Mechanisms of Brain Morphogenesis and Pathogenesis

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CCM cartoon

Cerebral Cavernous Malformations (CCM)

Together with the Gunel laboratory, we are investigating the biology of Ccm3, a gene implicated in the pathogenesis of CCM, a monogenic cerebrovascular disorder. We have generated a mouse...

Disorders of Cortical Development

We are using in vitro and in vivo approaches to examine the biology of novel genes implicated in human cortical development identified in the Gunel laboratory using genetic analyses and...

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Notch Lineages in the CNS

The Notch signaling pathway is an evolutionarily conserved cell interaction mechanism that is active in a wide range of organisms and tissues, is associated with early lineage decisions,...

CADASIL

CADASIL

Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy is the most common monogenic form of ischemic cerebral small-vessel disease. CADASIL is associated...