Insults to DNC in Mental Illness
Schizophrenia: Genetic Insults and Layer III of dlPFC
Many layer III dlPFC DNC proteins are genetically altered in schizophrenia, and/or have documented changes in expression. A number of proteins that normally serve to strengthen synaptic efficacy, e.g. by regulating Ca2+-cAMP signaling, are lost or weakened in schizophrenia, while those molecules that decrease PFC network connectivity by activating Ca2+-cAMP signaling are often increased in the dlPFC of patients with schizophrenia.
If you are interested: Arnsten AFT, Wang MJ, Paspalas CD (2012) Neuromodulation of thought: Flexibilities and vulnerabilities in prefrontal cortical network synapses. Neuron 76: 223-239.
- Genetic Insults
- Relevance to Treatment
Genetic Insults to Molecules that Inhibit the Stress Response
If you are interested: Arnsten and Manji(2008) Mania: A rational neurobiology. Future Neurology 3: 125-131. Arnsten (2011) Prefrontal cortical network connections: key site of vulnerability in stress and schizophrenia. Int J Dev Neuro. 29: 215-23.