Parental Age Linked to Increased Autism Spectrum Disorder Risk in Children
In a recent study published in JAMA Network Open, “Association of Grandparental and Parental Age at Childbirth With Autism Spectrum Disorder in Children,” a Yale researcher, Dr. Zeyan Liew, and collaborators, investigated ages of parents and grandparents to estimate associations for increased risk for autism spectrum disorders in children using data from health registries available in Denmark. Advanced parental ages have been associated with autism spectrum disorders in children, but scientists are trying to understand the mechanisms to explain the associations. Dr. Liew, from the Yale Center for Perinatal, Pediatric and Environmental Epidemiology, suggested that the age of grandparents at the time of the birth of the parents and future risk for autism spectrum disorders in the grandchildren may indicate possible transmission of autism spectrum disorder risk across generations.Source: HPCLive (R) Intellisphere, LLC
Older parents, grandparents increase austism risk in kids by up to 50%
In a study published in JAMA Network Open by Dr. Zeyan Liew and colleagues, multiple generations were analyzed for possible associations between autism spectrum disorders and the ages of parents and grandparents using health registry data from Denmark. Other studies have linked older parental age with increased risk for the disorders. However, Dr. Liew and the study team also looked at the ages of grandparents revealing higher risk among grandchildren of maternal grandmothers and grandfathers who were 19 years of age or younger at the time of giving birth to the parents compared to grandchildren of grandparents who were between 25 and 29 years old at the time of giving birth to the parents.Source: United Press International
Psychiatric disorders share an underlying genetic basis
Thomas Fernandez, MD, Assistant Professor in the Child Study Center and of Psychiatry, and Christopher Pittenger, MD, PhD, Associate Professor of Psychiatry, contributed to a paper published in Science that explores the genetic connections between disorders of the brain at a scale that far eclipses previous work on the subject.
How autism may stem from problems with prediction
A ‘predictive coding’ theory of autism suggests that many of the condition’s hallmark traits occur when sensory input overrides expectation in the brain. Yale researchers, Katarzyna Chawarska, James McPartland and Philip Corlett, are featured.Source: Spectrum
College students with autism have high rate of suicidal thoughts
Over the next decade, about 247,000 young adults with autism spectrum disorder (ASD) are expected to enroll in universities, colleges, or technical/vocational schools. Because post-secondary education is expected to present new challenges to individuals with ASD, new scholarship is being conducted to assess how ready post-secondary education is to serve a larger population with ASD.
Study testing first medication to treat symptoms of autism
Dr. Roger Jou, a psychiatrist at the Yale Child Study Center who treats and works with those on the autism spectrum, is testing a new medication, in a nationwide clinical trial, which could become the first drug to increase the ability of young people with autism to connect with others and to overcome the other symptoms of the disorder.Source: The New Haven Register
Twenty years and counting for Women's Health Research at Yale
Women’s Health Research at Yale (WHRY), a self-supporting center within Yale School of Medicine, will celebrate its 20th anniversary in February. With data developed through $5 million in WHRY grants to date, Yale scientists have gone on to secure $95 million in external grants to further their research into women’s health.Source: Medicine@Yale
Multicenter Trial Management Unit Expands the Scope of Research at Yale
In the past, Yale investigators who led multicenter trials had to put together ad hoc study teams, relying on unconnected siloed services to carry out their research. At the end of these trials, these teams, which had compiled so much experience and knowledge, disbanded and their knowledge was lost. This system was inefficient and put Yale at a disadvantage when competing with other institutions for grants for multicenter studies.