2024
Mental healthcare in paediatric epilepsy clinics: implementation by non-mental health professionals
Coughtrey A, Bennett S, Stanick C, Chorpita B, Dalrymple E, Fonagy P, Cross J, Ford T, Heyman I, Moss-Morris R, Jetha P, Myles-Hooton P, Shafran R. Mental healthcare in paediatric epilepsy clinics: implementation by non-mental health professionals. BMJ Paediatrics Open 2024, 8: e002973. PMID: 39557540, PMCID: PMC11574424, DOI: 10.1136/bmjpo-2024-002973.Peer-Reviewed Original ResearchConceptsPaediatric epilepsy clinicsMental health interventionsHealthcare professionalsHealth interventionsImplementation of mental health interventionsEvidence-based mental health interventionsBarriers to effective careNon-mental health professionalsCognitive behavioral therapy interventionPaediatric epilepsy servicesTrained healthcare professionalsEpilepsy clinicMental health experiencesMental health needsMental health disordersBehavioral therapy interventionSupervision packageMental healthcareTherapy interventionsEffective careHealth experiencesHealth professionalsHealth needsHealth disordersMICE protocolTrust under development: The Italian validation of the Epistemic Trust, Mistrust, and Credulity Questionnaire (ETMCQ) for adolescents
Milesi A, Liotti M, Locati F, De Carli P, Speranza A, Campbell C, Fonagy P, Lingiardi V, Parolin L. Trust under development: The Italian validation of the Epistemic Trust, Mistrust, and Credulity Questionnaire (ETMCQ) for adolescents. PLOS ONE 2024, 19: e0307229. PMID: 39186540, PMCID: PMC11346731, DOI: 10.1371/journal.pone.0307229.Peer-Reviewed Original ResearchConceptsSelf-report instrumentEpistemic trustContext of personality disordersConcept of epistemic trustDevelopment of mental disordersPersonality disorderEmotion dysregulationMeasure mentalizingMental disordersPsychological functioningItalian validationMental healthPsychopathologyAdolescent populationInterpersonal trustAdolescentsDisordersResearch contextEmpirical validationHigh schoolItalian adult populationAdult populationMentalQuestionnaireValidityHuman adolescent brain similarity development is different for paralimbic versus neocortical zones
Dorfschmidt L, Váša F, White S, Romero-García R, Kitzbichler M, Alexander-Bloch A, Cieslak M, Mehta K, Satterthwaite T, Consortium T, Bethlehem R, Seidlitz J, Vértes P, Bullmore E, Bullmore E, Dolan R, Goodyer I, Fonagy P, Jones P, Moutoussis M, Hauser T, Neufeld S, Romero-Garcia R, St Clair M, Vértes P, Whitaker K, Inkster B, Prabhu G, Ooi C, Toseeb U, Widmer B, Bhatti J, Villis L, Alrumaithi A, Birt S, Bowler A, Cleridou K, Dadabhoy H, Davies E, Firkins A, Granville S, Harding E, Hopkins A, Isaacs D, King J, Kokorikou D, Maurice C, McIntosh C, Memarzia J, Mills H, O’Donnell C, Pantaleone S, Scott J, Kiddle B, Polek E, Fearon P, Suckling J, van Harmelen A, Kievit R, Chamberlain S, Bethlehem R. Human adolescent brain similarity development is different for paralimbic versus neocortical zones. Proceedings Of The National Academy Of Sciences Of The United States Of America 2024, 121: e2314074121. PMID: 39121162, PMCID: PMC11331068, DOI: 10.1073/pnas.2314074121.Peer-Reviewed Original ResearchConceptsMorphometric similarity networksFunctional connectivityNeocortical areasCortical areasFunctional MRI scansCourse of adolescenceAccelerated longitudinal designMagnetic resonance imagingStructure-function couplingCingulate cortexParalimbic areasInteroceptive functionAssociated with increased strengthIncreased hubnessFMRI networksStructural scansLongitudinal designCortical thinningDevelopment of human brainAdolescent developmentMorphometric similarityHealthy adolescentsAssociated with reduced strengthHuman brainCortexExamination of a case of “treatment failure” in long-term psychoanalytic psychotherapy for treatment-resistant depression
Willemsen J, Rost F, Hustinx M, Fonagy P, Taylor D. Examination of a case of “treatment failure” in long-term psychoanalytic psychotherapy for treatment-resistant depression. The International Journal Of Psychoanalysis 2024, 105: 475-495. PMID: 39230487, DOI: 10.1080/00207578.2024.2352827.Peer-Reviewed Original ResearchConceptsTreatment-resistant depressionPsychoanalytic psychotherapyLong-term psychoanalytic psychotherapyLevels of depressionNegative therapeutic reactionExperiences of abandonmentPatients' levels of depressionStructured Clinical AssessmentPost-treatment outcomesTherapeutic relationshipPatterns of repetitionTherapy processTherapeutic reactionDepressionPsychic conflictPsychotherapyInternal worldInner worldClinical assessmentRandomized controlled trialsLack of symbolismDestructive patternsResearch contextInterpretive stanceTherapistsBrief Educational Workshops in Secondary Schools Trial (BESST trial), a school-based cluster randomised controlled trial of the DISCOVER workshop for 16–18-year-olds: recruitment and baseline characteristics
James K, Lisk S, Payne-Cook C, Farishta Z, Farrelly M, Sheikh A, Slusarczyk M, Byford S, Day C, Deighton J, Evans C, Fonagy P, Saunders D, Sclare I, Shearer J, Stallard P, Weaver T, Yarrum J, Carter B, Brown J. Brief Educational Workshops in Secondary Schools Trial (BESST trial), a school-based cluster randomised controlled trial of the DISCOVER workshop for 16–18-year-olds: recruitment and baseline characteristics. Trials 2024, 25: 302. PMID: 38702825, PMCID: PMC11069277, DOI: 10.1186/s13063-024-08116-7.Peer-Reviewed Original ResearchConceptsSchool-based cluster randomised controlled trialWarwick-Edinburgh Mental Wellbeing ScaleCluster randomised controlled trialRandomised controlled trialsSchools TrialEducational workshopsMental Wellbeing ScaleControlled trialsOutcome data collectionSymptoms of depressionEthnic minority groupsSecondary schoolsReduce stigmaBaseline characteristicsPost-randomisationWellbeing ScaleSelf-referralSelf-referredLower wellbeingStudentsDistressed studentsEthnically diverse sampleSchoolWorkshop programmeGeneral wellbeingImplementing and evaluating group interpersonal therapy for postnatal depression in Lebanon and Kenya—individually randomised superiority trial
Fonagy P, Chammay R, Ngunu C, Kumar M, Verdeli L, Allison E, Anani G, Fearon P, Fouad F, Hoare Z, Koyio L, Moore H, Nyandigisi A, Pilling S, Sender H, Skordis J, Evans R, Jaoude G, Madeghe B, Maradian S, O’Donnell C, Simes E, Truscott A, Wambua G, Yator O. Implementing and evaluating group interpersonal therapy for postnatal depression in Lebanon and Kenya—individually randomised superiority trial. Trials 2024, 25: 217. PMID: 38532432, PMCID: PMC10964704, DOI: 10.1186/s13063-024-08039-3.Peer-Reviewed Original ResearchConceptsPostnatal depressionInterpersonal psychotherapyChild developmental outcomesMulti-site randomised controlled trialWomen's mental health needsStandard careEfficacy of interpersonal psychotherapyMaternal postnatal depressionMental health needsMental health concernsMiddle-income countriesRandomised controlled trialsDevelopmental outcomesHigh-income countriesAntenatal servicesChildbearing womenMother-child bondingRandomised superiority trialChildren's developmental progressHealth needsOffspring of womenMaternal depressionCommunity settingsLMIC contextsInterpersonal therapyClinical effectiveness of the psychological therapy Mental Health Intervention for Children with Epilepsy in addition to usual care compared with assessment-enhanced usual care alone: a multicentre, randomised controlled clinical trial in the UK
Bennett S, Cross J, Chowdhury K, Ford T, Heyman I, Coughtrey A, Dalrymple E, Byford S, Chorpita B, Fonagy P, Moss-Morris R, Reilly C, Smith J, Stephenson T, Varadkar S, Blackstone J, Quartly H, Hughes T, Lewins A, Moore E, Walji F, Welch A, Whelan E, Zacharia A, D'Oelsnitz A, Shah M, Xu L, Vezyroglou A, Mitchell K, Nizza I, Ganguli P, Shafran R. Clinical effectiveness of the psychological therapy Mental Health Intervention for Children with Epilepsy in addition to usual care compared with assessment-enhanced usual care alone: a multicentre, randomised controlled clinical trial in the UK. The Lancet 2024, 403: 1254-1266. PMID: 38461840, DOI: 10.1016/s0140-6736(23)02791-5.Peer-Reviewed Original ResearchConceptsChronic health conditionsMental health disordersUsual careMental health interventionsMental health difficultiesHealth conditionsHealth disordersHealth interventionsHealth difficultiesProgramme Grants for Applied Research programmeNational Institute for Health Research Programme Grants for Applied Research programmeTreating common mental health conditionsMICE groupPrimary mental health disorderYoung peopleMental health comorbiditiesMonths post-randomisationStudy inclusionMental health conditionsEvidence-based psychological treatmentsMental health treatmentMental health assessmentIntellectual disabilityParent-reported StrengthsParticipants aged 3Brief Educational Workshops in Secondary Schools Trial (BESST): a cluster randomised controlled trial. Secondary analysis in those with elevated symptoms of depression
Lisk S, James K, Shearer J, Byford S, Stallard P, Deighton J, Saunders D, Yarrum J, Fonagy P, Weaver T, Sclare I, Day C, Evans C, Carter B, Brown J. Brief Educational Workshops in Secondary Schools Trial (BESST): a cluster randomised controlled trial. Secondary analysis in those with elevated symptoms of depression. BMJ Mental Health 2024, 27: e301192. PMID: 39209761, PMCID: PMC11367360, DOI: 10.1136/bmjment-2024-301192.Peer-Reviewed Original ResearchConceptsTreatment-as-usualCluster randomised controlled trialNational Health ServiceElevated symptoms of depressionQuality-adjusted life yearsElevated depressive symptomsSymptoms of depressionRandomised controlled trialsDepressive symptomsSchools TrialElevated symptomsEducational workshopsIntention-to-treatSecondary analysisPersonal Social Services perspectiveControlled trialsMultilevel linear regressionSocial Services perspectiveSchool-based interventionsCost-effectiveIntention-to-treat analysisOutcomes of participantsHealth servicesIncremental cost-effectiveness ratioClinically meaningful effect
2009
A cluster randomized controlled trial of child‐focused psychiatric consultation and a school systems‐focused intervention to reduce aggression
Fonagy P, Twemlow SW, Vernberg EM, Nelson JM, Dill EJ, Little TD, Sargent JA. A cluster randomized controlled trial of child‐focused psychiatric consultation and a school systems‐focused intervention to reduce aggression. Journal Of Child Psychology And Psychiatry 2009, 50: 607-616. PMID: 19207633, DOI: 10.1111/j.1469-7610.2008.02025.x.Peer-Reviewed Original ResearchConceptsPsychiatric consultationSchool-based anti-bullying programsPercent of childrenTrial of effectivenessSystem-focused interventionsTAU conditionOutcome measuresActive interventionSignificant decreaseTrialsInterventionBehavioral changesSchool childrenChildrenAnti-bullying programsElementary school childrenStudy conditionsConsultationDisturbed childrenSchool-wide interventionsYearsLegitimacy of aggression