Yale/NIDA Neuroproteomics Center Publications

Cover legend: Loss-of-function mutations in the depalmitoylating enzyme palmitoyl protein thioesterase 1 (PPT1) cause a devastating neurodegenerative disease, neuronal ceroid lipofuscinosis (NCL). The substrates of PPT1 are largely unknown, posing a limitation on molecular dissection of disease mechanisms and therapeutic development. This study used Acyl Resin-Assisted Capture and mass spectrometry to identify >100 novel PPT1 substrates with increased in vivo palmitoylation in PPT1-deficient mouse brains, and then validated putative substrates by direct depalmitoylation with recombinant PPT1. These data highlight the role of PPT1 in mediating synapse functions, implicate molecular pathways involved in NCL and advance our understanding of the function of depalmitoylation. The image shows a neuron lacking PPT1, stained for the neuronal marker MAP2 (blue), the synaptic marker synaptophysin (green), and a newly identified PPT1 substrate syncam 2 (red), a synaptic adhesion molecule. For more information see: Gorenberg et al. (2022) Identification of substrates of palmitoyl protein thioesterase 1 highlights roles of depalmitoylation in disulfide bond formation and synaptic function. PLoS Biol. 20(3): e3001590 (PMCID: PMC9004782).

Cover legend: Exosomes comprise a significant class of microvesicular bodies synthesized and secreted by different cell types in many tissues, including brain. Biomolecular cargo in exosomes consist of proteins, lipids, metabolites and microRNAs that reflect the physiological status of the cell-of-origin. The role of exosomes in pathogenesis and disease progression of neurodegenerative disorders is evident from their ability to transport pathogenetic proteins and to communicate signals between different brain cell types. The high sensitivity and specificity of MS/proteomics provides a valuable tool for identifying exosomal biomarker candidates. This review highlights advancements in exosome proteomics and its potential for identifying protein biomarkers for neurodegenerative and neuropsychiatric disorders. Image was created with BioRender.com. For more information see the article: Mathew, B., Mansuri, M.S., Williams, K., Nairn, A.C. (2021) Exosomes as emerging biomarker tools in neurodegenerative and neuropsychiatric disorders – A proteomics perspective. Brain Sciences, 11(2), 258 (PMCID: PMC7922222).

278. Hofford, R.S., Meckel, K.R., Wiser, E.J., Wang, W., Sens, J.P., Kim, M., Godino, A., Lam, T.T., Kiraly, D.D. (2024). Microbiome depletion increases fentanyl self-administration and alters the striatal proteome through short chain fatty acids. eNeuro 11(2): ENEURO.0388-23.2023 (PMCID: PMC10875718).

279. Jiang, C., DiLeone, R.J., Pittenger C., Duman, R.S. (2024) The endogenous opioid system in the medial prefrontal cortex mediates ketamine’s antidepressant-like actions, Translational Psychiatry 14(1): 90 (PMCID: PMC10861497).

280. Johnson, B., Iuliano, M., Lam, T., Biederer, T., De Camilli, P. (2024) A complex of the lipid transport ER proteins TMEM24 and C2CD2 with band 4.1 at cell-cell contacts. J. Cell Biol. 223(11) e202311137 (PMCID: PMC11334333).

281. Lallai, V., Lam, T.T., Garcia-Milian, R., Chen, Y-C. Fowler, J.P., Manca, L., Piomelli, D., Williams, K., Nairn, A., Fowler, C.D. (2024). Proteomic Profile of Circulating Extracellular Vesicles in the Brain after Δ9-Tetrahydrocannabinol Inhalation. Biomolecules 14(9), 1143 (PMCID: PMC11430348 ).

282. Mansuri, M.S., Bathla, S. Lam, T.T., Nairn, A.C., Williams, K., (2024) Optimal conditions for carrying out trypsin digestions on complex proteomes: from bulk samples to single cells, J. Proteomics 297, (PMID: 38325732; PMCID: PMC10939724, available on 2025-04-15).

283. Montalban E, Giralt A, Taing L, Nakamura Y, Pelosi A, Brown M, de Pins B, Valjent E, Martin M, Nairn AC, Greengard P, Flajolet M, Hervé D, Gambardella N, Roussarie JP, Girault JA. (2024) Operant Training for Highly Palatable Food Alters Translating Messenger RNA in Nucleus Accumbens D2 Neurons and Reveals a Modulatory Role of Ncdn. Biol Psychiatry. 95(10):926-937. (PMID: 37579933; PMCID: PMC11059129, available on 2025-05-15).

284. Park, D., Fujise, K., Wu, Y., Lujan, R., Olmo-Cabrera, S., Wesseling, J., De Camilli, P. (2024) Overlapping role of synaptophysin and synaptogyrin family proteins in determining the small size of synaptic vesicles. Proc. Natl. Acad. Sci. 121(29) e2409605121 (PMCID: PMC11260120).

285. Rafiq, N., Fujise, K., Rosenfeld, M., Xu, P., De Camilli, P. (2024) Parkinsonism Sac domain mutation in Synaptojanin-1 affects ciliary properties in iPSC-derived dopaminergic neurons. Proc. Natl. Acad. Sci.121(17): e2318943121 (PMCID: PMC11047088).

286. Reinisch, K.M., Melia, T.J. & De Camilli, P. (2024) Lipid dynamics at membrane contact sites. Ann Rev Biochem. Invited review in press.

287. Ugur, B., Schueder, F., Shin, J., Hanna, M., Wu, Y., Leonzino, M., Su, M., McAdow, A., Wilson, C., Postlethwait, J., Solnica-Krezel, L., Bewersdorf, J., De Camilli, P. (2024) VPS13B is localized at the cis-trans Golgi complex interface and is a functional partner of FAM177A1. J. Cell Biol. in press (bioRxiv. doi: https://doi.org/10.1101/2023.12.18.572081).

262. Amos. C., Xu, P., De Camilli, P., (2023) Erythroid Differentiation Dependent Interaction of VPS13A with XK at the Plasma Membrane of K562 Cells. Contact (Thousand Oaks) 6: 25152564231215133 (PMCID: PMC10748539).

263. Bathla, S., Datta, D., Liang, F., Barthelemy, N., Wiseman, R., Slusher, B.S., Asher, J., Zeiss, C., Ekanayake-Alper, D., Holden, D., Terwilliger, G., Duque, A., Arellano, J., van Dyck, C., Bateman, R.J., Xie, Z., Nairn, A.C., Arnsten, A.FT. (2023) Chronic GCPII (glutamate-carboxypeptidase-II) inhibition reduces pT217Tau levels in the entorhinal and dorsolateral prefrontal cortices of aged macaques. Alzheimers Dement 9(4): e12431. (PMCID: PMC10617575).

264. Ganesh, S. Lam, T.K., Garcia-Milian, R., D’Souza, D., Nairn, A.C., Elgert, K., Eitan, E., Ranganathan, M. (2023) Peripheral signature of altered synaptic integrity in young onset Cannabis Use Disorder: A proteomic study of circulating extracellular vesicles. World J. Biol. Psychiatry 24(7): 603-613 (PMCID: PMC10471733).

265. Guillén-Samander, A., De Camilli, P. (2023) Endoplasmic Reticulum Membrane Contact Sites, Lipid Transport, and Neurodegeneration. Cold Spring Harb. Perspect. Biol. 15(4): a041257. [PMID: 36123033, PMCID: PMC10071438 (available on 2025-04-01).

266. Hanna, M., Guillén-Samander, A. and De Camilli P. (2023) RBG-motif bridge-like lipid transport proteins: structure, functions, and open questions. Ann. Rev. Cell. & Dev. Biol. 39:409-434 (PMID: 37406299).

267. Ketchesin, K.D., Becker-Krail, D.D., Xue, X., Wilson, R.S., Lam, T.T., Williams, K.R., Nairn, A.C., Tseng, G.C., Logan, R.W. (2023) Differential Effects of Cocaine and Morphine on the Diurnal Regulation of the Mouse Nucleus Accumbens Proteome. J. Proteome Res. 22(7): 2377-2390 (PMCID: PMC10392613).

268. Mansuri, M.S., Williams, K., Nairn, A.C. (2023) Uncovering biology by single-cell proteomics. Communications Biology 6: 381 (PMCID: PMC10082756).

269. Martin-Lopez, E., Vidyadhara, D.J., Liberia, T., Meller, S. J., Harmon, L.E., Hsu, R.M., Han, K., Betül Yücel, B., Chandra, S.S. and Greer, C.A. (2023). Alpha-Synuclein pathology and reduced neurogenesis in the olfactory system affect olfaction in a mouse model of Parkinson's disease. J. Neurosci. 43(6) 1051-1071 (Cover article, PMCID: PMC9908323).

270. Maynard, G., Kannan, R., Liu, J., Wang, W., Lam, TKT., Wang, X., Adamson, C., Hackett, C., Schwab, J.M., Liu, C., Leslie, D.P., Chen, D., Marino, R., Zafonte, R., Flanders, A., Block, G., Smith, E., Strittmatter, S.M. (2023) Soluble Nogo-Receptor-Fc decoy (AXER-204) in patients with chronic cervical spinal cord injury in the USA: a first-in-human and randomized clinical trial. Lancet Neurol. 22(8): 672-684. (PMCID: PMC10410101).

271. Montalban, E., Giralt, A., Taking, L., Nakamura, Y., Pelosi, A., Brown, M., de Pins, B., Valjent, E., Martin, M., Nairn, A.C., Greengard, P., Fljolet, M., Herve, D., Gambardella, N., Roussarie, J., Girault, J. (2023) Operant Training for Highly Palatable Food Alters Translating Messenger RNA in Nucleus Accumbens D(2) Neurons and Reveals a Modulatory Role of Ncdn. Biol Psychiatry. 2023. Epub 20230812. doi: 10.1016/j.biopsych.2023.08.006. ( PMID: 37579933; PMCID: PMC11059129, available on 2025-05-15).

272. Ng, X.Y., Wu, Y., Lin, Y., Yaqoob, S.M., Greene, L.E., De Camilli, P., and Cao, M. (2023) Mutations in Parkinsonism-linked endocytic proteins synaptojanin1 and auxilin have synergistic effects on dopaminergic axonal pathology. NPJ Parkinsons Dis., 9(1):26 (PMCID: PMC9932162).

273. Park, D., Wu, Y., Wang, X., Gowrishankar, S., Baublis, A., DeCamilli, P. (2023) Synaptic vesicle proteins and ATG9A self-organize in distinct vesicle phases within synapsin condensates. Nature Commun. 14(1): 455 (PMCID: PMC9884207).

274. Umfress, A., Chakraborti, A., Devi, S., Adams, R., Epstein, D., Massicano A., Sorace A., Singh, S., Hossain, I., Anrabi, S., Crossman D., Kumar N., Mukhar S., Simpson C., Abell K., Stokes M., Widerhold T., Rosen C., Luo H., Lu H., Naterajan A., Bibb, J.A. (2023) Cdk5 mediates rotational force-induced brain injury. Scientific Reports 13(1): 3394 (PMCID: PMC9974974).

275. Vidyadhara, D.J., Somayaji, M., Wade, N., Yücel, B., Zhao, H., Ribaudo, J., Shashaank N., Gupta, J., Lam, T., Sames, D., Greene, L.E., Sulzer, D., Chandra, S.S. (2023). Dopamine transporter and synaptic vesicle sorting defects underlie auxilin-mediated Parkinson’s disease. Cell Reports 42(3): 112231 (PMCID: PMC10127800).

276. Wang, X., Espadas, J., Wu, Y., Cai, S., Ge, J., Shao, L., Roux, A., De Camilli, P. (2023) Membrane remodeling properties of the Parkinson’s disease protein LRRK2. Proc. Natl. Acad. Sci. U. S. A. 120(43): e2309698120 (PMCID: PMC10614619).

277. Yim, Y.Y., Nestler, E.J. (2023) Cell-Type-Specific Neuroproteomics of Synapses. Biomolecules 13(6): 998 (PMCID: PMC10296650).

261. Zhu, B., Li, H., Zhang, L., Chandra, S., Zhao, H. (2022). A Markov random field model-based approach for differentially expressed gene detection from single-cell RNA-seq data. Brief. Bioinform. 23(5): bbac166 (PMCID: PMC9487630).

260. Yang, S., Park, D., Manning,L., Hill, S., Cao, M., Xuan, Z., Gonzalez, I., Dong, Y., Clark, B. Shao, L., Okeke, L., Almoril-Porras, A., Bai, J., De Camilli, P., Colon-Ramos, D., (2022) Presynaptic autophagy is coupled to the synaptic vesicle cycle via ATG-9. Neuron 110(5): 824-840 (PMCID: PMC9017068).

259. Yang, S. and Colón-Ramos, D. (2022) Transmembrane protein ATG-9 links presynaptic autophagy with the synaptic vesicle cycle. Autophagy 18(7): 1746-1747 (PMCID: PMC9298430).

258. Umfress, A., Singh, S., Ryan, K., Yousef, M., Chakraborti, A., Plattner, F., Sonawane, Y., Mallareddy, R., Acosta, E., Natarajan, A., Bibb, J.A. (2022) Systemic administration of a brain permeable Cdk5 inhibitor alters neurobehavior, Frontiers in Pharmacology 13: 863762 (PMCID: PMC9134315).

257. Tieze, S.M., Chandra, S.S., Vidyadhara, D.J. (2022). Subcellular fractionation for isolation of synaptic components from the murine brain. JoVE 187 (PMID: 36190269).

256. Thomas, R., Hernandez, A., Benavides, D.R., Li, W., Tan, C., Umfress, A., Plattner, F., Chakraborti, A., Pozzo-Miller, L., Taylor, S.S., Bibb, J.A. (2022) Integrated regulation of PKA by fast and slow neurotransmission in the nucleus accumbens controls plasticity and stress responses. J. Biol. Chem. 298(8): 102245 (PMCID: PMC9386499).

255. Montalban, E., Giralt, A., Taking, L., Schut, E,, Supiot, L., Castell, L., Nakamura, Y., de Pins, B., Pelosi, A., Goutebroze, L., Tuduri, P., Wang, W., Neiburga, K., Vestito, L., Castel, J., Luquet, S., Nairn, A.C., Hervé, D., Heintz, N., Martin, C., Greengard, P., Valjent, E., Meye, F., Gambardella, N., Roussarie, J., Girault, J. (2022) Translational profiling of mouse dopaminoceptive neurons reveals region-specific gene expression, exon usage, and striatal prostaglandin E2 modulatory effects. Mol. Psychiatry 27(4): 2068-2079 (PMCID: PMC10009708).

254. Mickael, M., Bhaumik, S., Chakraborti, A. Umfress, A., van Groen, T., Macaluso, M., Totenhagen, J., Sorace, A., Bibb, J.A., Standaert, D., Basu, R. (2022) RORγt-expressing pathogenic CD4+T cells cause brain inflammation during chronic colitis, J. Immunol. 208(8): 2054-2066 (PMCID: PMC10103644).

253. Mathew, B., Bathla, S., Williams, K., and Nairn, A.C. (2022) Deciphering spatial protein-protein interactions in brain using proximity labeling approaches. Mol. & Cell. Proteomics 21(11): 100422 (PMCID: PMC9650050).

252. Hanna, M., Suen, P., Wu, Y., Reinisch, K., DeCamilli, P. (2022) SHIP164 is a chorein motif lipid transfer protein that controls endosome–Golgi membrane traffic. J. Cell Biol. 221(6): e202111018 (PMCID: PMC9067936).

251. Hancock-Cerutti, W., Wu, Z., Xu, P., Yadavalli, N., Leonzino, M., Tharkeshwar, A., Ferguson, S.M, Shadel, G.S., De Camilli, P. (2022). ER-lysosome lipid transfer protein VPS13C/PARK23 prevents aberrant mtDNA-dependent STING signaling. J. Cell Biol. 221(7): e202106046 (PMCID: PMC9170524).

250. Guillén-Samander, A., Wu, Y., Pineda, S., García, F., Eisen, J., Leonzino, M., Ugur, B., Kellis, M., Heiman, M., De Camilli, P. (2022) A partnership between the lipid scramblase XK and the lipid transfer protein VPS13A at the plasma membrane. Proc. Natl. Acad. Sci.119(35): e2205425119 (PMCID: PMC9436381).

249. Gorenberg, E., Tieze, S., Yucel, B., Zhao, H., Bishai, J., Chou, V., Wirak, G., Tomita, S., Lam, T.T., Chandra, S.S. (2022) Identification of substrates of palmitoyl protein thioesterase 1 highlights roles of depalmitoylation in disulfide bond formation and synaptic function. PLoS Biol. 20(3): e3001590 (PMCID: PMC9004782).

248. Ge, J., Bian, X., Ma, L., Cai, Y., Li, Y., Yang, J., Erdem, K., De Camilli, P. and Zhang, Y. (2022) Stepwise membrane binding of the C2 domains of the extended synaptotagmins revealed by optical tweezers. Nat. Chem. Biol.18(3): 313-320 (PMCID: PMC8891060).

247. Falahati, H., Wu, Y., Feuerer, V., Simon, H., De Camilli P. (2022) Proximity proteomics of synaptopodin provides insight into the molecular composition of the spine apparatus of dendritic spines. Proc. Natl. Acad. Sci. 119(42): e2203750119 (PMCID: PMC9586327).

246. Cai, S., Wu, Y., Guillén-Samander, A., Hancock-Cerutti, W., Liu, J., De Camilli, P. (2022) In situ architecture of the lipid transport protein VPS13C at ER-lysosome membrane contacts. Proc. Natl. Acad. Sci.119(29): e2203769119 (PMCID: PMC9303930).

245. Brody, A., Nies, S., Guan, F., Smith, L., Mukherjee, B., Salazar, S., Lee, S. Lam, T.T., Strittmatter, S. (2022). Alzheimer risk gene product Pyk2 suppresses Tau phosphorylation and phenotypic effects of tauopathy. Mol. Neurodegeneration 17(1): 32 (PMCID: PMC9063299).

244. Xu, P., Chang, J. Zhou, X., Wang, W., Bamkole, M., Wong, E., Bettayeb, K., Jiang, L., Huang, T., Luo, W., Xu, H., Nairn, A., Flajolet, M., Ip. N., Li, Y., Greengard, P. (2021) GSAP regulates lipid homeostasis and mitochondrial function associated with Alzheimer's disease. J. Exp. Med. 218(8): e20202446. (PMCID: PMC8222926).

243. Salter, C., Cai, Y., Lo, B., Helman, G. et al. (2021) Biallelic PI4KA variants cause neurological, intestinal and immunological disease. Brain 144(12): 3597-3610. (PMCID: PMC8719846).

242. Park, D., Wu, Y., Lee, S.E., Kim, G., Jeong. S., Milovanovic, D., De Camilli, P. and Chang, S. (2021) Cooperative function of synaptophysin and synapsin in the generation of synaptic vesicle-like clusters in non-neuronal cells. Nature Communications 12(1): 263 (PMCID: PMC7801664).

241. Nagayoshi, Y., Chujo, T., Hirata, S., Nakatsuka, H., Chen, C., Takakura, M., Miyauchi, K., Ikeuchi, Y., Carlyle, B., Kitchen, R., Suzuki, T., Katsuoka, F., Yamamoto, M., Goto, Y., Tanaka, M., Natsume, K., Nairn, A., Suzuki, T., Tomizawa, K., Wei, F. (2021) Loss of Ftsj1 perturbs codon-specific translation efficiency in the brain and is associated with X-linked intellectual disability. Sci. Adv. 7(13): eabf3072 (PMCID: PMC7997516).

240. Mathew, B., Mansuri, M.S., Williams, K., Nairn, A.C. (2021) Exosomes as emerging biomarker tools in neurodegenerative and neuropsychiatric disorders – A proteomics perspective. Brain Sciences 11(2): 258 (Journal cover https://www.mdpi.com/2076-3425/11/2, PMCID: PMC7922222).

239. Lopez, A.J., Johnson, A.R., Euston, T., Wilson, R, Nolan, S., Brady, L.J., Thibeault, K.C., Kelly, S., Kondev, V., Melugin, P., Kutlu, M.G., Chuang, E., Lam, T.T., Kiraly, D.D., Calipari, E.S. (2021) Cocaine self-administration induces sex-dependent protein expression in the nucleus accumbens Communications Biology 4(1): 883 (PMCID: PMC828552).

238. Leonzino, M., Reinisch, K., DeCamilli, P. (2021) Insights into VPS13 properties and function reveal a new mechanism of eukaryotic lipid transport. BBA - Molecular and Cell Biology of Lipids 1866: 159003, (PMCID: PMC8325632).

237. Lemos, D., M., Trimbake, N.A., Fan, X, Ram, A., Woods, C., Bobeck, E.N., Schechtman, D., and Devi, L.A. (2021) High throughput screening and validation of antibodies against synaptic proteins to explore opioid signaling dynamics. Comm. Biol. 4(1): 238 (PMCID: PMC7900253).

236. Lee, A.M. and Picciotto, M.R. (2021) Effects of nicotine on DARPP-32 and CaMKII signaling relevant to addiction. Advances in Pharmacology 90: 89-115 (PMCID: PMC8008986).

235. Lee, A.M, Mansuri, S.M., Wilson, R.S., Lam, T.T., Nairn, A.C. and Picciotto, M.R. (2021) Sex differences in the ventral tegmental area and nucleus accumbens proteome at baseline and following nicotine exposure, Frontiers in Molecular Neuroscience 14: 657064 (PMCID: PMC8317211).

234. Hofford, R.S., Euston, T., Peck, E.G., Kutlu, M.G., Meckel, K.R., Wilson, R., Lam, T.T., Calipari, E.S., Kiraly, D.D. (2021). Granulocyte-Colony Stimulating Factor Reduces Cocaine-seeking and Downregulates Glutamatergic Synaptic Proteins in Medial Prefrontal Cortex (2021) J. Neurosci. 41(7): 1553-1565 (PMCID: PMC7896012).

233. Guillén-Samander, A., Leonzino, M., Hanna, M.G., Tang, N., Shen, H., and De Camilli, P. (2021) VPS13D bridges the ER to VPS13D bridges the ER to both mitochondria and peroxisomes via Miro. J. Cell Biol. 220(5): e202010004 (PMCID: PMC8077184).

232. Girault, J. A. and Nairn, A.C. (2021) DARPP-32 40 years later. Advances in Pharmacology 90: 67-87, (PMID: 33706939).

231. Foley, K., McKee, C., Nairn, A.C., Xia, H. (2021) Regulation of Synaptic Transmission and Plasticity by Protein Phosphatase 1. J. Neurosci. 41(14): 3040-3050 (PMCID: PMC8026358).

230. Christensen, K.R., and Nairn, A.C. (2021) cAMP-Regulated phosphoproteins DARPP-32, ARPP16/19, and RCS modulate striatal signal transduction through protein kinases and phosphatases. Advances in Pharmacology 90: 39-65 (PMID: 33706938).

229. Chakraborti, A., Graham, C., Chehade, S., Bru, S., Vashi, B., Umfress, A., Kurup, P., Vickers, B., Chen, A., Telange, R., Berryhill, T., Van Der Pol, W., Powell, M., Barnes, S., Morrow, C., Smith, D., Mukhtar, M., Watts, S., Kennedy, G., Bibb, J. (2021) High Fructose Corn Syrup-Moderate Fat Diet Potentiates Anxio-Depressive Behavior and Alters Ventral Striatal Neuronal Signaling. Frontiers in Neuroscience 15: 669410 (PMCID: PMC8187874).

228. Benedetti, L. (2021) Optogenetic tools for manipulating protein subcellular localization and intracellular signaling at organelle contact sites. Current Protocols 1(3) (PMCID: PMC7954661).

227. Ugur B, Hancock-Cerutti W, Leonzino M, and De Camilli P. 2020. Role of VPS13, a protein with similarity to ATG2, in physiology and disease. Curr. Opin. in Genet. Dev. 65: 61-68 (PMCID: PMC7746581).

226. Smalley, J. Kontou, G., Choi, C., Ren, Q., Albrecht, D., Abiraman, K., Santos, M., Bope, C., Deeb, T., Davies, P., Brandon, N., Moss, S. (2020) Isolation and characterization of multi-protein complexes enriched in the K-CL co-transporter 2 from brain plasma membranes. Front. Mol. Sci. 13: 563091 (PMCID: PMC7643010).

225. Nakamura, Y., Morrow, D.H., Nathanson, A.J., Henley, J.M., Wilkinson, K.A., Moss, S.J. (2020) Phosphorylation on Ser-359 of the a2 subunit in GABA type A receptors down-regulates their density at inhibitory synapses. J. Biol. Chem. 295(35): 12330-12342 (JBC Editor’s Pick Publication (PMCID: PMC7458806).

224. Monsey, M., Ruiz, S.G., Taylor, J.R. (2020) Regulation of garcinol on histone acetylation in the amygdala and on the reconsolidation of a cocaine-associated memory. Frontiers in Behavioral Neurosci. 13: 281 (PMCID: PMC6961612).

223. Moin, A.N., Keip, A.J., Taylor, J.R., Lee, D., Groman, S. (2020) Reinforcement learning during adolescence in rats. J. Neuroscience 40(30): 5857-5870 (PMCID: PMC7380962).

222. Mansuri, S., Peng, G., Wilson, R.S., Lam, T., Zhao, H., Williams, K., Nairn, A.C. (2020) Differential Protein Expression in Striatal D1- and D2-Dopamine receptor-expressing Medium Spiny Neurons. Proteomes 8: 27 (PMCID: PMC7709116).

221. Li, X., Terunuma, M., Deeb, T.G., Wiseman, S., Pangalos, M.N., Nairn, A.C., Moss, S.J., Slesinger, P.A. (2020) Direct interaction of PP2A phosphatase with GABAB receptors alters functional signaling. J. Neurosci. 40(14): 2808-2816 (PMCID: PMC7117905).

220. Jin, J., Bhatti, D.L., Lee, K.W, Medrihan, L., Cheng, J., Wei, J., Zhong, P., Yan, Z., Kooiker, C., Song, C., Ahn, J.H., Obermair, G.J., Lee, A., Gresack, J., Greengard, P., Kim, Y. (2020) Ahnak scaffolds p11/Anxa2 complex and L-type voltage-gated calcium channel and modulates depressive behavior. Mol Psychiatry 25(5): 1035-1049 (PMCID: PMC6692256).

219. Franzen, A., Lam, T., Williams, K., Nairn, A.C., Duman, R., Sathyanesan, M., Kumar, V., Carpenter, L., Sathyanesan, S. (2020) Cerebrospinal Fluid Proteome Evaluation in Major Depressive Disorder by Mass Spectrometry. BMC Psychiatry, 20(1): 481 (PMCID: PMC7528485).

218. Cao, M., Park, D., Wu, Y. and De Camilli P, (2020) Absence of Sac2/INPP5F enhances the phenotype of a Parkinson’s disease mutation of synaptojanin 1. Proc. Natl. Acad. Sci. U.S.A. 117(22): 12428-1434 (PMCID: PMC7275725).

217. Benedetti, L., Marvin, J.S., Falahati, H., Guillén-Samander, A., Looger, L.L., and De Camilli, P. 2020. Optimized Vivid-derived Magnets photodimerizers for subcellular optogenetics in mammalian cells. eLife. 20;9:e63230 DOI: 10.7554/eLife.63230. (PMCID: PMC7735757).

216. Wilson, R. Rauniyar, N., Sakaue, F., Lam, T., Williams, K., Nairn, A. (2019) Development of targeted mass spectrometry-based approaches for quantitation of proteins enriched in the postsynaptic density (PSD), Proteomes Special Issue on Neuroproteomics, 7(2) (PMCID:PMC6630806) (PMID:30986977).

215. Williams, K., Nairn, A. (2019) Editorial for Special Issue: Neuroproteomics, Proteomes Special Issue on Neuroproteomics, Proteomes Special Issue on Neuroproteomics, 7(2) (PMCID:PMC6630506) (PMID: 31159207).

214. Torregrossa, M., MacDonald, M., Stone, K.L., Lam, T.T., Nairn, A.C., Taylor, J.R. (2019) Phosphoproteomic analysis of cocaine memory extinction and reconsolidation in the nucleus accumbens, Psychopharmacology 236(1) 531-543 (PMCID:PMC6374162) (PMID: 30411139).

213. Taguchi, Y.V., Nagy, M., Thrasher, D, Gorenberg, E., Fenton, W., Volpicelli-Daley, L. Horwich, A.L., Chandra, S.S. (2019). Hsp110 disaggregase influences a-synuclein pathology in vivo. Proc. Natl. Acad. Sci. 116(48): 24310-24316. (PMCID:PMC6883785) (PMID:31685606).

212. Sun, E.W., Guillén-Samander, A., Bian, X., Wu, Y., Cai, Y., Messa, M., De Camilli, P. (2019) The lipid transporter TMEM24/C2CD2L is a Ca2+-regulated component of ER-plasma membrane contacts in mammalian neurons. Proc. Nat. Acad. Sci. 116(12):5775-5784 (PMCID:PMC6431226) (PMID:30819882).

211. Rao, V., Zavala, G., Roy, A., Mains, R., Eipper, B. (2019) A pH-sensitive luminal His-cluster promotes interaction of PAM with V-ATPase along the secretory and endocytic pathways of peptidergic cells. J. Cellular Physiology (PMCID:PMC6395498) (PMID: 30317586).

210. Peng, G., Wilson, R., Tang, Y., Lam, T. Nairn, A., Williams, K., Zhao, H. (2018) ProteomicsBrowser: MS/Proteomics Data Visualization and Investigation, Bioinformatics 35(13): 2313-2314 (PMCID: PMC6596887) (PMID: 30462190).

209. Luscher, A., Fröhlich, F., Barisch, C., Littlewood, C., Metcalfe, J., Leuba, F., Palma, A., Pirruccello, M., Cesareni, G., Stagi, M., Walther, T.C., Soldati, T., De Camilli, P. and Swan, L.E. (2019) Lowe syndrome-linked endocytic adaptors direct membrane cycling kinetics with OCRL in Dictyostelium discoideum. Mol Biol Cell. 30: 2268-2282. (PMCID: PMC6743453) (PMID:31216233).

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207. Gunther, E.,Smith, L., Kostylev, M.,Cox, T., Kaufman, A., Lee, S.,Folta-Stogniew, E.,Maynard, G., Um, J., Stagi, M., Heiss, J., Stoner, A., Noble, J., Takahashi, H., Haas,L., Schneekloth, J., Merkel, J., Teran, C., Naderi, Z., Supattapone, S., Strittmatter, S.M. (2019) Rescue of transgenic Alzheimer’s pathophysiology by polymeric cellular Prion Protein antagonists. Cell Reports 26(1) 145-158 (PMCID: PMC6358723 (PMID:30605671.

206. Guillén-Samander, A., Bian, X. and De Camilli, P. (2019) PDZD8 mediates a Rab7 dependent interaction of the ER with late endosomes and lysosomes. Proc. Natl. Acad. Sci. USA. 116: 22619-22623. (PMCID: PMC6842579) PMID:31636202).

205. Chen Y, Youn J, Martinez A, Yang Y, Wu Y, De Camilli P, Fernandez-Busnadiego R, and Wu M. (2019). Dynamic instability of clathrin assembly provides proofreadying control for endocytosis. J. Cell Biol. 218: 3200-3211. (PMCID: PMC6781453) (PMID: 31451612).

204. Bian, X., Zhang. Z., De Camilli, P., Lin, C. (2019) A programmable DNA-origami platform for studying protein-mediated lipid transfer between bilayers. Nature Chem. Biol. 15(8) 830-837 (PMCID:PMC6650167) (PMID: 31320758).

203. Bian, X., De Camilli, P. (2019) In vitro assays to measure the membrane tethering and lipid transport activities of the Extended Synaptotagmins. Methods Mol Biol. 1949:201-212 (PMCID: PMC6481592) (PMID:30790258).

202. Wilson, R.S. and Nairn, A.C. (2018) Making brain proteomics true to type. Nature Biotechnology 36: 149-150 (PMID: 29406511).

201. Wilson, R.S. and Nairn, A.C. (2018) Cell-type-specific proteomics: A neuroscience perspective. Proteomes Special Issue on Neuroproteomics 6(4), 51 (PMCID:PMC6313874) (PMID:30544872)

200. Park, J. (2018) Phosphorylation of the AMPAR-TARP complex in synaptic plasticity. Proteomes Special Issue on Neuroproteomics 6(4), 40 (PMCID:PMC6313930.

199. Milovanovic, D., Wu, Y., Bian, X. De Camilli, P. (2018) A liquid phase of synapsin and lipid vesicles. Science 361, 604-607 (PMCID: PMC6191856) (PMID:29976799).

198. Miller, M., Wilson, R., Lam, T., Nairn, A., Picciotto, M., (2018) Evaluation of the phosphoproteome of mouse alpha 4/beta 2-containing nicotinic acetylcholine receptors in vitro and in vivo. Proteomes Special Issue on Neuroproteomics 6(4) 42 (PMCID: PMC6313896) (PMID: 30326594).

197. Mervosh, N., Wilson, R., Rauniyar, N., Hofford, R., Kutlu, M., Calipari, E., Lam, T. T., Kiraly, D., (2018) Granulocyte-colony stimulating factor alters the proteomic landscape of the ventral tegmental area. Proteomes Special Issue on Neuroproteomics 6(4), 35 (PMCID:PMC6313867) (PMID: 30249060).

196. Luxmi, R., Blaby-Haas, C., Kumar, D., Rauniyar, N., King, S., Mains, R., Eipper, B. (2018) Proteases shape the Chlamydomonas secretome: Comparison to classical neuropeptide processing machinery. Proteomes Special Issue on Neuroproteomics 6(4), 36 (PMCID:PMC6313938) (PMID: 30249063).

195. Li, D., Musante, V., Zhou, W., Picciotto, M.R., Nairn, A.C. (2018) Striatin-1 is a B subunit of protein phosphatase PP2A that regulates dendritic arborization and spine development in striatal neurons. J.Biol.Chem. 293(28):11179-11194 (PMCID: PMC6052221) (PMID: 29802198).

194. Levy, A., Xiao, X., Shaw, J., Devi, S., Katrancha, S., Bennett, A., Greer, C. Howe, J., Machida, K., and Koleske, A. (2018) Noonan Syndrome-Associated SHP2 Dephosphorylates GluN2B to Regulate NMDA Receptor Function. Cell Reports 24, 1523-1535 (PMCID: PMC6234505) (PMID: 30089263).

193. Kumar, N., Leonzino, M., Hancock-Cerutti, W., Horenkamp, F., Li, P., Lees, J., Wheeler, H., Reinish, K., De Camilli, P. (2018) VPS13A and VPS13C are lipid transport proteins differentially localized at ER contact sites. J. Cell Biology 217(10):3625-3639 (PMCID:PMC6168267)(PMID:30093493).

192. Dong, R., Zhu, T., Benedetti, L., Gowrishankar, S., Deng, H., Cai, Y., Wang, X., Shen, K., De Camilli P. (2018) The inositol 5-phosphatase INPP5K participates in the fine control of ER organization J. Cell Biol. 217(10):3577-3592 (PMCID:PMC6168264) (PMID: 30087126).

191. Cijsouw, T., Ramsey, A., Lam, T., Carbone, B., Blanpied, T., Biederer, T. (2018) Mapping the Proteome of the Synaptic Cleft Through Proximity Labeling Reveals New Cleft Proteins. Proteomes Special Issue on Neuroproteomics 6(4), 48 (PMCID:PMC6313906)(PMID:30487426).

190. Carlyle, B.C., Kitchen, R.R., Zhang, J., Wilson, R., Lam, T.T., Rozowsky, J.S., Williams, K., Sestan, N., Gerstein, M.B., Nairn, A.C. (2018) Isoform level interpretation of high-throughput proteomic data enabled by deep integration with RNA-seq. J. Proteome Research 17(10), 3431-3444 (PMCID:PMC6392456) (PMID: 30125121).

189. Bian, X., Saheki, Y., and De Camilli, P. (2018) Ca2+ releases E-Syt1 autoinhibition to couple ER-plasma membrane tethering with lipid transport. EMBO J. 37:219-234 (PMCID: PMC5770786) (PMID:29222176).

188. Bertholomey, M.L., Stone, K.L., Lam, T.T., Bang, S., Wu, W., Nairn, A.C., Taylor, J.R., Torregrossa, M.M. (2018) Phosphoproteomic analysis of the amygdala response to adolescent glucocorticoid exposure reveals G-protein coupled receptor kinase 2 (GRK2) as a target for reducing motivation for alcohol. Proteomes Special Issue on Neuroproteomics 6(4), 41 (PMCID:PMC6313880) (PMID:30322021).

187. Benedetti, L., Barentineb, A., Messa, M., Wheeler, H., Bewersdorf, J., De Camilli, P.(2018) Light-activated protein interaction with high spatial subcellular confinement. Proc. Natl. Acad. Sci. 115(10):E2238-E2245 (PMCID:PMC5877946) (PMID:29463750).

186. Yuan, Q., Ren, C., Xu, W., Petri, B., Zhang, J., Zhang, Y., Kubes, P., Wu, D., Tang, W. (2017) PKN1 Directs Polarized RAB21 Vesicle Trafficking via RPH3A and Is Important for Neutrophil Adhesion and Ischemia-Reperfusion Injury. Cell Reports 19, 2586; published online Epub Jun 20, 2017, (PMCID: PMC5548392) (PMID:28636945).

185. Stefan, C.J., Trimble, W.S., Grinstein, S., Drin, G., Reinisch, K., De Camilli, P., Cohen, S., Valm, A.M., Lippincott-Schwartz, J., Levine, T.P., Iaea, D.B., Maxfield, F.R., Futter, C.E., Eden, E.R., Judith, D., van Vliet, A.R., Agostinis, P., Tooze, S.A., Sugiura, A., McBride, H.M. (2017). Membrane dynamics and organelle biogenesis-lipid pipelines and vesicular carriers. BMC Biol. 15: 102. (PMCID: PMC5663033) (PMID: 29089042).

184. Saheki, Y. and De Camilli, P. (2017) The extended–Synaptotagmins. Biochim. Biophys. Acta 1864(9): 1490-1493 (PMCID:PMC5642939) (PMID: 28363589).

183. Saheki Y, De Camilli P. 2017. Endoplasmic Reticulum-Plasma Membrane Contact Sites. Annual Rev Biochem. 86:659-684 (PMID: 28301744).

182. Musante, V., Li L., Kanyo, J., Lam, T.T., Colangelo, C.M., Cheng, S.K., Brody, H., Greengard, P., Le Novère N., Nairn, A.C. (2017) Reciprocal regulation of ARPP-16 by PKA and MAST3 kinases provides a cAMP-regulated switch in protein phosphatase 2A inhibition. eLife 2017 June 14;6. pii: e24998 (PMCID:PMC5515580) PMID:28613156).

181. Milovanovic, D. and De Camilli, P. (2017) Synaptic vesicles clusters at synapses: a distinct liquid phase? Neuron 93(5): 995-1002 (PMCID: PMC5347463) ( PMID: 28279363).

180. Miller, M.B., Yan, Y., Machida, K., Kiraly, D.D., Levy, A.D., Wu, Y.I., Lam, T.T., Abbott, T., Koleske, A.J., Eipper, B.A., Mains, R.E. (2017) Brain Region and Isoform-Specific Phosphorylation Alters Kalirin SH2 Domain Interaction Sites and Calpain Sensitivity, ACS Chemical Neuroscience 8: 1554-1569 (PMCID: PMC5517348) (PMID: 28418645).

179. Lees, J.A., Messa, M., Sun, W.E., Wheeler, H., Torta, F., Wenk, M.R., De Camilli, P., and Reinisch, K.M. (2017) Lipid transport by TMEM24 at ER-PM contacts regulates pulsatile insulin secretion. Science 355 (6326): 709 (PMCID:PMC5414417) (PMID: 28209843).

178. Gorenberg, E., and Chandra, S.S. (2017). The Role of Co-Chaperones in Synaptic Proteostasis and Neurodegenerative Disease. Frontiers in Neuroscience (Roodveldt, C., Outeiro, T. F., Braun, J.E.A., Eds.) 11: 248 (PMCID: PMC5437171) (PMID:28579939)

177. Carlyle, B., Kitchen, R., Kanyo J., Voss, E., Pletikos, M., Lam, T. T., Gerstein, M., Sestan, N., Nairn, A.C. (2017) A Multiregional Proteomic Survey of the Postnatal Human Brain, Nature Neuroscience 20: 1787-1795 (PMCID:PMC5894337) (PMID: 29184206).

176. Cao, M., Wu, Y., Ashrafi, G., McCartney, A.J., Wheeler, H., Bushong, E.A., Boassa, D., Ellisman, M.H., Ryan, T.A., and De Camilli, P. (2017) Parkinson Sac Domain Mutation in Synaptojanin 1 Impairs Clathrin Uncoating at Synapses and Triggers Dystrophic Changes in Dopaminergic Axons. Neuron 93: 882-896 (PMCID: PMC5340420) (PMID: 28231468).

175. Andrade, E.C., Musante, V., Horiuchi, A., Matsuzaki, H., Harrison, A., Brody, H., Wu, T., Greengard, P., Taylor, J.R. and Nairn, A.C. (2017) ARPP-16 is a striatal-enriched inhibitor of protein phosphatase 2A regulated by microtubule-associated serine/threonine kinase 3 (Mast 3 kinase). J. Neurosci. 37(10): 2709-2722 (PMCID: PMC5354324) (PMID: 28167675).

174. Vishwanatha, K.S., Back, N., Lam, TuKiet T., Mains, R.E., Eipper, B.A. (2016) O-Glycosylation of a Secretory Granule Membrane Enzyme Is Essential for Its Endocytic Trafficking. J. Biol. Chem. 291(18):9835-50. (PMCID: PMC4850319) (PMID: 26961877).

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172. Saheki,Y., Bian,X., Schauder, C.M., Sawaki,Y., Surma, M.A.,Klose, C., Pincet,F., Reinisch,K.M., De Camilli, P. (2016) Control of plasma membrane lipid homeostasis by the extended synaptotagmins, Nature Cell Biology, 18: 504-515 (PMCID:PMC4848133) (PMID: 27065097).

171. Rich, M.T., Abbott, T., Chung, L., Gulcicek E.E., Stone, K.L., Colangelo, C.M., Lam, T.T., Nairn, A.C., Taylor, J.R., Torregrossa, M.M. (2016) Phosphoproteomic Analysis Reveals a Novel Mechanism of CaMKIIa Regulation Inversely Induced by Cocaine Memory Extinction versus Reconsolidation. J. Neuroscience 36(29):7613-27 (PMCID:PMC4951572) (PMID:27445140)

170. Reinisch KM, De Camilli P. (2016) SMP-domain proteins at membrane contact sites: Structure and function. Biochim Biophys Acta (PMCID 1861:924-927 (PMCID:PMC4902782) (PMID: 26686281).

169. Park J., Chávez, A.E., Mineur, Y.S., Morimoto-Tomita, M., Lutzu, S., Kim, K.S., Picciotto, M.R., Castillo P.E., Tomita, S. (2016) CaMKII Phosphorylation of TARP?-8 Is a Mediator of LTP and Learning and Memory. Neuron 92(1):75-83. (PMCID:PMC5059846) (PMID: 27667007).

168. McClure-Begley, T. D., Esterlis, I., Stone, K. L., Lam, T. T., Grady, S.R., Colangelo, C.M., Lindstrom, J.M., Marks, M.J., and Picciotto, M.R. (2016) Evaluation of the Nicotinic Acetylcholine Receptor-Associated Proteome at Baseline and Following Nicotine Exposure in Human and Mouse Cortex. eNeuro 3 (PMCID: PMC4985585) (PMID: 27559543)

167. Hernandez, A., Tan, C., Mettlach, G., Pozo, K., Plattner, F., Bibb (2016) Cdk5 Modulates Long-Term Synaptic Plasticity and Motor Learning in Dorsolateral Striatum. Scientific Reports (Nature) Jul 22; 6:29812 (PMCID:PMC4957238) (PMID:27443506).

166. Henderson, M.X., Wirak; G.S., Zhang, Y., Dai, F., Ginsberg, S.D., Dolzhanskaya, N., Staropoli, J.F., Nijssen, P.C.G., Lam, TuKiet T., Roth, A.F., Davis, N.G., Dawson, G., Velinov, M., Chandra, S.S. (2016) Neuronal ceroid lipofuscinosis with DNAJC5/CSPalpha mutation has PPT1 pathology and exhibit aberrant protein palmitoylation. Acta Neuropathologics 131 (4), 621-37 (PMCID: PMC4791186) (PMID: 26659577).

165. Hardies, K., Cai, Y., Jardel, C., Jansen, A., Cao, M., May, P., Djémié, T., Hachon, Le., Camus, C., Keymolen, K., Deconinck, T., Bhambhani, V., Long, C., Sajan, S., Helbig, K.L., AR working group of the EuroEPINOMICS RES Consortium, Suls, A., Balling, R., Helbig, I., De Jonghe, P., Depienne, C., De Camilli, P., Weckhuysen, S. (2016) Loss of SYNJ1 dual phosphatase activity leads to early onset refractory seizures and progressive neurological decline. Brain 139(Pt 9):2420-30. (PMCID: PMC4995362) (PMID: 27435091)

164. Fleming, M.R., Brown, M.R., Kronengold, J., Zhang, Y., Jenkins, D.P., Barcia, G., Nabbout, R., Bausch, A.E., Ruth, P., Lukowski, R., Navaratnam, D.S. and Kaczmarek, L.K. (2016) Stimulation of Slack K+ channels alters mass at the plasma membrane by triggering disassociation of a phosphatase-regulatory complex. Cell Reports 16: 2281-2288. (PMCID: PMC5123741) (PMID: 27545877).

163. Dong, R., Saheki, Y., Swarup, S., Lucast, L., Harper, J.W., and De Camilli, P. (2016) Endosome-ER contacts control actin nucleation and retromer function through VAP-dependent regulation of PI4P. Cell 166: 408-423. (PMCID: PMC4963242) (PMID: 27419871)

162. Clarke, D., Sethi, A., Li, S., Kumar, S., Chang, R.W., Chen, J., Gerstein, M. (2016) Identifying Allosteric Hotspots with Dynamics: Application to Inter- and Intra-species Conservation. Structure 24, 826-837 (PMCID:PMC4883016) (PMID: 27066750).

161. Baskin JM, Wu X, Christiano R, Oh MS, Schauder CM, Gazzerro E, Messa M, Baldassari S, Assereto S, Biancheri R, Zara F, Minetti C, Raimondi A, Simons M, Walther TC, Reinisch KM, De Camilli P. (2016) The leukodystrophy protein FAM126A (hyccin) regulates PtdIns(4)P synthesis at the plasma membrane. Nat Cell Biol. 18(1):132-8, doi: 10.1038/ncb3271 (PMCID: PMC4689616) (PMID:26571211)

160. Plattner F, Hayashi K, Hernández A, Benavides DR, Tassin TC, Tan C, Day J, Fina MW, Yuen EY, Yan Z, Goldberg MS, Nairn AC, Greengard P, Nestler EJ, Taussig R, Nishi A, Houslay MD, Bibb JA.(2015) The role of ventral striatal cAMP signaling in stress-induced behaviors. Nat Neurosci. 18(8):1094-100. (PMCID:PMC4519694) (PMID:26192746)

159. Nakatsu F, Messa M, Nández R, Czapla H, Zou Y, Strittmatter SM, De Camilli P. (2015) Sac2/INPP5F is an inositol 4-phosphatase that functions in the endocytic pathway. J Cell Biol. 209(1):85-95 (PMCID:PMC4395491) (PMID:25869668).

158. Idevall-Hagren O, and De Camilli P. (2015) Detection and manipulation of phosphoinositides. Biochim. Biophys. Acta. 6: 736-45 (PMCID: PMC4863076) (PMID: 25514766).

157. Gowrishankar S, Yuan P, Wu Y, Schrag M, Paradise S, Grutzendler J, De Camilli P, Ferguson SM. (2015) Massive accumulation of luminal protease-deficient axonal lysosomes at Alzheimer's disease amyloid plaques. Proc Natl Acad Sci U S A. 112(28):E3699-708. (PMCID: PMC4507205) (PMID:26124111)

156. Engmann, O., Giralt, A., Gervasi, N., Marion-Poll, L., Gasmi, L., Filhol, O., Picciotto, M.R., Gilligan, D., Greengard, P., Nairn, A.C., Hervé, D., Girault, J.A. (2015). DARPP-32 interaction with adducin may ediate rapid environment effects on striatal neurons. Nat Commun. 6:10099 | DOI: 10.1038/ncomms100996 (PMCID: PMC4675091) (PMID:26639316)

155. Colangelo, C., Shifman, M., Cheung, K., Stone, K.L., Carriero, N., Gulcicek, E., Lam, T.T., Wu, T., Bjornson, R.D., Bruce, C., Nairn, A.C., Rinehart, J., Miller, P.L., and Williams, K. (2015) YPED: An integrated bioinformatics suite and database for mass spectrometry based proteomics research. Genomics, Proteomics, and Bioinformatics 13, 25-35 (PMCID: PMC4411476) (PMID: 25712262).

154. Colangelo, C., Ivosev, G., Chung, L., Abbott, T., Shifman, M., Sakaue, F., Cox, D., Kitchen, R., Burton, L., Tate, S., Gulcicek, E., Bonner, R., Rinehart, J., Nairn, A., and Williams, K. (2015) Development, Implementation, and Verification of a Targeted Proteome Assay Pipeline. Proteomics 15: 1202-1214 (PMCID: PMC4698340) (PMID: 25476245).

153. Chung J, Torta F, Masai K, Lucast L, Czapla H, Tanner LB, Narayanaswamy P, Wenk MR, Nakatsu F, De Camilli P. (2015) Intracellular Transport. PI4P/phosphatidylserine countertransport at ORP5- and ORP8-mediated ER-plasma membrane contacts. Science 349(6246):428-32 (PMCID: PMC4638224) (PMID: 26206935)

152. Chung, J., Nakatsu, F., Baskin, J.M., De Camilli, P. (2015) Plasticity of PI4KIIIa interactions at the plasma membrane. EMBO Rep. 16(3): 312-20 (PMCID: PMC4364870) (PMID: 25608530).

151. Zhang, Y. and Chandra, S.S. (2014). Oligomerization of Cysteine String Protein alpha mutants causing adult neuronal ceroid lipofuscinosis. Biochim Biophys Acta 1842(11):2136-46 (PMCID: PMC4188699) (PMID:25064588).

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149. Wu, Y., O'Toole, E.T., Girard, M., Ritter, B., Messa, M., Liu, X., McPherson, P., Ferguson, S.M., De Camilli P. (2014) A dynamin 1-, dynamin 3- and clathrin-independent pathway of synaptic vesicle recycling mediated by bulk endocytosis. Elife. 2014 Jun 24; 3:e01621. doi: 10.7554/eLife.01621. (PMCID: PMC4107917) (PMID: 24963135).

148. Wu, X., Chi, R.J., Baskin, J.M., Lucast, L., Burd, C.G., De Camilli, P., and Reinisch, K.M. (2014) Structural insights into assembly and regulation of the plasma membrane phosphatidylinositol 4-kinase complex. Dev. Cell. 28: 19-29 (PMCID: PMC4349574)(PMID: 24360784).

147. Vargas, K.J., Makhani, S., Davis, T., Westphal, C., Castillo, P.E., and Chandra, S.S. (2014). Synucleins regulate the kinetics of synaptic vesicle endocytosis. J. Neuroscience. 34, 9364-9376. (PMCID: PMC4087213) (PMID: 25009269).

146. Uys, JD, PJ Mulholland and DM Townsend (2014) Glutathione and redox signaling in substance abuse. Biomedicine and Pharmacotherapy 68(6): 799-807 (PMCID: PMC4455547) (PMID: 25027386).

145. Shibata, S., Arroyo, J.P., Castañeda-Bueno, M., Puthumana, J., Zhang, J., Uchida, S., Stone, K.L., Lam, T.T., Lifton, R.P. (2014) Angiotensin II signaling via protein kinase C phosphorylates Kelch-like 3, preventing WNK4 degradation. Proc. Natl. Acad. Sci. U S A. 111(43):15556-61 (PMCID: PMC4217463) (PMID: 25313067).

144. Shen, H., Giordano, F., Wu, Y., Chan, J., Zhu, C., Milosevic, I., Wu, X., Yao, K., Chen, B., Baumgart, T., Sieburth, D., De Camilli, P. (2014) Coupling between endocytosis and sphingosine kinase 1 recruitment. Nat. Cell Biol. 16(7): 652-62 (PMCID: PMC4230894) (PMID: 24929359).

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142. Schauder CM, Wu X, Saheki Y, Narayanaswamy P, Torta F, Wenk MR, De Camilli P, and Reinisch, KM. (2014). Structure of a lipid-bound Extended-Synaptotagmin indicates a role in lipid transfer. Nature. 510: 552-555 (PMCID: PMC4135724) (PMID: 24847877).

141. Plattner, F., Hernandéz, A., Kistler, T. M., Pozo, K., Zhong, P., Yuen, E., Hawasli, A., Cooke, S., Tan, C., Guo, A., Weiderhold, T., Yan, Z., Bibb, J.A. (2014) Memory enhancement by targeting Cdk5 regulation of NR2B. Neuron 81: 1070-83 (PMCID: PMC4010123) (PMID:24607229)

140. Pirruccello M, Nandez R, Idevall-Hagren O, Alcazar-Roman A, Abriola L, Berwick SA, Lucast L, Morel D, De Camilli P. Identification of inhibitors of inositol 5-phosphatases through multiple screening strategies. ACS Chem Biol. 2014 Jun 20;9(6):1359-68. (PMCID: PMC4076014) (PMID: 24742366)

139. Nandez R, Balkin DM, Messa M, Paradise S, Czapla H, Hein MY, Mann M, and De Camilli P. (2014) A role of OCRL in clathrin-coated pit fission and uncoating revealed by studies of Lowe syndrome cells. Elife. 2014 Aug 8;3:e02975. doi: 10.7554/eLife.02975 (PMCID: PMC4358339) (PMID: 25107275).

138. Meyer, D., Torres-Altoro, M.I., Tan, Z., Tozzi, A., Di Filippo, M., DiNapoli, V., Plattner, F., Kansy, J.W., Benkovic, S.A., Huber, J., Miller, D.B., Greengard, P., Calibressi, P., Rosen, C.L., Bibb, J.A. (2014) Ischemic stroke injury is mediated by aberrant Cdk5, J. Neurosci., 34(24) 8259-8267. (PMCID: PMC4051977) (PMID: 24920629)

137. Messa, M., Fernández-Busnadiego, R., Sun, E.W., Chen, H., Czapla, H., Wrasman, K., Wu, Y., Ko, G., Ross, T., Wendland, B., De Camilli, P. (2014) Epsin deficiency impairs endocytosis by stalling the actin-dependent invagination of endocytic clathrin-coated pits. Elife. 3:e03311. doi: 10.7554/eLife.03311 (PMCID: PMC4161027) (PMID: 25122462).

136. McClure-Begley T.D., Papke R.L., Stone K.A., Stokes, C., Levy A.D., Gelernter J., Xie P., Lindstrom J.M., Picciotto M.R. (2014) Rare human nicotinic acetylcholine receptor alpha 4 subunit (CHRNA4) variants affect expression and function of high affinity nicotinic acetylcholine receptors. J. Pharmacol. Exp. Therapeutics 348: 410-420 (PMCID: PMC3935145) (PMID: 24385388).

135. Ma, X.M., Miller, M.B., Vishwanatha, K.S., Gross, M., Wang, Y., Abbott, T., Lam, T.T., Mains, R.E., Eipper, B.A. (2014) Non-enzymatic domains of Kalirin7 contribute to spine morphogenesis through interactions with phosphoinositides and Abl. Mol. Biol. Cell 25(9):1458-71 (PMCID: PMC4004595) (PMID: 24600045).

134. Lee, M., Skoura, A., Park, E.J., Landskroner-Eiger, S., Jozsef, L., Luciano, A., Murata, T, Pasula, S., Dong, Y., Bouaouina, M., Calderwood, D., Ferguson, S.M., De Camilli, P., and Sessa, W.C. (2014) Dynamin-2 regulation of integrin endocytosis, but not VEGF signaling, is critical for developmental angiogenesis. Development 141: 1465-1472 (PMCID: PMC3957370) (PMID: 24598168).

133. Kitchen, R.R., Rozowsky, J.S., Gerstein, M.B., and Nairn, A.G. (2014) Decoding neuroproteomics: integrating the genome, translatome, and functional neuroanatomy. Nature Neuroscience 17(11): 1491-1499. (PMCID: PMC4737617) (PMID: 25349915)

132. Idevall-Hagren O and De Camilli P. (2013) Manipulation of plasma membrane phosphoinositides using photoinduced protein-protein interactions. Methods Mol. Biol. 1148:109-148 (PMID: 24718798).

131. Frohlich F, Christiano R, Alcazar-Roman A, De Camilli P, and Walther TC. (2014) A role for eisosomes in maintenance of plasma membrane phosphoinositide levels. Mol. Biol. Cell. 25(18): 2797-806 (PMCID: PMC4161514) (PMID: 25057013).

130. Chung, L, Colangelo, CM, and Zhao, H.(2014) Data Pre-Processing of Label-Free Multiple Reaction Monitoring (MRM) Experiments. Biology (Basel) 3(2):383-402 (PMCID: PMC4085614) (PMID:24905083).

129. Cheadle, L. and Biederer, T. (2014) Activity-dependent regulation of dendritic complexity by Semaphorin 3A through Farp1. Journal of Neuroscience 34:7999-8009 (PMCID: PMC4044256) (PMID:24899721)

128. Cates, H, Thibault, M, Pfau, M, Heller, E, Eagle, A, Gajewski, P, Bagot, R, Colangelo, C Abbott, T, Rudenko, G, Neve, R, Nestler, R, Robison, A. (2014) Threonine 149 Phosphorylation Enhances ?FosB Transcriptional Activity to Control Psychomotor Responses to Cocaine. J. Neuroscience 34(34): 11461-11469 (PMCID: PMC4138349) (PMID: 25143625).

127. Cao, M., Milosevic, I., Giovedi, S., and De Camilli, P. (2014) Up-regulation of Parkin in endophilin mutant mice. J. Neurosci. 34: 16544-16549 (PMCID: PMC4252559) (PMID: 25471590).

126. Zhang, Y., Tang, W., Zhang, H., Niu, X., Xu, Y., Zhang, J., Gao, K., Pan, W., Boggon, T.J., Toomre, D., Min, W., and Wu, D. (2013) A Network of Interactions Enables CCM3 and STK24 to Coordinate UNC13D-Driven Vesicle Exocytosis in Neutrophils. Dev Cell 27: 215-26 (PMCID: PMC3834565) (PMID: 24176643).

125. Wu, M., Wu, X., and De Camilli, P. (2013) Calcium oscillations-coupled conversion of actin travelling waves to standing oscillations. Proc. Natl. Acad. Sci. USA. 4: 1339-1344 (PMCID: PMC3557052) (PMID: 23297209).

124. Wiseman, S.L., Shimizu, Y., Palfrey, H.C. and Nairn, A.C. (2013) Eukaryotic elongation factor-2 kinase (EF2K) is degraded by the proteasome in response to stimulation via the SCFßTRCP ubiquitin E3 ligase. J. Biol. Chem. 288: 17803-17811 (PMCID: PMC3682579) (PMID: 23640883).

123. Westphal, C. and Chandra, S.S. (2013). Monomeric synucleins generate membrane curvature. J. Biol. Chem. 288: 1829-1840 (PMCID: PMC3548493) (PMID: 23184946).

122. Shibata, S., Zhang, J., Puthumana, J., Stone, K.L., and Lifton, R.P. (2013) Kelch-like 3 and Cullin 3 regulate electrolyte homeostasis via ubiquitination and degradation of WNK4. Proc. Natl. Acad. Sci. U.S.A. 110: 7838-7843 (PMCID: PMC3651502) (PMID: 23576762).

121. Shibata, S., Rinehart, J., Zhang, J., Moeckel, G., Castañeda-Bueno, M., Stiegler, A.L., Boggon, T.J., Gamba, G., Lifton, R.P. (2013) Mineralocorticoid receptor phosphorylation regulates ligand binding and renal response to volume depletion and hyperkalemia. Cell Metabolism 18(5): 660-671 (PMCID: PMC3548493, PMID: 24206662).

120. Robison, A.J., Vialou, V., Mazei-Robison, M., Feng, J. Kourrich, S., Collins, M., Wee, S-M., Koob, G., Turecki, G., Neve, R., Thomas, M., Nestler, E. (2013) Behavioral and Structural Responses to Chronic Cocaine Require a Feedforward Loop Involving ?FosB and Calcium/Calmodulin-Dependent Protein Kinase II in the Nucleus Accumbens Shell. J. Neurosci. 33: 4295-4307 (PMCID: PMC3658178) (PMID: 23467346).

119. Park, R., Shen, H., Liu, L., Liu, X., Ferguson, S.M., and De Camilli, P. (2013) Dynamin triple knockout cells reveal off target effects of a commonly used dynamin inhibitor. J. Cell Sci. 126: 5305-5312 (PMCID:PMC3828596) (PMID: 24046449).

118. Newton, S.S., Fournier, N.M., Duman, R.S. (2013) Vascular growth factors in neuropsychiatry. Cell. Mol. Life Sci. 70(10): 1739-52 (PMCID: PMC3951730, PMID: 23475069).

117. McClure-Begley, T., Stone, K.L., Marks, M.J., Grady, S.R., Colangelo, C.M., Lindstrom, J.M., and Picciotto, M.R. (2013) Exploring the nicotinic acetylcholine receptor-associated proteome with iTRAQ and transgenic mice, Genomics, Proteomics & Bioinformatics, 11(4): 207-18 (PMCID: PMC3806329, PMID: 23891776).

116. Krebs CE, Karkheiran S, Powell JC, Cao M, Makarov V, Darvish H, Di Paolo G, WalkerRH, Shahidi GA, Buxbaum JD, De Camilli P, Yue Z, and Paisan-Ruiz C. 2013. The Sac1 domain of SYNJ1 identified mutated in a family with early-onsetprogressive Parkinsonism with generalized seizures. Hum. Mutat. 34: 1200-1207. (PMCID: PMC3790461) (PMID:23804563)

115. Kim, I., Pan, W., Jones, S.A., Zhang, Y., Zhuang, X., and Wu, D. (2013). Clathrin and AP2 are required for PtdIns(4,5)P2-mediated formation of LRP6 signalosomes. J. Cell Biol. 200: 419-428. (PMCID: PMC3575536) (PMID: 23400998).

114. Ivanov, A.R., Colangelo, C.M., Dufresne, C.P., Friedman, D.B., Lilley, K.S., Mechtler, K., Phinney, B.S., Rose, K.L., Rudnick, P.A., Searle, B.C., Shaffer, S.A., Weintraub, S.T. (2013) Interlaboratory studies and initiatives developing standards for proteomics. Proteomics 13(6):904-909 (PMCID: PMC3863631) (PMID: 23319436).

113. Giordano, F., Saheki, Y., Idevall-Hagren, O., Colombo, S.F., Pirruccello, M., Milosevic, I., Gracheva, E.O., Bagriantsev, S.N., Borgese, N., De Camilli, P. (2013) PI(4,5)P2-Dependent and Ca(2+)-Regulated ER-PM Interactions Mediated by the Extended Synaptotagmins. Cell. 153: 1494-1509 (PMCID: PMC3716012) (PMID: 23791178).

112. Devereaux, K., Dall’Armi, C., Alcazar-Roman, A., Ogasawara, Y., Zhou, X., Wang, F., Yamamoto, A., De Camilli, P., and Di Paolo, G. (2013) Regulation of mammalian autophagy by Class II and III Pi 3-kinases through PI3P synthesis. PLOS ONE. 8:e76405. (PMCID: PMC3789715) (PMID:24098492).

111. Destaing, O., Ferguson, S.M., Grichine, A., Oddou, C., De Camilli, P., Albiges-Rizo, C., and Baron, R. (2013) Essential function of dynamin in the invasive properties and actin architecture of v-SRC induced podosomes/invadosomes. PLOS ONE. 10: e77956. (PMCID: PMC3857171) (PMID: 24348990).

110. Craft, G.E., Chen, A., Nairn, A.C. (2013) Recent Advances in Quantitative Neuroproteomics. Methods (Elsevier) issue on Quantitative Proteomics 61(3) 186-218 (PMCID: PMC3891841) (PMID: 23623823).

109. Colangelo CM, Chung L, Bruce C, Chung KH (2013) Review of Software Tools for Design and Analysis of Large scale MRM Proteomic Datasets in Methods (Elsevier) issue on Quantitative Proteomics 61(3): 287-98 (PMCID:PMC3775261) (PMID: 23702368).

108. Cai X, Xu Y, Cheung AK, Tomlinson RC, Alcazar-Roman A, Murphy L. Billich A,Zhang B, Feng Y, Klumpp M, Rondeau JM, Fazal AN, Wilson CJ, Myer V, JobertyG, Bouwmeester T, Babow MA, Finan PM, Porter JA, Ploegh HL, Baird D, DeCamilli P, Tallarico JA, and Huang Q. (2013) PIKfyve, a Class III PI kinase, is the target of the small molecular IL-12/IL-23 inhibitor apilimod and a player in toll-likereceptor signaling. Chem. Biol. 20: 912-921 (PMCID: PMC4878021) (PMID:23890009)

107. Bruce, C., Stone, K., Gulcicek, E., and Williams, K. (2013) Proteomics and the Analysis of Proteomic Data: 2013 Overview of Current Protein-Profiling Technologies. Current Protocols Bioinformatics 41:13.21.1-13.21.17. (PMCID: PMC3688054) (PMID: 23504934).

106. Armbruster M, Messa M, Ferguson SM, De Camilli P, and Ryan TA. (2013) Dynamin phosphorylation controls optimization of endocytosis for brief action potential bursts. eLife, e00845. (PMCID: PMC3728620) (PMID: 23908769).

105. Antinone, S.E., Ghadge, G.D., Lam, T., Roos, R., and Green, W.N. (2013) Human Superoxide Dismutase (SOD1) is palmitoylated and familial ALS-linked SOD1 mutants are abnormally palmitoylated. J. Biol. Chem. 288: 21606-17 (PMCID: PMC3724620) (PMID: 23760509).

104. Zhang,Y., Henderson, M.X., Colangelo, C.M., Ginsberg, S., Bruce, C., Wu, T., and Chandra, S.S. (2012) Identification of CSPa clients reveals a role in dynamin 1 regulation. Neuron 74(1):136-50. (PMCID: PMC3328141) (PMID: 22500636) (YPED Repository).

103. Wu, M., and De Camilli, P. (2012) Supported native plasma membranes as platforms for reconstitution and visualization of endocytic membrane budding. in Lipids, Methods in Cell Biology (Wenk, M.R., Di Paolo, G., eds) Academic Press, volume 108:3-18. (PMID: 22325595) .

102. Sousa, L., Lax, I., Shen, H., Ferguson, S.M., De Camilli, P., and Schlessinger, J. (2012) Suppression of EGFR endocytosis by dynamin depletion reveals that EGFR signaling occurs primarily at the plasma membrane. Proc. Nat. Acad. Sci. 109:4419-2 (PMCID: PMC3311323) (PMID: 22371560) .

101. Shen H, Pirruccello M and De Camilli P. (2012) SnapShot: Membrane Curvature Sensors and Generators. Cell. 150: 1300-1300.e2 doi.1016/j.cell.2012.08.017. (PMID: 22980986).

100. Sathyanesan, M., Girgenti, M.J., Banasr, M., Stone, K., Bruce, C., Guilchicek, E., Wilczak-Havill, K., Nairn, A., Williams, K., Sass, S., Duman, J.G., Newton, S.S. (2012) A molecular characterization of the choroid plexus and stress-induced gene regulation. Transl Psychiatry 2(7): e139. (PMCID: PMC3410626) (PMID: 22781172) (YPED Repository).

99. Saheki, Y., and De Camilli, P. (2012) Synaptic vesicle endocytosis in The Synapse. (M. Sheng, B. Sabatini, and T.C. Südhof eds) Cold Spring Harb. Perspect. Biol. 4: a005645. doi: 10.1101/cshperspect.a005645. (PMCID: PMC3428771)(PMID: 22763746).

98. Rodriguez L, Simeonato E, Scimeni P, Anselmi F, Cali B, Crispino G, Ciubotaru CB, Bortolozzi M, Ramiro FG, Majumder P, Arslan E, De Camilli P, Pozzan T, and Mammano F. (2012). Reduced phosphatidylinositol 4,5-bisphosphate synthesis impairs inner ear Ca2+ signaling and high frequency hearing acquisition. Proc. Natl. Acad. Sci. 109: 14013-14018. (PMCID: PMC3435166) (PMID: 22891314).

97. Pirruccello, M., and De Camilli, P. (2012) The Inositol 5-phosphatases: insights from the Lowe Syndrome Protein OCRL. Trends. Biochem. Sci. 37(4):134-143. (PMCID: PMC3323734) (PMID: 22381590).

96. Nakatsu, F., Baskin, J.M., Chung, J., Tanner, L.B., Shui, G., Lee, S.Y., Pirruccello, M., Hao, M., Ingolia, N.T., Wenk, M.R., and De Camilli, P. (2012). PtdIns4P synthesis at the plasma membrane and its impact on PtdIns(4,5)P2 dynamics to control plasma membrane identity. J. Cell Biol. 199: 1003-1016. (PMCID: PMC3518224) (PMID: 23229899).

95. Lou, X, Fan F, Messa M, Raimondi A, Wu Y, Looger LL, Ferguson SM, De Camilli P. (2012) Reduced release probability prevents vesicle depletion and transmission failure at dynamin mutant synapses. Proc Natl Acad Sci 109(8):E515-23. (PMCID: PMC3286982) (PMID:22308498).

94. Idevall-Hagren O, Dickson EJ, Hille B, Toomre DK, and De Camilli P. (2012) Optogenetic control of phosphoinositide metabolism. Proc. Natl. Acad. Sci. 109: 2316-2323. (PMCID: PMC3435206, PMID: 22847441).

93. Ferguson, S.M., and De Camilli, P. (2012) Dynamin, a membrane-remodeling GTPase. Nature Rev. Mol. Cell Biol. 13: 75-88. (PMCID: PMC3519936) (PMID: 22233676).

92. Clarke, D., Bhardwaj, N., Gerstein, M.B. (2012) Novel insights through the integration of structural and functional genomics data with protein networks. J Struct Biol 179: 320-326. (PMCID: PMC4830681, PMID: 22343087).

91. Cheadle, L., Biederer, T. (2012) The novel synaptogenic protein Farp1 links postsynaptic cytoskeletal dynamics and transsynaptic organization. J Cell Biol. 199: 985-1001. (PMCID: PMC3518221, PMID: 23209303).

90. Yip, K.Y., Utz, L., Sitwell, S., Hu, X., Sidhu, S.S., Turk, B.E., Gerstein, M., Kim, P.M. (2011) Identification of specificity determining residues in peptide recognition domains using an information theoretic approach applied to large-scale binding maps. BMC Biology 9:53. (PMCID: PMC3224579) (PMID: 21835011).

89. Shen, H., Ferguson, S.M., Dephoure, N., Park, R., Volpicelli-Daley, L., Gygi, S., Schlessinger, J., and De Camilli P. (2011) Constitutive activated Cdc42-associated kinase (Ack) phosphorylation at arrested endocytic clathrin-coated pits of cells that lack dynamin. Mol Biol Cell. 22(4): 493-502. (PMCID: PCM3038647) (PMID: 21169560).

88. Rozowsky, J. , Abyzov, A., Wang, J., Alves, P., Raha, D., Harmanci, A., Leng, J., Bjornson, R., Kong, Y., Kitabayashi, N., Bhardwaj, N., Rubin, M., Snyder, M., Gerstein, M. (2011) AlleleSeq: analysis of allele-specific expression and binding in a network framework. Molecular Systems Biology 7:522. (PMCID: PMC3208341) (PMID: 21811232).

87. Rinehart J, Vazquez N, Kahle KT, Hodson CA, Ring AM, Gulcicek EE, Louvi, A., Bobadilla, N., Gamba, G., and Lifton, R.P. (2011) WNK2 kinase is a novel regulator of essential neuronal cation-chloride cotransporters. J. Biol. Chem. 286: 30171-30180. (PMC: PMC3191056) (PMID: 21733846).

86. Raimondi, A., Ferguson, S.M., Lou, X., Armbruster, M., Paradise, S., Giovedi, S., Messa, M., Kono, N., Takashi, J., Cappello, V., O’Toole, E., Ryan, T.A., and De Camilli, P. (2011) Overlapping role of dynamin isoforms in synaptic vesicle endocytosis. Neuron 70:1100-1114. (PMCID: PMC3190241) (PMID: 21689597).

85. Pirruccello, M., Swan, L.E., Folta-Stogniew, E., and De Camilli, P. (2011) Recognition of the F&H motif by the Lowe Syndrome protein OCRL. Nat Struct Mol Biol. 2011 18(7):789-795. (PMCID: PMC3130824) (PMID: 21666675).

84. Milosevic, I., Giovedi, S., Lou, X., Raimondi, A., Collesi, C., Paradise, S., O’Toole, E., Ferguson, S., Cremona, O., DeCamilli, P. (2011) Recruitment of endophilin to clathrin coated pit necks is required for uncoating but is dispensable for fission. Neuron 72: 587-601. (PMCID: PMC3258500) (PMID: 22099461).

83. Luo, R. and Zhao H. (2011). Bayesian hierarchical modeling for signaling pathway inference from single cell interventional data. Annals of Applied Statistics, Ann Appl Stat. 5(2A):725–745. (PMCID: PMC3233205) (PMID: 22162986).

82. Kiraly, D.D., Stone, K.L., Colangelo, C.M., Abbott, T., Wang, Y., Mains, R.E., Eipper, B.A. (2011). Identification of Kalirin-7 as a Potential Post-Synaptic Density Signaling Hub. J Proteome Res. 10(6):2828-2841. (PMCID: PMC3107868) (PMID: 21488700).

81. Gianoulis, T.A., Agarwal, A., Snyder, M., Gerstein, M.B. (2011) The CRIT framework for identifying cross patterns in systems biology and application to chemogenomics. Genome Biology, 12:R32. (PMCID: PMC3129682) (PMID: 21453526).

80. Bordner, K.A., George, E.D., Carlyle, B.C., Duque, A., Kitchen, R.R., Lam, T.T., Colangelo, C.M., Stone, K.L., Abbott, T.B., Mane, S.M., Nairn, A.C., Simen, A.A. (2011) Functional genomic and proteomic analysis reveals disruption of myelin related genes and translation in a mouse model of early life neglect. Front Psychiatry. 2:18. (PMCID: PMC3098717) (PMID: 21629843) (YPED Repository).

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78. Yim, Y.I., Sun, T., Wu, L.G., Raimondi, A., De Camilli, P., Eisenberg, E., Greene, L.E. (2010) Endocytosis and clathrin-uncoating defects at synapses of auxilin knockout mice. Proc Natl Acad Sci 2;107(9):4412-7. (PMCID: PMC2840126) (PMID:20160091).

77. Xu, W., Wang, P., Petri, B., Zhang, Y., Tang, W., Sun, L., Kress, H., Mann, T., Shi, Y., Kubes, P., Wu, D. (2010) Integrin-induced PIP5K1C kinase polarization regulates neutrophil polarization, directionality, and in vivo infiltration. Immunity 33(3):340-50. (PMCID: PMC2947797) (PMID:20850356).

76. Wu, M., Huang, B., Graham, M., Raimondi, A., Heuser, J.E., Zhuang, X., De Camilli, P. (2010) Coupling between clathrin-dependent endocytosis budding and F-BAR-dependent tubulation in a cell-free system. Nat. Cell Bio. 9: 902-908. (PMCID: PMC3338250) (PMID: 20729836).

75. Volpicelli-Daley, L.A., Lucast, L., Gong, L.W., Sasaki, J., Sasaki, T., Abrams, C.S., Kanaho, Y., and De Camilli P. (2010) Phosphatidylinositol 4-phosphatase 5-kinases and phosphatidylinositol 4,5-bisphosphate synthesis in the brain. J. Biol. Chem. 285: 28708-28714. (PMCID: PMC2937898) (PMID: 20622009).

74. Swan, L.E., Tomasini, L., Pirruccello, M., Lunardi, J., and De Camilli, P. (2010) Two closely related endocytic proteins that share a common OCRL binding motif with APPL1. Proc. Nat. Acad. Sci. 107: 3511-16. (PMCID: PMC2840420) (PMID: 20133602).

73. Sumioka A, Yan D, Tomita S. (2010). TARP phosphorylation regulates synaptic AMPA receptors through lipid bilayers. Neuron 66: 755-67. (PMCID: PMC2887694) (PMID: 20547132).

72. Rajagopal, C., Stone, K., Mains, R., and Eipper, B. (2010) Secretion Stimulates Intramembrane Proteolysis of a Secretory Granule Membrane Enzyme. J. Biol. Chem. 285: 34632-42. (PMCID: PMC2966079) (PMID: 20817724) (YPED Repository).

71. Nakatsu F, Perera R, Lucast L, Zoncu R, Domin J, Gertler F, Toomre D, and De Camilli P. (2010) Dual role of the inositol 5-phosphatase SHIP2 in clathrin-coated pit dynamics and signaling. J. Cell Biol. 190: 307-315. (PMCID: PMC2922640) (PMID: 20679431).

70. Lam, H.Y.K., Kim, P.M., Tonikian, R., Mok J., Turk, B., Bader, G., Boone. C., Snyder, M., Gerstein, M.B. (2010) MOTIPS: An Automated Motif Analysis Pipeline for Predicting Targets of Modular Protein Domains, BMC Bioinformatics 11: 243. (PMCID: PMC2882932) (PMID: 20459839).

69. Hu, F., Padukkavidana, T., Vægter, C.B., Brady, O.A., Zheng, Y., Mackenzie, I.R., Feldman, H.H., Nykjaer, A., Strittmatter, S.M. (2010) Sortilin-Mediated Endocytosis Determines Levels of the Fronto-Temporal Dementia Protein, Progranulin. Neuron 68: 654-667. (PMCID: PMC2990962) (PMID: 21092856).

68. Gimbel, D.A., Nygaard, H.B., Coffey, E.E., Gunther, E.C., Lauren, J., Gimbel, Z.A., Strittmatter, S.M. (2010) Memory Impairment in Transgenic Alzheimer Mice Requires Cellular Prion Protein. J. Neurosci, 30: 6367-6674. (PMCID: PMC3323924) (PMID: 20445063).

67. Fogel, A.I., Li, Y., Wang, Q., Lam, T.T., Modis, Y. and Biederer, T. (2010) N-Glycosylation at the SynCAM immunoglobulin interface modulates synaptic adhesion. J. Biol. Chem. 285: 34864-34874 (featured on cover). (PMCID: PMC2966101) (PMID: 20739279).

66. Alexander, J.K., Govind, A.P., Drisdel, R.C., Blanton, M.P., Vallejo, Y., Lam, T.T. and Green, W.N. (2010) Palmitoylation of Nicotinic Acetylcholine Receptors. J. Molec. Neurosci. 40:12-20. (PMCID: PMC3523180) (PMID: 19693711).

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