2024
Atypical Interpersonal Problem-Solving and Resting-state Functional Connectivity in Adolescents with Maltreatment Experience
Gerin M, Viding E, Puetz V, Armbruster-Genc D, Rankin G, McCrory E. Atypical Interpersonal Problem-Solving and Resting-state Functional Connectivity in Adolescents with Maltreatment Experience. Current Neuropharmacology 2024, 22: 290-301. PMID: 37818587, PMCID: PMC10788892, DOI: 10.2174/1570159x22666231002145440.Peer-Reviewed Original ResearchConceptsResting-state functional connectivityPosterior cingulate cortexMedial prefrontal cortexMental health symptomsMaltreatment experiencesSocial functioningLingual gyrusFunctional connectivityHealth symptomsInterpersonal problem-solving skillsRetrosplenial cortexElevated mental health symptomsDefault mode network hubInterpersonal problem solvingPoor social functioningAdverse environmental experiencesProblem-solving performanceNon-maltreated peersProblem-solving skillsExperiences of abuseSeed-based analysisNeurocognitive processingNeurocognitive functioningMental health disordersEarly adversity
2023
A systematic review of childhood maltreatment and resting state functional connectivity
Gerin M, Viding E, Herringa R, Russell J, McCrory E. A systematic review of childhood maltreatment and resting state functional connectivity. Developmental Cognitive Neuroscience 2023, 64: 101322. PMID: 37952287, PMCID: PMC10665826, DOI: 10.1016/j.dcn.2023.101322.Peer-Reviewed Original ResearchConceptsResting-state functional connectivityAnterior cingulate cortexFunctional connectivityCingulate cortexChildhood maltreatmentAltered functional connectivityState functional connectivityDorsal anterior cingulate cortexNegative psychiatric outcomesVentral anterior cingulate cortexDorsolateral prefrontal cortexRsFC alterationsAltered connectivityInclusion criteriaAmygdala connectivityNineteen studiesPsychiatric outcomesFuture symptomsSystematic reviewBrain regionsClinical disordersBrain circuitsAnterior insulaPrefrontal cortexMaltreatment exposure
2021
Functional brain plasticity following childhood maltreatment: A longitudinal fMRI investigation of autobiographical memory processing.
Puetz V, Viding E, Maguire E, Mechelli A, Armbruster-Genç D, Sharp M, Rankin G, Gerin M, McCrory E. Functional brain plasticity following childhood maltreatment: A longitudinal fMRI investigation of autobiographical memory processing. Development And Psychopathology 2021, 35: 1382-1389. PMID: 34924093, DOI: 10.1017/s0954579421001292.Peer-Reviewed Original ResearchConceptsChildhood maltreatmentAutobiographical memory processingCortical midline structuresValenced cue wordsPotential developmental plasticityCue wordsMemory processingFMRI studyBOLD signal changesNeural functioningPsychological assessmentBrain networksMaltreatmentMidline structuresMaturational changesLongitudinal analysisProcessingSignal changesFMRIPsychopathologyRecallAdolescentsFunctioningWordsDevelopmental plasticity
2020
Individual differences in sensitivity to the early environment as a function of amygdala and hippocampus volumes: An exploratory analysis in 12-year-old boys
Pluess M, De Brito S, Bartoli A, McCrory E, Viding E. Individual differences in sensitivity to the early environment as a function of amygdala and hippocampus volumes: An exploratory analysis in 12-year-old boys. Development And Psychopathology 2020, 34: 901-910. PMID: 33342453, DOI: 10.1017/s0954579420001698.Peer-Reviewed Original ResearchConceptsIndividual differencesLeft amygdalaEnvironmental influencesLeft amygdala volumeNeurobiological sensitivityImportant brain regionsChild behaviorBrain regionsEarly environmentContextual factorsPositive experiencesBrain structuresAmygdala volumePreliminary evidenceAmygdalaGeneral environmental qualityHippocampus volumeExploratory analysisBoysExploratory studyEnvironmental featuresDisruptive Behavior Disorders: The Challenge of Delineating Mechanisms in the Face of Heterogeneity
Viding E, McCrory E. Disruptive Behavior Disorders: The Challenge of Delineating Mechanisms in the Face of Heterogeneity. American Journal Of Psychiatry 2020, 177: 811-817. PMID: 32867523, DOI: 10.1176/appi.ajp.2020.20070998.Peer-Reviewed Original Research
2019
Towards understanding atypical social affiliation in psychopathy
Viding E, McCrory E. Towards understanding atypical social affiliation in psychopathy. The Lancet Psychiatry 2019, 6: 437-444. PMID: 31006435, DOI: 10.1016/s2215-0366(19)30049-5.Peer-Reviewed Original ResearchConceptsSocial affiliationNeural systemsNeurocognitive vulnerabilityNegative emotionsAuthentic social relationshipsProsocial behaviorProsocial interactionsNeurocognitive findingsPsychopathySocial relationshipsDistressResearch directionsIndividualsAffiliationEmotionsGuiltEnjoymentMotivationAttachmentFindingsVulnerabilityRelationshipResearch effortsBehavior
2018
Primary and Secondary Variants of Psychopathy in a Volunteer Sample Are Associated With Different Neurocognitive Mechanisms
Sethi A, McCrory E, Puetz V, Hoffmann F, Knodt A, Radtke S, Brigidi B, Hariri A, Viding E. Primary and Secondary Variants of Psychopathy in a Volunteer Sample Are Associated With Different Neurocognitive Mechanisms. Biological Psychiatry Cognitive Neuroscience And Neuroimaging 2018, 3: 1013-1021. PMID: 29752216, PMCID: PMC6185817, DOI: 10.1016/j.bpsc.2018.04.002.Peer-Reviewed Original ResearchConceptsAnterior cingulate cortexNeurocognitive mechanismsPsychopathic traitsPrimary psychopathySecondary psychopathyCingulate cortexEmotional face processing taskComparison groupDifferent neurocognitive mechanismsDistinct neural correlatesFace processing taskFunctional magnetic resonance imagingInferior parietal lobeVolunteer sampleAnger processingNeurocognitive correlatesInsula activityNeural correlatesNeural responsesAnxiety measuresNeural activationSecondary presentationLower anxietyPsychopathy groupHigh anxiety
2017
A neurocomputational investigation of reinforcement-based decision making as a candidate latent vulnerability mechanism in maltreated children
Gerin M, Puetz V, Blair R, White S, Sethi A, Hoffmann F, Palmer A, Viding E, McCrory E. A neurocomputational investigation of reinforcement-based decision making as a candidate latent vulnerability mechanism in maltreated children. Development And Psychopathology 2017, 29: 1689-1705. PMID: 29162176, DOI: 10.1017/s095457941700133x.Peer-Reviewed Original ResearchConceptsMaltreated groupReinforcement-based decisionEarly adverse environmentsFunctional magnetic resonanceSuperior temporal gyrusMedial temporal structuresPassive avoidance taskMiddle cingulate gyrusNegative cuesReinforcement expectanciesMaltreated childrenPsychosocial functioningTemporal gyrusPrediction errorVulnerability mechanismsAvoidance taskNonmaltreated peersOrbitofrontal cortexLatent vulnerabilityChildhood abuseWidespread networkValue processingPsychiatric vulnerabilityValue representationCingulate gyrus
2016
Regional grey matter volume and concentration in at-risk adolescents: Untangling associations with callous-unemotional traits and conduct disorder symptoms
Cohn M, Viding E, McCrory E, Pape L, van den Brink W, Doreleijers T, Veltman D, Popma A. Regional grey matter volume and concentration in at-risk adolescents: Untangling associations with callous-unemotional traits and conduct disorder symptoms. Psychiatry Research Neuroimaging 2016, 254: 180-187. PMID: 27479922, DOI: 10.1016/j.pscychresns.2016.07.003.Peer-Reviewed Original Research
2015
Childhood Trauma and Neural Responses to Personalized Stress, Favorite-Food and Neutral-Relaxing Cues in Adolescents
Elsey J, Coates A, Lacadie CM, McCrory EJ, Sinha R, Mayes LC, Potenza MN. Childhood Trauma and Neural Responses to Personalized Stress, Favorite-Food and Neutral-Relaxing Cues in Adolescents. Neuropsychopharmacology 2015, 40: 1580-1589. PMID: 25567424, PMCID: PMC4915266, DOI: 10.1038/npp.2015.6.Peer-Reviewed Original ResearchConceptsChildhood traumaPersonalized stressSubjective anxietyFavorite-food cuesFunctional magnetic resonance imagingPhysical health outcomesCortico-limbic circuitryNeural correlatesMotivational stateTrauma exposureNeural responsesFunctional neuroimagingPrefrontal cortexStress cuesAnterior cingulateEmotional disturbanceCerebellar regionsCuesGroup differencesRisky behaviorsBrain regionsAdolescentsSubcortical structuresAnxietyIncreased activation
2014
Neural bases of Theory of Mind in children with autism spectrum disorders and children with conduct problems and callous‐unemotional traits
O'Nions E, Sebastian C, McCrory E, Chantiluke K, Happé F, Viding E. Neural bases of Theory of Mind in children with autism spectrum disorders and children with conduct problems and callous‐unemotional traits. Developmental Science 2014, 17: 786-796. PMID: 24636205, PMCID: PMC4316185, DOI: 10.1111/desc.12167.Peer-Reviewed Original ResearchConceptsAutism spectrum disorderAutism Diagnostic Observation ScheduleCP/HCUASD groupTemporoparietal junctionConduct problemsSpectrum disorderMedial prefrontal cortex responsesAtypical neural processingRight temporoparietal junctionPrefrontal cortex responsesCallous-unemotional traitsMedial prefrontal cortexAtypical processingToM processingVignette taskNeural levelNeural underpinningsNeural basisTD controlsNeural processingSocial difficultiesNeural responsesObservation ScheduleFMRI responses
2013
Antisocial and Callous Behaviour in Children
Viding E, Seara-Cardoso A, McCrory E. Antisocial and Callous Behaviour in Children. Current Topics In Behavioral Neurosciences 2013, 17: 395-419. PMID: 24357438, DOI: 10.1007/7854_2013_266.Peer-Reviewed Original ResearchConceptsCallous-unemotional traitsAntisocial behaviorBrain imaging researchDevelopmental psychopathology researchProfiles of vulnerabilitySubstantial public health costsNeuroscience findingsPsychopathology researchCallous behaviorDevelopmental vulnerabilityMental healthImaging researchCurrent evidence baseFuture researchPublic health costsChildrenCommon reasonEvidence baseHeterogeneous groupHealth costsDistinct subgroupsTraitsInterventionResearchBehaviorAssociation of Callous Traits with Reduced Neural Response to Others’ Pain in Children with Conduct Problems
Lockwood P, Sebastian C, McCrory E, Hyde Z, Gu X, De Brito S, Viding E. Association of Callous Traits with Reduced Neural Response to Others’ Pain in Children with Conduct Problems. Current Biology 2013, 23: 901-905. PMID: 23643836, PMCID: PMC3918856, DOI: 10.1016/j.cub.2013.04.018.Peer-Reviewed Original ResearchConceptsAnterior cingulate cortexFunctional magnetic resonance imagingConduct problemsNeural responsesAnterior insulaCallous traitsAdult psychopathyReduced blood oxygen level-dependent responsesAtypical neural responsesBlood oxygen level-dependent (BOLD) responseInferior frontal gyrusBilateral anterior insulaLevel-dependent responsesConsiderable societal costsEmpathic processingEmpathic deficitsEmpathic responsesFrontal gyrusAntisocial behaviorCingulate cortexACC responseEmpathyLarge samplePsychopathyNegative associationNeural responses to fearful eyes in children with conduct problems and varying levels of callous–unemotional traits
Sebastian C, McCrory E, Dadds M, Cecil C, Lockwood P, Hyde Z, De Brito S, Viding E. Neural responses to fearful eyes in children with conduct problems and varying levels of callous–unemotional traits. Psychological Medicine 2013, 44: 99-109. PMID: 23510564, DOI: 10.1017/s0033291713000482.Peer-Reviewed Original ResearchConceptsFunctional magnetic resonance imagingSubgenual anterior cingulate cortexImportant translational implicationsNeural responsesAnterior cingulate cortexAmygdala responseMagnetic resonance imagingFearful eyesConduct problemsTrial participantsEye conditionsCingulate cortexCortex responsesResonance imagingEvidence baseAmygdala reactivityTranslational implicationsHeterogeneous groupTD controlsEyesChildrenFear recognition deficitsNeural levelParticipantsLow levels
2012
Reduced orbitofrontal and temporal grey matter in a community sample of maltreated children
De Brito S, Viding E, Sebastian C, Kelly P, Mechelli A, Maris H, McCrory E. Reduced orbitofrontal and temporal grey matter in a community sample of maltreated children. Journal Of Child Psychology And Psychiatry 2012, 54: 105-112. PMID: 22880630, DOI: 10.1111/j.1469-7610.2012.02597.x.Peer-Reviewed Original ResearchConceptsMedial orbitofrontal cortexPsychiatric disordersMiddle temporal gyrusOrbitofrontal cortexTemporal lobeGray matterTemporal gyrusConcurrent psychiatric disordersTemporal gray matterGray matter volumeVoxel-based morphometryCommunity sampleLeft middle temporal gyrusAtypical neural structurePrevious neuroimaging studiesNeurobiological risk factorsRisk factorsLevel of anxietyMatter volumePosttraumatic stress symptomsPsychiatric vulnerabilityConcurrent anxietyPrefrontal cortexCortexNeuroimaging studies
2011
Effects of DTNBP1 genotype on brain development in children
Tognin S, Viding E, McCrory E, Taylor L, O’Donovan M, McGuire P, Mechelli A. Effects of DTNBP1 genotype on brain development in children. Journal Of Child Psychology And Psychiatry 2011, 52: 1287-1294. PMID: 21639861, DOI: 10.1111/j.1469-7610.2011.02427.x.Peer-Reviewed Original ResearchConceptsBrain developmentBrain structuresWhite matter brain regionsLeft anterior cingulate gyrusAnterior cingulate gyrusWhite matter volumeLeft medial frontal areaLow-risk allelesVoxel-based morphometryHigh-risk allelesDystrobrevin-binding protein 1Magnetic resonance imagingInfluences brain developmentFamily-wise error correctionMedial frontal areasCingulate gyrusMatter volumeWhite matterWhole brainMale childrenPotential susceptibility geneResonance imagingBrain regionsSchizophrenia
2010
Effects of stressful life events on human brain structure: A longitudinal voxel-based morphometry study
Papagni S, Benetti S, Arulanantham S, McCrory E, McGuire P, Mechelli A. Effects of stressful life events on human brain structure: A longitudinal voxel-based morphometry study. Stress 2010, 14: 227-232. PMID: 21034297, DOI: 10.3109/10253890.2010.522279.Peer-Reviewed Original ResearchConceptsGray matter volumePost-traumatic stress disorderStressful life eventsNumber of SLEsPsychiatric diagnosisLongitudinal voxel-based morphometry studyVoxel-based morphometry studyGray matter changesFormal psychiatric diagnosisMagnetic resonance imagingRisk of illnessLife eventsMatter changesParahippocampal gyrusMatter volumeAnterior cingulateHealthy adultsMorphometry studyMental disordersResonance imagingBrain regionsBrain structuresStress disorderAnatomical scansTime pointsResearch Review: The neurobiology and genetics of maltreatment and adversity
McCrory E, De Brito SA, Viding E. Research Review: The neurobiology and genetics of maltreatment and adversity. Journal Of Child Psychology And Psychiatry 2010, 51: 1079-1095. PMID: 20546078, DOI: 10.1111/j.1469-7610.2010.02271.x.Peer-Reviewed Original ResearchConceptsChildhood maltreatmentEarly adversityFunctional brain differencesIndividual's genetic makeAdrenal axis stress responseAtypical developmentEmotional developmentNeurobiological developmentAtypical activationNeurobiological mechanismsBrain differencesPrefrontal cortexPsychiatric vulnerabilityEnvironmental experiencesAdversityEnvironmental adversityBrain regionsEarly stressMaltreatmentNeuroendocrine findingsChildrenAdultsCorpus callosumGenetic makeHuman studiesSmall, but not perfectly formed: decreased white matter concentration in boys with psychopathic tendencies
De Brito S, McCrory E, Mechelli A, Wilke M, Jones A, Hodgins S, Viding E. Small, but not perfectly formed: decreased white matter concentration in boys with psychopathic tendencies. Molecular Psychiatry 2010, 16: 476-477. PMID: 20548295, DOI: 10.1038/mp.2010.74.Peer-Reviewed Original ResearchHeritable Variations in Gray Matter Concentration as a Potential Endophenotype for Psychopathic Traits
Rijsdijsk F, Viding E, De Brito S, Forgiarini M, Mechelli A, Jones AP, McCrory E. Heritable Variations in Gray Matter Concentration as a Potential Endophenotype for Psychopathic Traits. JAMA Psychiatry 2010, 67: 406-413. PMID: 20368516, DOI: 10.1001/archgenpsychiatry.2010.20.Peer-Reviewed Original Research