Robert Pietrzak, PhD, MPH
Professor of Psychiatry and of Public Health (Social and Behavioral Sciences)Cards
Appointments
Additional Titles
Director, Translational Psychiatric Epidemiology Laboratory, Clinical Neurosciences Division, U.S. Department of Veterans Affairs National Center for PTSD
Contact Info
Psychiatry
National Center for PTSD, VA Connecticut Healthcare System
West Haven, CT 06516
United States
Appointments
Additional Titles
Director, Translational Psychiatric Epidemiology Laboratory, Clinical Neurosciences Division, U.S. Department of Veterans Affairs National Center for PTSD
Contact Info
Psychiatry
National Center for PTSD, VA Connecticut Healthcare System
West Haven, CT 06516
United States
Appointments
Additional Titles
Director, Translational Psychiatric Epidemiology Laboratory, Clinical Neurosciences Division, U.S. Department of Veterans Affairs National Center for PTSD
Contact Info
Psychiatry
National Center for PTSD, VA Connecticut Healthcare System
West Haven, CT 06516
United States
About
Titles
Professor of Psychiatry and of Public Health (Social and Behavioral Sciences)
Director, Translational Psychiatric Epidemiology Laboratory, Clinical Neurosciences Division, U.S. Department of Veterans Affairs National Center for PTSD
Biography
Robert H. Pietrzak completed a B.A. in Psychology at Clark University, and M.P.H. in Epidemiology and Ph.D. in Clinical Psychology with specialization in Clinical Neuropsychology at the University of Connecticut. Dr. Pietrzak is Director of the Translational Psychiatric Epidemiology Laboratory in the Clinical Neurosciences Division of the U.S. Department of Veterans Affairs National Center for PTSD and Professor of Psychiatry at Yale University School of Medicine and Professor of Public Health (Social and Behavioral Sciences) at Yale School of Public Health. His primary research interests include the psychosocial and genetic epidemiology of traumatic stress and resilience across the lifespan; dimensional models of stress-related psychopathology; and the effect of stress on cognition.
Appointments
Psychiatry
ProfessorPrimarySocial and Behavioral Sciences
ProfessorSecondary
Other Departments & Organizations
Education & Training
- Fellowship in Clinical Neuropsychology
- Gaylord Specialty Healthcare (2010)
- PhD
- University of Connecticut (2008)
- Internship in Clinical Psychology
- VA Connecticut Healthcare System-West Haven (2008)
- MPH
- University of Connecticut, Epidemiology (2003)
- BA
- Clark University, Psychology and Neuroscience (2001)
Research
Overview
"Risk and Resilience Factors in Iraq Combat Veterans" - This study aims to improve understanding of the needs, symptoms, and strengths of Connecticut OIF/OEF Veterans.
"Mental Health, Resilience, and Soldier's Perceptions about Psychotherapy, Medication, and Barriers to Care in the U.S. Military" - This study aims to determine characteristics that differentiate symptomatic soldiers who seek mental health treatment and symptomatic soldiers who do not seek professional mental health treatment.
"National Health and Resilience in Veterans Study" - The purpose of this NCPTSD-funded study is to characterize genetic, environmental, and gene x environmental determinants of longitudinal trajectories of posttraumatic stress disorder and related mental health outcomes in a nationally representative sample of U.S. veterans.
"Trajectories of Psychological Risk and Resilience in World Trade Center Responders" - This CDC/NIOSH-funded study aims to characterize the nature and correlates of trajectories of posttraumatic stress symptoms of a large cohort of World Trade Center responders.
"Biomarkers of Psychological Risk and Resilience in World Trade Center Responders" - This CDC/NIOSH-funded study aims to examine genetic, epigenetic, and neuroendocrine factors associated with posttraumatic stress disorder in World Trade Center responders.
Medical Subject Headings (MeSH)
Research at a Glance
Yale Co-Authors
Publications Timeline
Research Interests
Jack Tsai
Peter Jongho Na, MD, MPH
Ilan Harpaz-Rotem, PhD, ABPP
John Krystal, MD
Irina Esterlis, PhD
Joel Gelernter, MD
Stress Disorders, Post-Traumatic
Resilience, Psychological
Anxiety Disorders
Publications
2024
Association patterns of antisocial personality disorder across substance use disorders
Low A, Stiltner B, Nunez Y, Adhikari K, Deak J, Pietrzak R, Kranzler H, Gelernter J, Polimanti R. Association patterns of antisocial personality disorder across substance use disorders. Translational Psychiatry 2024, 14: 346. PMID: 39198385, PMCID: PMC11358160, DOI: 10.1038/s41398-024-03054-z.Peer-Reviewed Original ResearchMeSH Keywords and ConceptsConceptsAntisocial personality disorderSubstance use disordersPersonality disorderUse disorderAssociation of antisocial personality disorderPresence of antisocial personality disorderPrevalence of antisocial personality disorderHazardous useDSM-5 SUD diagnosesSubstance use disorder severityDiagnostic criteriaInteraction effects with sexTobacco use disorderDSM-5Association of alcoholSUD diagnosisDisordersCocaineRacial/ethnic backgroundsIndividualsCocUDSeverityCannabisAssociation patternsAssociationMicroglia-mediated neuroimmune suppression in PTSD is associated with anhedonia.
Bonomi R, Hillmer A, Woodcock E, Bhatt S, Rusowicz A, Angarita G, Carson R, Davis M, Esterlis I, Nabulsi N, Huang Y, Krystal J, Pietrzak R, Cosgrove K. Microglia-mediated neuroimmune suppression in PTSD is associated with anhedonia. Proceedings Of The National Academy Of Sciences Of The United States Of America 2024, 121: e2406005121. PMID: 39172786, PMCID: PMC11363315, DOI: 10.1073/pnas.2406005121.Peer-Reviewed Original ResearchAltmetricMeSH Keywords and ConceptsConceptsPTSD groupPrefrontal-limbic circuitsNeuroimmune responseAssociated with anhedoniaPosttraumatic stress disorderPositron emission tomography brain imagingTranslocator protein availabilityBrain immune functionAnhedonic symptomsStress disorderPeripheral immune dysfunctionPTSDGroup differencesSeverity of symptomsPsychiatric diseasesTranslocator proteinBrain imagingAdministration of lipopolysaccharideSymptomsMicroglial markersLPS-induced increaseCompared to controlsImmune functionSickness symptomsAnhedoniaPersistent distress related to systemic racism among black veterans in the United States
Whealin J, Jegede O, Na P, Haeny A, Pietrzak R. Persistent distress related to systemic racism among black veterans in the United States. Journal Of Affective Disorders 2024 PMID: 39147153, DOI: 10.1016/j.jad.2024.08.052.Peer-Reviewed Original ResearchConceptsAdverse mental health sequelaeRisk of mental health problemsMilitary veteransIncreased risk of mental health problemsEthnic minority veteransSystemic racismMental health sequelaeMental health problemsUse of self-reportsEthnic minority populationsNationally representative sampleUS military veteransMultinomial logistic regression analysisSignificant emotional burdenStudy periodNon-veteransLogistic regression analysisEmotional burdenMinority veteransBlack veteransUS veteransHealth sequelaeBaseline assessmentHealthcare systemUS populationUnveiling the Structure in Mental Disorder Presentations
Spiller T, Duek O, Helmer M, Murray J, Fielstein E, Pietrzak R, von Känel R, Harpaz-Rotem I. Unveiling the Structure in Mental Disorder Presentations. JAMA Psychiatry 2024, 81 PMID: 39110437, PMCID: PMC11307158, DOI: 10.1001/jamapsychiatry.2024.2047.Peer-Reviewed Original ResearchAltmetricConceptsSymptom combinationsNational Institute of Mental Health Data ArchivePosttraumatic stress disorderDiagnostic criteriaHeterogeneity of symptomsSecondary data analysisCross-sectional studyRevision of diagnostic criteriaSymptom-based definitionsDSM criteriaStress disorderSymptom heterogeneityDisorder presentationsClinical populationsMain OutcomesAssess symptomsGroup of individualsParticipantsSymptomsNational InstituteDisordersIndividualsSchizophreniaAnxietyIndividual frequenciesRole of homelessness and psychiatric disorders in suicide deaths among veterans: A four-way decomposition analysis
Beydoun H, Szymkowiak D, Pietrzak R, Beydoun M, Treadwell R, Tsai J. Role of homelessness and psychiatric disorders in suicide deaths among veterans: A four-way decomposition analysis. Psychiatry Research 2024, 340: 116120. PMID: 39121758, DOI: 10.1016/j.psychres.2024.116120.Peer-Reviewed Original ResearchConceptsMental health disordersFour-way decomposition analysisSubstance useHealth disordersPsychiatric disordersMortality riskSuicide deathsHomeless veteransVeterans AffairsSubstance use disordersU.S. Department of Veterans AffairsDepartment of Veterans AffairsPredictors of suicide deathVA healthcare systemFully-adjusted modelsMental health characteristicsEffects of homelessnessProportion of suicide deathsSuicide riskUse disorderHealth characteristicsRetrospective cohort studySuicideHealthcare systemDisordersPsychological Factors, Physical Conditions, and Functioning Among US Veterans
Fischer I, Na P, Feldman D, Krist A, Kudler H, Jeste D, Pietrzak R. Psychological Factors, Physical Conditions, and Functioning Among US Veterans. JAMA Network Open 2024, 7: e2427382. PMID: 39120905, PMCID: PMC11316230, DOI: 10.1001/jamanetworkopen.2024.27382.Peer-Reviewed Original ResearchAltmetricMental Health Apps and U.S. Military Veterans: Perceived Importance and Utilization of the National Center for Posttraumatic Stress Disorder App Portfolio
Jaworski B, Ramsey K, Taylor K, Heinz A, Senti S, Mackintosh M, Rosen C, Owen J, Pietrzak R. Mental Health Apps and U.S. Military Veterans: Perceived Importance and Utilization of the National Center for Posttraumatic Stress Disorder App Portfolio. Psychological Services 2024, 21: 538-551. PMID: 37917475, DOI: 10.1037/ser0000806.Peer-Reviewed Original ResearchCitationsConceptsMental health appsPosttraumatic stress disorderU.S. veteransHealth appsStress disorderVeterans Affairs (VA) National CenterMental health treatmentLower household incomeMore mental health concernsSelf-management appMental health concernsU.S. military veteransNeeds of veteransMedical conditionsGeneral populationVeteran populationHealth treatmentWhite veteransHealth concernConsistent associationVariety of barriersHealth careMilitary veteransBlack veteransVeteransLongitudinal associations between five factor model and impulsive personality traits and PTSD symptoms: Findings from the AURORA study
Hyatt C, Reddi P, Sharpe B, Michopoulos V, van Rooij S, House S, Beaudoin F, An X, Stevens J, Zeng D, Neylan T, Clifford G, Linnstaedt S, Germine L, Bollen K, Rauch S, Haran J, Lewandowski C, Musey P, Hendry P, Sheikh S, Jones C, Punches B, Kurz M, Swor R, Hudak L, Pascual J, Seamon M, Harris E, Pearson C, Peak D, Merchant R, Domeier R, Rathlev N, Sergot P, Sanchez L, Bruce S, Miller M, Pietrzak R, Joormann J, Pizzagalli D, Sheridan J, Smoller J, Harte S, Elliott J, McLean S, Kessler R, Ressler K, Koenen K, Maples-Keller J. Longitudinal associations between five factor model and impulsive personality traits and PTSD symptoms: Findings from the AURORA study. Journal Of Research In Personality 2024, 104524. DOI: 10.1016/j.jrp.2024.104524.Peer-Reviewed Original ResearchConceptsImpulsive personality traitsPTSD symptomsPersonality traitsOne-year post-traumaSevere PTSD symptomsPost-traumaFactor modelNegative urgencyLow agreeablenessLow conscientiousnessTrauma exposurePersonality assessmentPTSD riskProspective linksSymptom TotalPTSDLongitudinal associationsAURORA studyIncremental predictorNeuroticismTime pointsSymptomsTraitsAgreeablenessConscientiousnessSuccessful Aging in US Veterans with Mental Disorders: Results From the National Health and Resilience in Veterans Study
Shin J, Fischer I, Na P, Jeste D, Pietrzak R. Successful Aging in US Veterans with Mental Disorders: Results From the National Health and Resilience in Veterans Study. American Journal Of Geriatric Psychiatry 2024 DOI: 10.1016/j.jagp.2024.07.018.Peer-Reviewed Original ResearchAltmetricConceptsGeneralized anxiety disorderPosttraumatic stress disorderMental disordersSomatic symptomsNational Health and ResilienceUS military veteransSuccessful agingAnxiety disordersDepressive disorderUS veteransStress disorderPromote successful agingHigher gratitudeVeterans StudyMilitary veteransInterventions targeting psychosocial factorsOne-in-fiveVeteransMDDDisordersPsychosocial factorsGratitudeNegative associationSymptomsMultivariate logistic regressionUnraveling PTSD: Symptom Cluster Change During and 1 Year After Veterans’ Residential PTSD Treatment
Gross G, Spiller T, Ben-Zion Z, Rubenstein A, Pietrzak R, Duek O, Hoff R, Harpaz-Rotem I. Unraveling PTSD: Symptom Cluster Change During and 1 Year After Veterans’ Residential PTSD Treatment. Psychological Trauma Theory Research Practice And Policy 2024 PMID: 38990694, DOI: 10.1037/tra0001734.Peer-Reviewed Original ResearchAltmetricConceptsPosttraumatic stress disorderPosttraumatic stress disorder symptom clustersPosttraumatic stress disorder clustersSymptom clustersIntrusive symptomsResidential treatmentTreatment of posttraumatic stress disorderPosttraumatic stress disorder symptomsResidential PTSD treatmentPTSD symptom clustersNovel treatment interventionsDifferential treatment responseReduce symptom severityDifferential patterns of changeAvoidance symptomsPTSD treatmentTreatment gainsStress disorderVeterans AffairsSymptom severityCluster CTreatment interventionsCluster BIndividual symptomsCohort of veterans
Clinical Trials
Current Trials
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HIC ID2000033404RoleSub InvestigatorPrimary Completion Date08/31/2025Recruiting ParticipantsStudying the Adult Brain
HIC ID2000025671RoleSub InvestigatorPrimary Completion Date07/31/2025Recruiting ParticipantsImaging SV2A in mood disorders
HIC ID1511016789RoleSub InvestigatorPrimary Completion Date03/15/2022Recruiting ParticipantsGenderBothAge18 years - 70 years
Academic Achievements & Community Involvement
activity Psychological Injury and Law
Professional OrganizationsMemberDetailsEditorial Board11/01/2014 - Presentactivity Journal of Anxiety Disorders
Professional OrganizationsMemberDetailsEditorial Board08/10/2015 - Presentactivity PLoS One
Professional OrganizationsBoard MemberDetailsEditorial Board09/07/2018 - Presenthonor Outstanding Contributions to the Science of Trauma Psychology
National AwardAmerican Psychological AssociationDetails07/20/2022United Stateshonor 2022 Paul Wender Best Paper Award
National AwardAmerican Society of Clinical PsychopharmacologyDetails03/24/2022United States
News
News
- August 23, 2024
Microglia-Mediated Neuroimmune Suppression in PTSD Is Associated With Anhedonia
- August 22, 2024Source: Psychiatric News
Resilience and Gratitude Linked to Successful Aging Among Vets With Mental Disorders
- August 12, 2024
Study Links Life Purpose to Sustained Functioning in US Veterans
- July 02, 2024
Na Chosen to Receive VA Career Development Award
Get In Touch
Contacts
Psychiatry
National Center for PTSD, VA Connecticut Healthcare System
West Haven, CT 06516
United States