Hong Li
Associate Research Scholar in NeuroscienceCards
About
Research
Publications
2023
Origin and development of the claustrum in rhesus macaque
Li H, Duque A, Rakic P. Origin and development of the claustrum in rhesus macaque. Proceedings Of The National Academy Of Sciences Of The United States Of America 2023, 120: e2220918120. PMID: 37406098, PMCID: PMC10334778, DOI: 10.1073/pnas.2220918120.Peer-Reviewed Original Research
2022
Mitotic spindle disassembly in human cells relies on CRIPT having hierarchical redox signals
Xu K, Wang C, Keinänen K, Li H, Cai C. Mitotic spindle disassembly in human cells relies on CRIPT having hierarchical redox signals. Journal Of Cell Science 2022, 135 PMID: 36148798, DOI: 10.1242/jcs.259657.Peer-Reviewed Original ResearchConceptsSpindle disassemblyMicrotubule depolymerizationCysteine residuesDisease-relevant mutantsHuman cellsMitotic spindle disassemblyRedox control mechanismsRedox-dependent mannerCXXC pairsSpindle dissolutionLive cell microscopyLate mitosisLive-cell recordingsNucleolar concentrationSpindle remnantsCytoplasmic proteinsMammalian cellsNuclear localizationTubulin subunitsRedox signalingRedox modificationCell survivalMetaphase spindleBiochemical assaysCell types
2019
Maturation of thalamocortical synapses in the somatosensory cortex depends on neocortical AKAP5 expression
Zhang M, Lu M, Huang H, Liu X, Su H, Li H. Maturation of thalamocortical synapses in the somatosensory cortex depends on neocortical AKAP5 expression. Neuroscience Letters 2019, 709: 134374. PMID: 31310785, DOI: 10.1016/j.neulet.2019.134374.Peer-Reviewed Original ResearchConceptsThalamocortical synapsesSomatosensory cortexThalamocortical afferentsCortical neuronsLayer IV cortical neuronsDevelopment of cortical neuronsAMPA/NMDA ratioSilent synapsesFormation of topographic mapsBarrel mapPostnatal developmentFunctional maturationSensory cortexCortexElectrophysiological recordingsCortex developmentPKA signalingKinase AMiceSynapsesNeuronsSignaling pathwayAKAP5Topographic map formationAMPA/NMDADisruption of TCF4 regulatory networks leads to abnormal cortical development and mental disabilities
Li H, Zhu Y, Morozov YM, Chen X, Page SC, Rannals MD, Maher BJ, Rakic P. Disruption of TCF4 regulatory networks leads to abnormal cortical development and mental disabilities. Molecular Psychiatry 2019, 24: 1235-1246. PMID: 30705426, PMCID: PMC11019556, DOI: 10.1038/s41380-019-0353-0.Peer-Reviewed Original ResearchConceptsPitt-Hopkins syndromeNeuropsychiatric diseasesUpper layer cortical neuronsTransient embryonic zonesAbnormal cortical developmentTCF4 geneEarlier gestational ageRegion-specific mannerGestational ageCortical neuronsCortical developmentNeuronal proliferationPrecise molecular mechanismsRadial gliaExpression of TCF4Abnormal dendritesNeuronal migrationNeocortical developmentDiseaseNormal functionMolecular pathwaysSignificant increaseMental disabilitiesMiceStem cells
2018
Differential gene regulatory plasticity between upper and lower layer cortical excitatory neurons
Yang L, Chen L, Cai C, Li H. Differential gene regulatory plasticity between upper and lower layer cortical excitatory neurons. Molecular And Cellular Neuroscience 2018, 90: 22-32. PMID: 29802938, DOI: 10.1016/j.mcn.2018.05.007.Peer-Reviewed Original ResearchEpigenetic modifications of chromatinModification of chromatinActivity-dependent gene regulationEpigenetic modificationsGene regulationImmediate early geneRegulatory plasticityHeterochromatin markersTranscription assaysC-fosLayer-specific gene expressionLL neuronsNeocortical projection neuronsGene expressionEarly genesActivity in vivoCortical excitatory neuronsChromatinGenesEGR1Excitatory neuronsProjection neuronsNeocortical cytoarchitectureAfferent activityPostnatal developmentZinc-Finger Proteins in Brain Development and Mental Illness
Li H, Lu M, Liu X. Zinc-Finger Proteins in Brain Development and Mental Illness. Journal Of Translational Neurosciences 2018, 3 DOI: 10.21767/2573-5349.100017.Peer-Reviewed Original Research
2013
Laminar and Columnar Development of Barrel Cortex Relies on Thalamocortical Neurotransmission
Li H, Fertuzinhos S, Mohns E, Hnasko TS, Verhage M, Edwards R, Sestan N, Crair MC. Laminar and Columnar Development of Barrel Cortex Relies on Thalamocortical Neurotransmission. Neuron 2013, 79: 970-986. PMID: 24012009, PMCID: PMC3768017, DOI: 10.1016/j.neuron.2013.06.043.Peer-Reviewed Original ResearchConceptsThalamocortical neurotransmissionCortical developmentNeuronal differentiationGlutamatergic synaptic transmissionSuperficial cortical laminaeEarly cortical developmentActivity-dependent factorsThalamocortical neuronsSomatosensory cortexCortical cytoarchitectureCortical laminationSynaptic transmissionNeuronal activityCortical laminaeCytoarchitectonic criteriaExtrinsic activityNeurotransmissionCortical columnsMolecular cuesNeuronsMorphologic developmentLittle evidenceColumnar developmentGene expressionExtrinsic factors
2011
How do barrels form in somatosensory cortex?
Li H, Crair MC. How do barrels form in somatosensory cortex? Annals Of The New York Academy Of Sciences 2011, 1225: 119-129. PMID: 21534999, PMCID: PMC4700879, DOI: 10.1111/j.1749-6632.2011.06024.x.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus Statements
2008
Somatostatin receptor subtype 1 is a PDZ ligand for synapse-associated protein 97 and a potential regulator of growth cone dynamics
Cai C, Li H, Kangasniemi A, Pihlajamaa T, Von Ossowski L, Kerkelä K, Schulz S, Rivera C, Keinänen K. Somatostatin receptor subtype 1 is a PDZ ligand for synapse-associated protein 97 and a potential regulator of growth cone dynamics. Neuroscience 2008, 157: 833-843. PMID: 18951956, DOI: 10.1016/j.neuroscience.2008.09.048.Peer-Reviewed Original ResearchMeSH KeywordsAdaptor Proteins, Signal TransducingAmino Acid SequenceAnimalsAnimals, NewbornCells, CulturedChlorocebus aethiopsDiscs Large Homolog 1 ProteinEmbryo, MammalianGreen Fluorescent ProteinsGrowth ConesHumansImmunoprecipitationLigandsMembrane ProteinsMiceMicrotubule-Associated ProteinsMutationNeuronsPDZ DomainsProsencephalonReceptors, SomatostatinTransfectionConceptsPostsynaptic density-95/discs large/zona occludens-1Binding motifClass I PDZ-binding motifMembrane-associated guanylate kinase homologsGrowth conesHuman embryonic kidneyPull-down experimentsSomatostatin receptor subtypes 1Growth cone dynamicsNeuronal growth conesStructural organizationSst1 immunoreactivitySynapse-associated protein 97Receptor subtype 1Growth cone collapseKinase homologDomain proteinsProtein SAPScaffold proteinCone collapseMembrane complexDevelopmental roleSubtype 1SAP97Postnatal day 5
2007
KCC2 Interacts with the Dendritic Cytoskeleton to Promote Spine Development
Li H, Khirug S, Cai C, Ludwig A, Blaesse P, Kolikova J, Afzalov R, Coleman S, Lauri S, Airaksinen M, Keinänen K, Khiroug L, Saarma M, Kaila K, Rivera C. KCC2 Interacts with the Dendritic Cytoskeleton to Promote Spine Development. Neuron 2007, 56: 1019-1033. PMID: 18093524, DOI: 10.1016/j.neuron.2007.10.039.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAnimals, NewbornCells, CulturedCerebral CortexCytoskeletal ProteinsCytoskeletonDendritesDendritic SpinesEmbryo, MammalianExcitatory Postsynaptic PotentialsGreen Fluorescent ProteinsHumansIn Vitro TechniquesK Cl- CotransportersLysineMembrane ProteinsMiceMice, KnockoutMutationNerve Tissue ProteinsNeuronsNeuropeptidesPatch-Clamp TechniquesSymportersSynaptic TransmissionTransfectionConceptsNeuron-specific K-Cl cotransporterDevelopment of excitatory synapsesK-Cl cotransportMaturation of dendritic spinesGABAergic transmissionGABAergic synapsesKCC2Excitatory synapsesSpine cytoskeletonCortical neuronsDendritic spinesSpineMorphogenic roleSpine developmentTransport functionFunctional developmentSynapsesDendritic cytoskeletonCotransporterC-terminal domain