2024
Reconsidering evidence for psychedelic-induced psychosis: an overview of reviews, a systematic review, and meta-analysis of human studies
Sabé M, Sulstarova A, Glangetas A, De Pieri M, Mallet L, Curtis L, Richard-Lepouriel H, Penzenstadler L, Seragnoli F, Thorens G, Zullino D, Preller K, Böge K, Leucht S, Correll C, Solmi M, Kaiser S, Kirschner M. Reconsidering evidence for psychedelic-induced psychosis: an overview of reviews, a systematic review, and meta-analysis of human studies. Molecular Psychiatry 2024, 1-33. PMID: 39592825, DOI: 10.1038/s41380-024-02800-5.Peer-Reviewed Original ResearchRandomized-controlled trialsTreatment-resistant depressionEfficacy of psychedelicsPsychedelic-assisted therapyMeta-analysis of human studiesMeta-analytic dataOverview of reviewsMeta-analysisPre-registered protocolSystematic reviewNegative symptomsWorsen psychosisPsychotic symptomsPsychotic disordersSchizophreniaPsychosisCase-control studySymptom exacerbationPsychosis incidenceRandom-effects modelReview evidenceStandardized assessmentAssessment of study qualityCohort studyClinical trialsCorrection: Neural mechanisms of psychedelic visual imagery
Stoliker D, Preller K, Novelli L, Anticevic A, Egan G, Vollenweider F, Razi A. Correction: Neural mechanisms of psychedelic visual imagery. Molecular Psychiatry 2024, 1-1. PMID: 39572725, DOI: 10.1038/s41380-024-02818-9.Peer-Reviewed Original ResearchNew trends in the empirical study of consciousness: Measures and mechanisms
Tzovara A, Andrillon T, Preller K, Sarasso S. New trends in the empirical study of consciousness: Measures and mechanisms. European Journal Of Neuroscience 2024 PMID: 39558664, DOI: 10.1111/ejn.16606.Peer-Reviewed Original ResearchNeurobiological Correlates of Psychedelic Experiences and Psychedelic-Associated Adverse Effects
Rieser N, Schmidt T, Preller K. Neurobiological Correlates of Psychedelic Experiences and Psychedelic-Associated Adverse Effects. Current Topics In Behavioral Neurosciences 2024, 1-20. PMID: 39080245, DOI: 10.1007/7854_2024_507.Peer-Reviewed Original ResearchCortico-striato-thalamo-corticalPsychedelic experiencePathophysiology of psychiatric illnessPsychedelic drug actionEffects of psychedelicsHuman neuroimaging studiesAcute drug effectsEffects of psychedelic drugsEntropic brain hypothesisNeurobiological correlatesEgo dissolutionNeural correlatesNeurobiological mechanismsNeuroimaging studiesNeural mechanismsPsychiatric illnessPsychedelic drugsBrain hypothesisDrug effectsPET measurementsSubacute adverse effectsDrug actionGeneral effectEmotional impactLong-term adverse effectsNeural mechanisms of psychedelic visual imagery
Stoliker D, Preller K, Novelli L, Anticevic A, Egan G, Vollenweider F, Razi A. Neural mechanisms of psychedelic visual imagery. Molecular Psychiatry 2024, 1-8. PMID: 38862674, DOI: 10.1038/s41380-024-02632-3.Peer-Reviewed Original ResearchVisual association regionsVisual imageryConsistent with preclinical findingsInferior frontal gyrusSerotonergic psychedelic drugTop-down feedback connectionsFunctional MRI scansVisual areasDynamic causal modelingEffective connectivity modelsTop-down connectionsEarly visual areasFusiform gyrusFrontal gyrusClassic psychedelicsIntraparietal sulcusBehavioral measuresNeural mechanismsPsychedelic experiencePsychedelic drugsConnectivity changesAffect balancePlacebo-controlledPreclinical findingsCausal modelThe influence of psilocybin on subconscious and conscious emotional learning
Casanova A, Ort A, Smallridge J, Preller K, Seifritz E, Vollenweider F. The influence of psilocybin on subconscious and conscious emotional learning. IScience 2024, 27: 110034. PMID: 38883812, PMCID: PMC11177198, DOI: 10.1016/j.isci.2024.110034.Peer-Reviewed Original ResearchPsychedelic-assisted psychotherapyAgonist psilocybinFearful facesNeutral cuesEmotional cuesPsychiatric disordersSerotonergic psychedelicsSerotonin signalingExploratory behaviorPsilocybinEmotional learningLearning effectCuesPlacebo groupPlaceboPsychotherapyLearning rateLearningPsychedelicsSerotoninReinforcement learningDisordersTreatment modalitiesBrainTaskPsychedelics in Medicine: Can Evidence Keep Up With Enthusiasm?
de Wit H, Holze F, Preller K. Psychedelics in Medicine: Can Evidence Keep Up With Enthusiasm? Biological Psychiatry Cognitive Neuroscience And Neuroimaging 2024, 9: 460-461. PMID: 38719373, DOI: 10.1016/j.bpsc.2024.02.010.Peer-Reviewed Original ResearchKetamine induces multiple individually distinct whole-brain functional connectivity signatures
Moujaes F, Ji J, Rahmati M, Burt J, Schleifer C, Adkinson B, Savic A, Santamauro N, Tamayo Z, Diehl C, Kolobaric A, Flynn M, Rieser N, Fonteneau C, Camarro T, Xu J, Cho Y, Repovs G, Fineberg S, Morgan P, Seifritz E, Vollenweider F, Krystal J, Murray J, Preller K, Anticevic A. Ketamine induces multiple individually distinct whole-brain functional connectivity signatures. ELife 2024, 13: e84173. PMID: 38629811, PMCID: PMC11023699, DOI: 10.7554/elife.84173.Peer-Reviewed Original ResearchConceptsResponse to ketamineAcute ketamineBehavioral effectsQuantified resting-state functional connectivityEffects of acute ketamineSymptom variationResting-state functional connectivityTreatment-resistant depressionFunctional connectivity signaturesGlobal brain connectivitySingle-subject levelInter-individual variabilityPlacebo-controlled studyFunctional connectivityConnectivity signaturesBrain connectivityHealthy participantsSingle-blind placebo-controlled studyNeural variationsTreatment conditionsKetamineGene expression targetsPharmacological biomarkersPilot awardParvalbuminNeuroimaging Biomarkers for Drug Discovery and Development in Schizophrenia
Preller K, Scholpp J, Wunder A, Rosenbrock H. Neuroimaging Biomarkers for Drug Discovery and Development in Schizophrenia. Biological Psychiatry 2024, 96: 666-673. PMID: 38272287, DOI: 10.1016/j.biopsych.2024.01.009.Peer-Reviewed Original ResearchNMDA receptor hypofunctionPsychosis spectrum disordersNeuroimaging data acquisitionField of neuroimagingNegative symptomsPharmacological neuroimagingPositive symptomsReceptor hypofunctionPsychotic disordersNeuroimaging resultsSpectrum disorderNeuroimaging technologiesNeuroimaging biomarkersSchizophreniaNeuroimagingPathophysiology of symptomsDrug developmentDecades of researchTarget engagementClinical drug developmentPredictive biomarkersDisordersSymptomsHealthy volunteersDose selectionNeural Mechanisms of Resting-State Networks and the Amygdala Underlying the Cognitive and Emotional Effects of Psilocybin
Stoliker D, Novelli L, Vollenweider F, Egan G, Preller K, Razi A. Neural Mechanisms of Resting-State Networks and the Amygdala Underlying the Cognitive and Emotional Effects of Psilocybin. Biological Psychiatry 2024, 96: 57-66. PMID: 38185235, DOI: 10.1016/j.biopsych.2024.01.002.Peer-Reviewed Original ResearchCentral executive networkDefault mode networkResting-state networksEffective connectivitySalience networkNeural mechanismsAltered cognitionLarge-scale resting-state networksBasic cognitive functionsCognitive systemBehavioral measuresExecutive networkHierarchical organizationEmotional effectsMode networkCognitive functionSubcortical systemsSubjective experienceCognitionFunctional MRIPsychedelic therapyAmygdalaEmotionsHealthy adultsPsychiatric disordersKnowledge gaps in psychedelic medicalisation: Preclinical and neuroimaging mechanisms
McCulloch D, Lopez J, Dalla C, Castrén E, Erritzoe D, Frokjaer V, Lundberg J, Preller K, Fisher P, Knudsen G. Knowledge gaps in psychedelic medicalisation: Preclinical and neuroimaging mechanisms. Neuroscience Applied 2024, 3: 103929. DOI: 10.1016/j.nsa.2023.103929.Peer-Reviewed Original ResearchSerotonin 2A receptorFunctional brain activityMechanism of actionClinical effectsPreclinical modelsBrain disordersClinical neuroimagingDose optimizationNeurotransmitter releaseEffects of psychedelicsBrain activitySex differencesPsychedelic drugsMolecular mechanismsKnowledge gapsPsychedelicsAppropriate behavioral modelsPreclinicalNeuroimagingReceptorsAmygdala response to emotional faces following acute administration of psilocybin in healthy individuals
Armand S, Larsen K, Madsen M, Ozenne B, Preller K, Knudsen G, Stenbæk D, Fisher P. Amygdala response to emotional faces following acute administration of psilocybin in healthy individuals. Neuroscience Applied 2024, 3: 103934. DOI: 10.1016/j.nsa.2023.103934.Peer-Reviewed Original ResearchPlasma psilocin levelsFunctional magnetic resonance imagingAmygdala reactivityHealthy individualsAmygdala responseMagnetic resonance imagingAcute administrationDrug intensityAcute exposureTherapeutic outcomesResonance imagingSignificant associationBrain regionsPsychedelic psilocybinPsilocybinBaselineFuture studiesSignificant changesExposureFearful facesEmotion processingResponseIndividualsAdministration
2023
Investigating functional brain connectivity patterns associated with two hypnotic states
de Matos N, Staempfli P, Seifritz E, Preller K, Bruegger M. Investigating functional brain connectivity patterns associated with two hypnotic states. Frontiers In Human Neuroscience 2023, 17: 1286336. PMID: 38192504, PMCID: PMC10773817, DOI: 10.3389/fnhum.2023.1286336.Peer-Reviewed Original ResearchLingual gyrusFunctional brain connectivity patternsConnectivity changesUnbiased whole-brain analysesFunctional connectivity changesRegion-specific increaseFunctional connectivity patternsWhole-brain analysisBrain connectivity patternsConnectivity patternsHypnotic stateOccipital cortexOccipital poleClinical successTemporal areaNeural hubPlanum temporaleSupramarginal gyrusVoxel analysisGyrusFMRI studyNeurobiological underpinningsControl conditionHypnosis stateHypnosisNeural correlates of an altered state of consciousness in patients with alcohol use disorder
Rieser N, Kreis Y, Vollenweider F, Herdener M, Preller K. Neural correlates of an altered state of consciousness in patients with alcohol use disorder. Neuroscience Applied 2023, 2: 103411. DOI: 10.1016/j.nsa.2023.103411.Peer-Reviewed Original ResearchN-acetylcysteine modulates prefrontal response to cocaine cues
Engeli E, Preller K, Rieser N, Klar J, Zoelch N, Hock A, Staempfli P, Hulka L, Kirschner M, Seifritz E, Quednow B, Herdener M. N-acetylcysteine modulates prefrontal response to cocaine cues. Neuroscience Applied 2023, 2: 103414. DOI: 10.1016/j.nsa.2023.103414.Peer-Reviewed Original ResearchDoes serotonin system stimulation increase pro-social behavior? A comparative pharmacological neuroscientific study in healthy humans
Belinger L, Engeli E, Rieser N, Becciolini L, Herdener M, Preller K. Does serotonin system stimulation increase pro-social behavior? A comparative pharmacological neuroscientific study in healthy humans. Neuroscience Applied 2023, 2: 102589. DOI: 10.1016/j.nsa.2023.102589.Peer-Reviewed Original Research