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High-Throughput Cryo-ET
The Liu laboratory is dedicated to developing a high-throughput cryo-electron tomography (cryo-ET) pipeline for high-resolution structure determination of molecular machines in cells.
Our state-of-the-art imaging system has been utilized to gain molecular insights into fundamental biochemical processes: bacterial motility, chemotactic signaling, protein secretion, and DNA translocation.
Molecular Machines in Cells
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Fig 4 J Bact 2017 Nat Mic 2019 T3SS Cell 2017 Fig 2 eLife 2018 Fig 4 Nat Micro 2018 Fig 5 PNAS 2012 Cryo-ET purple Cryo-ET red Fig 1 Nat Mic 2019 viral infection Fig 4 J Bact 2017 Nat Mic 2019 T3SS Cell 2017 Fig 2 eLife 2018 Fig 4 Nat Micro 2018 Fig 5 PNAS 2012 Cryo-ET purple Cryo-ET red Fig 1 Nat Mic 2019 viral infection Fig 4 J Bact 2017 Nat Mic 2019 T3SS Cell 2017 Fig 2 eLife 2018 Fig 4 Nat Micro 2018 Fig 5 PNAS 2012 Cryo-ET purple Cryo-ET red Fig 1 Nat Mic 2019 viral infection
Cryo-electron tomography reveals cellular architecture of Treponema pallidum
Video by Jun Liu00:00:37
Molecular mechanism for rotational switching of the bacterial flagellar motor
Credit: Yunjie Chang, Kai Zhang, Brittany L. Carroll, Xiaowei Zhao, Nyles W. Charon, Steven J. Norris, Md A. Motaleb, Chunhao Li , Jun Liu
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