controlling Primordial Follicle Growth Activation. Trends In Molecular Medicine 2018, 24: 319-331. PMID: 29452791, PMCID: PMC6482944, DOI: 10.1016/j.molmed.2018.01.008.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsFemaleHumansInfertilityOocytesOvarian FollicleOvumPregnancyReproductive Techniques, AssistedConceptsPrimordial follicle growth activationDormant primordial folliclesRecovery of eggsCare treatmentHuman ovaryCommon causeLive birthsPrimordial folliclesOocyte qualityOvarian folliclesHealthy offspringGrowth activationReproductive technologiesFolliclesBirthHigh-quality eggsActivationEpigenetic strategiesInfertilityWomen