Wangbiao (Seven) Guo
Postdoctoral AssociateDownloadHi-Res Photo
About
Titles
Postdoctoral Associate
Biography
Academic Background
- Postdoctoral Associate, Department of Microbial Pathogenesis, Yale University, (9/1/2021-present)
- Postgraduate Fellow, Department of Microbial Pathogenesis, Yale University (9/1/2019-3/6/2020)
- Joint Ph.D., Center of Cryo-Electron Microscopy, Zhejiang University (9/1/2018-6/30/2020 )
- Ph.D., Institute for Thermal Power Engineering, Zhejiang University (9/1/2016-6/30/2021)
- Exchange Student, Major in mining engineering, University of Wollongong, Australia (7/22/2015-1/22/2016)
- B.S. Safety Engineering, China University of Mining and Technology (9/1/2012-6/30/2016)
Research Interests
- How the rotatory motor functions
- Subcellular 3D imaging inside the cell
- Biosynthesis and bioengineering of microalgae cells
Specialized Skills
- Cryo-Electron Tomography:
Focused Ion Beam (FIB) milling (Aquilos 1 and 2, Thermo Fisher), cryo-correlative light and electron microscopy (Cryo-CLEM, Leica), data collection (FEI Polara, Krios, Glacios); Cryo-ET data processing, subtomogram averaging (i3, EMAN2), 3D modeling (Chimera, Amira, IMOD, EMAN2)
- Technology of flue gas CO2 fixation by microalgae:
Microalgae culture, photobioreactor design, computational fluid dynamics (CFD) simulation (FLUENT, Ansys)
Appointments
Microbial Pathogenesis
Postdoctoral AssociatePrimary
Other Departments & Organizations
Education & Training
- PhD
- Zhejiang University (2021)
Research
Overview
Medical Research Interests
Cryoelectron Microscopy; Microalgae; Microbiology; Molecular Structure; Photobioreactors; Tomography
Research at a Glance
Publications Timeline
A big-picture view of Wangbiao (Seven) Guo's research output by year.
Research Interests
Research topics Wangbiao (Seven) Guo is interested in exploring.
33Publications
677Citations
Microalgae
Photobioreactors
Publications
2024
Chapter 3 Improvement of mass transfer in microalgal photobioreactors
Guo W, Song Y. Chapter 3 Improvement of mass transfer in microalgal photobioreactors. 2024, 41-57. DOI: 10.1016/b978-0-443-19213-5.00003-0.Peer-Reviewed Original ResearchConceptsMicroalgal solutionHighest CO2 fixation rateMicroalgal photobioreactorsMass transfer coefficientCO2 fixation rateCO2 fixation processTransfer coefficientMicroalgal biomassMicroalgal cellsMicroalgalPhotobioreactorFixation ratesMass transferMixing timeFunction of material propertiesCO2 bubblesFixation processGas-liquid phaseMass transfer rateMaterial propertiesModification parametersFlow regimeMicroalgaeTransfer rateTheoretical equations
2023
Ice nucleation proteins self-assemble into large fibres to trigger freezing at near 0 °C
Hansen T, Lee J, Reicher N, Ovadia G, Guo S, Guo W, Liu J, Braslavsky I, Rudich Y, Davies P. Ice nucleation proteins self-assemble into large fibres to trigger freezing at near 0 °C. ELife 2023, 12: rp91976. PMID: 38109272, PMCID: PMC10727499, DOI: 10.7554/elife.91976.Peer-Reviewed Original ResearchIce nucleation proteins self-assemble into large fibres to trigger freezing at near 0 °C
Hansen T, Lee J, Reicher N, Ovadia G, Guo S, Guo W, Liu J, Braslavsky I, Rudich Y, Davies P. Ice nucleation proteins self-assemble into large fibres to trigger freezing at near 0 °C. ELife 2023, 12 DOI: 10.7554/elife.91976.3.Peer-Reviewed Original ResearchAnti-σ28 Factor FlgM Regulates Flagellin Gene Expression and Flagellar Polarity of Treponema denticola
Kurniyati K, Chang Y, Guo W, Liu J, Malkowski M, Li C. Anti-σ28 Factor FlgM Regulates Flagellin Gene Expression and Flagellar Polarity of Treponema denticola. Journal Of Bacteriology 2023, 205: e00463-22. PMID: 36715541, PMCID: PMC9945498, DOI: 10.1128/jb.00463-22.Peer-Reviewed Original ResearchMeSH Keywords and ConceptsConceptsFlagellin gene expressionPeriplasmic flagellaGene expressionSpirochete Treponema denticolaOral spirochete Treponema denticolaCryo-electron tomography analysisFlagellar gene expressionCore RNA polymeraseGroup of bacteriaFlgM proteinFlagellar genesBipolar flagellaHeterologous expressionDependent promotersFlagellar numberRNA polymeraseFlgMFliAMutational analysisFlagellin geneMolecular mechanismsSpirochete motilityHuman diseasesLines of evidenceEnds of cells
2022
Three‐dimensional analysis of membrane structures associated with tomato spotted wilt virus infection
Guo J, Wang G, Xie L, Wang X, Feng L, Guo W, Tao X, Humbel B, Zhang Z, Hong J. Three‐dimensional analysis of membrane structures associated with tomato spotted wilt virus infection. Plant Cell & Environment 2022, 46: 650-664. PMID: 36482792, PMCID: PMC10107360, DOI: 10.1111/pce.14511.Peer-Reviewed Original ResearchMeSH Keywords and ConceptsConceptsEndoplasmic reticulumInfected plant tissuesViral intracellular traffickingInvestigation of virus-host cell interactionsVirus-host cell interactionsMembranes of neighboring cellsLipid-like bodiesNeighboring cellsViral life cycleVirus-infected cellsMembrane tubulesClustered mitochondriaIntracellular traffickingPlant cellsViral traffickingViral morphogenesisFocused ion beam scanning EMMembrane networkCell wallPlant tissuesViral infectionVirus attachmentUltrastructural detailsConventional electron microscopyMyelin-like bodiesFIB-SEM analysis on three-dimensional structures of growing organelles in wild Chlorella pyrenoidosa cells
Feng L, Guo W, Guo J, Zhang X, Zou X, Rao M, Ye J, Kuang C, Chen G, Chen C, Qin S, Yang W, Cheng J. FIB-SEM analysis on three-dimensional structures of growing organelles in wild Chlorella pyrenoidosa cells. Protoplasma 2022, 260: 885-897. PMID: 36416933, DOI: 10.1007/s00709-022-01821-7.Peer-Reviewed Original ResearchMeSH Keywords and ConceptsConceptsSingle pyrenoidThree-dimensional structurePhotosynthetic growthCO2 fixationChlorella pyrenoidosa cellsStarch grainsBeam scanning electron microscopyIon beam scanning electron microscopyMitochondriaGrowth periodCellsMature statePyrenoidChloroplastsMeristemDynamic changesOrganellesNucleoliReplicationLarge partElongationGrowthLife-cycle assessment of flue gas CO2 fixation from coal-fired power plant and coal chemical plant by microalgae
Ye Q, Shen Y, Zhang Q, Wu X, Guo W. Life-cycle assessment of flue gas CO2 fixation from coal-fired power plant and coal chemical plant by microalgae. The Science Of The Total Environment 2022, 848: 157728. PMID: 35917957, DOI: 10.1016/j.scitotenv.2022.157728.Peer-Reviewed Original ResearchMeSH Keywords and ConceptsConceptsFlue gas COCoal-fired power plantsCoal chemical plantLife cycle assessmentGas COPower plantsMicroalgae growth rateEnergy conversion characteristicsChemical plantsTotal energy consumptionAeration efficiencyConversion characteristicsEnergy conversionEnergy consumptionAeration rateGas emissionsMJ/Environmental impactsWhole processSensitive parametersEmissionCOTechnologyMicroalgaeGrowth rateIn-situ high-resolution 3D imaging combined with proteomics and metabolomics reveals enlargement of subcellular architecture and enhancement of photosynthesis pathways in nuclear-irradiated Chlorella pyrenoidosa
Guo W, Feng L, Wang Z, Guo J, Park D, Carroll B, Zhang X, Liu J, Cheng J. In-situ high-resolution 3D imaging combined with proteomics and metabolomics reveals enlargement of subcellular architecture and enhancement of photosynthesis pathways in nuclear-irradiated Chlorella pyrenoidosa. Chemical Engineering Journal 2022, 430: 133037. DOI: 10.1016/j.cej.2021.133037.Peer-Reviewed Original ResearchConceptsPhotosynthetic efficiencySubcellular organellesChlorella pyrenoidosaHigh growth rateCryo-electron tomographyWild-type cellsPhotosynthesis pathwaySubcellular architectureCarbon fixationCryo-FIB millingChlorophyll synthesisMutantsGrowth rateMacroscopic traitsOrganellesSubcellular morphologyC. pyrenoidosaProteomicsBeam scanning electron microscopyIon beam scanning electron microscopyMetabolomics dataPyrenoidosaUnprecedented detailSuch modificationsChloroplasts
2021
Developing a three-dimensional tangential swirl plate photobioreactor to enhance mass transfer and flashlight effect for microalgal CO2 fixation
Song Y, Cheng J, Lai X, Guo W, Yang W. Developing a three-dimensional tangential swirl plate photobioreactor to enhance mass transfer and flashlight effect for microalgal CO2 fixation. Chemical Engineering Science 2021, 244: 116837. DOI: 10.1016/j.ces.2021.116837.Peer-Reviewed Original ResearchSO2 Impurity in Simulated Flue Gas with 15% CO2 Affects Dynamic Bubble Dissolution and Arthrospira Photosynthetic Growth
Song Y, Cheng J, Miao Y, Guo W, Zhou J. SO2 Impurity in Simulated Flue Gas with 15% CO2 Affects Dynamic Bubble Dissolution and Arthrospira Photosynthetic Growth. ACS Sustainable Chemistry & Engineering 2021, 9: 5580-5589. DOI: 10.1021/acssuschemeng.0c09197.Peer-Reviewed Original ResearchConceptsFlue gasSO2 impurityBubble diameterCO2 dissolutionBubble dissolutionCoal-fired power plantsFlue gas treatmentReal flue gasSimulated Flue GasInitial bubble diameterHigher solution pH valuePower plantsSolution pH valueGasGas treatmentHigh biomass densityTrace impuritiesSO2 concentrationImpuritiesDissolutionCO2DiameterPH valueInitial solutionEconomic benefits
Academic Achievements & Community Involvement
activity Chemical Engineering Journal
Journal ServiceReviewerDetails2020 - Presentactivity Bioresource Technology
Journal ServiceReviewerDetails2020 - Presentactivity Waste Management
Journal ServiceReviewerDetails2020 - Presentactivity Frontiers in Marine Science
Journal ServiceGuest EditorDetails2022 - Presentactivity Frontiers in Bioengineering and Biotechnology
Journal ServiceGuest EditorDetails2022 - Present
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Mailing Address
Jun Liu Lab
840 West Campus Drive, Yale University School of Medicine
West Haven, CONNECTICUT 06516
United States
Locations
West Campus Advanced Biosciences Center
Lab
840 West Campus Drive
West Haven, CT 06516