Cortical structure and subcortical volumes in conduct disorder: a coordinated analysis of 15 international cohorts from the ENIGMA-Antisocial Behavior Working Group
Gao Y, Staginnus M, Group E, Gao Y, Staginnus M, Townend S, Arango C, Bajaj S, Banaschewski T, Barker E, Benegal V, Berluti K, Bernhard A, Blair R, Boateng C, Bokde A, Brandeis D, Buitelaar J, Burt S, Cardinale E, Castro-Fornieles J, Chen H, Chen X, Chester S, Colins O, Cornwell H, Craig M, Cubillo A, Desrivieres S, Díaz D, Dietrich A, Dong D, Dykstra A, Franke B, Freitag C, Glennon J, Gonzalez-Madruga K, Hagan C, Hoekstra P, Holla B, Hyde L, Ibrahim K, Jabeen N, Jackson R, Jiang Y, Kohls G, Konrad K, Kypta-Vivanco A, Lamers K, Ma R, Marsh A, Martinelli A, Martinot J, Michalska K, Ming Q, Minosse S, Mitchell C, Monk C, Murphy D, Mycue L, Naaijen J, Oosterling M, Passamonti L, Pauli R, Alonso M, Phillips H, Ploe M, Raschle N, Roberts R, Rogers J, Rosa-Justicia M, Sagar-Ouriaghli I, Schulze U, Schumann G, Sethi A, Smaragdi A, Sonuga-Barke E, Stadler C, Stevens M, Sukhodolsky D, Sully K, Sun X, Toschi N, Townsend C, van der Wee N, Vermeiren R, Viding E, Wang X, Westerman H, Wu Q, Yao S, Zhang J, Zhou J, Zhou J, Jahanshad N, Thomopoulos S, Ching C, Kang M, Thompson P, Klapwijk E, Pine D, Baskin-Sommers A, Cecil C, Aghajani M, Walton E, Fairchild G, De Brito S. Cortical structure and subcortical volumes in conduct disorder: a coordinated analysis of 15 international cohorts from the ENIGMA-Antisocial Behavior Working Group. The Lancet Psychiatry 2024, 11: 620-632. PMID: 39025633, DOI: 10.1016/s2215-0366(24)00187-1.Peer-Reviewed Original ResearchConceptsGroup-by-age interactionCallous-unemotional traitsConduct disorder groupConduct disorderBrain structural alterationsSubcortical volumesDisorder groupDiagnosis of conduct disorderCaudal anterior cingulate cortexAnalysis of structural MRI dataCortical thicknessT1-weighted MRI brain scansBrain structural correlatesAnterior cingulate cortexSuperior temporal sulcusStructural MRI dataAssess group differencesMRI brain scansNucleus accumbensADHD comorbidityCingulate cortexDisorder subtypesSmaller amygdalaBrain alterationsTemporal sulcusSocial Learning and Preferences in Adolescents With Conduct Problems and Varying Levels of Callous-Unemotional Traits
Gaule A, Bevilacqua L, Molleman L, van den Bos W, van Duijvenvoorde A, Roberts R, Pease C, McCrory E, Viding E. Social Learning and Preferences in Adolescents With Conduct Problems and Varying Levels of Callous-Unemotional Traits. JAACAP Open 2024, 2: 79-89. PMCID: PMC11562431, DOI: 10.1016/j.jaacop.2023.12.008.Peer-Reviewed Original ResearchCallous-unemotional traitsConduct problemsTD adolescentsLevels of callous-unemotional traitsLevels of CU traitsDisplay aggressive behaviorCU traitsAdolescents' CPSocial learningSocial environmentNon-socialGroup differencesAggressive behaviorCP/LCUSocial behaviorObject learningDifficulty learningEconomic gamesSocial partnersSocial preferencesCP/HCUAdolescentsSocial relationshipsResults AdolescentsSocial worldWhy Should I? Examining How Childhood Callous-Unemotional Traits Relate to Prosocial and Affiliative Behaviors and Motivations
Paz Y, All K, Kohli S, Plate R, Viding E, Waller R. Why Should I? Examining How Childhood Callous-Unemotional Traits Relate to Prosocial and Affiliative Behaviors and Motivations. Research On Child And Adolescent Psychopathology 2024, 52: 1075-1087. PMID: 38498231, DOI: 10.1007/s10802-024-01170-4.Peer-Reviewed Original ResearchCU traitsHigh CU traitsAffiliative behaviorProsocial behaviorNeutral situationsSocial affiliationChild CU traitsCallous-unemotional traitsDifficulties of childrenCallous-unemotionalLow empathyEmotional needsSocial motivationMotivational difficultiesAssess recognitionConduct problemsAssociated with different subtypesYoung childrenProsocialityTraitsInstrumental needsMotivationChildrenSelfChildhoodReciprocal Effects Between Negative Parenting and Children’s Callous-Unemotional Traits From Mid to Late Childhood
Pezzoli P, Pingault J, Malanchini M, Voronin I, McCrory E, Fearon P, Viding E. Reciprocal Effects Between Negative Parenting and Children’s Callous-Unemotional Traits From Mid to Late Childhood. American Journal Of Psychiatry 2024, 181: 310-321. PMID: 38476045, DOI: 10.1176/appi.ajp.20230208.Peer-Reviewed Original ResearchChild CU traitsDevelopment of CU traitsCU traitsMid-to-late childhoodNegative parentingCallous-unemotionalTwins Early Development StudyLate childhoodLongitudinal cross-lagged modelsEffects of negative parentingCallous-unemotional traitsEarly Development StudyReciprocal effectsCross-lagged modelsCross-lagged effectsFamilies of childrenTwin pairsGenetic factorsParental disciplineParental feelingsChildhoodSmall effectsTraitsEnvironmental factorsParentsEvaluating the sensitivity to threat and affiliative reward (STAR) model in relation to the development of conduct problems and callous‐unemotional traits across early adolescence
Paz Y, Perkins E, Colins O, Perlstein S, Wagner N, Hawes S, Byrd A, Viding E, Waller R. Evaluating the sensitivity to threat and affiliative reward (STAR) model in relation to the development of conduct problems and callous‐unemotional traits across early adolescence. Journal Of Child Psychology And Psychiatry 2024, 65: 1327-1339. PMID: 38480986, PMCID: PMC11393184, DOI: 10.1111/jcpp.13976.Peer-Reviewed Original ResearchCU traitsSensitivity to threatThreat sensitivityLow affiliationConduct problemsCallous-unemotionalAffiliative rewardsParent-reported CU traitsDevelopment of conduct problemsCallous-unemotional traitsTransdiagnostic risk factorSevere conduct problemsChild-reported dataMeasures of affiliationDSM-5Early adolescenceLate childhoodPreliminary evidencePsychopathologyAdolescentsAnxietyEarly childhoodRewardAssessment modalitiesTraitsReduced prosocial motivation and effort in adolescents with conduct problems and callous‐unemotional traits
Gaule A, Martin P, Lockwood P, Cutler J, Apps M, Roberts R, Phillips H, Brown K, McCrory E, Viding E. Reduced prosocial motivation and effort in adolescents with conduct problems and callous‐unemotional traits. Journal Of Child Psychology And Psychiatry 2024, 65: 1061-1071. PMID: 38287126, DOI: 10.1111/jcpp.13945.Peer-Reviewed Original ResearchLevels of CU traitsCallous-unemotional traitsProsocial behaviorProsocial choicesConduct problemsProsocial actsCU traitsLevels of callous-unemotional traitsPsychopathy in adulthoodCognitive-affective mechanismsReduced prosocial behaviorLow prosocial behaviorBenefit othersTD peersAntisocial behaviorCP/HCUBehavioral levelBenefit oneselfCP/LCUReduced engagementProsocial motivationAdolescentsAdolescent boysTraitsReduced exertion