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Maudry Laurent-Rolle, MD, PhD, BS

Assistant Professor
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About

Titles

Assistant Professor

Biography

Dr. Maudry Laurent-Rolle received her B.S. from Long Island University, Brooklyn Campus in Biology in 2001. She then obtained her MD and PhD from Icahn School of Medicine at Mount Sinai. Her dissertation research was funded by an NIH pre-doctoral fellowship, which allowed her to examine the molecular mechanisms by which flaviviruses inhibit host innate immune responses. She completed residency training in Internal Medicine at Albert Einstein/Montefiore Medical Center in 2016 then joined the Infectious Diseases Fellowship program here at Yale University. Her research focus is on vaccine design and development of antivirals. She is originally from the beautiful Caribbean island of Dominica, known for its many rivers, tropical rainforests, and natural hot springs.

Appointments

Other Departments & Organizations

Education & Training

Research Fellow in Infectious Diseases
Section of Infectious Diseases (2020)
Fellow
Yale University (2019)
Resident
Albert Einstein/Montefiore Medical Center (2016)
MD
Icahn School of Medicine at Mount Sinai (2013)
PhD
Icahn School of Medicine at Mount Sinai, Microbiology (2011)
Non Degree Program
Icahn School of Medicine at Mount Sinai, Postbaccalaureate Research Education Program (2004)
BS
Long Island University, Biology (2001)

Research

Overview

I spent the last 16 years studying the molecular mechanisms utilized by pathogenic viruses, specifically flaviviruses, to antagonize host immune responses. During my training in the Post Baccalaureate Research Education Program (PREP) at the Icahn School of Medicine at Mount Sinai I helped developed a reporter assay system that was used to screen dengue virus-encoded proteins’ ability to inhibit the type I interferon response. During my graduate school years, I was awarded a competitive NIH F31 grant based on my doctoral studies focused on understanding how West Nile virus (WNV), dengue virus (DENV) and yellow fever virus (YFV) inhibit the host innate immune response. I characterized the molecular mechanisms by which these viruses use the nonstructural protein 5 (NS5) to inhibit interferon signaling albeit through distinct mechanisms. My thesis project as well as several collaborations resulted in a provisional vaccine patent, a book chapter, and several articles that have been published in high impact journals.

After completing my Internal Medicine residency, I joined the Infectious Diseases Fellowship program here at Yale University. After the first intensive clinical year, I transitioned to basic science research where I focus on characterizing the molecular mechanism(s) by which the antiviral protein, CMPK2 restricts viral replication. The results of this work may lead to the development of new drug targets. In addition to my research, I am also a lecturer in the department of Molecular Biophysics and Biochemistry here at Yale School of Medicine. My clinical experiences and research training in virology as well as biochemical and immunological methods place me in a position to answer the fundamental questions that will contribute to my overall long term goal of vaccine design and development of antivirals.


Research at a Glance

Yale Co-Authors

Frequent collaborators of Maudry Laurent-Rolle's published research.

Publications

2024

2023

2022

2021

2020

Academic Achievements & Community Involvement

  • activity

    Infectious Disease Society of America

  • activity

    American Society for Virology

  • activity

    American Medical Association

  • activity

    American College of Physicians

  • activity

    Yale Intern Selection Committee (ISC) for the Yale Internal Medicine-Traditional Residency Program (categorical applicants)

Get In Touch

Contacts

Locations

  • 300 George Street

    Academic Office

    Rm 2308

    New Haven, CT 06511

Events