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Gary Stack, MD, PhD

Professor Emeritus
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Additional Titles

Chief, Pathology and Laboratory Medicine at VA Connecticut

Contact Info

Laboratory Medicine

PO Box 208035, 333 Cedar Street

New Haven, CT 06520-8035

United States

About

Titles

Professor Emeritus

Chief, Pathology and Laboratory Medicine at VA Connecticut

Appointments

Other Departments & Organizations

Education & Training

Fellow
Yale-New Haven Hospital (1991)
Resident
Yale-New Haven Hospital (1990)
Fellow
Institut de Chimie Bioligique (1987)
MD
Johns Hopkins University (1984)
PhD
University of Wisconsin (1983)
BS
University of Maryland-College Park, Biochemistry (1975)

Board Certifications

  • Blood Banking/Transfusion Medicine

    Certification Organization
    AB of Pathology
    Original Certification Date
    1992
  • Pathology Clinical

    Certification Organization
    AB of Pathology
    Original Certification Date
    1992

Research

Overview

We have investigated the role of pro-inflammatory cytokines in mediating adverse effects of blood transfusion. We have shown that leukocyte-derived cytokines such as interleukins-1, -6, - 8, as well as MIP-1 alpha, GRO-alpha, and TNF-alpha are present in the plasma portion of stored platelet concentrates and are generated in vitro during blood bank preparation and storage. Some cytokines were also detected in the supernatant portion of red blood cell units. These cytokines are generated in direct proportion to the leukocyte content of the component, the storage temperature, and the storage time. Bacterial contamination of blood components, as might occur in the setting of a septic transfusion reaction, further stimulates cytokine generation. Pre-storage leukoreduction of blood components prevents the generation of leukocyte-dereived cytokines.

Medical Subject Headings (MeSH)

Blood Banks; Blood Transfusion; Cytokines; Medical Laboratory Science; Pathology; Pharmacogenetics

Research at a Glance

Yale Co-Authors

Frequent collaborators of Gary Stack's published research.

Publications

2023

2010

2009

2008

2003

Get In Touch

Contacts

Academic Office Number
Office Fax Number
Mailing Address

Laboratory Medicine

PO Box 208035, 333 Cedar Street

New Haven, CT 06520-8035

United States