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Illuminating chemistry at the human:microbe interface

In the Schaefer Lab, our goal is to develop a molecular understanding of community crosstalk among human and bacterial cells.

What is the chemical basis for cell-cell communication at the human:microbe interface?

Throughout our bodies, human cells coexist with diverse and abundant bacteria, and a vast library of chemicals and macromolecules is exchanged between them. Our immune system plays dual physiological roles in this ecosystem, fighting against pathogenic bacteria while conversely maintaining complex, stable commensal populations. Concordantly, microbial networks play myriad and profound roles in human physiology and illness.

To identify, understand, and modulate signaling at the human:microbe interface, our laboratory integrates leading-edge chemical biology, proteomics, microbiology, immunology, and structural biology.

About us

We are building a scientifically diverse team

We welcome enthusiastic and curious scientists from diverse personal and professional backgrounds. Our group strives to advance science and profoundly impact human health. Our mission requires tackling challenging science, and we value a positive work environment that promotes mentorship, communication, and transparent and rigorous science. Lab members should feel supported and a sense of agency in their work

Reflecting our collaborative atmosphere within our lab, we are excited to work with the broader scientific community.