W.M. Keck Biotechnology Resource Laboratory

The Keck Biotechnology Resource Laboratory provides genomic, proteomic, biostatistical, bioinformatics, and high performance computing technologies to hundreds of Yale and non-Yale investigators. The 8 Keck Resources provide a wide range of syntheses and analyses that include gene expression and SNP genotyping using microarray technologies, oligo synthesis, DNA sequencing, biophysical analysis of proteins and other biopolymers, biostatistical and bioinformatics analyses, mass spectrometry (MS), protein profiling, and high performance computing.

Keck Cores

Keck Bioinformatics Resource
Software support; consultation on DNA/protein sequence, microarray, protein structure, and pathway analysis; and collaboration.
Keck Biophysical Resource
Resources to study the oligomeric state of biomolecular assemblies as well as the thermodynamics and kinetics of macromolecular interactions.
Keck Biostatistics Resource
Consultation related to statistical and computational analysis of various types of biological and biomedical data, such as gene expression, genotyping, mass spectrometry, and next-generation sequencing.
Keck DNA Sequencing Facility
Keck DNA Sequencing provides Sanger sequencing and other services, with costs starting as low as $1.99/well and $3.50/tube submission. Sequencing is performed using Thermo Fisher technologies.
Keck Mass Spectrometry & Proteomics Resource
Efficient and cost-effective proteomics and state-of-the-art small-molecule mass spectrometry-based services.
Keck Microarray Shared Resource
Microarray platforms available for high-throughput gene-expression detection.
Keck Oligo Synthesis Resource
High-quality, timely DNA and RNA synthesis in individual tubes or plates.
Yale NIDA Neuroproteomics Center
Cutting edge proteomic technologies to analyze neuronal signal transduction mechanisms and the adaptive changes that occur in response to drugs of abuse.

Contact

Amy Blanchard, Director of Research Cores, Yale School of Medicine

amy.blanchard@yale.edu