Publications
2024
- Imaging a putative marker of brain cortisol regulation in alcohol use disorder.Verplaetse TL, Hillmer AT, Bhatt S, Rusowicz A, Li S, Nabulsi N, Matuskey D, Huang Y, McKee SA, Cosgrove KP. Neurobiol Stress. 2024 Mar; 2024 Jan 21. PMID: 38304303.
- Lower dorsal putamen D2/3 receptor availability and amphetamine-induced dopamine release are related to poorer cognitive function in recently abstinent people who smoke and healthy controls.Cheung F, Calakos KC, Gueorguieva R, Hillmer AT, Cosgrove KP, Zakiniaeiz Y. Nicotine Tob Res. 2024 Feb 17; 2024 Feb 17. PMID: 38367211.
- First-in-Human Study of (18)F-SynVesT-2: An SV2A PET Imaging Probe with Fast Brain Kinetics and High Specific Binding.Drake LR, Wu Y, Naganawa M, Asch R, Zheng C, Najafzadeh S, Pracitto R, Lindemann M, Li S, Ropchan J, Labaree D, Emery PR, Dias M, Henry S, Nabulsi N, Matuskey D, Hillmer AT, Gallezot JD, Carson RE, Cai Z, Huang Y. J Nucl Med. 2024 Feb 15; 2024 Feb 15. PMID: 38360052.
- Fluoride transport in Arabidopsis thaliana plants is impaired in Fluoride EXporter (FEX) mutants.Tausta SL, Fontaine K, Hillmer AT, Strobel SA. Plant Mol Biol. 2024 Feb 11; 2024 Feb 11. PMID: 38342783.
- Improving SUVR quantification by correcting for radiotracer clearance in tissue.Honhar P, Matuskey D, Carson RE, Hillmer AT. J Cereb Blood Flow Metab. 2024 Feb; 2023 Aug 17. PMID: 37589538.
2023
- Imaging the brain's immune response to alcohol with [(11)C]PBR28 TSPO Positron Emission Tomography.Raval NR, Angarita G, Matuskey D, Miller R, Drake LR, Kapinos M, Nabulsi N, Huang Y, Carson RE, O'Malley SS, Cosgrove KP, Hillmer AT. Mol Psychiatry. 2023 Aug; 2023 Aug 2. PMID: 37532797.
- Cholinergic system adaptations are associated with cognitive function in people recently abstinent from smoking: a (-)-[(18)F]flubatine PET study.Calakos KC, Hillmer AT, Anderson JM, LeVasseur B, Baldassarri SR, Angarita GA, Matuskey D, Kapinos M, Zheng MQ, Huang Y, Cosgrove KP. Neuropsychopharmacology. 2023 Mar; 2023 Jan 21. PMID: 36681758.
- Positron Emission Tomography of Neuroimmune Responses in Humans: Insights and Intricacies.Raval NR, Wetherill RR, Wiers CE, Dubroff JG, Hillmer AT. Semin Nucl Med. 2023 Mar; 2022 Oct 19. PMID: 36270830.
- Nicotine Use and Metabotropic Glutamate Receptor 5 in Individuals With Major Depressive and Posttraumatic Stress Disorders.Baldassarri SR, Asch RH, Hillmer AT, Pietrzak RH, DellaGioia N, Esterlis I, Davis MT. Chronic Stress (Thousand Oaks). 2023 Jan-Dec; 2023 Feb 9. PMID: 36843572.
- The metabotropic glutamate receptor 5 as a biomarker for psychiatric disorders.Asch RH, Hillmer AT, Baldassarri SR, Esterlis I. Int Rev Neurobiol. 2023; 2022 Nov 18. PMID: 36868631.
2022
- Multimodal neuroimaging of metabotropic glutamate 5 receptors and functional connectivity in alcohol use disorder.Smart K, Worhunsky PD, Scheinost D, Angarita GA, Esterlis I, Carson RE, Krystal JH, O'Malley SS, Cosgrove KP, Hillmer AT. Alcohol Clin Exp Res. 2022 May; 2022 Apr 21. PMID: 35342968.
- Systematic review of structural and functional neuroimaging studies of cannabis use in adolescence and emerging adulthood: evidence from 90 studies and 9441 participants.Lichenstein SD, Manco N, Cope LM, Egbo L, Garrison KA, Hardee J, Hillmer AT, Reeder K, Stern EF, Worhunsky P, Yip SW. Neuropsychopharmacology. 2022 Apr; 2021 Nov 27. PMID: 34839363.
- Recently Abstinent Smokers Exhibit Mood-Associated Dopamine Dysfunction in the Ventral Striatum Compared to Nonsmokers: A [11C]-(+)-PHNO PET Study.Calakos KC, Hillmer AT, Angarita GA, Baldassarri SR, Najafzadeh S, Emery PR, Matuskey D, Huang Y, Cosgrove KP. Nicotine Tob Res. 2022 Mar 26. PMID: 34628508.
2021
- TSPO imaging in animal models of brain diseases.Van Camp N, Lavisse S, Roost P, Gubinelli F, Hillmer A, Boutin H. Eur J Nucl Med Mol Imaging. 2021 Dec; 2021 Jul 10. PMID: 34245328.
- In vivo evidence of lower synaptic vesicle density in schizophrenia.Radhakrishnan R, Skosnik PD, Ranganathan M, Naganawa M, Toyonaga T, Finnema S, Hillmer AT, Esterlis I, Huang Y, Nabulsi N, Carson RE, D'Souza DC. Mol Psychiatry. 2021 Dec; 2021 Jun 16. PMID: 34135473.
- Kinetic modeling and parameter estimation of TSPO PET imaging in the human brain.Wimberley C, Lavisse S, Hillmer A, Hinz R, Turkheimer F, Zanotti-Fregonara P. Eur J Nucl Med Mol Imaging. 2021 Dec; 2021 Mar 11. PMID: 33693967.
- Data-driven analysis of kappa opioid receptor binding in major depressive disorder measured by positron emission tomography.Smart K, Yttredahl A, Oquendo MA, Mann JJ, Hillmer AT, Carson RE, Miller JM. Transl Psychiatry. 2021 Nov 27; 2021 Nov 27. PMID: 34839360.
- Imaging brain cortisol regulation in PTSD with a target for 11β-hydroxysteroid dehydrogenase type 1.Bhatt S, Hillmer AT, Rusowicz A, Nabulsi N, Matuskey D, Angarita GA, Najafzadeh S, Kapinos M, Southwick SM, Krystal JH, Carson RE, Huang Y, Cosgrove KP. J Clin Invest. 2021 Oct 15. PMID: 34651587.
- Assessment of transient dopamine responses to smoked cannabis.Calakos KC, Liu H, Lu Y, Anderson JM, Matuskey D, Nabulsi N, Ye Y, Skosnik PD, D'Souza DC, Morris ED, Cosgrove KP, Hillmer AT. Drug Alcohol Depend. 2021 Oct 1; 2021 Jul 29. PMID: 34399137.
- Effect of age on brain metabotropic glutamate receptor subtype 5 measured with [(18)F]FPEB PET.Mecca AP, Rogers K, Jacobs Z, McDonald JW, Michalak HR, DellaGioia N, Zhao W, Hillmer AT, Nabulsi N, Lim K, Ropchan J, Huang Y, Matuskey D, Esterlis I, Carson RE, van Dyck CH. Neuroimage. 2021 Sep; 2021 May 27. PMID: 34052464.
- Identifying brain networks in synaptic density PET ((11)C-UCB-J) with independent component analysis.Fang XT, Toyonaga T, Hillmer AT, Matuskey D, Holmes SE, Radhakrishnan R, Mecca AP, van Dyck CH, D'Souza DC, Esterlis I, Worhunsky PD, Carson RE. Neuroimage. 2021 Aug 15; 2021 May 15. PMID: 34000404.
- PET Imaging Estimates of Regional Acetylcholine Concentration Variation in Living Human Brain.Smart K, Naganawa M, Baldassarri SR, Nabulsi N, Ropchan J, Najafzadeh S, Gao H, Navarro A, Barth V, Esterlis I, Cosgrove KP, Huang Y, Carson RE, Hillmer AT. Cereb Cortex. 2021 May 10. PMID: 33442731.
- Binding of the synaptic vesicle radiotracer [(11)C]UCB-J is unchanged during functional brain activation using a visual stimulation task.Smart K, Liu H, Matuskey D, Chen MK, Torres K, Nabulsi N, Labaree D, Ropchan J, Hillmer AT, Huang Y, Carson RE. J Cereb Blood Flow Metab. 2021 May; 2020 Aug 5. PMID: 32757741.
- FDG PET imaging of vascular inflammation in post-traumatic stress disorder: A pilot case-control study.Toczek J, Hillmer AT, Han J, Liu C, Peters D, Emami H, Wu J, Esterlis I, Cosgrove KP, Sadeghi MM. J Nucl Cardiol. 2021 Apr; 2019 May 9. PMID: 31073848.
- Nondisplaceable Binding Is a Potential Confounding Factor in (11)C-PBR28 Translocator Protein PET Studies.Laurell GL, Plavén-Sigray P, Jucaite A, Varrone A, Cosgrove KP, Svarer C, Knudsen GM, Ogden RT, Zanderigo F, Cervenka S, Hillmer AT, Schain M. J Nucl Med. 2021 Mar; 2020 Jul 17. PMID: 32680926.
- Acute neuroimmune stimulation impairs verbal memory in adults: A PET brain imaging study.Woodcock EA, Hillmer AT, Sandiego CM, Maruff P, Carson RE, Cosgrove KP, Pietrzak RH. Brain Behav Immun. 2021 Jan; 2020 Sep 28. PMID: 33002632.
- Longitudinal imaging of metabotropic glutamate 5 receptors during early and extended alcohol abstinence.Hillmer AT, Angarita GA, Esterlis I, Anderson JM, Nabulsi N, Lim K, Ropchan J, Carson RE, Krystal JH, Malley SSO, Cosgrove KP. Neuropsychopharmacology. 2021 Jan; 2020 Sep 12. PMID: 32919411.
2020
- Dysregulation of Decision Making Related to Metabotropic Glutamate 5, but Not Midbrain D(3), Receptor Availability Following Cocaine Self-administration in Rats.Groman SM, Hillmer AT, Liu H, Fowles K, Holden D, Morris ED, Lee D, Taylor JR. Biol Psychiatry. 2020 Nov 15; 2020 Jun 29. PMID: 32826065.
- Midbrain D(3) Receptor Availability Predicts Escalation in Cocaine Self-administration.Groman SM, Hillmer AT, Liu H, Fowles K, Holden D, Morris ED, Lee D, Taylor JR. Biol Psychiatry. 2020 Nov 15; 2020 Feb 27. PMID: 32312578.
- Accuracy of arterial [(18)F]-Fluorodeoxyglucose uptake quantification: A kinetic modeling study.Toczek J, Wu J, Hillmer AT, Han J, Esterlis I, Cosgrove KP, Liu C, Sadeghi MM. J Nucl Cardiol. 2020 Oct; 2020 Feb 10. PMID: 32043239.
- Body Mass Index and Age Effects on Brain 11β-Hydroxysteroid Dehydrogenase Type 1: a Positron Emission Tomography Study.Bini J, Bhatt S, Hillmer AT, Gallezot JD, Nabulsi N, Pracitto R, Labaree D, Kapinos M, Ropchan J, Matuskey D, Sherwin RS, Jastreboff AM, Carson RE, Cosgrove K, Huang Y. Mol Imaging Biol. 2020 Aug. PMID: 32133575.
- Tobacco Smoking in People Is Not Associated with Altered 18-kDa Translocator Protein Levels: A PET Study.Hillmer AT, Matuskey D, Huang Y, Nabulsi N, Ropchan J, Carson RE, O'Malley SS, Cosgrove KP. J Nucl Med. 2020 Aug; 2020 Jan 31. PMID: 32005773.
- Separating dopamine D(2) and D(3) receptor sources of [(11)C]-(+)-PHNO binding potential: Independent component analysis of competitive binding.Smart K, Gallezot JD, Nabulsi N, Labaree D, Zheng MQ, Huang Y, Carson RE, Hillmer AT, Worhunsky PD. Neuroimage. 2020 Jul 1; 2020 Mar 19. PMID: 32201327.
- Acute alcohol consumption alters the peripheral cytokines IL-8 and TNF-α.Hillmer AT, Nadim H, Devine L, Jatlow P, O'Malley SS. Alcohol. 2020 Jun; 2019 Nov 20. PMID: 31759072.
- PTSD is associated with neuroimmune suppression: evidence from PET imaging and postmortem transcriptomic studies.Bhatt S, Hillmer AT, Girgenti MJ, Rusowicz A, Kapinos M, Nabulsi N, Huang Y, Matuskey D, Angarita GA, Esterlis I, Davis MT, Southwick SM, Friedman MJ, Duman RS, Carson RE, Krystal JH, Pietrzak RH, Cosgrove KP. Nat Commun. 2020 May 12; 2020 May 12. PMID: 32398677.
- Quantification of PET infusion studies without true equilibrium: A tissue clearance correction.Hillmer AT, Carson RE. J Cereb Blood Flow Metab. 2020 Apr; 2019 May 14. PMID: 31088233.
- First in-human PET study and kinetic evaluation of [(18)F]AS2471907 for imaging 11β-hydroxysteroid dehydrogenase type 1.Bhatt S, Nabulsi NB, Li S, Cai Z, Matuskey D, Bini J, Najafzadeh S, Kapinos M, Ropchan JR, Carson RE, Cosgrove KP, Huang Y, Hillmer AT. J Cereb Blood Flow Metab. 2020 Apr; 2019 Mar 21. PMID: 30895878.
- Quantification of [(11)C]PBR28 data after systemic lipopolysaccharide challenge.Woodcock EA, Schain M, Cosgrove KP, Hillmer AT. EJNMMI Res. 2020 Mar 12; 2020 Mar 12. PMID: 32166497.
- Approaches to PET Imaging of Glioblastoma.Drake LR, Hillmer AT, Cai Z. Molecules. 2020 Jan 28; 2020 Jan 28. PMID: 32012954.
2019
- Sex differences in amphetamine-induced dopamine release in the dorsolateral prefrontal cortex of tobacco smokers.Zakiniaeiz Y, Hillmer AT, Matuskey D, Nabulsi N, Ropchan J, Mazure CM, Picciotto MR, Huang Y, McKee SA, Morris ED, Cosgrove KP. Neuropsychopharmacology. 2019 Dec; 2019 Jul 3. PMID: 31269510.
- Effects of age, BMI and sex on the glial cell marker TSPO - a multicentre [(11)C]PBR28 HRRT PET study.Tuisku J, Plavén-Sigray P, Gaiser EC, Airas L, Al-Abdulrasul H, Brück A, Carson RE, Chen MK, Cosgrove KP, Ekblad L, Esterlis I, Farde L, Forsberg A, Halldin C, Helin S, Kosek E, Lekander M, Lindgren N, Marjamäki P, Rissanen E, Sucksdorff M, Varrone A, Collste K, Gallezot JD, Hillmer A, Huang Y, Höglund CO, Johansson J, Jucaite A, Lampa J, Nabulsi N, Pittman B, Sandiego CM, Stenkrona P, Rinne J, Matuskey D, Cervenka S. Eur J Nucl Med Mol Imaging. 2019 Oct; 2019 Jul 30. PMID: 31363804.
- In vivo evidence for dysregulation of mGluR5 as a biomarker of suicidal ideation.Davis MT, Hillmer A, Holmes SE, Pietrzak RH, DellaGioia N, Nabulsi N, Matuskey D, Angarita GA, Carson RE, Krystal JH, Esterlis I. Proc Natl Acad Sci U S A. 2019 Jun 4; 2019 May 13. PMID: 31085640.
- Imaging Biomarkers of the Neuroimmune System among Substance Use Disorders: A Systematic Review.Woodcock EA, Hillmer AT, Mason GF, Cosgrove KP. Mol Neuropsychiatry. 2019 Jun; 2019 May 9. PMID: 31312635.
2018
- The Importance of Drug and Sex Effects in Psychiatric Research.Hillmer AT. Biol Psychiatry. 2018 Nov 15. PMID: 30360777.
- Use of Electronic Cigarettes Leads to Significant Beta2-Nicotinic Acetylcholine Receptor Occupancy: Evidence From a PET Imaging Study.Baldassarri SR, Hillmer AT, Anderson JM, Jatlow P, Nabulsi N, Labaree D, Cosgrove KP, O'Malley SS, Eissenberg T, Krishnan-Sarin S, Esterlis I. Nicotine Tob Res. 2018 Mar 6. PMID: 28460123.
- Evaluation of (-)-[(18) F]Flubatine-specific binding: Implications for reference region approaches.Bhatt S, Hillmer AT, Nabulsi N, Matuskey D, Lim K, Lin SF, Esterlis I, Carson RE, Huang Y, Cosgrove KP. Synapse. 2018 Mar; 2017 Nov 17. PMID: 29105121.
2017
- Human biodistribution and dosimetry of [(18)F]nifene, an α4β2* nicotinic acetylcholine receptor PET tracer.Betthauser TJ, Hillmer AT, Lao PJ, Ehlerding E, Mukherjee J, Stone CK, Christian BT. Nucl Med Biol. 2017 Dec; 2017 Aug 17. PMID: 28963927.
- Microglial depletion and activation: A [(11)C]PBR28 PET study in nonhuman primates.Hillmer AT, Holden D, Fowles K, Nabulsi N, West BL, Carson RE, Cosgrove KP. EJNMMI Res. 2017 Dec; 2017 Jul 24. PMID: 28741281.
- In vivo imaging of translocator protein, a marker of activated microglia, in alcohol dependence.Hillmer AT, Sandiego CM, Hannestad J, Angarita GA, Kumar A, McGovern EM, Huang Y, O'Connor KC, Carson RE, O'Malley SS, Cosgrove KP. Mol Psychiatry. 2017 Dec; 2017 Feb 28. PMID: 28242869.
- [(18) F]Nifene test-retest reproducibility in first-in-human imaging of α4β2* nicotinic acetylcholine receptors.Lao PJ, Betthauser TJ, Tudorascu DL, Barnhart TE, Hillmer AT, Stone CK, Mukherjee J, Christian BT. Synapse. 2017 Aug; 2017 Apr 26. PMID: 28420041.