Publications

Stephanie Halene's Publications

2022

Targeting the EIF2AK1 signaling pathway rescues red blood cell production in SF3B1-mutant myelodysplastic syndromes with ringed sideroblasts.Adema V, Ma F, Kanagal-Shamanna R, Thongon N, Montalban-Bravo G, Yang H, Peslak SA, Wang F, Acha P, Sole F, Lockyer P, Cassari M, Maciejewski JP, Visconte V, Ganan-Gomez I, Song Y, Bueso-Ramos C, Pellegrini M, Tan TM, Bejar R, Carew JS, Halene S, Santini V, Al-Atrash G, Clise-Dwyer K, Garcia-Manero G, Blobel GA, Colla S. Blood Cancer Discov. 2022 Aug 4; 2022 Aug 4. PMID: 35926182.
A humanized mouse model of chronic COVID-19.Sefik E, Israelow B, Mirza H, Zhao J, Qu R, Kaffe E, Song E, Halene S, Meffre E, Kluger Y, Nussenzweig M, Wilen CB, Iwasaki A, Flavell RA. Nat Biotechnol. 2022 Jun; 2021 Dec 17. PMID: 34921308.
Inflammasome activation in infected macrophages drives COVID-19 pathology.Sefik E, Qu R, Junqueira C, Kaffe E, Mirza H, Zhao J, Brewer JR, Han A, Steach HR, Israelow B, Blackburn HN, Velazquez SE, Chen YG, Halene S, Iwasaki A, Meffre E, Nussenzweig M, Lieberman J, Wilen CB, Kluger Y, Flavell RA. Nature. 2022 Jun; 2022 Apr 28. PMID: 35483404.
Pre-mRNA splicing factor U2AF2 recognizes distinct conformations of nucleotide variants at the center of the pre-mRNA splice site signal.Glasser E, Maji D, Biancon G, Puthenpeedikakkal AMK, Cavender CE, Tebaldi T, Jenkins JL, Mathews DH, Halene S, Kielkopf CL. Nucleic Acids Res. 2022 May 20. PMID: 35524551.
Are We Moving the Needle for Patients with TP53-Mutated Acute Myeloid Leukemia?Shallis RM, Bewersdorf JP, Stahl MF, Halene S, Zeidan AM. Cancers (Basel). 2022 May 14; 2022 May 14. PMID: 35626039.
In vivo anti-tumor effect of PARP inhibition in IDH1/2 mutant MDS/AML resistant to targeted inhibitors of mutant IDH1/2.Gbyli R, Song Y, Liu W, Gao Y, Biancon G, Chandhok NS, Wang X, Fu X, Patel A, Sundaram R, Tebaldi T, Mamillapalli P, Zeidan AM, Flavell RA, Prebet T, Bindra RS, Halene S. Leukemia. 2022 May; 2022 Mar 10. PMID: 35273342.
Mission, Organization, and Future Direction of the Serological Sciences Network for COVID-19 (SeroNet) Epidemiologic Cohort Studies.Figueiredo JC, Hirsch FR, Kushi LH, Nembhard WN, Crawford JM, Mantis N, Finster L, Merin NM, Merchant A, Reckamp KL, Melmed GY, Braun J, McGovern D, Parekh S, Corley DA, Zohoori N, Amick BC, Du R, Gregersen PK, Diamond B, Taioli E, Sariol C, Espino A, Weiskopf D, Gifoni A, Brien J, Hanege W, Lipsitch M, Zidar DA, Scheck McAlearney A, Wajnberg A, LaBaer J, Yvonne Lewis E, Binder RA, Moormann AM, Forconi C, Forrester S, Batista J, Schieffelin J, Kim D, Biancon G, VanOudenhove J, Halene S, Fan R, Barouch DH, Alter G, Pinninti S, Boppana SB, Pati SK, Latting M, Karaba AH, Roback J, Sekaly R, Neish A, Brincks AM, Granger DA, Karger AB, Thyagarajan B, Thomas SN, Klein SL, Cox AL, Lucas T, Furr-Holden D, Key K, Jones N, Wrammerr J, Suthar M, Yu Wong S, Bowman NM, Simon V, Richardson LD, McBride R, Krammer F, Rana M, Kennedy J, Boehme K, Forrest C, Granger SW, Heaney CD, Knight Lapinski M, Wallet S, Baric RS, Schifanella L, Lopez M, Fernández S, Kenah E, Panchal AR, Britt WJ, Sanz I, Dhodapkar M, Ahmed R, Bartelt LA, Markmann AJ, Lin JT, Hagan RS, Wolfgang MC, Skarbinski J. Open Forum Infect Dis. 2022 Jun; 2022 Apr 27. PMID: 35765315.
Inflammasome activation in infected macrophages drives COVID-19 pathology.Sefik E, Qu R, Junqueira C, Kaffe E, Mirza H, Zhao J, Brewer JR, Han A, Steach HR, Israelow B, Blackburn HN, Velazquez S, Chen YG, Halene S, Iwasaki A, Meffre E, Nussenzweig M, Lieberman J, Wilen CB, Kluger Y, Flavell RA. bioRxiv. 2022 Apr 1; 2022 Apr 1. PMID: 34611663.
Spatial-CITE-seq: spatially resolved high-plex protein and whole transcriptome co-mapping.Fan R, Liu Y, DiStasio M, Su G, Asashima H, Enninful A, Qin X, Deng Y, Bordignon P, Cassano M, Tomayko M, Xu M, Halene S, Craft J, Hafler D. Res Sq. 2022 Mar 30; 2022 Mar 30. PMID: 35378748.
Precision analysis of mutant U2AF1 activity reveals deployment of stress granules in myeloid malignancies.Biancon G, Joshi P, Zimmer JT, Hunck T, Gao Y, Lessard MD, Courchaine E, Barentine AES, Machyna M, Botti V, Qin A, Gbyli R, Patel A, Song Y, Kiefer L, Viero G, Neuenkirchen N, Lin H, Bewersdorf J, Simon MD, Neugebauer KM, Tebaldi T, Halene S. Mol Cell. 2022 Mar 17. PMID: 35303483.
The Coming of Age of Preclinical Models of MDS.Liu W, Teodorescu P, Halene S, Ghiaur G. Front Oncol. 2022; 2022 Mar 16. PMID: 35372085.
DNMT3A R882 Mutations Confer Unique Clinicopathologic Features in MDS Including a High Risk of AML Transformation.Jawad M, Afkhami M, Ding Y, Zhang X, Li P, Young K, Xu ML, Cui W, Zhao Y, Halene S, Al-Kali A, Viswanatha D, Chen D, He R, Zheng G. Front Oncol. 2022; 2022 Feb 28. PMID: 35296003.
A Phase 2 Randomized, Double-Blind, Placebo-controlled Trial of Oral Camostat Mesylate for Early Treatment of COVID-19 Outpatients Showed Shorter Illness Course and Attenuation of Loss of Smell and Taste.Chupp G, Spichler-Moffarah A, Søgaard OS, Esserman D, Dziura J, Danzig L, Chaurasia R, Patra KP, Salovey A, Nunez A, May J, Astorino L, Patel A, Halene S, Wang J, Hui P, Patel P, Lu J, Li F, Gan G, Parziale S, Katsovich L, Desir GV, Vinetz JM. medRxiv. 2022 Jan 31; 2022 Jan 31. PMID: 35132421.

2021

Comprehensive Clinicopathologic and Molecular Analysis of Mast Cell Leukemia With Associated Hematologic Neoplasm: A Report and In-Depth Study of 5 Cases.Li P, Biancon G, Patel T, Pan Z, Kothari S, Halene S, Prebet T, Xu ML. Front Oncol. 2021; 2021 Sep 13. PMID: 34589432.
Challenges in the Evaluation and Management of Toxicities Arising From Immune Checkpoint Inhibitor Therapy for Patients With Myeloid Malignancies.Shallis RM, Bewersdorf JP, Swoboda DM, Wei W, Gowda L, Prebet T, Halene S, Pillai MM, Parker T, Neparidze N, Podoltsev NA, Seropian S, Sallman DA, Gore SD, Zeidan AM. Clin Lymphoma Myeloma Leuk. 2021 May; 2021 Jan 12. PMID: 33551344.
Transcriptome-wide quantification of double-stranded RNAs in live mouse tissues by dsRIP-Seq.Gao Y, Chen S, Halene S, Tebaldi T. STAR Protoc. 2021 Mar 19; 2021 Mar 18. PMID: 33778776.
A humanized mouse model of chronic COVID-19 to evaluate disease mechanisms and treatment options.Sefik E, Israelow B, Zhao J, Qu R, Song E, Mirza H, Kaffe E, Halene S, Meffre E, Kluger Y, Nussenzweig M, Wilen C, Iwasaki A, Flavell RA. Res Sq. 2021 Mar 17; 2021 Mar 17. PMID: 33758831.
A neutrophil activation signature predicts critical illness and mortality in COVID-19.Meizlish ML, Pine AB, Bishai JD, Goshua G, Nadelmann ER, Simonov M, Chang CH, Zhang H, Shallow M, Bahel P, Owusu K, Yamamoto Y, Arora T, Atri DS, Patel A, Gbyli R, Kwan J, Won CH, Dela Cruz C, Price C, Koff J, King BA, Rinder HM, Wilson FP, Hwa J, Halene S, Damsky W, van Dijk D, Lee AI, Chun HJ. Blood Adv. 2021 Mar 9. PMID: 33635335.
Combined liver-cytokine humanization comes to the rescue of circulating human red blood cells.Song Y, Shan L, Gbyli R, Liu W, Strowig T, Patel A, Fu X, Wang X, Xu ML, Gao Y, Qin A, Bruscia EM, Tebaldi T, Biancon G, Mamillapalli P, Urbonas D, Eynon E, Gonzalez DG, Chen J, Krause DS, Alderman J, Halene S, Flavell RA. Science. 2021 Mar 5. PMID: 33674488.
Editorial: Do not lose focus on myeloid biology in the era of COVID-19.Halene S, Prebet T. Curr Opin Hematol. 2021 Mar 1. PMID: 33394725.
Thrombocytopathy and endotheliopathy: crucial contributors to COVID-19 thromboinflammation.Gu SX, Tyagi T, Jain K, Gu VW, Lee SH, Hwa JM, Kwan JM, Krause DS, Lee AI, Halene S, Martin KA, Chun HJ, Hwa J. Nat Rev Cardiol. 2021 Mar; 2020 Nov 19. PMID: 33214651.

2020

High-Spatial-Resolution Multi-Omics Sequencing via Deterministic Barcoding in Tissue.Liu Y, Yang M, Deng Y, Su G, Enninful A, Guo CC, Tebaldi T, Zhang D, Kim D, Bai Z, Norris E, Pan A, Li J, Xiao Y, Halene S, Fan R. Cell. 2020 Dec 10; 2020 Nov 13. PMID: 33188776.
The role of RNA epigenetic modification in normal and malignant hematopoiesis.Vasic R, Gao Y, Liu C, Halene S. Curr Stem Cell Rep. 2020 Dec; 2020 Aug 12. PMID: 33777659.
Circulating markers of angiogenesis and endotheliopathy in COVID-19.Pine AB, Meizlish ML, Goshua G, Chang CH, Zhang H, Bishai J, Bahel P, Patel A, Gbyli R, Kwan JM, Won CH, Price C, Dela Cruz CS, Halene S, van Dijk D, Hwa J, Lee AI, Chun HJ. Pulm Circ. 2020 Oct-Dec; 2020 Nov 25. PMID: 33282193.
Single-cell genomics reveals the genetic and molecular bases for escape from mutational epistasis in myeloid neoplasms.Taylor J, Mi X, North K, Binder M, Penson A, Lasho T, Knorr K, Haddadin M, Liu B, Pangallo J, Benbarche S, Wiseman D, Tefferi A, Halene S, Liang Y, Patnaik MM, Bradley RK, Abdel-Wahab O. Blood. 2020 Sep 24. PMID: 32640014.
A neutrophil activation signature predicts critical illness and mortality in COVID-19.Meizlish ML, Pine AB, Bishai JD, Goshua G, Nadelmann ER, Simonov M, Chang CH, Zhang H, Shallow M, Bahel P, Owusu K, Yamamoto Y, Arora T, Atri DS, Patel A, Gbyli R, Kwan J, Won CH, Dela Cruz C, Price C, Koff J, King BA, Rinder HM, Wilson FP, Hwa J, Halene S, Damsky W, van Dijk D, Lee AI, Chun H. medRxiv. 2020 Sep 2; 2020 Sep 2. PMID: 32908988.
The minimal that kills: Why defining and targeting measurable residual disease is the "Sine Qua Non" for further progress in management of acute myeloid leukemia.Bewersdorf JP, Shallis RM, Boddu PC, Wood B, Radich J, Halene S, Zeidan AM. Blood Rev. 2020 Sep; 2019 Dec 20. PMID: 31883804.
Endotheliopathy in COVID-19-associated coagulopathy: evidence from a single-centre, cross-sectional study.Goshua G, Pine AB, Meizlish ML, Chang CH, Zhang H, Bahel P, Baluha A, Bar N, Bona RD, Burns AJ, Dela Cruz CS, Dumont A, Halene S, Hwa J, Koff J, Menninger H, Neparidze N, Price C, Siner JM, Tormey C, Rinder HM, Chun HJ, Lee AI. Lancet Haematol. 2020 Aug; 2020 Jun 30. PMID: 32619411.
Circulating Markers of Angiogenesis and Endotheliopathy in COVID-19.Meizlish ML, Pine AB, Goshua G, Chang CH, Zhang H, Bishai J, Bahel P, Patel A, Gbyli R, Kwan J, Price C, Cruz CSD, Halene S, van Dijk D, Hwa J, Lee AI, Chun HJ. medRxiv. 2020 Jul 1; 2020 Jul 1. PMID: 32637968.
m⁶A Modification Prevents Formation of Endogenous Double-Stranded RNAs and Deleterious Innate Immune Responses during Hematopoietic Development.Gao Y, Vasic R, Song Y, Teng R, Liu C, Gbyli R, Biancon G, Nelakanti R, Lobben K, Kudo E, Liu W, Ardasheva A, Fu X, Wang X, Joshi P, Lee V, Dura B, Viero G, Iwasaki A, Fan R, Xiao A, Flavell RA, Li HB, Tebaldi T, Halene S. Immunity. 2020 Jun 16; 2020 Jun 3. PMID: 32497523.
Cyclosporine enhances the sensitivity to lenalidomide in MDS/AML in vitro.He X, Dou A, Feng S, Roman-Rivera A, Hawkins C, Lawley L, Zhang J, Wunderlich M, Mizukawa B, Halene S, Patel A, Fang J. Exp Hematol. 2020 Jun; 2020 May 8. PMID: 32437909.
Design of Hydrazide-Bearing HDACIs Based on Panobinostat and Their p53 and FLT3-ITD Dependency in Antileukemia Activity.Li X, Jiang Y, Peterson YK, Xu T, Himes RA, Luo X, Yin G, Inks ES, Dolloff N, Halene S, Chan SSL, Chou CJ. J Med Chem. 2020 May 28; 2020 May 6. PMID: 32321249.
Humanized mice as preclinical models for myeloid malignancies.Gbyli R, Song Y, Halene S. Biochem Pharmacol. 2020 Apr; 2020 Jan 10. PMID: 31926939.
Functional Analysis of Human Hematopoietic Stem Cells In Vivo in Humanized Mice.Song Y, Gbyli R, Fu X, Halene S. Methods Mol Biol. 2020. PMID: 31776933.

2019

LAM-003, a new drug for treatment of tyrosine kinase inhibitor-resistant FLT3-ITD-positive AML.Beeharry N, Landrette S, Gayle S, Hernandez M, Grotzke JE, Young PR, Beckett P, Zhang X, Carter BZ, Andreeff M, Halene S, Xu T, Rothberg J, Lichenstein H. Blood Adv. 2019 Nov 26. PMID: 31751472.
Low iron promotes megakaryocytic commitment of megakaryocytic-erythroid progenitors in humans and mice.Xavier-Ferrucio J, Scanlon V, Li X, Zhang PX, Lozovatsky L, Ayala-Lopez N, Tebaldi T, Halene S, Cao C, Fleming MD, Finberg KE, Krause DS. Blood. 2019 Oct 31. PMID: 31439541.
From clonal hematopoiesis to myeloid leukemia and what happens in between: Will improved understanding lead to new therapeutic and preventive opportunities?Bewersdorf JP, Ardasheva A, Podoltsev NA, Singh A, Biancon G, Halene S, Zeidan AM. Blood Rev. 2019 Sep; 2019 Jul 4. PMID: 31400824.
A highly efficient and faithful MDS patient-derived xenotransplantation model for pre-clinical studies.Song Y, Rongvaux A, Taylor A, Jiang T, Tebaldi T, Balasubramanian K, Bagale A, Terzi YK, Gbyli R, Wang X, Fu X, Gao Y, Zhao J, Podoltsev N, Xu M, Neparidze N, Wong E, Torres R, Bruscia EM, Kluger Y, Manz MG, Flavell RA, Halene S. Nat Commun. 2019 Jan 21; 2019 Jan 21. PMID: 30664659.

2018

SRSF2 mutations drive oncogenesis by activating a global program of aberrant alternative splicing in hematopoietic cells.Liang Y, Tebaldi T, Rejeski K, Joshi P, Stefani G, Taylor A, Song Y, Vasic R, Maziarz J, Balasubramanian K, Ardasheva A, Ding A, Quattrone A, Halene S. Leukemia. 2018 Dec; 2018 Jun 1. PMID: 29858584.
Role of alternative splicing in hematopoietic stem cells during development.Gao Y, Vasic R, Halene S. Stem Cell Investig. 2018; 2018 Aug 23. PMID: 30221171.
Small Cell Variant of Intravascular Large B-Cell Lymphoma: Highlighting a Potentially Fatal and Easily Missed Diagnosis.Rahmani M, Halene S, Xu ML. Biomed Res Int. 2018; 2018 Apr 3. PMID: 29850589.

2017

Corrigendum: Development and function of human innate immune cells in a humanized mouse model.Rongvaux A, Willinger T, Martinek J, Strowig T, Gearty SV, Teichmann LL, Saito Y, Marches F, Halene S, Palucka AK, Manz MG, Flavell RA. Nat Biotechnol. 2017 Dec 8. PMID: 29220023.
Health Care Use by Older Adults With Acute Myeloid Leukemia at the End of Life.Wang R, Zeidan AM, Halene S, Xu X, Davidoff AJ, Huntington SF, Podoltsev NA, Gross CP, Gore SD, Ma X. J Clin Oncol. 2017 Oct 20; 2017 Aug 7. PMID: 28783450.
Whole-exome sequencing in evaluation of patients with venous thromboembolism.Lee EJ, Dykas DJ, Leavitt AD, Camire RM, Ebberink E, García de Frutos P, Gnanasambandan K, Gu SX, Huntington JA, Lentz SR, Mertens K, Parish CR, Rezaie AR, Sayeski PP, Cromwell C, Bar N, Halene S, Neparidze N, Parker TL, Burns AJ, Dumont A, Yao X, Chaar CIO, Connors JM, Bale AE, Lee AI. Blood Adv. 2017 Jul 11; 2017 Jun 29. PMID: 29296762.
Rusty neutrophils in β-thalassemia: no traction!Gaines P, Halene S. Blood. 2017 Jun 8. PMID: 28596437.
How do messenger RNA splicing alterations drive myelodysplasia?Joshi P, Halene S, Abdel-Wahab O. Blood. 2017 May 4; 2017 Mar 27. PMID: 28348147.
Pediatric non-Down syndrome acute megakaryoblastic leukemia is characterized by distinct genomic subsets with varying outcomes.de Rooij JD, Branstetter C, Ma J, Li Y, Walsh MP, Cheng J, Obulkasim A, Dang J, Easton J, Verboon LJ, Mulder HL, Zimmermann M, Koss C, Gupta P, Edmonson M, Rusch M, Lim JY, Reinhardt K, Pigazzi M, Song G, Yeoh AE, Shih LY, Liang DC, Halene S, Krause DS, Zhang J, Downing JR, Locatelli F, Reinhardt D, van den Heuvel-Eibrink MM, Zwaan CM, Fornerod M, Gruber TA. Nat Genet. 2017 Mar; 2017 Jan 23. PMID: 28112737.
Single cell transcriptomics reveals unanticipated features of early hematopoietic precursors.Yang J, Tanaka Y, Seay M, Li Z, Jin J, Garmire LX, Zhu X, Taylor A, Li W, Euskirchen G, Halene S, Kluger Y, Snyder MP, Park IH, Pan X, Weissman SM. Nucleic Acids Res. 2017 Feb 17. PMID: 28003475.
2-Hydroxyglutarate produced by neomorphic IDH mutations suppresses homologous recombination and induces PARP inhibitor sensitivity.Sulkowski PL, Corso CD, Robinson ND, Scanlon SE, Purshouse KR, Bai H, Liu Y, Sundaram RK, Hegan DC, Fons NR, Breuer GA, Song Y, Mishra-Gorur K, De Feyter HM, de Graaf RA, Surovtseva YV, Kachman M, Halene S, Günel M, Glazer PM, Bindra RS. Sci Transl Med. 2017 Feb 1. PMID: 28148839.

2016

Novel Developments in Leukopenia and Pancytopenia.Onuoha C, Arshad J, Astle J, Xu M, Halene S. Prim Care. 2016 Dec. PMID: 27866577.
Peripheral blood CD34⁺ cells efficiently engraft human cytokine knock-in mice.Saito Y, Ellegast JM, Rafiei A, Song Y, Kull D, Heikenwalder M, Rongvaux A, Halene S, Flavell RA, Manz MG. Blood. 2016 Oct 6; 2016 Aug 19. PMID: 27543436.
Cooperative Activity of GABP with PU.1 or C/EBPε Regulates Lamin B Receptor Gene Expression, Implicating Their Roles in Granulocyte Nuclear Maturation.Malu K, Garhwal R, Pelletier MG, Gotur D, Halene S, Zwerger M, Yang ZF, Rosmarin AG, Gaines P. J Immunol. 2016 Aug 1; 2016 Jun 24. PMID: 27342846.
Adding insult to injury: autoimmune haemolytic anaemia complicated by pulmonary embolism.Woodson KA, Lee Y, Gopalratnam K, Halene S. BMJ Case Rep. 2016 Jan 14; 2016 Jan 14. PMID: 26768839.

2015

Regulation of actin polymerization by tropomodulin-3 controls megakaryocyte actin organization and platelet biogenesis.Sui Z, Nowak RB, Sanada C, Halene S, Krause DS, Fowler VM. Blood. 2015 Jul 23; 2015 May 11. PMID: 25964668.
SRSF2 Mutations Contribute to Myelodysplasia by Mutant-Specific Effects on Exon Recognition.Kim E, Ilagan JO, Liang Y, Daubner GM, Lee SC, Ramakrishnan A, Li Y, Chung YR, Micol JB, Murphy ME, Cho H, Kim MK, Zebari AS, Aumann S, Park CY, Buonamici S, Smith PG, Deeg HJ, Lobry C, Aifantis I, Modis Y, Allain FH, Halene S, Bradley RK, Abdel-Wahab O. Cancer Cell. 2015 May 11. PMID: 25965569.
Oxaliplatin-related acute disseminated intravascular coagulation syndrome in a patient with metastatic colon cancer.Malkhasyan K, Halene S, Lacy J. Clin Colorectal Cancer. 2015 Mar; 2014 Oct 2. PMID: 25446051.
Stem cell maintenance: aMPLe splicing choices.Halene S, Krause DS. Blood. 2015 Feb 5. PMID: 25655452.
The regulatory role of serum response factor pathway in neutrophil inflammatory response.Taylor A, Halene S. Curr Opin Hematol. 2015 Jan. PMID: 25402621.

2014

SRF is required for neutrophil migration in response to inflammation.Taylor A, Tang W, Bruscia EM, Zhang PX, Lin A, Gaines P, Wu D, Halene S. Blood. 2014 May 8; 2014 Feb 26. PMID: 24574460.
Whole-exome sequencing identifies a novel somatic mutation in MMP8 associated with a t(1;22)-acute megakaryoblastic leukemia.Kim Y, Schulz VP, Satake N, Gruber TA, Teixeira AM, Halene S, Gallagher PG, Krause DS. Leukemia. 2014 Apr; 2013 Oct 25. PMID: 24157583.
Development and function of human innate immune cells in a humanized mouse model.Rongvaux A, Willinger T, Martinek J, Strowig T, Gearty SV, Teichmann LL, Saito Y, Marches F, Halene S, Palucka AK, Manz MG, Flavell RA. Nat Biotechnol. 2014 Apr; 2014 Mar 16. PMID: 24633240.

2012

Complex oncogene dependence in microRNA-125a-induced myeloproliferative neoplasms.Guo S, Bai H, Megyola CM, Halene S, Krause DS, Scadden DT, Lu J. Proc Natl Acad Sci U S A. 2012 Oct 9; 2012 Sep 24. PMID: 23012470.
Up-regulation of translation eukaryotic initiation factor 4E in nucleophosmin 1 haploinsufficient cells results in changes in CCAAT enhancer-binding protein α activity: implications in myelodysplastic syndrome and acute myeloid leukemia.Khanna-Gupta A, Abayasekara N, Levine M, Sun H, Virgilio M, Nia N, Halene S, Sportoletti P, Jeong JY, Pandolfi PP, Berliner N. J Biol Chem. 2012 Sep 21; 2012 Jul 31. PMID: 22851180.
MKL1 and MKL2 play redundant and crucial roles in megakaryocyte maturation and platelet formation.Smith EC, Thon JN, Devine MT, Lin S, Schulz VP, Guo Y, Massaro SA, Halene S, Gallagher P, Italiano JE Jr, Krause DS. Blood. 2012 Sep 13; 2012 Jul 17. PMID: 22806889.
Gaucher disease gene GBA functions in immune regulation.Liu J, Halene S, Yang M, Iqbal J, Yang R, Mehal WZ, Chuang WL, Jain D, Yuen T, Sun L, Zaidi M, Mistry PK. Proc Natl Acad Sci U S A. 2012 Jun 19; 2012 Jun 4. PMID: 22665763.
Role of RhoA-specific guanine exchange factors in regulation of endomitosis in megakaryocytes.Gao Y, Smith E, Ker E, Campbell P, Cheng EC, Zou S, Lin S, Wang L, Halene S, Krause DS. Dev Cell. 2012 Mar 13; 2012 Mar 1. PMID: 22387001.

2011

Pattern of hypomethylating agents use among elderly patients with myelodysplastic syndromes.Wang R, Gross CP, Maggiore RJ, Halene S, Soulos PR, Raza A, Galili N, Ma X. Leuk Res. 2011 Jul; 2010 Nov 9. PMID: 21067809.
Evidence-based genomic diagnosis characterized chromosomal and cryptic imbalances in 30 elderly patients with myelodysplastic syndrome and acute myeloid leukemia.Bajaj R, Xu F, Xiang B, Wilcox K, Diadamo AJ, Kumar R, Pietraszkiewicz A, Halene S, Li P. Mol Cytogenet. 2011 Jan 20; 2011 Jan 20. PMID: 21251322.

2010

Serum response factor is an essential transcription factor in megakaryocytic maturation.Halene S, Gao Y, Hahn K, Massaro S, Italiano JE Jr, Schulz V, Lin S, Kupfer GM, Krause DS. Blood. 2010 Sep 16; 2010 Jun 4. PMID: 20525922.
Different roles of G protein subunits beta1 and beta2 in neutrophil function revealed by gene expression silencing in primary mouse neutrophils.Zhang Y, Tang W, Jones MC, Xu W, Halene S, Wu D. J Biol Chem. 2010 Aug 6; 2010 Jun 4. PMID: 20525682.
C/EBPepsilon directs granulocytic-vs-monocytic lineage determination and confers chemotactic function via Hlx.Halene S, Gaines P, Sun H, Zibello T, Lin S, Khanna-Gupta A, Williams SC, Perkins A, Krause D, Berliner N. Exp Hematol. 2010 Feb; 2009 Dec 5. PMID: 19925846.

1998

Consistent, persistent expression from modified retroviral vectors in murine hematopoietic stem cells.Robbins PB, Skelton DC, Yu XJ, Halene S, Leonard EH, Kohn DB. Proc Natl Acad Sci U S A. 1998 Aug 18. PMID: 9707621.

1997

Ruptured aortic pseudo-aneurysm: a rare presentation as aortocaval fistula.Pagni S, Halene S, Kwass W, Khachane V. J Cardiovasc Surg (Torino). 1997 Apr. PMID: 9201129.

Publications

Stephanie Halene's Publications

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1997