2023
The Aging Ovary and the Tales Learned Since Fetal Development
Lopez J, Hohensee G, Liang J, Sela M, Johnson J, Kallen A. The Aging Ovary and the Tales Learned Since Fetal Development. Sexual Development 2023, 17: 156-168. PMID: 37598664, PMCID: PMC10841896, DOI: 10.1159/000532072.Peer-Reviewed Original ResearchConceptsOvarian agingGerm cell populationsQuality of oocytesTreatment of ovarian agingStem cell exhaustionOocyte behaviorWoman's reproductive lifespanFollicle poolOvarian reserveFetal lifeFetal developmentAging ovariesReproductive ageCell exhaustionCell populationsOocytesFolliclesOvaryReproductive lifespanGenomic instabilityOverall agingHallmarks of agingAgeTelomere attritionDNA damage
2018
Untapped Reserves: Controlling Primordial Follicle Growth Activation
Kallen A, Polotsky AJ, Johnson J. Untapped Reserves: Controlling Primordial Follicle Growth Activation. Trends In Molecular Medicine 2018, 24: 319-331. PMID: 29452791, PMCID: PMC6482944, DOI: 10.1016/j.molmed.2018.01.008.Peer-Reviewed Original ResearchConceptsPrimordial follicle growth activationDormant primordial folliclesRecovery of eggsCare treatmentHuman ovaryCommon causeLive birthsPrimordial folliclesOocyte qualityOvarian folliclesHealthy offspringGrowth activationReproductive technologiesFolliclesBirthHigh-quality eggsActivationEpigenetic strategiesInfertilityWomen