Christine Bakhoum, MD, MAS
Assistant ProfessorCards
About
Research
Publications
2024
Blood DNA Methylation Is Associated with Histopathological Changes in Patients with Lupus Nephritis
Bakhoum C, Demkowicz P, Kumar D, Ix J, Moledina D, Bakhoum M. Blood DNA Methylation Is Associated with Histopathological Changes in Patients with Lupus Nephritis. Journal Of The American Society Of Nephrology 2024, 35: 10.1681/asn.2024bqw1nbby. DOI: 10.1681/asn.2024bqw1nbby.Peer-Reviewed Original ResearchRetinal Ischemic Perivascular Lesions Are Associated With Stroke in Individuals With Atrial Fibrillation.
Bakhoum C, Au A, Bousquet E, Matesva M, Singer M, Jayaraj C, Romero-Morales V, Somisetty S, Santina A, Bajar B, DeMaria A, Goldbaum M, Meadows J, Spatz E, Sarraf D, Bakhoum M. Retinal Ischemic Perivascular Lesions Are Associated With Stroke in Individuals With Atrial Fibrillation. Journal Of The American Heart Association 2024, 13: e035079. PMID: 39190603, DOI: 10.1161/jaha.123.035079.Peer-Reviewed Original ResearchThe Study of the Epidemiology of Pediatric Hypertension Registry (SUPERHERO): Rationale and Methods
South A, Giammattei V, Bagley K, Bakhoum C, Beasley W, Bily M, Biswas S, Bridges A, Byfield R, Campbell J, Chanchlani R, Chen A, McGowan L, Downs S, Fergeson G, Greenberg J, Hill-Horowitz T, Jensen E, Kallash M, Kamel M, Kiessling S, Kline D, Laisure J, Liu G, Londeree J, Lucas C, Mannemuddhu S, Mao K, Misurac J, Murphy M, Nugent J, Onugha E, Pudupakkam A, Redmond K, Riar S, Sethna C, Siddiqui S, Thumann A, Uss S, Vincent C, Viviano I, Walsh M, White B, Woroniecki R, Wu M, Yamaguchi I, Yun E, Weaver D. The Study of the Epidemiology of Pediatric Hypertension Registry (SUPERHERO): Rationale and Methods. American Journal Of Epidemiology 2024, kwae116. PMID: 38881045, DOI: 10.1093/aje/kwae116.Peer-Reviewed Original ResearchManual record reviewHypertensive disordersRecord reviewElectronic health record dataICD-10Health record dataInternational Classification of Diseases diagnostic codesReduce CVD burdenPrevalence of hypertensionIncreased prevalence of hypertensionCardiovascular mortality ratesCVD burdenBlood pressureInternational ClassificationDiagnostic codesClinical careRecord dataInclusion criteriaLife courseIncreased prevalencePediatric hypertensionLong-term consequencesMortality rateEpidemiologyBiomedical informatics
2023
Differentiating Lupus Nephritis Classes Using Peripheral Blood DNA Methylation
Bakhoum C, Faulkner S, Ix J, Moledina D, Bakhoum M. Differentiating Lupus Nephritis Classes Using Peripheral Blood DNA Methylation. Journal Of The American Society Of Nephrology 2023, 34: 243-243. DOI: 10.1681/asn.20233411s1243b.Peer-Reviewed Original ResearchRetinal Ischemic Perivascular Lesions in Individuals With Atrial Fibrillation
Bakhoum C, Madala S, Lando L, Yarmohammadi A, Long C, Miguez S, Chan A, Singer M, Jin A, Steren B, Adabifirouzjaei F, Goldbaum M, DeMaria A, Sarraf D, Bakhoum M. Retinal Ischemic Perivascular Lesions in Individuals With Atrial Fibrillation. Journal Of The American Heart Association 2023, 12: e028853. PMID: 37577936, PMCID: PMC10492933, DOI: 10.1161/jaha.122.028853.Peer-Reviewed Original ResearchConceptsOptical coherence tomography scansAtrial fibrillationPerivascular lesionsTomography scanSpectral domain optical coherence tomography scansMacular spectral-domain optical coherence tomographySpectral-domain optical coherence tomographyMultivariable logistic regression modelCardiovascular risk factorsDomain optical coherence tomographyAtrial fibrillation groupCoronary artery diseaseIschemic heart diseaseSex-matched individualsCase-control studyPercentage of subjectsIschemic cardiovascular diseaseOptical coherence tomographyLogistic regression modelsCardiovascular workupCardiac emboliFibrillation groupSmoking historyArtery diseaseCarotid stenosisThe Role of Water in Uromodulin Regulation
Bakhoum C, Garimella P. The Role of Water in Uromodulin Regulation. Clinical Journal Of The American Society Of Nephrology 2023, 18: 985-987. PMID: 37418253, PMCID: PMC10564335, DOI: 10.2215/cjn.0000000000000233.Peer-Reviewed Original ResearchHypertension, Blood Pressure Variability, and Acute Kidney Injury in Hospitalized Children
Nugent J, Ghazi L, Yamamoto Y, Bakhoum C, Wilson F, Greenberg J. Hypertension, Blood Pressure Variability, and Acute Kidney Injury in Hospitalized Children. Journal Of The American Heart Association 2023, 12: e029059. PMID: 37119062, PMCID: PMC10227226, DOI: 10.1161/jaha.122.029059.Peer-Reviewed Original ResearchConceptsAcute kidney injuryBlood pressure variabilityBlood pressure measurementsHospitalized childrenKidney injuryBlood pressurePressure variabilityIncident acute kidney injuryTime-updated Cox modelsMean blood pressureEnd-organ complicationsAnalysis of hypertensionAKI riskConclusions HypertensionHypertension thresholdInpatient hypertensionNormotensive patientsOrgan complicationsNonpharmacologic interventionsRetrospective cohortPediatric inpatientsMultivariable modelPediatric encountersHypertensionCox modelAssociation of clinical characteristics with urine uromodulin in children with chronic kidney disease
Faulkner S, Matheson M, Greenberg J, Garimella P, Furth S, Ix J, Bakhoum C. Association of clinical characteristics with urine uromodulin in children with chronic kidney disease. Pediatric Nephrology 2023, 38: 3859-3862. PMID: 36988691, PMCID: PMC10528151, DOI: 10.1007/s00467-023-05947-5.Peer-Reviewed Original ResearchConceptsChronic kidney diseaseUrine uromodulinUromodulin levelsGlomerular diseaseKidney diseaseEtiology of CKDGraphical abstractA higher resolution versionOlder ageMultivariable linear regressionAge-specific referenceGreater kidney sizeHigh urine concentrationsRelationship of ageConclusionsAmong childrenTubular healthClinical characteristicsMedian eGFRMedian agePrimary outcomeKidney functionKidney sizeMultivariable modelChild CohortUrine concentrationsHealthy adultsDoes This Child With High Blood Pressure Have Secondary Hypertension?
Nugent J, Jiang K, Funaro M, Saran I, Young C, Ghazi L, Bakhoum C, Wilson F, Greenberg J. Does This Child With High Blood Pressure Have Secondary Hypertension? JAMA 2023, 329: 1012-1021. PMID: 36976276, DOI: 10.1001/jama.2023.3184.Peer-Reviewed Original ResearchConceptsBlood pressure loadAmbulatory blood pressure monitoringSecondary hypertensionBlood pressure monitoringPrimary hypertensionFamily historyBlood pressurePressure monitoringDiastolic blood pressure loadSystolic blood pressure loadSerum uric acid concentrationAmbulatory blood pressureHigh blood pressureHistory of prematurityPrimary care clinicsRisk of biasNumber of patientsDatabases of MEDLINEDiagnostic Accuracy Studies toolLower body weightRandom-effects modelingUric acid concentrationWeb of ScienceLikelihood ratioAsymptomatic presentation
2022
Effect of intravenous antihypertensives on outcomes of severe hypertension in hospitalized patients without acute target organ damage
Ghazi L, Li F, Simonov M, Yamamoto Y, Nugent J, Greenberg J, Bakhoum C, Peixoto A, Wilson F. Effect of intravenous antihypertensives on outcomes of severe hypertension in hospitalized patients without acute target organ damage. Journal Of Hypertension 2022, 41: 288-294. PMID: 36583354, PMCID: PMC9799038, DOI: 10.1097/hjh.0000000000003328.Peer-Reviewed Original ResearchConceptsAcute target organ damageTarget organ damageSevere hypertensionOrgan damageIntravenous antihypertensivesBP elevationClinical outcomesMyocardial injuryTarget end-organ damageOverlap propensity scoreSevere BP elevationAcute kidney injuryBlood pressure reductionEnd-organ damageRisk of strokeInpatient hypertensionCardiovascular eventsIndex hospitalizationKidney injuryRetrospective studyHypertensionAntihypertensivesHospitalizationCox modelPatients
Academic Achievements & Community Involvement
Clinical Care
Overview
Christine Bakhoum, MD, is a pediatric nephrologist who says she was drawn to specializing in kidney disease because of its complexity.
“Nephrology is a lot of complex physiology and continuity of care with patients. I love being able to see a child with kidney disease through dialysis to transplant and watching them grow and flourish,” she says. “I enjoy walking parents through things step by step, as a lot of what I do is chronic disease and it can be overwhelming.”
Chronic kidney disease in children is progressive, and children are at high risk for cardiovascular diseases, Dr. Bakhoum says. “They will eventually need dialysis and a transplant, and to lessen their risk for cardiovascular disease and other problems, we try to modify the progression of the disease,” she says. “Because blood pressure causes more rapid progression, we make sure our children can accurately measure and control it. We want to optimize how that is done at home and in the clinic.”
When she’s talking with families. Dr. Bakhoum says she makes a point to explain things as best as she can and to lay out various options. “A lot of these situations are challenging and I like to show families what the journey ahead looks like, letting them know that our entire team, from doctors to social workers to nurses to dietitians will be with them the whole way,” she says.
“I love the moment when things get better for a child, when we’ve all been working together on the big picture and things click suddenly and things are going well.”
Dr. Bakhoum’s research focuses on optimizing blood pressure measurement and management in children with kidney disease.
Clinical Specialties
Board Certifications
Pediatric Nephrology
- Certification Organization
- AB of Pediatrics
- Original Certification Date
- 2022
Pediatrics
- Certification Organization
- AB of Pediatrics
- Original Certification Date
- 2018
Yale Medicine News
News
News
- July 11, 2024Source: Yale Ventures
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