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Shubham Misra, PhD, BTech

Postdoctoral Associate
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Postdoctoral Associate

Biography

Dr. Misra is a Postdoctoral Associate in the Department of Neurology at Yale University School of Medicine. He is a clinical researcher with an avid interest in biomarker discovery and outcomes research in neurological disorders. He is serving as a member of the COVID-19 global forum in the Brain Health Unit of the World Health Organization. He is also the Guest Editor at Frontiers in Neurology, where he is leading a research collection on omics-based approaches in stroke research. His long-term goal is to become an independent investigator and build a career in clinical biomarker discovery and data sciences.

Dr. Misra obtained his Ph.D. in Neurology from the All India Institute of Medical Sciences, New Delhi, India. His thesis was aimed at determining diagnostic and prognostic biomarkers of stroke using high-throughput proteomics and machine learning approaches. He received the prestigious DST-INSPIRE Fellowship from the Department of Science and Technology, Government of India, for pursuing his doctoral studies. He completed his B. Tech and M. Tech degrees in Biotechnology from Amity University, Noida, India, and had the distinction of being the University Gold Medalist.

Dr. Misra has co-authored over 50 peer-reviewed research publications, including first-author articles in leading journals such as JAMA Neurology, Neurology, the European Journal of Neurology, and the International Journal of Stroke. His work has been cited more than 1,000 times. He took a 2-hour lecture on "Proteomics data analysis in R" at the peer-to-peer teaching sessions organized by the Bioinformatics Support Hub in the Cushing/Whitney Medical Library at Yale School of Medicine. Dr. Misra is a recipient of the Young Investigator Award from the World Stroke Organization for his contributions to the field of stroke research.

He is open to research collaborations on research topics, including:

  1. Biomarker research in stroke
  2. Proteomics data analysis
  3. Evidence synthesis through systematic reviews and meta-analyses
  4. Clinical trials in stroke

    For research collaborations, reach out to Dr. Misra at shubham.misra@yale.edu.

    For more details regarding his academic interests, please visit his website at https://sites.google.com/view/shubham-misra.

    Appointments

    Departments & Organizations

    Education & Training

    PhD
    All India Institute of Medical Sciences, New Delhi, Neurology (2022)
    BTech
    Amity University, Biotechnology (2014)
    Project trainee (Master's thesis)
    Amity University (2014)
    Project trainee
    Defence Research & Development Organisation- Defence Institute of Physiology & Allied Sciences (DRDO- DIPAS) (2013)
    Project trainee
    Vardhman Mahavir Medical College and Safdarjung Hospital (2012)
    Project trainee
    National Centre for Disease Control (NCDC) (2011)

    Research

    Overview

    Dr. Misra has over 9 years of research experience in clinical biomarker research, proteomics and statistical data analyses, and evidence synthesis using systematic reviews and meta-analyses. Over the years, his research has pinpointed key biomarkers associated with stroke diagnosis and prognosis and has provided quality evidence in the field of neurological disorders.

    Biomarker Discovery and Outcome Prediction in Post-Stroke Epilepsy: His research identified TRMP6, ALDH2, and CD40 gene polymorphisms linked to post-stroke epilepsy risk. In a retrospective study, he contributed to developing a polygenic risk score, indicating elevated predisposition increases the post-stroke epilepsy risk. In an additional study, he identified biofluid biomarkers such as IL-6 and IL1β associated with increased post-stroke epilepsy risk. In a large meta-analysis comprising over 1 million patients, his research demonstrated that post-stroke epilepsy is a critical public health concern, and patients with this condition have a greater risk of mortality, poor functional outcomes, disability, and dementia.

    Proteomics-based biomarker discovery: Dr. Misra employed meta-analysis, high-throughput proteomics, and machine learning algorithms to identify blood-based protein biomarkers distinguishing ischemic from hemorrhagic stroke in acute settings. His research highlighted 15 distinct protein biomarkers; among them, the addition of GFAP, MMP-9, and APO-C1 to prediction models containing clinical variables independently increased the discrimination ability. His research extended to exploring these biomarkers' role in predicting short-term outcomes and mortality after both types of strokes, revealing enhanced predictive ability.

    Additionally, he used label-free proteomics and bioinformatic tools to identify 37 differentially expressed cerebrospinal fluid biomarkers in patients with idiopathic intracranial hypertension.

    Neurologic manifestations in COVID-19: In collaboration with the Global Forum at the Brain Health Unit of the World Health Organization, Dr. Misra contributed to formulating two living guidance documents and a scientific brief focusing on the clinical management of COVID-19. As part of this global forum, Dr. Misra led a large collaborative effort comprising colleagues from seven distinct countries and provided high-quality evidence on the neurologic manifestations of COVID-19. His research, which drew from a substantial cohort of 145,721 COVID-19 patients for the first time, highlighted a 2% prevalence of stroke in patients with COVID-19.

    Genetic markers of stroke risk: Dr. Misra identified genetic single nucleotide polymorphisms linked to ischemic and hemorrhagic stroke risk in the north Indian population. Through case-control studies and systematic reviews, his research pinpointed candidate genetic markers like MMP-9, ACE, TGF beta-1, and lymphotoxin alpha associated with stroke risk.

    Medical Subject Headings (MeSH)

    Biomarkers; Biostatistics; Cerebrovascular Disorders; Clinical Trial; Data Science; Epidemiology; Epilepsy; Machine Learning; Meta-Analysis; Network Meta-Analysis; Neurology; Proteomics; Public Health; Stroke; Systematic Review

    Research at a Glance

    Yale Co-Authors

    Frequent collaborators of Shubham Misra's published research.

    Publications

    Featured Publications

    Academic Achievements & Community Involvement

    • activity

      Frontiers in Neurology

    • activity

      World Health Organization

    • activity

      International Journal of Surgery

    • activity

      Neurology

    • activity

      PLOS ONE

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