- 2020-Present
- 2010-2019
- 2000-2009
- 1990-1999
- 1988-1989

## Publications

- C. Zhang, B. Balbo, M. Ma, J. Zhao, X. Tian, Y. Kluger, and S. Somlo, "Cyclin-Dependent Kinase 1 Activity Is a Driver of Cyst Growth in Polycystic Kidney Disease," Journal of the American Society of Nephrology, vol. 32, pp. 41-51, 2021.
- E. Sefik, B. Israelow, J. Zhao, R. Qu, E. Song, H. Mirza, E. Kaffe, S. Halene, E. Meffre, and Y. Kluger, "A humanized mouse model of chronic COVID-19 to evaluate disease mechanisms and treatment options," 2021.
- M. S. B. Raredon, J. Yang, J. Garritano, M. Wang, D. Kushnir, J. C. Schupp, T. S. Adams, A. M. Greaney, K. L. Leiby, N. Kaminski, Y. Kluger, A. Levchenko, and L. E. Niklason, "Connectome: computation and visualization of cell-cell signaling topologies in single-cell systems data," bioRxiv, p. 2021.01.21.427529, 2021.
- T. Qing, H. Mohsen, V. L. Cannataro, M. Marczyk, M. Rozenblit, J. Foldi, M. F. Murray, J. P. Townsend, Y. Kluger, and M. Gerstein, "Cancer relevance of human genes," bioRxiv, 2021.
- Lindenbaum, N. Nouri, Y. Kluger, and S. H. Kleinstein, "Alignment free identification of clones in B cell receptor repertoires," Nucleic Acids Res, vol. 49, p. e21, Feb 26 2021.
- Y.-W. E. Lin, T. Shnitzer, R. Talmon, F. Villarroel-Espindola, S. Desai, K. Schalper, and Y. Kluger, "Graph of graphs analysis for multiplexed data with application to imaging mass cytometry," PLOS Computational Biology, vol. 17, p. e1008741, 2021.
- B. Landa, T. T. Zhang, and Y. Kluger, "Biwhitening Reveals the Rank of a Count Matrix," arXiv preprint arXiv:2103.13840, 2021.
- B. Landa, R. R. Coifman, and Y. Kluger, "Doubly Stochastic Normalization of the Gaussian Kernel Is Robust to Heteroskedastic Noise," SIAM Journal on Mathematics of Data Science, pp. 388-413, 2021/01/01 2021.
- A. Jaffe, N. Amsel, Y. Aizenbud, B. Nadler, J. T. Chang, and Y. Kluger, "Spectral Neighbor Joining for Reconstruction of Latent Tree Models," SIAM Journal on Mathematics of Data Science, vol. 3, pp. 113-141, 2021.
- Y. Aizenbud, A. Jaffe, M. Wang, A. Hu, N. Amsel, B. Nadler, J. T. Chang, and Y. Kluger, "Spectral Top-Down Recovery of Latent Tree Models," arXiv preprint arXiv:2102.13276, 2021.
- J. Zhao, A. Jaffe, H. Li, O. Lindenbaum, E. Sefik, R. Jackson, X. Cheng, R. Flavell, and Y. Kluger, "Detection of differentially abundant cell subpopulations discriminates biological states in scRNA-seq data," bioRxiv, p. 711929, 2020.
- H. Zhang, H. Zhu, G. Deng, C. R. Zito, V. O. Oria, C. K. Rane, S. Zhang, S. A. Weiss, T. Tran, A. Adeniran, F. Zhang , J. Zhou, Y. Kluger, M. W. Bosenberg , H. M. Kluger, and L. B. Jilaveanu, "PLEKHA5 regulates tumor growth in metastatic melanoma,"
*Cancer,*vol. 126, pp. 1016-1030, 2020. - Y. Yamada, O. Lindenbaum, S. Negahban, and Y. Kluger, "Feature selection using stochastic gates," in International Conference on Machine Learning, 2020, pp. 10648-10659.
- M. Roulis, A. Kaklamanos, M. Schernthanner, P. Bielecki, J. Zhao, E. Kaffe, L. S. Frommelt, R. Qu, M. S. Knapp, A. Henriques, N. Chalkidi, V. Koliaraki, J. Jiao, J. R. Brewer, M. Bacher, H. N. Blackburn, X. Zhao, R. M. Breyer, V. Aidinis, D. Jain, B. Su, H. R. Herschman, Y. Kluger, G. Kollias, and R. A. Flavell, "Paracrine orchestration of intestinal tumorigenesis by a mesenchymal niche," Nature, vol. 580, pp. 524-529, Apr 2020.
- T. Qing, H. Mohsen, M. Marczyk, Y. Ye, T. O’Meara, H. Zhao, J. P. Townsend, M. Gerstein, T. Qing, H. Mohsen, M. Marczyk, Y. Ye, T. O’Meara, H. Zhao, J. P. Townsend, M. Gerstein, C. Hatzis, Y. Kluger, and L. Pusztai, "Germline variant burden in cancer genes correlates with age at diagnosis and somatic mutation burden,"
*Nature communications,*vol. 11, pp. 1-8, 2020. - M. Marczyk, G. A. Patwardhan, J. Zhao, R. Qu, X. Li, V. B. Wali, A. K. Gupta, M. M. Pillai, Y. Kluger, Q. Yan, C. Hatzis, L. Pusztai, and V. Gunasekharan, "Multi-Omics Investigation of Innate Navitoclax Resistance in Triple-Negative Breast Cancer Cells,"
*Cancers,*vol. 12, p. 2551, 2020. - Lindenbaum, U. Shaham, J. Svirsky, E. Peterfreund, and Y. Kluger, "Let the Data Choose its Features: Differentiable Unsupervised Feature Selection," arXiv preprint arXiv:2007.04728, 2020.
- Lindenbaum, M. Salhov, A. Averbuch, and Y. Kluger, "Deep Gated Canonical Correlation Analysis," arXiv preprint arXiv:2010.05620, 2020.
- B. Landa, R. Qu, J. Chang, and Y. Kluger, "Local Two-Sample Testing over Graphs and Point-Clouds by Random-Walk Distributions," arXiv preprint arXiv:2011.03418, 2020.
- D. M. Kluger, Y. Aizenbud, A. Jaffe, F. Parisi, L. Aizenbud, E. Minsky-Fenick, J. M. Kluger, S. Farhadian, H. M. Kluger, and Y. Kluger, "Impact of healthcare worker shift scheduling on workforce preservation during the COVID-19 pandemic," Infection Control & Hospital Epidemiology, vol. 41, pp. 1443-1445, 2020.
- A.Jarret, R. Jackson, C. Duizer, M. E. Healy, J. Zhao, J. M. Rone, P. Bielecki, E. Sefik, M. Roulis, T. Rice, K. N. Sivanathan, T. Zhou, A. G. Solis, H. Honcharova-Biletska, K. Vélez, S. Hartner, J. S. Low, R. Qu, M. R. de Zoete, N. W. Palm, A. M. Ring, A. Weber, A. E. Moor, Y. Kluger, R. Nowarski, and R. A. Flavell, "Enteric Nervous System-Derived IL-18 Orchestrates Mucosal Barrier Immunity,"
*Cell,*vol. 180, pp. 50-63.e12, 2020/01/09/ 2020. - A. Jaffe, Y. Kluger, G. C. Linderman, G. Mishne, and S. Steinerberger, "Randomized near-neighbor graphs, giant components and applications in data science," Journal of applied probability, vol. 57, pp. 458-476, 2020.
- A. Jaffe, Y. Kluger, O. Lindenbaum, J. Patsenker, E. Peterfreund, and S. Steinerberger, "The Spectral Underpinning of word2vec," Frontiers in Applied Mathematics and Statistics, vol. 6, 2020-December-03 2020.
- S. B. Goldberg, K. A. Schalper, S. N. Gettinger, A. Mahajan, R. S. Herbst, A. C. Chiang, R. Lilenbaum, F. H. Wilson, S. B. Omay, J. B. Yu, L. Jilaveanu, T. Tran, K. Pavlik, E. Rowen, H. Gerrish, A. Komlo, R. Gupta, H. Wyatt, M. Ribeiro, Y. Kluger, G. Zhou, W. Wei, V. L. Chiang, and H. M. Kluger, "Pembrolizumab for management of patients with NSCLC and brain metastases: long-term results and biomarker analysis from a non-randomised, open-label, phase 2 trial,"
*The Lancet Oncology,*vol. 21, pp. 655-663, 2020/05/01/ 2020.