Publications

• SARS-CoV-2-related bat viruses evade human intrinsic immunity but lack efficient transmission capacity.Peña-Hernández MA, Alfajaro MM, Filler RB, Moriyama M, Keeler EL, Ranglin ZE, Kong Y, Mao T, Menasche BL, Mankowski MC, Zhao Z, Vogels CBF, Hahn AM, Kalinich CC, Zhang S, Huston N, Wan H, Araujo-Tavares R, Lindenbach BD, Homer R, Pyle AM, Martinez DR, Grubaugh ND, Israelow B, Iwasaki A, Wilen CB. Nat Microbiol. 2024 Aug; 2024 Jul 29. PMID: 39075235.
• Proof-of-concept studies with a computationally designed M(pro) inhibitor as a synergistic combination regimen alternative to Paxlovid.Papini C, Ullah I, Ranjan AP, Zhang S, Wu Q, Spasov KA, Zhang C, Mothes W, Crawford JM, Lindenbach BD, Uchil PD, Kumar P, Jorgensen WL, Anderson KS. Proc Natl Acad Sci U S A. 2024 Apr 23; 2024 Apr 15. PMID: 38621119.
• Correction for Rasmussen et al., "Virology-the path forward".Rasmussen AL, Gronvall GK, Lowen AC, Goodrum F, Alwine J, Andersen KG, Anthony SJ, Baines J, Banerjee A, Broadbent AJ, Brooke CB, Campos SK, Caposio P, Casadevall A, Chan GC, Cliffe AR, Collins-McMillen D, Connell N, Damania B, Daugherty MD, Debbink K, Dermody TS, DiMaio D, Duprex WP, Emerman M, Galloway DA, Garry RF, Goldstein SA, Greninger AL, Hartman AL, Hogue BG, Horner SM, Hotez PJ, Jung JU, Kamil JP, Karst SM, Laimins L, Lakdawala SS, Landais I, Letko M, Lindenbach B, Liu S-L, Luftig M, McFadden G, Mehle A, Morrison J, Moscona A, Mühlberger E, Munger J, Münger K, Murphy E, Neufeldt CJ, Nikolich JZ, O'Connor CM, Pekosz A, Permar SR, Pfeiffer JK, Popescu SV, Purdy JG, Racaniello VR, Rice CM, Runstadler JA, Sapp MJ, Scott RS, Smith GA, Sorrell EM, Speranza E, Streblow D, Tibbetts SA, Toth Z, Van Doorslaer K, Weiss SR, White EA, White TM, Wobus CE, Worobey M, Yamaoka S, Yurochko A. J Virol. 2024 Mar 19; 2024 Feb 9. PMID: 38334328.
• Prior Influenza Infection Mitigates SARS-CoV-2 Disease in Syrian Hamsters.Di Pietro C, Haberman AM, Lindenbach BD, Smith PC, Bruscia EM, Allore HG, Vander Wyk B, Tyagi A, Zeiss CJ. Viruses. 2024 Feb 3; 2024 Feb 3. PMID: 38400021.
• Virology-the path forward.Rasmussen AL, Gronvall GK, Lowen AC, Goodrum F, Alwine J, Andersen KG, Anthony SJ, Baines J, Banerjee A, Broadbent AJ, Brooke CB, Campos SK, Caposio P, Casadevall A, Chan GC, Cliffe AR, Collins-McMillen D, Connell N, Damania B, Daugherty MD, Debbink K, Dermody TS, DiMaio D, Duprex WP, Emerman M, Galloway DA, Garry RF, Goldstein SA, Greninger AL, Hartman AL, Hogue BG, Horner SM, Hotez PJ, Jung JU, Kamil JP, Karst SM, Laimins L, Lakdawala SS, Landais I, Letko M, Lindenbach B, Liu S-L, Luftig M, McFadden G, Mehle A, Morrison J, Moscona A, Mühlberger E, Munger J, Münger K, Murphy E, Neufeldt CJ, Nikolich JZ, O'Connor CM, Pekosz A, Permar SR, Pfeiffer JK, Popescu SV, Purdy JG, Racaniello VR, Rice CM, Runstadler JA, Sapp MJ, Scott RS, Smith GA, Sorrell EM, Speranza E, Streblow D, Tibbetts SA, Toth Z, Van Doorslaer K, Weiss SR, White EA, White TM, Wobus CE, Worobey M, Yamaoka S, Yurochko A. J Virol. 2024 Jan 23; 2024 Jan 3. PMID: 38168672.
• Astrovirus replication is dependent on induction of double-membrane vesicles through a PI3K-dependent, LC3-independent pathway.Bub T, Hargest V, Tan S, Smith M, Vazquez-Pagan A, Flerlage T, Brigleb P, Meliopoulos V, Lindenbach B, Ramanathan HN, Cortez V, Crawford JC, Schultz-Cherry S. J Virol. 2023 Sep 28; 2023 Sep 5. PMID: 37668367.
• Astrovirus replication is dependent on induction of double membrane vesicles through a PI3K-dependent, LC3-independent pathway.Bub T, Hargest V, Tan S, Smith M, Vazquez-Pagan A, Flerlage T, Brigleb PH, Meliopoulos V, Lindenbach B, Cortez V, Crawford JC, Schultz-Cherry S. bioRxiv. 2023 Apr 12; 2023 Apr 12. PMID: 37090568.
• Positive-strand RNA viruses-a Keystone Symposia report.Cable J, Denison MR, Kielian M, Jackson WT, Bartenschlager R, Ahola T, Mukhopadhyay S, Fremont DH, Kuhn RJ, Shannon A, Frazier MN, Yuen KY, Coyne CB, Wolthers KC, Ming GL, Guenther CS, Moshiri J, Best SM, Schoggins JW, Jurado KA, Ebel GD, Schäfer A, Ng LFP, Kikkert M, Sette A, Harris E, Wing PAC, Eggenberger J, Krishnamurthy SR, Mah MG, Meganck RM, Chung D, Maurer-Stroh S, Andino R, Korber B, Perlman S, Shi PY, Bárcena M, Aicher SM, Vu MN, Kenney DJ, Lindenbach BD, Nishida Y, Rénia L, Williams EP. Ann N Y Acad Sci. 2023 Mar; 2023 Jan 25. PMID: 36697369.
• The In Vivo and In Vitro Architecture of the Hepatitis C Virus RNA Genome Uncovers Functional RNA Secondary and Tertiary Structures.Wan H, Adams RL, Lindenbach BD, Pyle AM. J Virol. 2022 Apr 27; 2022 Mar 30. PMID: 35353000.
• De novo emergence of a remdesivir resistance mutation during treatment of persistent SARS-CoV-2 infection in an immunocompromised patient: a case report.Gandhi S, Klein J, Robertson AJ, Peña-Hernández MA, Lin MJ, Roychoudhury P, Lu P, Fournier J, Ferguson D, Mohamed Bakhash SAK, Catherine Muenker M, Srivathsan A, Wunder EA Jr, Kerantzas N, Wang W, Lindenbach B, Pyle A, Wilen CB, Ogbuagu O, Greninger AL, Iwasaki A, Schulz WL, Ko AI. Nat Commun. 2022 Mar 17; 2022 Mar 17. PMID: 35301314.
• Reinventing positive-strand RNA virus reverse genetics.Lindenbach BD. Adv Virus Res. 2022; 2022 Mar 29. PMID: 35840179.
• De novo emergence of a remdesivir resistance mutation during treatment of persistent SARS-CoV-2 infection in an immunocompromised patient: A case report.Gandhi S, Klein J, Robertson A, Peña-Hernández MA, Lin MJ, Roychoudhury P, Lu P, Fournier J, Ferguson D, Mohamed Bakhash SA, Catherine Muenker M, Srivathsan A, Wunder EA, Kerantzas N, Wang W, Lindenbach B, Pyle A, Wilen CB, Ogbuagu O, Greninger AL, Iwasaki A, Schulz WL, Ko AI. medRxiv. 2021 Dec 7; 2021 Dec 7. PMID: 34909781.
• Placenta-derived interferon-stimulated gene 20 controls ZIKA virus infection.Ding J, Aldo P, Roberts CM, Stabach P, Liu H, You Y, Qiu X, Jeong J, Maxwell A, Lindenbach B, Braddock D, Liao A, Mor G. EMBO Rep. 2021 Oct 5; 2021 Aug 18. PMID: 34405956.
• Optimization of Triarylpyridinone Inhibitors of the Main Protease of SARS-CoV-2 to Low-Nanomolar Antiviral Potency.Zhang CH, Spasov KA, Reilly RA, Hollander K, Stone EA, Ippolito JA, Liosi ME, Deshmukh MG, Tirado-Rives J, Zhang S, Liang Z, Miller SJ, Isaacs F, Lindenbach BD, Anderson KS, Jorgensen WL. ACS Med Chem Lett. 2021 Aug 12; 2021 Jul 14. PMID: 34408808.
• Restriction of SARS-CoV-2 replication by targeting programmed -1 ribosomal frameshifting.Sun Y, Abriola L, Niederer RO, Pedersen SF, Alfajaro MM, Silva Monteiro V, Wilen CB, Ho YC, Gilbert WV, Surovtseva YV, Lindenbach BD, Guo JU. Proc Natl Acad Sci U S A. 2021 Jun 29. PMID: 34185680.
• Potent Noncovalent Inhibitors of the Main Protease of SARS-CoV-2 from Molecular Sculpting of the Drug Perampanel Guided by Free Energy Perturbation Calculations.Zhang CH, Stone EA, Deshmukh M, Ippolito JA, Ghahremanpour MM, Tirado-Rives J, Spasov KA, Zhang S, Takeo Y, Kudalkar SN, Liang Z, Isaacs F, Lindenbach B, Miller SJ, Anderson KS, Jorgensen WL. ACS Cent Sci. 2021 Mar 24; 2021 Feb 22. PMID: 33786375.
• Genome-wide CRISPR Screens Reveal Host Factors Critical for SARS-CoV-2 Infection.Wei J, Alfajaro MM, DeWeirdt PC, Hanna RE, Lu-Culligan WJ, Cai WL, Strine MS, Zhang SM, Graziano VR, Schmitz CO, Chen JS, Mankowski MC, Filler RB, Ravindra NG, Gasque V, de Miguel FJ, Patil A, Chen H, Oguntuyo KY, Abriola L, Surovtseva YV, Orchard RC, Lee B, Lindenbach BD, Politi K, van Dijk D, Kadoch C, Simon MD, Yan Q, Doench JG, Wilen CB. Cell. 2021 Jan 7; 2020 Oct 20. PMID: 33147444.
• Restriction of SARS-CoV-2 Replication by Targeting Programmed -1 Ribosomal Frameshifting In Vitro.Sun Y, Abriola L, Surovtseva YV, Lindenbach BD, Guo JU. bioRxiv. 2020 Oct 21; 2020 Oct 21. PMID: 33106809.
• Hepatitis C virus NS3-4A protease regulates the lipid environment for RNA replication by cleaving host enzyme 24-dehydrocholesterol reductase.Tallorin L, Villareal VA, Hsia CY, Rodgers MA, Burri DJ, Pfeil MP, Llopis PM, Lindenbach BD, Yang PL. J Biol Chem. 2020 Aug 28; 2020 Jul 8. PMID: 32641492.
• Genome-wide CRISPR screen reveals host genes that regulate SARS-CoV-2 infection.Wei J, Alfajaro MM, Hanna RE, DeWeirdt PC, Strine MS, Lu-Culligan WJ, Zhang SM, Graziano VR, Schmitz CO, Chen JS, Mankowski MC, Filler RB, Gasque V, de Miguel F, Chen H, Oguntuyo K, Abriola L, Surovtseva YV, Orchard RC, Lee B, Lindenbach B, Politi K, van Dijk D, Simon MD, Yan Q, Doench JG, Wilen CB. bioRxiv. 2020 Jun 17; 2020 Jun 17. PMID: 32869025.
• A Sensitive Yellow Fever Virus Entry Reporter Identifies Valosin-Containing Protein (VCP/p97) as an Essential Host Factor for Flavivirus Uncoating.Ramanathan HN, Zhang S, Douam F, Mar KB, Chang J, Yang PL, Schoggins JW, Ploss A, Lindenbach BD. mBio. 2020 Apr 14; 2020 Apr 14. PMID: 32291299.
• Screening Legionella effectors for antiviral effects reveals Rab1 GTPase as a proviral factor coopted for tombusvirus replication.Inaba JI, Xu K, Kovalev N, Ramanathan H, Roy CR, Lindenbach BD, Nagy PD. Proc Natl Acad Sci U S A. 2019 Oct 22; 2019 Oct 7. PMID: 31591191.
• MARCH8 Ubiquitinates the Hepatitis C Virus Nonstructural 2 Protein and Mediates Viral Envelopment.Kumar S, Barouch-Bentov R, Xiao F, Schor S, Pu S, Biquand E, Lu A, Lindenbach BD, Jacob Y, Demeret C, Einav S. Cell Rep. 2019 Feb 12. PMID: 30759391.
• Critical challenges and emerging opportunities in hepatitis C virus research in an era of potent antiviral therapy: Considerations for scientists and funding agencies.Bartenschlager R, Baumert TF, Bukh J, Houghton M, Lemon SM, Lindenbach BD, Lohmann V, Moradpour D, Pietschmann T, Rice CM, Thimme R, Wakita T. Virus Res. 2018 Mar 15; 2018 Mar 2. PMID: 29477639.
• Interactions between the Hepatitis C Virus Nonstructural 2 Protein and Host Adaptor Proteins 1 and 4 Orchestrate Virus Release.Xiao F, Wang S, Barouch-Bentov R, Neveu G, Pu S, Beer M, Schor S, Kumar S, Nicolaescu V, Lindenbach BD, Randall G, Einav S. mBio. 2018 Mar 13; 2018 Mar 13. PMID: 29535204.
• Recovery of Infectious Hepatitis C Virus From Injection Paraphernalia: Implications for Prevention Programs Serving People Who Inject Drugs.Heimer R, Binka M, Koester S, Grund JC, Patel A, Paintsil E, Lindenbach BD. J Infect Dis. 2018 Jan 17. PMID: 28968665.
• Erratum for Barouch-Bentov et al., "Hepatitis C Virus Proteins Interact with the Endosomal Sorting Complex Required for Transport (ESCRT) Machinery via Ubiquitination To Facilitate Viral Envelopment".Barouch-Bentov R, Neveu G, Xiao F, Beer M, Bekerman E, Schor S, Campbell J, Boonyaratanakornkit J, Lindenbach B, Lu A, Jacob Y, Einav S. mBio. 2018 Jan 9; 2018 Jan 9. PMID: 29317514.
• The amino-terminus of the hepatitis C virus (HCV) p7 viroporin and its cleavage from glycoprotein E2-p7 precursor determine specific infectivity and secretion levels of HCV particle types.Denolly S, Mialon C, Bourlet T, Amirache F, Penin F, Lindenbach B, Boson B, Cosset FL. PLoS Pathog. 2017 Dec; 2017 Dec 18. PMID: 29253880.
• IRE1α promotes viral infection by conferring resistance to apoptosis.Fink SL, Jayewickreme TR, Molony RD, Iwawaki T, Landis CS, Lindenbach BD, Iwasaki A. Sci Signal. 2017 Jun 6; 2017 Jun 6. PMID: 28588082.
• Hepatitis C Virus Proteins Interact with the Endosomal Sorting Complex Required for Transport (ESCRT) Machinery via Ubiquitination To Facilitate Viral Envelopment.Barouch-Bentov R, Neveu G, Xiao F, Beer M, Bekerman E, Schor S, Campbell J, Boonyaratanakornkit J, Lindenbach B, Lu A, Jacob Y, Einav S. mBio. 2016 Nov 1; 2016 Nov 1. PMID: 27803188.
• HSV-2 enhances ZIKV infection of the placenta and induces apoptosis in first-trimester trophoblast cells.Aldo P, You Y, Szigeti K, Horvath TL, Lindenbach B, Mor G. Am J Reprod Immunol. 2016 Nov; 2016 Sep 10. PMID: 27613665.
• Full Genome Sequence and sfRNA Interferon Antagonist Activity of Zika Virus from Recife, Brazil.Donald CL, Brennan B, Cumberworth SL, Rezelj VV, Clark JJ, Cordeiro MT, Freitas de Oliveira França R, Pena LJ, Wilkie GS, Da Silva Filipe A, Davis C, Hughes J, Varjak M, Selinger M, Zuvanov L, Owsianka AM, Patel AH, McLauchlan J, Lindenbach BD, Fall G, Sall AA, Biek R, Rehwinkel J, Schnettler E, Kohl A. PLoS Negl Trop Dis. 2016 Oct; 2016 Oct 5. PMID: 27706161.
• Zika Virus Disrupts Phospho-TBK1 Localization and Mitosis in Human Neuroepithelial Stem Cells and Radial Glia.Onorati M, Li Z, Liu F, Sousa AMM, Nakagawa N, Li M, Dell'Anno MT, Gulden FO, Pochareddy S, Tebbenkamp ATN, Han W, Pletikos M, Gao T, Zhu Y, Bichsel C, Varela L, Szigeti-Buck K, Lisgo S, Zhang Y, Testen A, Gao XB, Mlakar J, Popovic M, Flamand M, Strittmatter SM, Kaczmarek LK, Anton ES, Horvath TL, Lindenbach BD, Sestan N. Cell Rep. 2016 Sep 6; 2016 Aug 24. PMID: 27568284.
• Vaginal Exposure to Zika Virus during Pregnancy Leads to Fetal Brain Infection.Yockey LJ, Varela L, Rakib T, Khoury-Hanold W, Fink SL, Stutz B, Szigeti-Buck K, Van den Pol A, Lindenbach BD, Horvath TL, Iwasaki A. Cell. 2016 Aug 25. PMID: 27565347.
• Zika virus productively infects primary human placenta-specific macrophages.Jurado KA, Simoni MK, Tang Z, Uraki R, Hwang J, Householder S, Wu M, Lindenbach BD, Abrahams VM, Guller S, Fikrig E. JCI Insight. 2016 Aug 18. PMID: 27595140.
• What's next for hepatitis C virus research?Lindenbach BD. Hepatology. 2016 May; 2016 Mar 19. PMID: 26853717.
• The Coding Region of the HCV Genome Contains a Network of Regulatory RNA Structures.Pirakitikulr N, Kohlway A, Lindenbach BD, Pyle AM. Mol Cell. 2016 Apr 7; 2016 Feb 25. PMID: 26924328.
• Correction: A Conserved NS3 Surface Patch Orchestrates NS2 Protease Stimulation, NS5A Hyperphosphorylation and HCV Genome Replication.Isken O, Langerwisch U, Jirasko V, Rehders D, Redecke L, Ramanathan H, Lindenbach BD, Bartenschlager R, Tautz N. PLoS Pathog. 2016 Jan; 2016 Jan 8. PMID: 26745726.
• Correction: Survival of Hepatitis C Virus in Syringes Is Dependent on the Design of the Syringe-Needle and Dead Space Volume.Binka M, Paintsil E, Patel A, Lindenbach BD, Heimer R. PLoS One. 2015; 2015 Dec 23. PMID: 26700029.
• Survival of Hepatitis C Virus in Syringes Is Dependent on the Design of the Syringe-Needle and Dead Space Volume.Binka M, Paintsil E, Patel A, Lindenbach BD, Heimer R. PLoS One. 2015; 2015 Nov 4. PMID: 26536599.
• Hepatitis C virus RNA replication depends on specific cis- and trans-acting activities of viral nonstructural proteins.Kazakov T, Yang F, Ramanathan HN, Kohlway A, Diamond MS, Lindenbach BD. PLoS Pathog. 2015 Apr; 2015 Apr 13. PMID: 25875808.
• A conserved NS3 surface patch orchestrates NS2 protease stimulation, NS5A hyperphosphorylation and HCV genome replication.Isken O, Langerwisch U, Jirasko V, Rehders D, Redecke L, Ramanathan H, Lindenbach BD, Bartenschlager R, Tautz N. PLoS Pathog. 2015 Mar; 2015 Mar 16. PMID: 25774920.
• Disinfection of syringes contaminated with hepatitis C virus by rinsing with household products.Binka M, Paintsil E, Patel A, Lindenbach BD, Heimer R. Open Forum Infect Dis. 2015 Jan; 2015 Feb 23. PMID: 26034767.
• The linker region of NS3 plays a critical role in the replication and infectivity of hepatitis C virus.Kohlway A, Pirakitikulr N, Ding SC, Yang F, Luo D, Lindenbach BD, Pyle AM. J Virol. 2014 Sep; 2014 Jun 25. PMID: 24965468.
• Expanding the proteome of an RNA virus by phosphorylation of an intrinsically disordered viral protein.Cordek DG, Croom-Perez TJ, Hwang J, Hargittai MR, Subba-Reddy CV, Han Q, Lodeiro MF, Ning G, McCrory TS, Arnold JJ, Koc H, Lindenbach BD, Showalter SA, Cameron CE. J Biol Chem. 2014 Aug 29; 2014 Jul 16. PMID: 25031324.
• Genome-wide analysis of host factors in nodavirus RNA replication.Hao L, Lindenbach B, Wang X, Dye B, Kushner D, He Q, Newton M, Ahlquist P. PLoS One. 2014; 2014 Apr 21. PMID: 24752411.
• Hepatitis C virus maintains infectivity for weeks after drying on inanimate surfaces at room temperature: implications for risks of transmission.Paintsil E, Binka M, Patel A, Lindenbach BD, Heimer R. J Infect Dis. 2014 Apr 15; 2013 Nov 23. PMID: 24273176.
• Hepatitis C virus RNA replication and virus particle assembly require specific dimerization of the NS4A protein transmembrane domain.Kohlway A, Pirakitikulr N, Barrera FN, Potapova O, Engelman DM, Pyle AM, Lindenbach BD. J Virol. 2014 Jan; 2013 Oct 30. PMID: 24173222.
• The ins and outs of hepatitis C virus entry and assembly.Lindenbach BD, Rice CM. Nat Rev Microbiol. 2013 Oct; 2013 Sep 10. PMID: 24018384.
• Virion assembly and release.Lindenbach BD. Curr Top Microbiol Immunol. 2013. PMID: 23463202.
• A summary of the 18th International Symposium on Hepatitis C Virus and Related Viruses.Polyak SJ, Morishima C, Scott JD, Gastaminza P, Cox A, de Araújo ES, Higgs MR, Loo YM, Golden-Mason L, Lindenbach BD, Baumert TF, Randall G, Gale M Jr. Gastroenterology. 2012 Jan. PMID: 22185796.
• Structural insights into RNA recognition by RIG-I.Luo D, Ding SC, Vela A, Kohlway A, Lindenbach BD, Pyle AM. Cell. 2011 Oct 14. PMID: 22000018.
• Trafficking of hepatitis C virus core protein during virus particle assembly.Counihan NA, Rawlinson SM, Lindenbach BD. PLoS Pathog. 2011 Oct; 2011 Oct 20. PMID: 22028650.
• Hepatitis C virus NS2 coordinates virus particle assembly through physical interactions with the E1-E2 glycoprotein and NS3-NS4A enzyme complexes.Stapleford KA, Lindenbach BD. J Virol. 2011 Feb; 2010 Dec 8. PMID: 21147927.
• The acidic domain of hepatitis C virus NS4A contributes to RNA replication and virus particle assembly.Phan T, Kohlway A, Dimberu P, Pyle AM, Lindenbach BD. J Virol. 2011 Feb; 2010 Nov 3. PMID: 21047963.
• Understanding how hepatitis C virus builds its unctuous home.Lindenbach BD. Cell Host Microbe. 2011 Jan 20. PMID: 21238940.
• New cell culture models of hepatitis C virus entry, replication, and virus production.Lindenbach BD. Gastroenterology. 2010 Oct; 2010 Aug 24. PMID: 20797436.
• Survival of hepatitis C virus in syringes: implication for transmission among injection drug users.Paintsil E, He H, Peters C, Lindenbach BD, Heimer R. J Infect Dis. 2010 Oct 1. PMID: 20726768.
• An implantable vascularized protein gel construct that supports human fetal hepatoblast survival and infection by hepatitis C virus in mice.Harding MJ, Lepus CM, Gibson TF, Shepherd BR, Gerber SA, Graham M, Paturzo FX, Rahner C, Madri JA, Bothwell AL, Lindenbach BD, Pober JS. PLoS One. 2010 Apr 1; 2010 Apr 1. PMID: 20376322.
• A novel class of meso-tetrakis-porphyrin derivatives exhibits potent activities against hepatitis C virus genotype 1b replicons in vitro.Cheng Y, Tsou LK, Cai J, Aya T, Dutschman GE, Gullen EA, Grill SP, Chen AP, Lindenbach BD, Hamilton AD, Cheng YC. Antimicrob Agents Chemother. 2010 Jan; 2009 Nov 9. PMID: 19901090.
• Hepatitis C virus NS2 protein contributes to virus particle assembly via opposing epistatic interactions with the E1-E2 glycoprotein and NS3-NS4A enzyme complexes.Phan T, Beran RK, Peters C, Lorenz IC, Lindenbach BD. J Virol. 2009 Sep; 2009 Jun 10. PMID: 19515772.
• Gumming up the works: DNA polymers as HCV entry inhibitors.Counihan NA, Lindenbach BD. Gastroenterology. 2009 Aug; 2009 Jun 27. PMID: 19563837.
• The NS4A protein of hepatitis C virus promotes RNA-coupled ATP hydrolysis by the NS3 helicase.Beran RK, Lindenbach BD, Pyle AM. J Virol. 2009 Apr; 2009 Jan 19. PMID: 19153239.
• The accelerating pace of HCV research: a summary of the 15th International Symposium on Hepatitis C Virus And Related Viruses.Lanford RE, Evans MJ, Lohmann V, Lindenbach B, Gale M Jr, Rehermann B, Chang KM, Lemon SM. Gastroenterology. 2009 Jan; 2008 Nov 19. PMID: 19026648.
• Measuring HCV infectivity produced in cell culture and in vivo.Lindenbach BD. Methods Mol Biol. 2009. PMID: 19009272.
• Reverse transcription PCR-based sequence analysis of hepatitis C virus replicon RNA.Tellinghuisen TL, Lindenbach BD. Methods Mol Biol. 2009. PMID: 19009260.
• Brett Lindenbach: deconstructing and reconstructing hepatitis C. Interview by Ruth Williams.Lindenbach B. J Cell Biol. 2008 Dec 1. PMID: 19047458.
• The C terminus of hepatitis C virus NS4A encodes an electrostatic switch that regulates NS5A hyperphosphorylation and viral replication.Lindenbach BD, Prágai BM, Montserret R, Beran RK, Pyle AM, Penin F, Rice CM. J Virol. 2007 Sep; 2007 Jun 20. PMID: 17581983.
• Cellular cofactors affecting hepatitis C virus infection and replication.Randall G, Panis M, Cooper JD, Tellinghuisen TL, Sukhodolets KE, Pfeffer S, Landthaler M, Landgraf P, Kan S, Lindenbach BD, Chien M, Weir DB, Russo JJ, Ju J, Brownstein MJ, Sheridan R, Sander C, Zavolan M, Tuschl T, Rice CM. Proc Natl Acad Sci U S A. 2007 Jul 31; 2007 Jul 6. PMID: 17616579.
• Superinfection exclusion in cells infected with hepatitis C virus.Tscherne DM, Evans MJ, von Hahn T, Jones CT, Stamataki Z, McKeating JA, Lindenbach BD, Rice CM. J Virol. 2007 Apr; 2007 Feb 7. PMID: 17287280.
• Silencing of USP18 potentiates the antiviral activity of interferon against hepatitis C virus infection.Randall G, Chen L, Panis M, Fischer AK, Lindenbach BD, Sun J, Heathcote J, Rice CM, Edwards AM, McGilvray ID. Gastroenterology. 2006 Nov; 2006 Aug 22. PMID: 17101330.
• Oxidized low-density lipoprotein inhibits hepatitis C virus cell entry in human hepatoma cells.von Hahn T, Lindenbach BD, Boullier A, Quehenberger O, Paulson M, Rice CM, McKeating JA. Hepatology. 2006 May. PMID: 16628670.
• Cell culture-grown hepatitis C virus is infectious in vivo and can be recultured in vitro.Lindenbach BD, Meuleman P, Ploss A, Vanwolleghem T, Syder AJ, McKeating JA, Lanford RE, Feinstone SM, Major ME, Leroux-Roels G, Rice CM. Proc Natl Acad Sci U S A. 2006 Mar 7; 2006 Feb 16. PMID: 16484368.
• Time- and temperature-dependent activation of hepatitis C virus for low-pH-triggered entry.Tscherne DM, Jones CT, Evans MJ, Lindenbach BD, McKeating JA, Rice CM. J Virol. 2006 Feb. PMID: 16439530.
• Unravelling hepatitis C virus replication from genome to function.Lindenbach BD, Rice CM. Nature. 2005 Aug 18. PMID: 16107832.
• Complete replication of hepatitis C virus in cell culture.Lindenbach BD, Evans MJ, Syder AJ, Wölk B, Tellinghuisen TL, Liu CC, Maruyama T, Hynes RO, Burton DR, McKeating JA, Rice CM. Science. 2005 Jul 22; 2005 Jun 9. PMID: 15947137.
• Identification of microRNAs of the herpesvirus family.Pfeffer S, Sewer A, Lagos-Quintana M, Sheridan R, Sander C, Grässer FA, van Dyk LF, Ho CK, Shuman S, Chien M, Russo JJ, Ju J, Randall G, Lindenbach BD, Rice CM, Simon V, Ho DD, Zavolan M, Tuschl T. Nat Methods. 2005 Apr; 2005 Feb 16. PMID: 15782219.
• Insertion of green fluorescent protein into nonstructural protein 5A allows direct visualization of functional hepatitis C virus replication complexes.Moradpour D, Evans MJ, Gosert R, Yuan Z, Blum HE, Goff SP, Lindenbach BD, Rice CM. J Virol. 2004 Jul. PMID: 15220413.
• Systematic, genome-wide identification of host genes affecting replication of a positive-strand RNA virus.Kushner DB, Lindenbach BD, Grdzelishvili VZ, Noueiry AO, Paul SM, Ahlquist P. Proc Natl Acad Sci U S A. 2003 Dec 23; 2003 Dec 11. PMID: 14671320.
• Evasive maneuvers by hepatitis C virus.Lindenbach BD, Rice CM. Hepatology. 2003 Sep. PMID: 12939603.
• A stable full-length yellow fever virus cDNA clone and the role of conserved RNA elements in flavivirus replication.Bredenbeek PJ, Kooi EA, Lindenbach B, Huijkman N, Rice CM, Spaan WJM. J Gen Virol. 2003 May. PMID: 12692292.
• Molecular biology of flaviviruses.Lindenbach BD, Rice CM. Adv Virus Res. 2003. PMID: 14696326.
• RNAi targeting an animal virus: news from the front.Lindenbach BD, Rice CM. Mol Cell. 2002 May. PMID: 12049728.
• Long-distance base pairing in flock house virus RNA1 regulates subgenomic RNA3 synthesis and RNA2 replication.Lindenbach BD, Sgro JY, Ahlquist P. J Virol. 2002 Apr. PMID: 11907230.
• Genetic interaction of flavivirus nonstructural proteins NS1 and NS4A as a determinant of replicase function.Lindenbach BD, Rice CM. J Virol. 1999 Jun. PMID: 10233920.
• Construction of recombinant sindbis-based expression vectors for the study of HCV genes and their products.Lindenbach BD, Frolov I, Rice CM. Methods Mol Med. 1999. PMID: 21374397.
• Noncytopathic Sindbis virus RNA vectors for heterologous gene expression.Agapov EV, Frolov I, Lindenbach BD, Prágai BM, Schlesinger S, Rice CM. Proc Natl Acad Sci U S A. 1998 Oct 27. PMID: 9789028.
• trans-Complementation of yellow fever virus NS1 reveals a role in early RNA replication.Lindenbach BD, Rice CM. J Virol. 1997 Dec. PMID: 9371625.
• Processing in the hepatitis C virus E2-NS2 region: identification of p7 and two distinct E2-specific products with different C termini.Lin C, Lindenbach BD, Prágai BM, McCourt DW, Rice CM. J Virol. 1994 Aug. PMID: 7518529.
• Component A2 of methylcoenzyme M reductase system from Methanobacterium thermoautotrophicum delta H: nucleotide sequence and functional expression by Escherichia coli.Kuhner CH, Lindenbach BD, Wolfe RS. J Bacteriol. 1993 May. PMID: 8491734.