Veronica Lee
Research
Publications
2020
m6A Modification Prevents Formation of Endogenous Double-Stranded RNAs and Deleterious Innate Immune Responses during Hematopoietic Development
Gao Y, Vasic R, Song Y, Teng R, Liu C, Gbyli R, Biancon G, Nelakanti R, Lobben K, Kudo E, Liu W, Ardasheva A, Fu X, Wang X, Joshi P, Lee V, Dura B, Viero G, Iwasaki A, Fan R, Xiao A, Flavell RA, Li HB, Tebaldi T, Halene S. m6A Modification Prevents Formation of Endogenous Double-Stranded RNAs and Deleterious Innate Immune Responses during Hematopoietic Development. Immunity 2020, 52: 1007-1021.e8. PMID: 32497523, PMCID: PMC7408742, DOI: 10.1016/j.immuni.2020.05.003.Peer-Reviewed Original ResearchConceptsDouble-stranded RNADeleterious innate immune responseMammalian hematopoietic developmentEndogenous double-stranded RNAHematopoietic developmentInnate immune responseAbundant RNA modificationMurine fetal liverPattern recognition receptor pathwaysImmune responseProtein codingDsRNA formationRNA modificationsWriter METTL3Hematopoietic defectsPerinatal lethalityNative stateConditional deletionAberrant innate immune responsesLoss of METTL3Hematopoietic failureReceptor pathwayAberrant immune responsePrevents formationFetal liver
2018
Activation of RhoA, Smad2, c‐Src, PKC‐βII/δ and JNK in atopic dermatitis
Lu J, Yin R, Fu Z, Lee V, Nelson J, Tan W. Activation of RhoA, Smad2, c‐Src, PKC‐βII/δ and JNK in atopic dermatitis. Australasian Journal Of Dermatology 2018, 59: e258-e261. PMID: 29498756, PMCID: PMC6978706, DOI: 10.1111/ajd.12801.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedDermatitis, AtopicDermisEpidermisFemaleHumansJNK Mitogen-Activated Protein KinasesMaleMiddle AgedPhosphorylationProtein Kinase C betaReceptor, Transforming Growth Factor-beta Type IRhoA GTP-Binding ProteinSeverity of Illness IndexSmad2 ProteinSrc-Family KinasesUp-RegulationYoung AdultConceptsExpression of TGFβR1Atopic dermatitisAtopic dermatitis severityInfiltrated inflammatory cellsMultifactorial skin diseaseActivation of Smad2C-SrcDermatitis severityInflammatory progressionInflammatory cellsSkin diseasesActivation of RhoAPhosphorylation levelsDermatitisTGFβR1JNKSmad2ActivationInflammationChronicPathogenesisExpressionRhoADiseaseProgression