Morphogenic gradients governing areal identity in the neorcortex
Graded expression patterns of several factors thought to be responsible for shaping the ultimate neocortical landscape that is highly partitioned and specialized. Supplement list to Figure 4 in Rakic P, Ayoub AE, Breunig JJ, Dominguez MH. Decision by division: making cortical maps. Trends Neurosci. 2009 May;32(5):291-301. Epub 2009 Apr 18. Review. PubMed PMID: 19380167.
| Image | Molecule | Repressses | Induces | Repressors | Inducers | References |
|---|---|---|---|---|---|---|
|
BMPs (4,6,7; also 2,5) | Foxg1, FGF8 | Msx1 | FGF8, Noggin | Pubmed | |
|
Cadherin-11 | Pubmed | ||||
|
Cadherin-6 | FGFs | Pubmed | |||
|
Cadherin-8 | FGFs | Pubmed | |||
|
Clim1a | Pubmed | ||||
|
COUP-TFI (Nr2f1) | FGF8 > FGF17 | Pubmed | |||
|
EGFs (TNFalpha, Nrg1, Nrg2, Nrg3) | Pax6 (required) | Pubmed | |||
|
Emx2 | FGFs, Pax6 | Reelin | FGF8 >>> FGF17, Pax6 | Wnts | Pubmed |
|
EphA2 | Pubmed | ||||
|
EphA7 | Pubmed | ||||
|
Ephrin-A5 | FGFs | Pubmed | |||
|
Etv1(Er81) | FGF8 | Pubmed | |||
|
FGF15 | Pubmed | ||||
|
FGF17 | Sp8 | Sp8 | Pubmed | ||
|
FGF8 | BMP4, Wnts, COUP-TF1, Emx2, Otx2 | FGFs, Sp8, Nkx2.1, Ets Factors (Pea3, Erm, Etv1), Spry1 and Spry2 | Emx2 | Shh, Sp8 | Pubmed |
| FGFR3 | FGF8 | Pubmed | ||||
|
Foxg1 (BF1) | BMPs | BMP2, BMP4, Wnts | Pubmed | ||
|
Id2 | Pubmed | ||||
|
Lhx2 | Wnts | Pubmed | |||
|
Lmo3 | Pubmed | ||||
|
Lmo4 | Pubmed | ||||
|
Nt3 | Pubmed | ||||
|
Otx2 | FGF8 | Pubmed | |||
|
p75 | Emx2 | Pubmed | |||
|
Pax6 | Emx2 | sFrp2 | Emx2 | Pubmed | |
| Pea3 | FGF8 | Pubmed | ||||
|
RORbeta | FGFs | Pubmed | |||
|
SCIP (Pou3f1) | Pubmed | ||||
|
Sfrps (sFrp2) | Wnts | Pubmed | |||
| Shh | Gli3 | FGF8, Gli3R | Nkx2.1 | Pubmed | ||
|
Sp5 | Pubmed | ||||
|
|
Sp8 | FGF8 | FGFs | Pubmed | ||
| Spry1 | Ets factors?? | Pubmed | ||||
|
Tbr1 | FGF8 | Pubmed | |||
|
|
Wnts (Wnt3a,Wnt2b,Wnt5a,Wnt8b) | FGFs | NOT BMP | Pubmed |