Publications

Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms

Gordon D, Hiatt J, Bouhaddou M, Rezelj V, Ulferts S, Braberg H, Jureka A, Obernier K, Guo J, Batra J, Kaake R, Weckstein A, Owens T, Gupta M, Pourmal S, Titus E, Cakir M, Soucheray M, McGregor M, Cakir Z, Jang G, O’Meara M, Tummino T, Zhang Z, Foussard H, Rojc A, Zhou Y, Kuchenov D, Hüttenhain R, Xu J, Eckhardt M, Swaney D, Fabius J, Ummadi M, Tutuncuoglu B, Rathore U, Modak M, Haas P, Haas K, Naing Z, Pulido E, Shi Y, Barrio-Hernandez I, Memon D, Petsalaki E, Dunham A, Marrero M, Burke D, Koh C, Vallet T, Silvas J, Azumaya C, Billesbølle C, Brilot A, Campbell M, Diallo A, Dickinson M, Diwanji D, Herrera N, Hoppe N, Kratochvil H, Liu Y, Merz G, Moritz M, Nguyen H, Nowotny C, Puchades C, Rizo A, Schulze-Gahmen U, Smith A, Sun M, Young I, Zhao J, Asarnow D, Biel J, Bowen A, Braxton J, Chen J, Chio C, Chio U, Deshpande I, Doan L, Faust B, Flores S, Jin M, Kim K, Lam V, Li F, Li J, Li Y, Li Y, Liu X, Lo M, Lopez K, Melo A, Moss F, Nguyen P, Paulino J, Pawar K, Peters J, Pospiech T, Safari M, Sangwan S, Schaefer K, Thomas P, Thwin A, Trenker R, Tse E, Tsui T, Wang F, Whitis N, Yu Z, Zhang K, Zhang Y, Zhou F, Saltzberg D, Hodder A, Shun-Shion A, Williams D, White K, Rosales R, Kehrer T, Miorin L, Moreno E, Patel A, Rihn S, Khalid M, Vallejo-Gracia A, Fozouni P, Simoneau C, Roth T, Wu D, Karim M, Ghoussaini M, Dunham I, Berardi F, Weigang S, Chazal M, Park J, Logue J, McGrath M, Weston S, Haupt R, Hastie C, Elliott M, Brown F, Burness K, Reid E, Dorward M, Johnson C, Wilkinson S, Geyer A, Giesel D, Baillie C, Raggett S, Leech H, Toth R, Goodman N, Keough K, Lind A, Klesh R, Hemphill K, Carlson-Stevermer J, Oki J, Holden K, Maures T, Pollard K, Sali A, Agard D, Cheng Y, Fraser J, Frost A, Jura N, Kortemme T, Manglik A, Southworth D, Stroud R, Alessi D, Davies P, Frieman M, Ideker T, Abate C, Jouvenet N, Kochs G, Shoichet B, Ott M, Palmarini M, Shokat K, García-Sastre A, Rassen J, Grosse R, Rosenberg O, Verba K, Basler C, Vignuzzi M, Peden A, Beltrao P, Krogan N, Owens T, Gupta M, Pourmal S, Titus E, Azumaya C, Billesbølle C, Brilot A, Campbell M, Diallo A, Dickinson M, Diwanji D, Herrera N, Hoppe N, Kratochvil H, Liu Y, Merz G, Moritz M, Nguyen H, Nowotny C, Puchades C, Rizo A, Schulze-Gahmen U, Smith A, Sun M, Young I, Zhao J, Asarnow D, Biel J, Bowen A, Braxton J, Chen J, Chio C, Chio U, Deshpande I, Doan L, Faust B, Flores S, Jin M, Kim K, Lam V, Li F, Li J, Li Y, Li Y, Liu X, Lo M, Lopez K, Melo A, Moss F, Nguyen P, Paulino J, Pawar K, Peters J, Pospiech T, Safari M, Sangwan S, Schaefer K, Thomas P, Thwin A, Trenker R, Tse E, Tsui T, Wang F, Whitis N, Yu Z, Zhang K, Zhang Y, Zhou F, Trinidad D, Agard D, Cheng Y, Fraser J, Frost A, Jura N, Kortemme T, Manglik A, Southworth D, Stroud R, Rosenberg O, Verba K, Damas J, Hughes G, Keough K, Painter C, Persky N, Corbo M, Kirilenko B, Hiller M, Koepfli K, Kaplow I, Wirthlin M, Pfenning A, Zhao H, Genereux D, Swofford R, Lind A, Pollard K, Ryderq O, Nweeia M, Meadows J, Dong M, Wallerman O, Marinescu V, Lindblad-Toh K, Ray D, Power S, Teeling E, Chauhan G, Li S, Karlsson E, Lewin H. Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms. Science 2020, 370: eabe9403. PMID: 33060197, PMCID: PMC7808408, DOI: 10.1126/science.abe9403.

Peer-Reviewed Original Research

MeSH Keywords and Concepts

Publications

2025

Hijacking Extracellular Targeted Protein Degrader–Drug Conjugates for Enhanced Drug Delivery

Hypoxia Induces Extensive Protein and Proteolytic Remodeling of the Cell Surface in Pancreatic Adenocarcinoma (PDAC) Cell Lines

Engineered Proteins and Chemical Tools to Probe the Cell Surface Proteome

2024

Multiscale photocatalytic proximity labeling reveals cell surface neighbors on and between cells

2022

Direct Identification of Proteolytic Cleavages on Living Cells Using a Glycan-Tethered Peptide Ligase

2020

Lipoteichoic acid polymer length is determined by competition between free starter units

Structure and reconstitution of a hydrolase complex that may release peptidoglycan from the membrane after polymerization

An ultrapotent synthetic nanobody neutralizes SARS-CoV-2 by stabilizing inactive Spike

Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms

Staphylococcus aureus cell growth and division are regulated by an amidase that trims peptides from uncrosslinked peptidoglycan

2019

Direction of Chain Growth and Substrate Preferences of Shape, Elongation, Division, and Sporulation-Family Peptidoglycan Glycosyltransferases

2018

MreB filaments align along greatest principal membrane curvature to orient cell wall synthesis

Substrate Preferences Establish the Order of Cell Wall Assembly in Staphylococcus aureus

2017

Identification of a Functionally Unique Family of Penicillin-Binding Proteins

Peptidoglycan Cross-Linking Preferences of Staphylococcus aureus Penicillin-Binding Proteins Have Implications for Treating MRSA Infections

Lipid II overproduction allows direct assay of transpeptidase inhibition by β-lactams

In vitro reconstitution demonstrates the cell wall ligase activity of LCP proteins

2015

The Mechanism of Action of Lysobactin

2014

Detection of Lipid-Linked Peptidoglycan Precursors by Exploiting an Unexpected Transpeptidase Reaction

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