Current Lab Members
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I am interested in studying molecular mechanisms of cortical developmental malformations in neurodevelopmental disorders and psychiatric diseases. By establishing animal models of human brain disorders and recruiting variety of molecular biology, genetic, morphology as well as transcriptomics methods, I hope my study will facilitate understanding the basics of neuopsychiatric diseases and developing time efficient therapeutic strategies.
Brain; Dopaminergic Neurons; Embryo, Mammalian; GABAergic Neurons; Induced Pluripotent Stem Cells; Interneurons; Mental Disorders; Neural Stem Cells; Neurodegenerative Diseases; Neurons; Organizers, Embryonic; Pluripotent Stem Cells; Synapses
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Dr. Micali is associate research scientist in Rakic lab. He received his Ph.D in Genetics, Molecular and Cellular Biology from State University of Milan-Italy in 2006. From 2003 to 2008, he worked at the Molecular Genetics unit lead by Professor Francesco Blasi, at the San Raffaele Scientific Institute (Milan). He was interested in studying the role of TALE transcription factors (Pbx, Prep and Meis) in controlling cell survival and proliferation genes during mammalian development, using mouse...
Central Nervous System; Neurodegenerative Diseases
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Many years of experience in
worldwide laboratories (Russia,
lend to expertise in the methods of scanning and transmission electron
microscopy including pre- and post-embedding immunolabeling. This also let me
introduce to Yale the method of three-dimensional reconstruction of large cell
fragments such as neuron cell bodies or processes from serial electron
Anatomy; Brain; Cell Biology; Chemicals and Drugs; Disorders of Environmental Origin; Embryo Research; Embryology; Fetal Research; Genetic Research; Nervous System Malformations; Neurogenesis; Neurosciences; Optogenetics; Stem Cells
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My interests in cerebral cortex development emerged from studies of axon guidance of the corpus callosum while a post-baccalaureate student at the University of Maryland, Baltimore. This work turned into a masters thesis as I began doctoral studies at the University of Chicago in the field of telencephalic patterning. The formation of the mammalian brain is one of the most fascinating subjects in science and I decided to continue this line of research with post-doctoral studies of brain...
Summary of Research and Future Directions: My interest is in how neurons change their connectivity and structure during the "critical period" of development and how this may be applicable to human disorders. Currently, I am investigating the possibility of inducing critical period-like synaptic plasticity in an adult
I am interested in developmental dynamics, i.e. changes to the neural stem cell niche as development proceeds through time. I am interested in neural molecular identity, differentiation, and cell fate restriction in early cortical progenitors. My thesis work focuses on the interactions between both novel and well-established transcriptional regulators in cortex development.