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Serena Susan Spudich, MD, MA

she/her/hers
Gilbert H. Glaser Professor of Neurology
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Additional Titles

Division Chief, Neurological Infections & Global Neurology

Co-Director, Yale Center for Brain & Mind Health

Affiliated Faculty, Yale Institute for Global Health

About

Titles

Gilbert H. Glaser Professor of Neurology

Division Chief, Neurological Infections & Global Neurology; Co-Director, Yale Center for Brain & Mind Health; Affiliated Faculty, Yale Institute for Global Health

Appointments

Other Departments & Organizations

Education & Training

Fellow
University of California at San Francisco (2004)
Fellow
Harvard Medical School (2003)
Resident
Harvard Medical School (2002)
Resident
University of Washington School of Medicine (1999)
Intern
University of Washington School of Medicine (1998)
MD
University of California at San Francisco (1997)
MA
Stanford University, Philosophy of Science (1992)
BA
Stanford University, Human Biology/Humanities (1991)

Research

Overview

Medical Research Interests

Acquired Immunodeficiency Syndrome; Antiviral Agents; Biomarkers; Cerebrospinal Fluid; COVID-19; Dementia; HIV; Nervous System; Neurodegenerative Diseases; Neuroinflammatory Diseases; Neurology; Positron-Emission Tomography; Post-Acute COVID-19 Syndrome; Virology

Public Health Interests

HIV/AIDS; Infectious Diseases; Immunology; Viruses; COVID-19; Biomarkers

Research at a Glance

Publications Timeline

A big-picture view of Serena Susan Spudich's research output by year.
227Publications
12,162Citations

Publications

2026

2025

  • Greater Accumulation of Brain White Matter Hyperintensities in People Diagnosed and Treated During Acute HIV Compared With People Without HIV
    Holroyd K, Chan P, Sacdalan C, Dumrongpisutikul N, Sriplienchan S, Promensa P, Sailasuta P, Pothisri M, Puttamaswin S, Vasan S, Valcour V, Trautmann L, Spudich S, Paul R, Bolzenius J. Greater Accumulation of Brain White Matter Hyperintensities in People Diagnosed and Treated During Acute HIV Compared With People Without HIV. Neurology 2025, 105: e214445. PMID: 41172230, DOI: 10.1212/wnl.0000000000214445.
    Peer-Reviewed Original Research
  • Neurosymptomatic CSF escape is a CNS-focused form of ART treatment failure
    Kincer L, Dravid A, Zhou S, Vercesi R, Spudich S, Gisslén M, Price R, Cinque P, Joseph S. Neurosymptomatic CSF escape is a CNS-focused form of ART treatment failure. Open Forum Infectious Diseases 2025, ofaf659. DOI: 10.1093/ofid/ofaf659.
    Peer-Reviewed Original Research
  • Antiretroviral Therapy Intensification With Dolutegravir and/or Maraviroc Did Not Affect HIV-1 Cell-Associated DNA, RNA, and 2­–LTR Circles Over 12 Weeks
    Reed J, Hall L, McKhann A, Kwak G, Goecker E, Coombs R, Chen H, Roa J, Vecchio A, Daar E, Hunt P, Marra C, Campbell T, Ma Q, Swaminathan S, Macatangay B, Morse G, Miller T, Rusin D, Ha B, Alston-Smith B, Paul R, Letendre S, Spudich S, Greninger A. Antiretroviral Therapy Intensification With Dolutegravir and/or Maraviroc Did Not Affect HIV-1 Cell-Associated DNA, RNA, and 2­–LTR Circles Over 12 Weeks. Open Forum Infectious Diseases 2025, 12: ofaf594. PMID: 41141451, PMCID: PMC12548372, DOI: 10.1093/ofid/ofaf594.
    Peer-Reviewed Original Research
  • Cerebrospinal Fluid Immune Cell Alterations in Women With Neuropsychiatric Long COVID
    Orlinick B, Mehta S, McAlpine L, Khoshbakht S, Fertuzinhos S, Nelson A, Chiarella J, Das B, Patel V, Filippidis P, Corley M, Spudich S, Farhadian S. Cerebrospinal Fluid Immune Cell Alterations in Women With Neuropsychiatric Long COVID. Journal Of Infectious Diseases 2025, jiaf468. PMID: 40920586, DOI: 10.1093/infdis/jiaf468.
    Peer-Reviewed Original Research
  • Olfactory Dysfunction After SARS-CoV-2 Infection in the RECOVER Adult Cohort
    Horwitz L, Becker J, Huang W, Akintonwa T, Hornig-Rohan M, Maranga G, Adams D, Albers M, Ayache M, Berry J, Brim H, Bryan T, Charney A, Clark R, Cortez M, D’Anza B, Davis H, Donohue S, Erdmann N, Flaherman V, Fong T, Frontera J, Goldberg M, Goldman J, Harkins M, Hodder S, Jacoby V, Jagannathan P, Jia X, Kelly J, Krishnan J, Kumar A, Laiyemo A, Levitan E, Martin J, McCaffrey K, McComsey G, Metz T, Murthy G, Nguyen H, Okumura M, Parry S, Parthasarathy S, Patterson T, Peluso M, Sorochinsky C, Walker T, Wiegand S, Wiley Z, Wisnivesky J, Ashktorab H, Foulkes A, Lee-Iannotti J, Han J, Marconi V, Ofotokun I, Patzer R, Walker T, Abraham R, Aguilar F, Ahmadi-Izad G, Ahmed D, Alvarez A, Anderson B, Asencios W, Beaty C, Bedi B, Berry J, Boone D, Bower M, Bremner J, Brent C, Brown-Smith K, Bull R, Capo G, Carl-Igwe K, Chitadze C, Chukwumerije N, Clyburn E, Collins S, Costello J, Couture G, Craft A, Cui X, del Rio C, Detelich J, Dixon C, Dow J, Doyle D, Elchommali J, Elsey I, Franks N, Gallini J, Gutter E, Harding J, Hernandez L, Holloway C, Ifejika C, Jasarevic R, Javia V, Jeter M, Joseph Y, Juarez M, Kirkpatrick C, Koumanelis A, Krishnan S, Leon J, Lew V, Maier C, Makkaoui N, Maroney M, Martin C, Mbogo L, McCaslin A, McIntyre J, Moanna A, Montoya M, Morales E, Moran C, Murray C, Nelson R, Nguyen T, Ojoawo B, Osinski E, Oviedo S, Paredes-Gaitan Y, Prude M, Ramakrishnan G, Rebolledo P, Roberts M, Robinson K, Rogers C, Rouphael N, Searles C, Segall M, Shah A, Silva R, Simpson C, Simpson-Derrell K, Sirajud-Deen T, Stroud J, Suthar M, Sylber C, Sylvera A, Teunis L, Thomas K, Titanji K, Toy C, Truong A, Vaccarino V, Varney K, Vyas K, Vyas K, Walkow M, Wesley T, Winston J, Winter T, Wongtrakool C, Cribbs S, Collins O, Fournier C, Francis A, Hang T, Ingram K, Lainez J, Rubinsztain L, Yeung H, Wiley Z, Ager A, Gray N, Grimes A, Gromer D, Hewitt L, Huerta C, Johnson B, Kelley C, Khalil L, Kleinhenz D, Koumanelis A, Kozoman R, Lee M, Lewis K, Litvack M, Maramba T, Mehta C, Panganiban B, Rahman K, Smith V, Stringer A, Tolbert M, Traenkner J, Unterberger K, Wang H, Wimberly E, Yang Q, Ryerson A, Hjortsberg R, Hudgins A, Martinez M, Neuman R, Thompson S, Agu C, Pemu P, Afani A, Ariri C, Dandy A, Harper K, Ibeawuchi C, Lawrence B, Morgan-Billingslea J, Ojemakinde E, Smith K, Levy B, Aikawa M, Baden L, Baslet G, Bennett L, Bhattacharyya S, Buring J, Cagnina R, Chen L, Clark C, Cohen P, Czeisler C, Estill P, Gay E, Hong J, Lamas D, Lay S, Levy-Carrick N, Manson J, Monafrared T, Redline S, Remis E, Schilkrut D, Sesso H, Solomon S, Sparks J, Spencer L, Systrom D, Thu P, Walt D, Washko G, Whittelsey M, Wiener R, Bassett I, Alba G, Aung T, Fitch K, Ginns L, Haas J, Hu Y, Juelg B, Kanjilal D, Kim A, Klerman E, Lewis G, Musa A, Ojikutu B, Perlis R, Rosand J, Wallace Z, Xerras D, Zionts D, Mullington J, Collier A, Fong T, Haack M, Hauser K, Maley J, Quintana Y, Shaughnessy L, Stephenson K, Thomas R, Torres R, Marathe J, Duffy E, Hamburg N, O'Connor G, Zhang H, John J, Ticotsky A, Ward H, Blazey-Martin D, Ghamloush M, Jordan M, Kogelman L, Marryshow T, Erdmann N, Levitan E, Tita A, Armstrong D, Binkley S, Blackwell K, Causey A, Cook F, Domingo J, Donahue C, Eady M, Edberg J, Forehand K, Frazier P, Garcia-McClaney N, Garner M, Gray B, Hall W, Hart C, Hebson C, Hidalgo B, Higgins B, Holtzapfel K, Horton G, Jinright A, Judd S, Kennedy T, Kirkwood L, Maier M, McCormack P, Mitchell K, Montgomery A, Nieters D, Peralta-Carcelen M, Pilco J, Powell L, Royster J, Shevin R, Skipworth S, Spurgeon L, Steele C, Vines J, Ware G, Wilson R, Woodruff D, Young B, Gillespie M, Daniel C, Hansel J, Wu J, Carton T, Miele L, Brown T, Sutherland E, Fuloria J, Datri P, Hagensee M, Leggio C, Perkins A, Trauth A, Trotter S, Van Deerlin A, Weiser S, Young M, Ashktorab H, Brim H, Laiyemo A, Sherif Z, Durrani S, Nezamloo A, Ngwa J, Njoku N, Gentil M, Mehari A, Solemani A, Chang L, Thuluvath P, Alemu M, Anderson J, Chauhan M, Cho S, Goodman K, Lanke G, Lebron R, Maheshwari A, Ok J, To C, Hodder S, Bardes J, Dominique-Villanueva D, Juskowich J, Reece R, Sarwari A, Shellito J, Greenway F, Kirwan J, Rodemann G, Rosen C, Arruda A, Brunet T, Emery I, Roelke T, Berger P, Black L, Hoover S, Tjarks B, Fonseca V, Gupta S, Longo M, Yang M, Shikuma C, Chow D, MarGangcuangco L, Castro M, Bengtson C, Howard T, Koontz B, Spikes L, Simmons C, Whiteheart S, Garvy B, Wood J, Marshall G, Garla V, Kuebler J, Nandi U, Vasey A, Warren D, Dickinson J, VanWagoner T, Bogie A, Heyanka D, James J, Scott J, Sukhera F, Luciano Roman C, Perez Frontera S, Santana Bagur J, Klein J, Krishnan J, Lin J, Muramatsu N, Prabhakar B, Prendergast H, Vanden Hoek T, Adams D, Baker A, Barbera S, Basu S, Bleasdale S, Boyd A, Breiter T, Buhimschi I, Carrithers M, Chalamalla R, Chestek D, Cook J, Darbar D, Dasgupta R, Davis Blakley F, DeLisa J, Diviak K, Donlon M, Dworkin M, Ellison A, Flanigan C, Freedman M, Gerald L, Giles W, Gordon H, Hammad B, Hasek S, Hasse W, Hryniewicka M, Illendula S, Ismail N, Jain A, Jennette K, Kadubek G, Kent D, Kent D, Kim K, Kotini-Shah P, Large L, Lash J, Lu J, Mahamed A, Malchenko S, Martinez M, Mauntel-Medici C, McCauley M, Menchaca M, Mermelstein R, Moreno D, Morrissy L, Musick H, Norwick L, Novak R, Ortiz M, Patel K, Perez N, Pliskin N, Pope S, Prasad B, Predki B, Quigley J, Ramchandran R, Ramirez A, Rappe S, Rehman J, Rowley M, Rudraraju G, Rutherfoord M, Sculley J, Smith-Mack J, Sun J, Tartt N, Villanueva L, Warfield Kelly S, Yazici C, Certa M, Chessier E, Everett E, Kindred E, Harris P, Sudhindra P, Olds L, Aponte-Soto L, Del Rios M, Diaz M, Ibanez A, Rolon C, Cranford S, Brown D, Dixon J, Gale L, Hammerl S, Hartwig K, Madineni A, Swearingen P, Hendrickson M, Noland S, Terlinde T, Hobbs B, Stewart de Ramirez S, Bolliger D, Boyineni J, Chebrolu P, Curry H, Donohue S, Edmonds S, Kelly S, Maholovich P, Sader S, Thompson T, Welter H, Woolley B, Hafner J, Hanson K, Hutton R, Charney A, Kovatch P, Merad M, Nadkarni G, Wisnivesky J, Aberg J, Ascolillo S, Bagiella E, Bartram L, Becker J, Beckmann N, Bendl A, Chen B, Civil A, Crawford G, Dhar K, Evo-Ortega L, Fierer D, Gallagher E, Garcia-Sastre A, Gnjatic S, Gray I, Guliyeva S, Harvey-Ingram L, Herrera-Moreno J, Hill M, Horowitz C, Jackson R, Kastrat D, Lala-Trindade A, Lin J, Macaluso N, Marcon K, Meyer D, Morinigo J, Natelson B, Nussenzweig M, Padua T, Putrino D, Richardson L, Russo S, Seifert A, Serri A, Walker J, Yee M, Bateman L, Hess R, Truong D, Alekhina N, Barlocker J, Brown J, Cortez M, Donohue D, Facelli J, Gouripeddi R, Hermansen J, Johnny J, Lindsay A, Lloyd J, Lu Y, Medina J, Morimoto S, Pace L, Rius D, Scholand M, Shah K, Sharareh N, Spivak A, Stringham C, Trinity J, Velinder M, Weaver L, West J, Vernon S, Deakyne Davies S, Gardner E, Buck K, Gonzalez Rivas E, Hawkins K, Oakes J, Sanchez Vazquez W, Horne B, Knowlton K, Woller S, Aguirre B, Anderson J, Bair T, Bosh L, Evans L, Garrett C, Harris D, Herrera K, Iverson L, Jensen M, Juan J, Knight S, Leither L, Maestas H, May H, Zubal S, Erlandson K, Sokol R, Brightman M, Davis D, Feuerriegel E, Fudge H, Garg L, Higgins J, Jolley S, Lockie T, McCandless S, Pitch C, Reusch J, Thurman B, Tran H, West S, Friedman N, Ludwig K, Decker L, Raissy H, Adolphi N, Archuleta D, Bradfute S, Brito R, Elifritz J, Garcia-Soberanez N, Gentry F, Harkins M, Martinez N, Montoya L, Parada A, Quinn D, Ramos A, Sheehan E, Treacher I, McComsey G, Adams C, Andrefsky J, Atieh O, Baissary J, Boldt N, Chemali K, Ciborek E, Conrad A, D’Anza B, Daher J, DiFrancesco K, Foster (Rodgers) T, Gallagher M, Gupta A, Harrill J, Harris P, Jacono F, Kelly J, Koberssy Z, Kumar R, Labbato D, Lim J, Pettinato K, Rodgers M, Rosolia B, Roy A, Sattiraju S, Scott S, Smith B, Tejani V, Tribout M, Yendewa G, Singer N, Ayache M, Barnboym E, Brown A, Chesnick H, Edminston M, Greenwood C, Haghiac M, Kaufman E, Lengu K, Lowenthal R, Malakooti S, Oleson C, Pearman A, Rizea A, Smith C, Washington M, Weinberger E, Heath J, Brennan C, Edmark R, Gutierrez V, Hadlock J, Li S, Magis A, McDonald C, Murray K, Rowen L, Yuan D, Chen P, Banitaba A, Caudill A, Chopra T, Dahlke L, Diaz M, Gudipudi L, Jackman S, Mattison B, Modes M, Nelson C, Nwafor C, Parimon T, Pascual E, Salinas N, Torbati S, Watson S, Tuttle K, Alicic R, Baxter J, Emerson S, Hood S, Kuykendall K, White S, Wilcox L, Goldman J, Algren H, Del Alcazar J, Duven A, Kaneko J, Kim C, Manner P, Mason C, Okada A, Poussier R, Satira R, Wallick J, Chu H, Elias-Warren A, Harteloo A, Logue J, McCaffrey K, Nguyen H, Nambiar A, Patterson T, Potter J, Salehi M, Sharma K, Verduzco-Gutierrez M, Anderson R, Arellanes A, Barajas R, Chauhan S, Clarke G, Farner C, Fischer M, Goldberg M, Hastings G, Heard P, Hernandez J, Herrera I, Infante E, Johnson H, Jones J, Kellogg D, Kraig E, Longoria L, Okafor E, Patterson J, Pinones A, Reeves W, Scholler I, Seshadri S, Shah P, Shah D, Smith M, Soileau B, Solis P, Stoebner C, Sullivan M, Taylor B, Tragus R, Tsevat J, Hasbani K, Saade G, Hernandez Martinez G, Recabarren C, Sharma K, Paredes C, Alvarado S, Kumar A, Maldonado Y, Utz P, Blish C, Go M, Jagannathan P, Singh U, Ahuja N, Blomkalns A, Bonilla H, Brotherton R, Clinton K, Dingankar V, Geng L, Haddad F, Jamero C, Jee K, Jia X, Khurana N, Miglis M, O'Conor E, Olszewski K, Pathak D, Quintero O, Saperia C, Scott J, Urdaneta A, Varkey M, Nikolich J, Parthasarathy S, Ernst K, Esquivel D, Harris D, Harris S, Hernandez M, Hsu H, James M, Karnafel M, Knox K, Koleski A, LaFleur B, Lambert B, LaRue S, Lutrick K, Merchant N, Morton C, Mosier J, Olorunnisola T, Peralta J, Pilling W, Pogreba-Brown K, Rischard F, Ryan L, Smith T, Snyder M, Subbian V, Suhr K, Reiman E, Lee-Iannotti J, Autry L, Beydoun H, Borwege S, Copeland J, DiLise-Russo M, Fadden S, Gomez I, Grischo G, Hartley W, Hillier L, Ismail H, Iusim S, Kala M, Kim D, Murthy G, Unzek S, Vadovicky S, Veres S, Bime C, Hansen L, Hughes T, Khalid S, Lieberman D, Soto F, Wilson C, Zapien A, Deeks S, Kelly J, Martin J, Peluso M, Anderson G, Anglin K, Argueta U, Asare K, Buitrago M, Chang Song C, Clark A, Conway E, Del Castillo N, Deswal M, Durstenfeld M, Eilkhani E, Eun A, Fehrman E, Figueroa T, Flores D, Grebe H, Henrich T, Hoh R, Hsue P, Huang B, Ibrahim R, Kerbleski M, Kirtikar R, Lew M, Lombardo J, Lopez M, Luna M, Marquez C, Munter S, Ngo L, Pineda-Ramirez J, Prather A, Rhoads K, Rodriguez A, Romero J, Ryder D, So M, Somsouk M, Tai V, Tran B, Uy J, Valdivieso D, Verma D, Williams M, Zamora A, Flaherman V, Jacoby V, Araya N, Arellano-Mechor C, Basi Y, Chang A, Christopher L, De La Torre I, Gade S, Guerreros E, Laleau V, Martin Herz S, Monzon V, Oceguera Barragan Y, Rait M, Salem M, Tolentino M, Metz T, Lamb D, Mcfarland E, Nelsen A, Phillips K, Schlater S, Sharma J, Sowles A, Valencia Vazquez J, Zaldivar M, Rouse D, Allard D, Beati L, DeMartino A, Lefebvre H, Milano J, Miller E, Hoffman M, Kitto C, Vanneman A, Reddy U, Bousleiman S, Eccheveri S, Gutierrez Y, Loffredo M, Perez A, Ravi R, Zork N, Hughes B, Ferrara J, Longo M, Mitchell M, Esplin M, Palatnik A, Karasti M, Peterson Z, Saffian E, Wiegand S, Fennig K, Snow E, Skupski D, Pao R, Patel R, Zaw H, Plunkett B, Anglemire K, Kapogiannis C, Kearns K, Suresh S, Yee L, Brinson M, Jones^ D, Kominiarek M, Mallett G, Reynolds T, Williams E, Palomares K, Beche I, Graziano-Carrete D, Perez C, Clifton R, Barrett K, Mullowney C, Sandoval G, Weiner S, Gibson K, Dalton W, Desantis B, Gill-Jones P, Pierse A, Polito L, Rosolowski B, Sweet E, Costantine M, Bartholomew A, Cackovic B, Dembroski C, Grobman W, Klopfenstein B, Mast D, McDaniel K, Paglione M, Rigsby C, Hackney^ D, Tita A, Armstrong D, Burrell N, Casey B, Dunn D, Mann M, Hoffman M, Docter O, Fischer L, Phipers J, Thorp J, Clark K, Leatherland M, Timlin S, Parry S, Filipczak A, Long E, McCabe M, Pizzi C, Simhan H, Bauer E, Boyce J, Facco F, Hankle S, Hines R, Hohn M, Muthukrishnan A, Sciurba F, Vargo J, Pacheco L, Cornwell J, DeVolder J, Nounes A, Salazar A, Thibodeaux L, Mendez-Figueroa H, Ortiz F, Rugerio J, Treadway J, Beamon C, Dufresne I, Grinnan C, Phillips H, Pettker C, Perley L, Rink L, Newman L, Abella J, Barnette Q, Bevc C, Beverly J, Ceger P, Croxford J, Cunningham E, Enger M, Fain K, Farris T, Hanlon S, Hines D, Johnson-Lawrence V, Jordan K, Lefebvre C, Linas B, Luukinen B, Mandal M, McKoy N, Nance S, Oakland A, Pasquarelli D, Quiner C, Sembajwe R, Shaw G, Thornburg V, Tosco K, Wright H, Gross R, Hochman J, Horwitz L, Katz S, Troxel A, Adler L, Akinbo P, Almenana R, Bello O, Bhuiyan S, Blachman N, Branski R, Briscoe J, Brosnahan S, Bueler E, Burgos Y, Caplin N, Chaplin D, Chen Y, Cheng S, Choe P, Choi J, Chung A, Church R, Cobos S, Croft N, Cruz Irving A, Del Boccio P, Díaz I, Doshi V, Ebel S, Faustin A, Febres E, Fine J, Fink S, Frontera J, Gallagher R, Gonzalez-Duarte A, Hasson D, Hill S, Islam S, Johnson S, Kansal N, Kenney R, Kewlani D, Lamendola-Essel M, Laynor G, Leon T, Lewczak Z, Linton J, Logan M, Malik N, Mamistvalova L, Mandel H, Maranga G, Mathews P, Mattoo A, Mei T, Mendelsohn A, Mercier E, Millar Vernetti P, Miller M, Mitchell M, Moreira A, Mudumbi P, Nahin E, Nair N, Nekulak J, Owens K, Parent B, Patibandla N, Petrov P, Postelnicu R, Randall I, Rao P, Rapkiewicz A, Rizzo J, Rosas J, Rose C, Saint-Jean C, Santacatterina M, Shah B, Shaukat A, Simon N, Simsir A, Stinson M, Tang W, Tatapudi V, Thawani S, Thomas M, Thorpe L, Tom M, Treiha E, Truong J, Udosen M, Velazquez-Perez J, Vernetti P, Vidal C, Viswanathan A, Wong C, Wood M, Wuller S, Yin S, Young C, Zaretsky J, Zavlunova S, Foulkes A, Karlson E, Murphy S, Ahirwar S, Ahmed S, Ainsworth L, Atchley-Challenner R, Avilach P, Balan T, Benik N, Benoit B, Bind M, Bonaventura W, Boutin N, Brion B, Cagan A, Cai T, Cao T, Castro V, Cerretani X, Chan J, Cheng D, Chibnik L, Ciriello M, Costenbader K, Dimitrov D, Estiri H, Fayad M, Feldman C, Gainer V, Ghosh B, Gollub R, Guan Z, Harris A, Helmer K, Hendrix A, Holzbach A, Huang W, Kaufman D, Keogh D, Kerr J, Klann J, Krishnamoorthy A, Lasky-Su J, Liao K, MacFadden D, Maram A, Martel M, Mendis M, Metta R, Monteiro J, Morales E, Morse R, Nazaire M, Neils G, Nguyen A, Norman J, Paik H, Pant D, Park H, Rabideau D, Reeder H, Rossi-Roh K, Santacroce L, Schlepphorst K, Schulte C, Selvaggi C, Shinnick D, Simons W, Simpson L, St. Jean Flanders M, Strasser Z, Thakrar M, Thaweethai T, Thorn M, Trewett P, Van Fleet D, Wagholikar K, Wang T, Wattanasin N, Weber G, Williams M, Zhang R, Cicek M, Flotte T, Boysen E, Chang N, Ellingworth E, Frisch E, Welch G, Yusuf A, Zahnle N, Cerda M, Clash V, Taylor B, Zissis M, Akintonwa T, Blancero F, Brown H, Carmilani M, Copeland D, Hall Y, kondo K, Lerma L, Lindsay J, Marti H, Maughan C, Minor T, Vincent H, Burns J, Spudich S, Bailey C, Cortez M, Foulkes A, Goff D, Lasky-Su J, Ofotokun I, Stockwell M, Stone J, Taylor B, Utz P, Williams N, Warburton D, Davis H, Erdmann N, Gage Witvliet M, Jain M, Martinez T, McGrath R, Rutter J, Bishof K, Dumitriu D, Goepfert P, Goldman S, Hewitt S, Huentelman M, Karp B, Lachowicz-Scroggins M, Nikolich-Zugich J, Perlowski A, Reeves B, Salazar J, Valantine H, Waldrop D, Anderson K, Aragon L, Azor-Sterlin M, Bander B, Basu L, Bolecek J, Burke C, Carignan E, Castro Baucom L, Chen H, Clash V, Cohen A, Cole S, Coombs K, Copeland V, Covington L, Cox W, Crawford S, Debrosse A, DeRosa R, Diggs M, Doster J, Douglas J, Dunn M, Edwards B, Evans L, Fisher L, Fisher K, Fitzgerald M, Fleming D, Gage Witliet M, Garbutt C, Ghormley T, Godwin T, Gressley A, Gustafson T, Hanlon W, Hassey T, Holmes V, Hornig M, Hornig M, Huff-Davis A, Jackson Love J, Jain N, Jones J, Kaleponi G, Karwowsky J, La Londe-Pinkston J, Lam J, Letts R, Lewis J, Lima J, Lindsay D, Martinez A, McCorkell L, McCray N, McNulty M, Nguyen K, Nichols L, Noriega E, Nunes P, O'Brien L, Ortiz G, Owen S, Page J, Peddie A, Phillips-Lorenzo E, Prentiss L, Raytselis N, Regino L, Rockwell M, Saldino R, Sapunar L, Savage S, Seibert E, Sekar A, Souder A, Spier E, Stanislawczyk M, Stein-Seroussi D, Sullivan C, Taylor E, Taylor K, Terry D, Wallace A, Warner J, White B, Wilensky R, Williams M, Williams N, Williams-Dawson K, Wylam A. Olfactory Dysfunction After SARS-CoV-2 Infection in the RECOVER Adult Cohort. JAMA Network Open 2025, 8: e2533815. PMID: 40996759, PMCID: PMC12464792, DOI: 10.1001/jamanetworkopen.2025.33815.
    Peer-Reviewed Original Research
  • Blood pressure and metabolic outcomes after efavirenz‐ or dolutegravir‐based therapy started in acute HIV infection
    Chan P, Moreland S, Sacdalan C, Colby D, Ocampo F, Promsena P, Sriplienchan S, Wattana J, Intasan J, Phanuphak N, Vasan S, Paul R, Trautmann L, Spudich S, Kroon E, Team T. Blood pressure and metabolic outcomes after efavirenz‐ or dolutegravir‐based therapy started in acute HIV infection. HIV Medicine 2025, 26: 1619-1625. PMID: 41047593, DOI: 10.1111/hiv.70085.
    Peer-Reviewed Original Research
  • Inside out: TNFa-RII and sexualized drug use in acute HIV predicts persistent depressive symptoms despite antiretroviral therapy
    Chavez J, Bolzenius J, Chan P, Cho K, Mannarino J, Sacdalan C, Farhadian S, Trautmann L, Ndhlovu L, Tipsuk S, Crowell T, Krebs S, Slike B, Suttichom D, Colby D, Phanuphak N, Kroon E, Vasan S, Sriplienchan S, Spudich S, Paul R, Carrico A. Inside out: TNFa-RII and sexualized drug use in acute HIV predicts persistent depressive symptoms despite antiretroviral therapy. Brain Behavior & Immunity - Health 2025, 48: 101079. PMID: 40808976, PMCID: PMC12345309, DOI: 10.1016/j.bbih.2025.101079.
    Peer-Reviewed Original Research
  • Characterizing Long COVID Symptoms During Early Childhood
    Gross R, Thaweethai T, Salisbury A, Kleinman L, Mohandas S, Rhee K, Snowden J, Tantisira K, Warburton D, Wood J, Kinser P, Milner J, Rosenzweig E, Irby K, Flaherman V, Karlson E, Chibnik L, Pant D, Krishnamoorthy A, Gallagher R, Lamendola-Essel M, Hasson D, Katz S, Yin S, Dreyer B, Blancero F, Carmilani M, Coombs K, Fitzgerald M, Letts R, Peddie A, Foulkes A, Stockwell M, Darden P, Dixon L, Evans D, Garbe C, Hobart-Porter L, Howard L, Hummel K, Krehbiel H, Spradlin H, Yount P, Adam G, Angal J, Barber M, Clark K, Dos Reis C, Freesemann M, Friedrich C, Hockett C, Johannsen R, Johnson-Vonk E, Kaiser C, Kruse A, Lang J, Lim P, McCoy M, Miller L, Petereit (Cerkovnik) S, RiChard (Werpy) J, Seiler J, Sundleaf B, Svendsen J, Trosper B, Vermeulen O, Young S, Dabney S, Fahrner M, Gallagher T, Martini K, McNally M, Vivensi Stiverson S, Balaraman V, Cheung J, Hong T, Kalua S, Minami E, Siu A, Tong M, Dantas M, Kasmarcak T, Milks K, Ikomi C, Meyer M, Nguyen C, Pellicciotti G, Phan T, Ravin K, Reynolds V, Strang A, Thacker D, Eckrich D, Goetter A, Katz C, Kowal K, McDevitt C, Agosto Roman G, Alshawabkeh A, Ayala Ortiz I, Casey V, Cordero J, De Jesus J, Galan Rivera C, Huerta-Montanez G, Otero N, Rivera Robles M, Roman P, Roman G, Rosario-Pabon Z, Santiago X, Velez-Vega C, Vergara C, Albarado B, Allen T, Attuso A, Ayers T, Bebler E, Bella G, Bennett A, Brown J, Carville A, Darby S, Devall K, Dragg A, Elderedge A, Fontenot E, Fry G, Gildersleeve B, Goff S, Harrington L, Jones L, Kaiser V, Lee Y, Lee S, LeJeune E, Leonhard R, Levatino J, Lewis D, Lloyd A, Monce R, Munro S, Phillips M, Pucheu B, Rachal E, Rood J, Roussel S, Rumsey R, Sanford C, Santos M, Stafford A, Thomassie A, Waguespack C, Walgamotte K, Welch M, Windham A, Bell T, Boyd J, Dasgupta S, Deans S, Harris K, Hemmerle M, King S, McGuire C, Merten B, Morris S, Ray M, Reinhardt B, Shemwell S, Simeon T, Walker K, Watson S, Weakley K, Figliomeni J, Fischer L, Hoover D, Morse M, Nabower A, Roberts E, Sato A, Von Bon J, Archuleta D, Brito R, Campbell R, Chavez J, Dehority W, Garcia-Soberanez N, Gronert E, Kadish M, Larrabee J, Lovato D, Luo K, Martinez N, Merlino A, Reese E, Ward S, Wilson K, Brown R, Butchee R, Fergeson G, McKee R, Mohler B, Moore T, Owens V, Stubbs S, VanWagoner T, Bethel M, Chassereau L, Lahiri T, Lake L, Moffett K, Polak E, Stutler S, Workman C, Carpenter E, Dhindsa I, Mejia S, Moghadam N, Mulder C, O'Neil S, Osornio A, Rios A, Rosen S, Smith A, Tabibi D, Tang S, Teame A, Stockwell M, Anderson B, Aquino T, Berg E, Caddle S, Catallozzi M, Chung W, Connors T, De A, Diaz Perez A, DiLorenzo M, Dumitriu D, Farooqi K, Fremed M, Goldman S, Kaplan K, Krishnan U, Layton A, Lignelli-Dipple A, McClaren S, Overdevest J, Rodriguez M, Selman J, Silver W, Silverio R, Valdez de Romero A, Vargas C, Caputo D, Leggieri C, Pretsch P, Davis K, Griffith M, Harris D, Macario E, Steffes J, Torres A, Day C, Howell K, Mains M, Bean E, DeFelice C, El Chebib H, Herbst K, Lesmes S, Santos M, Schulman N, Brooks-Greien A, Colin K, Juarez-Colunga A, Manning B, Shields J, York D, Griswold J, Lee D, Nowakowski A, Riordan M, Aamir R, Abuzahrieh M, Bangalore N, Brown A, Dalton W, Fortuna S, Minium J, Rosolowski B, Ahmed A, Braniecki S, Contreras M, Jain S, Kaseta S, Messer Z, Ramirez A, Singh A, WIlliams R, Akerlundh A, Akshoomoff N, Arroyo M, Barrientos W, Bhattacharjee R, Chao B, Diaz M, Garcia S, Garcia S, Gomez G, Herrera T, Holguin M, Khare M, Kiernan E, Landeo Gutierrez J, Matta I, Reyes S, Ryu J, Sanchez C, Schreck A, Warner M, Cerracchio L, Folnagy A, Gzemski S, Hao Y, Li S, Moroso S, Ness-Cochinwala M, Patel A, Richlin B, Sharma H, Soto D, Suarez C, Vargas Forero B, Ricciardi E, Trespalacios V, Kluko M, Rhee K, Tantisira K, Acosta Valle D, Chao B, Choudhary A, Glenn-Arroyo M, Kiernan E, Landeo-Gutierrez J, Madan A, McConnaughey K, Ramos Vallejo L, Sanchez C, Suarez M, Caldas S, Castro Ovalle T, Chung A, Farkas J, Isidoro-Chino M, Kesebir D, Kim E, Quarless A, Schlechter A, Srinivasan R, Barry F, Burton P, Cano Lorente R, Cummins C, Wehbe S, Espinoza J, Moyer S, Rider A, Russell S, Schecter M, Stevenson L, Burns J, Spudich S, Bailey C, Cicek M, Cortez M, Davis Blakley F, Goff D, Lasky-Su J, Newman L, Ofotokun I, Seshadri S, Stone J, Taylor B, Utz P, Williams N, Abella J, Barnette Q, Bevc C, Beverly J, Ceger P, Croxford J, Cunningham E, Enger M, Fain K, Farris T, Hanlon S, Hines D, Johnson-Lawrence V, Jordan K, Lefebvre C, Linas B, Luukinen B, Mandal M, McKoy N, Nance S, Oakland A, Pasquarelli D, Quiner C, Sembajwe R, Shaw G, Thornburg V, Tosco K, Wright H, Hochman J, Horwitz L, Katz S, Troxel A, Adler L, Akinbo P, Almenana R, Bello O, Bhuiyan S, Blachman N, Branski R, Briscoe J, Brosnahan S, Bueler E, Burgos Y, Caplin N, Chaplin D, Chen Y, Cheng S, Choe P, Choi J, Chung A, Church R, Cobos S, Croft N, Cruz Irving A, Del Boccio P, Díaz I, Doshi V, Ebel S, Faustin A, Febres E, Fine J, Fink S, Frontera J, Gonzalez-Duarte A, Hill S, Islam S, Johnson S, Kansal N, Kenney R, Kewlani D, Laynor G, Leon T, Lewczak Z, Linton J, Logan M, Malik N, Mamistvalova L, Mandel H, Maranga G, Mathews P, Mattoo A, Mei T, Mendelsohn A, Mercier E, Millar Vernetti P, Miller M, Mitchell M, Moreira A, Mudumbi P, Nahin E, Nair N, Nekulak J, Owens K, Parent B, Patibandla N, Petrov P, Postelnicu R, Randall I, Rao P, Rapkiewicz A, Rizzo J, Rosas J, Rose C, Saint-Jean C, Santacatterina M, Shah B, Shaukat A, Simon N, Simsir A, Stinson M, Tang W, Tatapudi V, Thawani S, Thomas M, Thorpe L, Tom M, Treiha E, Truong J, Udosen M, Velazquez-Perez J, Vernetti P, Vidal C, Viswanathan A, Wong C, Wood M, Wuller S, Young C, Zaretsky J, Zavlunova S, Foulkes A, Murphy S, Ahirwar S, Ainsworth L, Ajani S, Alsheikh A, Atchley-Challenner R, Avilach P, Balan T, Benik N, Benoit B, Bonaventura W, Boutin N, Brion B, Cagan A, Cai T, Cao T, Castro V, Cerretani X, Ciriello M, Costenbader K, Dimitrov D, Estiri H, Fang M, Fayad M, Feldman C, Gainer V, Ghosh B, Gollub R, Harris A, Helmer K, Hendrix A, Holzbach A, Huang W, Kaufman D, Keogh D, Kerr J, Klann J, Lasky-Su J, Liao K, MacFadden D, Maram A, Martel M, Mendis M, Metta R, Monteiro J, Morales E, Nazaire M, Neils G, Norman J, Paik H, Park H, Qian Z, Rossi-Roh K, Santacroce L, Selvaggi C, Simons W, Simpson L, Strasser Z, Tariq A, Thorn M, Trewett P, Van Fleet D, Wagholikar K, Wang H, Wang T, Wattanasin N, Weber G, Williams M, Flotte T, Boysen E, Chang N, Ellingworth E, Frisch E, Welch G, Yusuf A, Zahnle N, Cerda M, Clash V, Taylor B, Zissis M, Akintonwa T, Brown H, Copeland D, Hall Y, kondo K, Lerma L, Lindsay J, Marti H, Maughan C, Minor T, Vincent H, Blomkalns A, Bassett I, Clifton R, Davis H, Erdmann N, Gage Witvliet M, Goldberg M, Guan Z, Jain M, Klein J, Martinez T, McGrath R, Parthasarathy S, Pemu P, Rutter J, Aschner J, Atz A, Banerjee D, Bogie A, Bukulmez H, Clouser K, Cottrell L, Cowan K, D’Sa V, Dozor A, Elliott A, Faustino E, Fiks A, Gaur S, Gennaro M, Gordon S, Hasan U, Hester C, Hogan A, Hsia D, Kaelber D, Kosut J, Krishnan S, McCulloh R, Michelow I, Nolan S, Oliveira C, Olson L, Pace W, Palumbo P, Raissy H, Reyes A, Ross J, Salazar J, Selvarangan R, Stein C, Stevenson M, Teufel R, Werzberger A, Westfall J, Zani K, Zempsky W, Zimmerman E, Bind M, Chan J, Guan Z, Morse R, Reeder H, Metz T, Newburger J, Truong D. Characterizing Long COVID Symptoms During Early Childhood. JAMA Pediatrics 2025, 179: 781-792. PMID: 40554463, PMCID: PMC12117493, DOI: 10.1001/jamapediatrics.2025.1066.
    Peer-Reviewed Original Research
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Clinical Trials

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Academic Achievements & Community Involvement

Activities

  • activity

    Investigations in CNS HIV Reservoirs and HIV Cure

    01/01/2013 - PresentResearch
  • activity

    Effects of Acute HIV Infection in the Central Nervous System

    01/01/2011 - PresentResearch

Clinical Care

Overview

Serena Spudich, MD, MA, is one of only a few neurologists in the United States with specialized training in infections of the nervous system and a clinical practice focusing on neurological issues in patients with HIV.

She primarily cares for patients with HIV who suffer from such neurological problems as cognitive disturbances, memory loss and infections. “Many of these are directly related to HIV,” she says. In addition, she consults with patients who have such infections of the nervous system as Lyme disease and West Nile virus, and those with general neurological disorders.

A professor of neurology at Yale School of Medicine and division chief of neurological infections and global neurology, Dr. Spudich strongly believes patients can lead longer and healthier lives when HIV is diagnosed and treated early. “The example that one patient has proven to be cured of HIV, which was previously thought to be an ‘incurable’ disease, brings hope to the 37 million people worldwide infected with HIV, and to those with other chronic infections that impact the brain,” she says.

Clinical Specialties

Neurology; HIV & AIDs Medicine; Infectious Diseases

Fact Sheets

Board Certifications

  • Neurology

    Certification Organization
    AB of Psychiatry & Neurology
    Latest Certification Date
    2023
    Original Certification Date
    2003

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  • Neuroinfectious Disease Research Program

    Lab

    135 College Street, Fl 3

    New Haven, CT 06510

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