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Lindenbach Lab
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Lindenbach Lab

Research Summary

In the Lindenbach Laboratory, we combine genetic, biochemical, and cell biological approaches to take viruses apart and put them back together — to see how they work. We study several different positive-strand RNA viruses including hepatitis C virus, yellow fever virus, dengue virus, Zika virus, and SARS-CoV-2. The overarching goal of our research is to contribute to improved antiviral therapies and vaccines.

Research

The Lindenbach laboratory is focused on the molecular biology of positive-strand RNA viruses. Much of our work focuses on the Flaviviridae, a large and diverse family of positive-strand RNA viruses, including the flaviviruses (e.g., yellow fever virus), hepaciviruses (e.g., hepatitis C virus), pestiviruses (e.g., bovine viral diarrhea virus), and pegiviruses (e.g., human pegivirus).
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Projects

We are focused on understanding the mechanisms by which positive-strand RNA viruses enter cells, express their genes, replicate their RNA genomes, and produce new virus particles, all while minimizing or subverting cellular antiviral defenses.