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How Studying Cellular Senescence Can Help Researchers Learn to Delay Aging

Chronic inflammation, one of the major hallmarks of aging, is thought to be partly caused by senescent cells that may accumulate in older individuals. Now, Yale researchers have received a grant from the National Institutes of Health (NIH) Common Fund’s Cellular Senescence Network Program (SenNet) to study these specialized cells.

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  • Why Are Some COVID Cases More Severe? ‘Humanized’ Mice Offer a Clue

    Why do 80 to 90% of people infected with COVID-19 experience only mild cases while 10 to 20% face more severe or life-threatening symptoms? Researchers in the lab of Yale’s Richard Flavell decided to pose this question to a “humanized mice” and revealed that the causes of severe COVID may lie in our own antiviral inflammatory response to the virus, the researchers report Dec. 17 in the journal Nature Biotechnology, https://doi.org/10.1038/s41587-021-01155-4. “Early in the course of disease, a strong immune response is crucial for survival,” Sefik said. “Later in the disease, it can be fatal.” The humanized mice models might also reveal strong clues to the causes and potential treatments of so-called long and severe COVID, the scientists said. The research was done in collaboration with Yale’s Akiko Iwasaki, Craig Wilen, Yuval Kluger, Eric Meffre, and Stephanie Halene.

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  • $15M NIDA Grant Awarded to Serena Spudich, Mark Gerstein, and Yuval Kluger

    Principal Investigators Serena Spudich, MD, MA (Neurology), Mark Gerstein, PhD (Molecular Biophysics and Biochemistry), and Yuval Kluger, PhD (Pathology) were recently awarded a $15 million grant from the National Institute on Drug Abuse (NIDA) to establish a Data Center to coordinate, analyze, and make accessible single-cell and other molecular data sets generated by Single-Cell Opioid Responses in the Context of HIV (SCORCH) and other NIDA-funded HIV and substance use disorder projects.

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