Sampling of Recent Publications

• Comparison of [(11)C]UCB-J and [(18)F]FDG PET in Alzheimer's disease: A tracer kinetic modeling study.Chen MK, Mecca AP, Naganawa M, Gallezot JD, Toyonaga T, Mondal J, Finnema SJ, Lin SF, O'Dell RS, McDonald JW, Michalak HR, Vander Wyk B, Nabulsi NB, Huang Y, Arnsten AF, van Dyck CH, Carson RE. J Cereb Blood Flow Metab. 2021 Sep; 2021 Mar 24. PMID: 33757318.
• M1 receptors interacting with NMDAR enhance delay-related neuronal firing and improve working memory performance.Galvin VC, Yang S, Lowet AS, Datta D, Duque A, Arnsten AF, Wang M. Curr Res Neurobiol. 2021; 2021 Jul 12. PMID: 35098156.
• Nicotinic α4β2 Cholinergic Receptor Influences on Dorsolateral Prefrontal Cortical Neuronal Firing during a Working Memory Task.Sun Y, Yang Y, Galvin VC, Yang S, Arnsten AF, Wang M. J Neurosci. 2017 May 24; 2017 Apr 27. PMID: 28450546.
• Novel Dopamine Therapeutics for Cognitive Deficits in Schizophrenia.Arnsten AF, Girgis RR, Gray DL, Mailman RB. Biol Psychiatry. 2017 Jan 1; 2016 Jan 18. PMID: 26946382.
• Ketamine's Antidepressant Actions: Potential Mechanisms in the Primate Medial Prefrontal Circuits That Represent Aversive Experience.Arnsten AF, Murray JD, Seo H, Lee D. Biol Psychiatry. 2016 May 1. PMID: 27079495.
• Ameliorating treatment-refractory depression with intranasal ketamine: potential NMDA receptor actions in the pain circuitry representing mental anguish.Opler LA, Opler MG, Arnsten AF. CNS Spectr. 2016 Feb; 2015 Jan 26. PMID: 25619798.
• Glutamate and norepinephrine interaction: Relevance to higher cognitive operations and psychopathology.Abdallah CG, Averill LA, Krystal JH, Southwick SM, Arnsten AF. Behav Brain Sci. 2016 Jan. PMID: 28347382.
• Targeting Prefrontal Cortical Systems for Drug Development: Potential Therapies for Cognitive Disorders.Arnsten AF, Wang M. Annu Rev Pharmacol Toxicol. 2016. PMID: 26738476.
• Stress Impairs Prefrontal Cortical Function via D1 Dopamine Receptor Interactions With Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels.Gamo NJ, Lur G, Higley MJ, Wang M, Paspalas CD, Vijayraghavan S, Yang Y, Ramos BP, Peng K, Kata A, Boven L, Lin F, Roman L, Lee D, Arnsten AF. Biol Psychiatry. 2015 Dec 15; 2015 Feb 4. PMID: 25731884.
• Physiological approaches to understanding molecular actions on dorsolateral prefrontal cortical neurons underlying higher cognitive processing.Wang M, Arnsten AF. Dongwuxue Yanjiu. 2015 Nov 18. PMID: 26646567.
• Stress weakens prefrontal networks: molecular insults to higher cognition.Arnsten AF. Nat Neurosci. 2015 Oct; 2015 Sep 25. PMID: 26404712.
• Dopamine's Actions in Primate Prefrontal Cortex: Challenges for Treating Cognitive Disorders.Arnsten AF, Wang M, Paspalas CD. Pharmacol Rev. 2015 Jul. PMID: 26106146.
• An Update on Posttraumatic Stress Disorder in Children and Adolescents.Connor DF, Ford JD, Arnsten AF, Greene CA. Clin Pediatr (Phila). 2015 Jun; 2014 Jul 2. PMID: 24990362.
• Contribution of NMDA receptors to dorsolateral prefrontal cortical networks in primates.Wang M, Arnsten AF. Neurosci Bull. 2015 Apr; 2015 Mar 9. PMID: 25754145.
• A translational investigation targeting stress-reactivity and prefrontal cognitive control with guanfacine for smoking cessation.McKee SA, Potenza MN, Kober H, Sofuoglu M, Arnsten AF, Picciotto MR, Weinberger AH, Ashare R, Sinha R. J Psychopharmacol. 2015 Mar; 2014 Dec 16. PMID: 25516371.
• Chronic Stimulation of Alpha-2A-Adrenoceptors With Guanfacine Protects Rodent Prefrontal Cortex Dendritic Spines and Cognition From the Effects of Chronic Stress.Hains AB, Yabe Y, Arnsten AF. Neurobiol Stress. 2015. PMID: 25664335.
• The Effects of Stress Exposure on Prefrontal Cortex: Translating Basic Research into Successful Treatments for Post-Traumatic Stress Disorder.Arnsten AF, Raskind MA, Taylor FB, Connor DF. Neurobiol Stress. 2015 Jan 1. PMID: 25436222.
• Disrupted in schizophrenia 1 modulates medial prefrontal cortex pyramidal neuron activity through cAMP regulation of transient receptor potential C and small-conductance K+ channels.El-Hassar L, Simen AA, Duque A, Patel KD, Kaczmarek LK, Arnsten AF, Yeckel MF. Biol Psychiatry. 2014 Sep 15; 2014 Jan 20. PMID: 24560582.
• Guanfacine extended release for the treatment of attention-deficit/hyperactivity disorder in children and adolescents.Connor DF, Arnsten AF, Pearson GS, Greco GF. Expert Opin Pharmacother. 2014 Aug; 2014 Jul 3. PMID: 24992513.
• cAMP-PKA phosphorylation of tau confers risk for degeneration in aging association cortex.Carlyle BC, Nairn AC, Wang M, Yang Y, Jin LE, Simen AA, Ramos BP, Bordner KA, Craft GE, Davies P, Pletikos M, Šestan N, Arnsten AF, Paspalas CD. Proc Natl Acad Sci U S A. 2014 Apr 1; 2014 Mar 18. PMID: 24707050.
• Molecular influences on working memory circuits in dorsolateral prefrontal cortex.Arnsten AF, Jin LE. Prog Mol Biol Transl Sci. 2014. PMID: 24484703.
• Role of disrupted in schizophrenia 1 (DISC1) in stress-induced prefrontal cognitive dysfunction.Gamo NJ, Duque A, Paspalas CD, Kata A, Fine R, Boven L, Bryan C, Lo T, Anighoro K, Bermudez L, Peng K, Annor A, Raja A, Mansson E, Taylor SR, Patel K, Simen AA, Arnsten AF. Transl Psychiatry. 2013 Dec 3; 2013 Dec 3. PMID: 24301646.
• Psychostimulants and motivated behavior: arousal and cognition.Berridge CW, Arnsten AF. Neurosci Biobehav Rev. 2013 Nov; 2012 Nov 16. PMID: 23164814.
• The neurobiology of thought: the groundbreaking discoveries of Patricia Goldman-Rakic 1937-2003.Arnsten AF. Cereb Cortex. 2013 Oct; 2013 Aug 7. PMID: 23926115.
• Nicotinic α7 receptors enhance NMDA cognitive circuits in dorsolateral prefrontal cortex.Yang Y, Paspalas CD, Jin LE, Picciotto MR, Arnsten AF, Wang M. Proc Natl Acad Sci U S A. 2013 Jul 16; 2013 Jul 1. PMID: 23818597.
• Constellation of HCN channels and cAMP regulating proteins in dendritic spines of the primate prefrontal cortex: potential substrate for working memory deficits in schizophrenia.Paspalas CD, Wang M, Arnsten AF. Cereb Cortex. 2013 Jul; 2012 Jun 12. PMID: 22693343.
• NMDA receptors subserve persistent neuronal firing during working memory in dorsolateral prefrontal cortex.Wang M, Yang Y, Wang CJ, Gamo NJ, Jin LE, Mazer JA, Morrison JH, Wang XJ, Arnsten AF. Neuron. 2013 Feb 20. PMID: 23439125.
• Noradrenergic control of error perseveration in medial prefrontal cortex.Caetano MS, Jin LE, Harenberg L, Stachenfeld KL, Arnsten AF, Laubach M. Front Integr Neurosci. 2012; 2013 Jan 2. PMID: 23293590.
• Neuromodulation of thought: flexibilities and vulnerabilities in prefrontal cortical network synapses.Arnsten AF, Wang MJ, Paspalas CD. Neuron. 2012 Oct 4. PMID: 23040817.
• Neurobiological circuits regulating attention, cognitive control, motivation, and emotion: disruptions in neurodevelopmental psychiatric disorders.Arnsten AF, Rubia K. J Am Acad Child Adolesc Psychiatry. 2012 Apr; 2012 Mar 3. PMID: 22449642.
• Lost in transition: aging-related changes in executive control by the medial prefrontal cortex.Caetano MS, Horst NK, Harenberg L, Liu B, Arnsten AF, Laubach M. J Neurosci. 2012 Mar 14. PMID: 22423097.
• Guanfacine for the treatment of cognitive disorders: a century of discoveries at Yale.Arnsten AF, Jin LE. Yale J Biol Med. 2012 Mar; 2012 Mar 29. PMID: 22461743.
• Effects of α-2A adrenergic receptor agonist on time and risk preference in primates.Kim S, Bobeica I, Gamo NJ, Arnsten AF, Lee D. Psychopharmacology (Berl). 2012 Jan; 2011 Oct 7. PMID: 21979441.
• Catecholamine influences on prefrontal cortical function: relevance to treatment of attention deficit/hyperactivity disorder and related disorders.Arnsten AF, Pliszka SR. Pharmacol Biochem Behav. 2011 Aug; 2011 Feb 2. PMID: 21295057.
• Neuronal basis of age-related working memory decline.Wang M, Gamo NJ, Yang Y, Jin LE, Wang XJ, Laubach M, Mazer JA, Lee D, Arnsten AF. Nature. 2011 Jul 27; 2011 Jul 27. PMID: 21796118.
• Prefrontal cortical organization and function: implications for externalizing disorders.Arnsten AF, Casey BJ. Biol Psychiatry. 2011 Jun 15. PMID: 21640860.
• Catecholamine influences on dorsolateral prefrontal cortical networks.Arnsten AF. Biol Psychiatry. 2011 Jun 15; 2011 Apr 13. PMID: 21489408.
• Molecular modulation of prefrontal cortex: rational development of treatments for psychiatric disorders.Gamo NJ, Arnsten AF. Behav Neurosci. 2011 Jun. PMID: 21480691.
• Prefrontal cortical network connections: key site of vulnerability in stress and schizophrenia.Arnsten AF. Int J Dev Neurosci. 2011 May; 2011 Feb 21. PMID: 21345366.
• The use of α-2A adrenergic agonists for the treatment of attention-deficit/hyperactivity disorder.Arnsten AF. Expert Rev Neurother. 2010 Oct. PMID: 20925474.
• Methylphenidate and atomoxetine enhance prefrontal function through α2-adrenergic and dopamine D1 receptors.Gamo NJ, Wang M, Arnsten AF. J Am Acad Child Adolesc Psychiatry. 2010 Oct; 2010 Sep 1. PMID: 20855046.
• Dynamic Network Connectivity: A new form of neuroplasticity.Arnsten AF, Paspalas CD, Gamo NJ, Yang Y, Wang M. Trends Cogn Sci. 2010 Aug; 2010 Jun 16. PMID: 20554470.
• Inhibition of protein kinase C signaling protects prefrontal cortex dendritic spines and cognition from the effects of chronic stress.Hains AB, Vu MA, Maciejewski PK, van Dyck CH, Gottron M, Arnsten AF. Proc Natl Acad Sci U S A. 2009 Oct 20; 2009 Sep 11. PMID: 19805148.
• Mapping the regulator of G protein signaling 4 (RGS4): presynaptic and postsynaptic substrates for neuroregulation in prefrontal cortex.Paspalas CD, Selemon LD, Arnsten AF. Cereb Cortex. 2009 Sep; 2009 Jan 19. PMID: 19153107.
• Estrogen prevents norepinephrine alpha-2a receptor reversal of stress-induced working memory impairment.Shansky RM, Bender G, Arnsten AF. Stress. 2009 Sep. PMID: 19005873.
• Stress signalling pathways that impair prefrontal cortex structure and function.Arnsten AF. Nat Rev Neurosci. 2009 Jun. PMID: 19455173.
• The Emerging Neurobiology of Attention Deficit Hyperactivity Disorder: The Key Role of the Prefrontal Association Cortex.Arnsten AF. J Pediatr. 2009 May 1. PMID: 20596295.
• Protein kinase C activity is associated with prefrontal cortical decline in aging.Brennan AR, Yuan P, Dickstein DL, Rocher AB, Hof PR, Manji H, Arnsten AF. Neurobiol Aging. 2009 May; 2007 Oct 4. PMID: 17919783.
• Primate models of schizophrenia: future possibilities.Simen AA, DiLeone R, Arnsten AF. Prog Brain Res. 2009; 2009 Nov 20. PMID: 20302824.
• Toward a new understanding of attention-deficit hyperactivity disorder pathophysiology: an important role for prefrontal cortex dysfunction.Arnsten AF. CNS Drugs. 2009. PMID: 19621976.
• The neuropsychopharmacology of fronto-executive function: monoaminergic modulation.Robbins TW, Arnsten AF. Annu Rev Neurosci. 2009. PMID: 19555290.
• Ameliorating prefrontal cortical dysfunction in mental illness: inhibition of phosphotidyl inositol-protein kinase C signaling.Arnsten AF. Psychopharmacology (Berl). 2009 Jan; 2008 Aug 22. PMID: 18719894.
• Genetic variants of Nogo-66 receptor with possible association to schizophrenia block myelin inhibition of axon growth.Budel S, Padukkavidana T, Liu BP, Feng Z, Hu F, Johnson S, Lauren J, Park JH, McGee AW, Liao J, Stillman A, Kim JE, Yang BZ, Sodi S, Gelernter J, Zhao H, Hisama F, Arnsten AF, Strittmatter SM. J Neurosci. 2008 Dec 3. PMID: 19052207.
• Molecular mechanisms of stress-induced prefrontal cortical impairment: implications for mental illness.Hains AB, Arnsten AF. Learn Mem. 2008 Aug; 2008 Aug 6. PMID: 18685145.
• Striatal dopamine transporters correlate with simple reaction time in elderly subjects.van Dyck CH, Avery RA, MacAvoy MG, Marek KL, Quinlan DM, Baldwin RM, Seibyl JP, Innis RB, Arnsten AF. Neurobiol Aging. 2008 Aug; 2007 Mar 23. PMID: 17363113.
• Beta2 adrenergic agonist, clenbuterol, enhances working memory performance in aging animals.Ramos BP, Colgan LA, Nou E, Arnsten AF. Neurobiol Aging. 2008 Jul; 2007 Mar 23. PMID: 17363115.
• Blockade of IP3-mediated SK channel signaling in the rat medial prefrontal cortex improves spatial working memory.Brennan AR, Dolinsky B, Vu MA, Stanley M, Yeckel MF, Arnsten AF. Learn Mem. 2008 Mar; 2008 Feb 19. PMID: 18285467.
• Neuronal mechanisms underlying attention deficit hyperactivity disorder: the influence of arousal on prefrontal cortical function.Brennan AR, Arnsten AF. Ann N Y Acad Sci. 2008. PMID: 18591484.
• Catecholamine and second messenger influences on prefrontal cortical networks of "representational knowledge": a rational bridge between genetics and the symptoms of mental illness.Arnsten AF. Cereb Cortex. 2007 Sep; 2007 Apr 13. PMID: 17434919.
• alpha2-Adrenergic receptor agonists for the treatment of attention-deficit/hyperactivity disorder: emerging concepts from new data.Arnsten AF, Scahill L, Findling RL. J Child Adolesc Psychopharmacol. 2007 Aug. PMID: 17822336.
• Alpha2A-adrenoceptors strengthen working memory networks by inhibiting cAMP-HCN channel signaling in prefrontal cortex.Wang M, Ramos BP, Paspalas CD, Shu Y, Simen A, Duque A, Vijayraghavan S, Brennan A, Dudley A, Nou E, Mazer JA, McCormick DA, Arnsten AF. Cell. 2007 Apr 20. PMID: 17448997.
• Adrenergic pharmacology and cognition: focus on the prefrontal cortex.Ramos BP, Arnsten AF. Pharmacol Ther. 2007 Mar; 2006 Dec 28. PMID: 17303246.
• Inverted-U dopamine D1 receptor actions on prefrontal neurons engaged in working memory.Vijayraghavan S, Wang M, Birnbaum SG, Williams GV, Arnsten AF. Nat Neurosci. 2007 Mar; 2007 Feb 4. PMID: 17277774.
• Methylphenidate preferentially increases catecholamine neurotransmission within the prefrontal cortex at low doses that enhance cognitive function.Berridge CW, Devilbiss DM, Andrzejewski ME, Arnsten AF, Kelley AE, Schmeichel B, Hamilton C, Spencer RC. Biol Psychiatry. 2006 Nov 15; 2006 Jun 23. PMID: 16806100.
• Alpha2A-adrenoceptor stimulation improves prefrontal cortical regulation of behavior through inhibition of cAMP signaling in aging animals.Ramos BP, Stark D, Verduzco L, van Dyck CH, Arnsten AF. Learn Mem. 2006 Nov-Dec; 2006 Nov 13. PMID: 17101879.
• Stimulants: Therapeutic actions in ADHD.Arnsten AF. Neuropsychopharmacology. 2006 Nov; 2006 Jul 19. PMID: 16855530.
• Staying in touch with methylphenidate: AHDH and sensory processing. Focus on "methylphenidate enhances noradrenergic transmission and suppresses mid- and long-latency sensory responses in the primary somatosensory cortex of awake rats".Arnsten AF, Vijayraghavan S. J Neurophysiol. 2006 Aug. PMID: 16835361.
• The effects of sex and hormonal status on restraint-stress-induced working memory impairment.Shansky RM, Rubinow K, Brennan A, Arnsten AF. Behav Brain Funct. 2006 Mar 7; 2006 Mar 7. PMID: 16522198.
• Fundamentals of attention-deficit/hyperactivity disorder: circuits and pathways.Arnsten AF. J Clin Psychiatry. 2006. PMID: 16961424.
• New developments in the treatment of ADHD.Biederman J, Arnsten AF, Faraone SV, Doyle AE, Spencer TJ, Wilens TE, Weiss MD, Safren SA, Culpepper L. J Clin Psychiatry. 2006 Jan. PMID: 16426101.
• The beta-1 adrenergic antagonist, betaxolol, improves working memory performance in rats and monkeys.Ramos BP, Colgan L, Nou E, Ovadia S, Wilson SR, Arnsten AF. Biol Psychiatry. 2005 Dec 1; 2005 Jul 25. PMID: 16043136.
• Neurobiology of executive functions: catecholamine influences on prefrontal cortical functions.Arnsten AF, Li BM. Biol Psychiatry. 2005 Jun 1. PMID: 15950011.
• Methylphenidate improves prefrontal cortical cognitive function through alpha2 adrenoceptor and dopamine D1 receptor actions: Relevance to therapeutic effects in Attention Deficit Hyperactivity Disorder.Arnsten AF, Dudley AG. Behav Brain Funct. 2005 Apr 22; 2005 Apr 22. PMID: 15916700.
• Protein kinase A as a therapeutic target for memory disorders: rationale and challenges.Arnsten AF, Ramos BP, Birnbaum SG, Taylor JR. Trends Mol Med. 2005 Mar. PMID: 15760770.
• Locomotor hyperactivity induced by blockade of prefrontal cortical alpha2-adrenoceptors in monkeys.Ma CL, Arnsten AF, Li BM. Biol Psychiatry. 2005 Jan 15. PMID: 15652880.
• Protein kinase C overactivity impairs prefrontal cortical regulation of working memory.Birnbaum SG, Yuan PX, Wang M, Vijayraghavan S, Bloom AK, Davis DJ, Gobeske KT, Sweatt JD, Manji HK, Arnsten AF. Science. 2004 Oct 29. PMID: 15514161.
• Adolescence: vulnerable period for stress-induced prefrontal cortical function? Introduction to part IV.Arnsten AF, Shansky RM. Ann N Y Acad Sci. 2004 Jun. PMID: 15251883.
• Adrenergic targets for the treatment of cognitive deficits in schizophrenia.Arnsten AF. Psychopharmacology (Berl). 2004 Jun; 2003 Dec 19. PMID: 15205875.
• Estrogen mediates sex differences in stress-induced prefrontal cortex dysfunction.Shansky RM, Glavis-Bloom C, Lerman D, McRae P, Benson C, Miller K, Cosand L, Horvath TL, Arnsten AF. Mol Psychiatry. 2004 May. PMID: 14569273.
• Dysregulation of protein kinase a signaling in the aged prefrontal cortex: new strategy for treating age-related cognitive decline.Ramos BP, Birnbaum SG, Lindenmayer I, Newton SS, Duman RS, Arnsten AF. Neuron. 2003 Nov 13. PMID: 14622586.
• D1 dopamine receptors in the mouse prefrontal cortex: Immunocytochemical and cognitive neuropharmacological analyses.Lidow MS, Koh PO, Arnsten AF. Synapse. 2003 Feb. PMID: 12454947.
• Mutation of the alpha2A-adrenoceptor impairs working memory performance and annuls cognitive enhancement by guanfacine.Franowicz JS, Kessler LE, Borja CM, Kobilka BK, Limbird LE, Arnsten AF. J Neurosci. 2002 Oct 1. PMID: 12351753.
• Actions of alpha-2 noradrenergic agonists on spatial working memory and blood pressure in rhesus monkeys appear to be mediated by the same receptor subtype.Franowicz JS, Arnsten AF. Psychopharmacology (Berl). 2002 Jul; 2002 Jun 13. PMID: 12122489.
• A placebo-controlled study of guanfacine in the treatment of children with tic disorders and attention deficit hyperactivity disorder.Scahill L, Chappell PB, Kim YS, Schultz RT, Katsovich L, Shepherd E, Arnsten AF, Cohen DJ, Leckman JF. Am J Psychiatry. 2001 Jul. PMID: 11431228.
• Modulation of prefrontal cortical-striatal circuits: relevance to therapeutic treatments for Tourette syndrome and attention-deficit hyperactivity disorder.Arnsten AF. Adv Neurol. 2001. PMID: 11530441.
• Noradrenergic alpha-2 receptor agonists reverse working memory deficits induced by the anxiogenic drug, FG7142, in rats.Birnbaum SG, Podell DM, Arnsten AF. Pharmacol Biochem Behav. 2000 Nov. PMID: 11164065.
• The selective dopamine D4 receptor antagonist, PNU-101387G, prevents stress-induced cognitive deficits in monkeys.Arnsten AF, Murphy B, Merchant K. Neuropsychopharmacology. 2000 Oct. PMID: 10989267.
• Genetics of childhood disorders: XVIII. ADHD, Part. 2: Norepinephrine has a critical modulatory influence on prefrontal cortical function.Arnsten AF. J Am Acad Child Adolesc Psychiatry. 2000 Sep. PMID: 10986819.
• The alpha-2A-adrenoceptor agonist, guanfacine, increases regional cerebral blood flow in dorsolateral prefrontal cortex of monkeys performing a spatial working memory task.Avery RA, Franowicz JS, Studholme C, van Dyck CH, Arnsten AF. Neuropsychopharmacology. 2000 Sep. PMID: 10942848.
• Use of guanfacine to control self-injurious behavior in two rhesus macaques (Macaca mulatta) and one baboon (Papio anubis).Macy JD Jr, Beattie TA, Morgenstern SE, Arnsten AF. Comp Med. 2000 Aug. PMID: 11020162.
• Stress impairs prefrontal cortical function in rats and monkeys: role of dopamine D1 and norepinephrine alpha-1 receptor mechanisms.Arnsten AF. Prog Brain Res. 2000. PMID: 11105647.
• Through the looking glass: differential noradenergic modulation of prefrontal cortical function.Arnsten AF. Neural Plast. 2000. PMID: 10709220.
• A role for norepinephrine in stress-induced cognitive deficits: alpha-1-adrenoceptor mediation in the prefrontal cortex.Birnbaum S, Gobeske KT, Auerbach J, Taylor JR, Arnsten AF. Biol Psychiatry. 1999 Nov 1. PMID: 10560032.
• Local infusion of an alpha-1 adrenergic agonist into the prefrontal cortex impairs spatial working memory performance in monkeys.Mao ZM, Arnsten AF, Li BM. Biol Psychiatry. 1999 Nov 1. PMID: 10560031.
• Treatment with the noradrenergic alpha-2 agonist clonidine, but not diazepam, improves spatial working memory in normal young rhesus monkeys.Franowicz JS, Arnsten AF. Neuropsychopharmacology. 1999 Nov. PMID: 10516957.
• Activation of cAMP-dependent protein kinase A in prefrontal cortex impairs working memory performance.Taylor JR, Birnbaum S, Ubriani R, Arnsten AF. J Neurosci. 1999 Sep 15. PMID: 10479716.
• Development of the cerebral cortex: XIV. Stress impairs prefrontal cortical function.Arnsten AF. J Am Acad Child Adolesc Psychiatry. 1999 Feb. PMID: 9951224.
• [Roles of alpha-2 adrenoceptor in prefrontal cortical cognitive functions].Mao ZM, Li BM, Arnsten AF. Sheng Li Ke Xue Jin Zhan. 1999 Jan. PMID: 12532843.
• Alpha-1 noradrenergic receptor stimulation impairs prefrontal cortical cognitive function.Arnsten AF, Mathew R, Ubriani R, Taylor JR, Li BM. Biol Psychiatry. 1999 Jan 1. PMID: 9894572.
• Catecholamine modulation of prefrontal cortical cognitive function.Arnsten AF. Trends Cogn Sci. 1998 Nov 1. PMID: 21227275.
• The biology of being frazzled.Arnsten AF. Science. 1998 Jun 12. PMID: 9660710.
• Noise stress impairs prefrontal cortical cognitive function in monkeys: evidence for a hyperdopaminergic mechanism.Arnsten AF, Goldman-Rakic PS. Arch Gen Psychiatry. 1998 Apr. PMID: 9554432.
• The alpha-2a noradrenergic agonist, guanfacine, improves delayed response performance in young adult rhesus monkeys.Franowicz JS, Arnsten AF. Psychopharmacology (Berl). 1998 Mar. PMID: 9537677.
• Noradrenergic influences on prefrontal cortical cognitive function: opposing actions at postjunctional alpha 1 versus alpha 2-adrenergic receptors.Arnsten AF, Steere JC, Jentsch DJ, Li BM. Adv Pharmacol. 1998. PMID: 9328010.
• Supranormal stimulation of D1 dopamine receptors in the rodent prefrontal cortex impairs spatial working memory performance.Zahrt J, Taylor JR, Mathew RG, Arnsten AF. J Neurosci. 1997 Nov 1. PMID: 9334425.
• The alpha-2A noradrenergic receptor agonist guanfacine improves visual object discrimination reversal performance in aged rhesus monkeys.Steere JC, Arnsten AF. Behav Neurosci. 1997 Oct. PMID: 9383511.
• Dose-dependent effects of the dopamine D1 receptor agonists A77636 or SKF81297 on spatial working memory in aged monkeys.Cai JX, Arnsten AF. J Pharmacol Exp Ther. 1997 Oct. PMID: 9336323.
• The alpha-1 adrenergic agonist, cirazoline, impairs spatial working memory performance in aged monkeys.Arnsten AF, Jentsch JD. Pharmacol Biochem Behav. 1997 Sep. PMID: 9264070.
• The acetylcholine releaser linopirdine increases parietal regional cerebral blood flow in Alzheimer's disease.van Dyck CH, Lin CH, Robinson R, Cellar J, Smith EO, Nelson JC, Arnsten AF, Hoffer PB. Psychopharmacology (Berl). 1997 Aug. PMID: 9292621.
• Clozapine reverses the spatial working memory deficits induced by FG7142 in monkeys.Murphy BL, Roth RH, Arnsten AF. Neuropsychopharmacology. 1997 Jun. PMID: 9165499.
• Pathogenesis of Tourette's syndrome.Leckman JF, Peterson BS, Anderson GM, Arnsten AF, Pauls DL, Cohen DJ. J Child Psychol Psychiatry. 1997 Jan. PMID: 9232461.
• Catecholamine regulation of the prefrontal cortex.Arnsten AF. J Psychopharmacol. 1997. PMID: 9208378.
• The effects of 5-HT3 receptor antagonists on cognitive performance in aged monkeys.Arnsten AF, Lin CH, Van Dyck CH, Stanhope KJ. Neurobiol Aging. 1997 Jan-Feb. PMID: 8983029.
• Dopamine and spatial working memory in rats and monkeys: pharmacological reversal of stress-induced impairment.Murphy BL, Arnsten AF, Jentsch JD, Roth RH. J Neurosci. 1996 Dec 1. PMID: 8922432.
• The contribution of alpha 2-noradrenergic mechanisms of prefrontal cortical cognitive function. Potential significance for attention-deficit hyperactivity disorder.Arnsten AF, Steere JC, Hunt RD. Arch Gen Psychiatry. 1996 May. PMID: 8624188.
• Increased dopamine turnover in the prefrontal cortex impairs spatial working memory performance in rats and monkeys.Murphy BL, Arnsten AF, Goldman-Rakic PS, Roth RH. Proc Natl Acad Sci U S A. 1996 Feb 6. PMID: 8577763.
• Corpus callosum morphology in ADHD.Steere JC, Arnsten AF. Am J Psychiatry. 1995 Jul. PMID: 7793463.
• Dopamine D2 receptor mechanisms contribute to age-related cognitive decline: the effects of quinpirole on memory and motor performance in monkeys.Arnsten AF, Cai JX, Steere JC, Goldman-Rakic PS. J Neurosci. 1995 May. PMID: 7751922.
• An open trial of guanfacine in the treatment of attention-deficit hyperactivity disorder.Hunt RD, Arnsten AF, Asbell MD. J Am Acad Child Adolesc Psychiatry. 1995 Jan. PMID: 7860456.
• Dopamine D1 receptor mechanisms in the cognitive performance of young adult and aged monkeys.Arnsten AF, Cai JX, Murphy BL, Goldman-Rakic PS. Psychopharmacology (Berl). 1994 Oct. PMID: 7862943.
• Catecholamine mechanisms in age-related cognitive decline.Arnsten AF. Neurobiol Aging. 1993 Nov-Dec. PMID: 7905190.
• Postsynaptic alpha-2 receptor stimulation improves memory in aged monkeys: indirect effects of yohimbine versus direct effects of clonidine.Arnsten AF, Cai JX. Neurobiol Aging. 1993 Nov-Dec. PMID: 7905189.
• Noradrenergic modulation of cognitive function: clinical implications of anatomical, electrophysiological and behavioural studies in animal models.Berridge CW, Arnsten AF, Foote SL. Psychol Med. 1993 Aug. PMID: 8234565.
• Alpha-2 adrenergic agonists decrease distractibility in aged monkeys performing the delayed response task.Arnsten AF, Contant TA. Psychopharmacology (Berl). 1992. PMID: 1357704.
• Behavioral and receptor binding analysis of the alpha 2-adrenergic agonist, 5-bromo-6 [2-imidazoline-2-yl amino] quinoxaline (UK-14304): evidence for cognitive enhancement at an alpha 2-adrenoceptor subtype.Arnsten AF, Leslie FM. Neuropharmacology. 1991 Dec. PMID: 1686301.
• Analysis of alpha-2 adrenergic agonist effects on the delayed nonmatch-to-sample performance of aged rhesus monkeys.Arnsten AF, Goldman-Rakic PS. Neurobiol Aging. 1990 Nov-Dec. PMID: 1980719.
• The alpha-2 adrenergic agonist guanfacine improves memory in aged monkeys without sedative or hypotensive side effects: evidence for alpha-2 receptor subtypes.Arnsten AF, Cai JX, Goldman-Rakic PS. J Neurosci. 1988 Nov. PMID: 2903226.
• Noradrenergic mechanisms in age-related cognitive decline.Arnsten AF, Goldman-Rakic PS. J Neural Transm Suppl. 1987. PMID: 2824692.
• Alpha 2-adrenergic mechanisms in prefrontal cortex associated with cognitive decline in aged nonhuman primates.Arnsten AF, Goldman-Rakic PS. Science. 1985 Dec 13. PMID: 2999977.
• Stress produces opioid-like effects on investigatory behavior.Arnsten AF, Berridge C, Segal DS. Pharmacol Biochem Behav. 1985 May. PMID: 4011639.
• Catecholamines and cognitive decline in aged nonhuman primates.Arnsten AF, Goldman-Rakic PS. Ann N Y Acad Sci. 1985. PMID: 3925850.
• Naloxone increases electrophysiological measures of selective information processing in humans.Arnsten AF, Neville HJ, Hillyard SA, Janowsky DS, Segal DS. J Neurosci. 1984 Dec. PMID: 6502211.
• Selective prefrontal cortical projections to the region of the locus coeruleus and raphe nuclei in the rhesus monkey.Arnsten AF, Goldman-Rakic PS. Brain Res. 1984 Jul 23. PMID: 6466989.
• Naloxone augments electrophysiological signs of selective attention in man.Arnsten AF, Segal DS, Neville HJ, Hillyard SA, Janowsky DS, Judd LL, Bloom FE. Nature. 1983 Aug 25-31. PMID: 6888538.
• Evidence for an interaction of opioid and noradrenergic locus coeruleus systems in the regulation of environmental stimulus-directed behavior.Arnsten AF, Segal DS, Loughlin SE, Roberts DC. Brain Res. 1981 Oct 19. PMID: 7284783.