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Frederick Sigworth, PhD

Professor of Cellular and Molecular Physiology and of Biomedical Engineering and of Molecular Biophysics and Biochemistry

Contact Information

Frederick Sigworth, PhD

Office Location

Mailing Address

  • Cellular & Molecular Physiology

    PO Box 208026, 333 Cedar Street

    New Haven, CT 06520-8026

    United States



Fred Sigworth studied applied physics at Caltech and was a graduate student at Yale, working in the neuroscience laboratory of Charles F. Stevens. He received the PhD in physiology from Yale in 1979 and was a postdoc in the laboratory of Erwin Neher in Göttingen, Germany where he was a co-developer of patch-clamp techniques for single-channel electrophysiology. He returned to Yale as a faculty member at Yale in 1984. His current research is in the structural biology of ion-channel proteins, making use of novel cryo-EM methods. "How do I see the scientific enterprise? An old book puts it this way: one generation commends God's works to another. It is a great privilege to unravel the workings of ion channels, and to pass on the excitement about these molecular machines to students, colleagues and anyone else who will listen!"

Education & Training

  • Research Associate
    Max Planck Institute for Biophysical Chemistry, Göttingen, Germany. (1984)
  • Post-Doctoral Fellow
    Max Planck Institute for Biophysical Chemistry, Göttingen, Germany. (1981)
  • PhD
    Yale University (1979)

Honors & Recognition

AwardAwarding OrganizationDate
FellowAmerican Association for the Advancement of Science (AAAS) 2023
MemberNational Academy of Sciences2016
Bohmfalk Teaching PrizeYale School of Medicine2002
K. C. Cole AwardBiophysical Society1997
Yale Science and Engineering AwardYale University1996
Jacob Javits Neuroscience Investigator AwardNIH1992
FellowAlexander von Humboldt Foundation1979

Departments & Organizations